I-Wholesale Yokudla Ibanga Lobuningi I-Pranlukast Powder Ngenani Elingcono Kakhulu
Incazelo Yomkhiqizo
I-Pranlukast iyisidakamizwa somlomo esilwa nokungezwani nomzimba ikakhulukazi esisetshenziselwa ukwelapha izifo ezingezwani nomzimba, ikakhulukazi i-rhinitis engezwani ne-allergic kanye nesifuba somoya. I-leukotriene receptor antagonist ekhethiwe engakwazi ukuvimba ngempumelelo imiphumela ye-leukotrienes, ngaleyo ndlela inciphise ukungezwani komzimba nokuvuvukala.
Izici Eziyinhloko kanye Nemisebenzi
1. Indlela:I-Pranlukast ikhetha ukulwa nama-CysLT1 receptors, ivimbele ukuminyana komzila womoya, ukukhishwa kwamafinyila kanye nokwanda kokungena kwemithambo okubangelwa ama-leukotrienes (njenge-cysteine leukotrienes), ngaleyo ndlela kudambise izimpawu zokungezwani nomzimba nokuhlasela kwesifuba somoya.
2. Izinkomba:
- I-Allergic rhinitis:Isetshenziselwa ukukhulula izimpawu ezifana nokucinana kwamakhala, ikhala eligijimayo, ukuthimula, njll. okubangelwa impova, izibungu zothuli, njll.
- Isifuba somoya:Njengokwelashwa okungeziwe kwesifuba somoya, kuyasiza ukulawula izimpawu zesifuba somoya futhi kunciphise imvamisa yokuhlaselwa.
3. Ifomu lomthamo:I-Pranlukast ivame ukutholakala ngendlela yamaphilisi omlomo, iziguli ezingawathatha ngokweseluleko sikadokotela.
Sengiphetha, i-Pranlukast iyisidakamizwa esiphumelelayo sokulwa nokungezwani komzimba, ikakhulukazi esetshenziselwa ukwelapha i-rhinitis engezwani ne-asthma, enciphisa ukungezwani komzimba nokuvuvukala ngokuphikisana nama-leukotriene receptors. Uma uyisebenzisa, kufanele ulandele isiqondiso sikadokotela ukuze uqinisekise ukuphepha nokusebenza.
I-COA
| Izinto | Imininingwane | Imiphumela |
| Ukubukeka | Impushana emhlophe noma emhlophe | Impushana Emhlophe |
| I-HPLC Identification | Ngokuhambisana nereferensi isikhathi sokugcina isiqongo esiyinhloko | Kuyavumelana |
| Ukuzungezisa okuqondile | +20.0.-+22.0. | +21. |
| Izinsimbi ezinzima | ≤ 10ppm | <10ppm |
| PH | 7.5-8.5 | 8.0 |
| Ukulahlekelwa ekomisweni | ≤ 1.0% | 0.25% |
| Ukuhola | ≤3ppm | Kuyavumelana |
| I-Arsenic | ≤1ppm | Kuyavumelana |
| I-Cadmium | ≤1ppm | Kuyavumelana |
| I-Mercury | ≤0. 1 ppm | Kuyavumelana |
| Iphoyinti lokuncibilika | 250.0℃~265.0℃ | 254.7 ~ 255.8℃ |
| Izinsalela ekushiseni | ≤0. 1% | 0.03% |
| IHydrazine | ≤2ppm | Kuyavumelana |
| Ukuminyana ngobuningi | / | 0.21g/ml |
| Ukuminyana okuthenjiwe | / | 0.45g/ml |
| I-Assay (Pranlukast) | 99.0%~ 101.0% | 99.62% |
| Izibalo eziphelele ze-aerobes | ≤1000CFU/g | <2CFU/g |
| Isikhunta & Imvubelo | ≤100CFU/g | <2CFU/g |
| E.coli | Okubi | Okubi |
| I-Salmonella | Okubi | Okubi |
| Isitoreji | Gcina endaweni epholile neyomile, vikela ukukhanya okuqinile. | |
| Isiphetho | Ufanelekile | |
Umsebenzi
I-Pranlukast iyisidakamizwa somlomo esilwa nokungezwani nomzimba ikakhulukazi esetshenziselwa ukwelapha isifuba somoya kanye ne-rhinitis. I-leukotriene receptor antagonist ekhethiwe evimbela ngokuphumelelayo imiphumela ye-leukotrienes, ngaleyo ndlela inciphise izimpawu ezihambisana nokungezwani komzimba nesifuba somoya. Okulandelayo imisebenzi eyinhloko ye-Pranlukast:
1. Umphumela wokuqeda ukuvuvukala:I-Pranlukast isiza ukulawula izimpawu zesifuba somoya ngokuvimbela imiphumela ye-leukotrienes nokunciphisa impendulo yokuvuvukala emigwaqweni yomoya.
2. Thuthukisa umsebenzi wokuphefumula:Ngokunciphisa ukuvinjelwa nokuvuvukala kwemigudu yomoya, i-Pranlukast ingathuthukisa umsebenzi wokuphefumula weziguli ezinesifuba somoya futhi inciphise ukuvela kokuphefumula kanye nobunzima bokuphefumula.
3. Ehlisa izimpawu zokungezwani komzimba nezinto ezithile:I-Pranlukast iphinde isetshenziselwe ukwelapha i-rhinitis ye-allergic futhi ingadambisa izimpawu zokungezwani komzimba njengokuminyana emakhaleni, ikhala eligijimayo, ukuthimula, njll.
4. Ukuvimbela Ukuhlaselwa Kwesifuba Somoya:Ukusetshenziswa isikhathi eside kwe-Pranlukast kungasiza ekuvimbeleni ukuhlaselwa kwesifuba somoya okunamandla, ikakhulukazi ezigulini ezinesifuba somoya esibangelwa ukuvivinya umzimba.
5. Ukusetshenziswa okuhlangene nezinye izidakamizwa:I-Pranlukast ingasetshenziswa ngokuhambisana nezinye izidakamizwa zokulwa nesifuba somoya (njenge-corticosteroids ehogelwe) ukuze kuthuthukiswe umphumela wokwelapha.
Ngamafuphi, umsebenzi oyinhloko we-Pranlukast ukukhulula izimpawu zesifuba somoya kanye ne-rhinitis engezwani nomzimba kanye nokwenza ngcono izinga lempilo yeziguli ngokuphikisa ama-leukotriene receptors. Uma uyisebenzisa, kufanele ulandele isiqondiso sikadokotela ukuze uqinisekise ukuphepha nokusebenza.
Isicelo
Ukusetshenziswa kwe-Pranlukast kugxile kakhulu ekwelapheni izifo ezihlobene nokungezwani komzimba, okuhlanganisa izici ezilandelayo:
1. I-Allergic rhinitis:I-Pranlukast isetshenziselwa ukukhulula izimpawu ze-rhinitis engezwani ne-allergies ebangelwa impova, izibungu zothuli, isikhumba sezilwane, njll., njengokuminyana emakhaleni, ikhala eligijimayo, ukuthimula kanye nokuluma emakhaleni. Inciphisa ukusabela kokuvuvukala komgodi wamakhala ngokuphikisana nemiphumela ye-leukotrienes.
2. Isifuba Somoya:I-Pranlukast isetshenziswa njengokwelashwa okungeziwe kwesifuba somoya ukusiza ukulawula izimpawu zesifuba somoya kanye nokunciphisa imvamisa nokuqina kokuhlaselwa yisifuba somoya. Ingasetshenziswa ngokuhambisana nezinye izidakamizwa zokulwa nesifuba somoya (njenge-corticosteroids ehogeliwe nama-bronchodilators) ukuze kuthuthukiswe umphumela wokwelapha.
3. I-Bronchoconstriction Ebangelwa Ukuzivocavoca:I-Pranlukast ingasetshenziswa futhi ezimweni ezithile ukuvimbela i-bronchoconstriction ebangelwa ukuvivinya umzimba, ukusiza abagijimi nabantu abakhuthele ukulawula izimpendulo zabo zendlela yomoya ngaphambi kokuzivocavoca.
4. Izifo Ezingamahlalakhona Ezingezwani Nezinto:I-Pranlukast ingase futhi ibhekwe njengengxenye yohlu lwemithi yokwelapha ekulawuleni ezinye izifo ezingamahlalakhona zokungezwani komzimba nezinto ezithile.
Ukusetshenziswa
I-Pranlukast ivamise ukutholakala iwuhlobo lwamaphilisi omlomo, okumele iziguli zizithathe ngokweseluleko sikadokotela wazo, ngokuvamile kanye ngosuku.
Amanothi
Lapho zisebenzisa i-Pranlukast, iziguli kufanele zitshele udokotela wazo uma zinezinye izinkinga zempilo noma zisebenzisa eminye imithi ukuze zigweme ukusebenzisana kwezidakamizwa okungase kube khona. Ukwengeza, nakuba i-Pranlukast ingasiza ekulawuleni ukungezwani komzimba nezimpawu zesifuba somoya, akuhloselwe ukwelapha ukuhlasela kwesifuba somoya okunzima.
Sengiphetha, i-Pranlukast iyisidakamizwa esiphumelelayo sokulwa nokungezwani komzimba, esisetshenziswa kabanzi ekwelapheni i-rhinitis engezwani ne-asthma, esiza iziguli ukuba zithuthukise izinga lempilo yazo. Uma uyisebenzisa, kufanele ulandele isiqondiso sikadokotela ukuze uqinisekise ukuphepha nokusebenza.
Iphakheji Nokulethwa
