I-Terbinafine Hydrochloride High Purity API Material CAS 78628-80-5
Incazelo Yomkhiqizo
I-Terbinafine Hydrochlorideumuthi we-antifungal osetshenziselwa ukwelapha izifo ezahlukahlukene. Ngokuvamile kusesimweni samaphilisi noma okhilimu. I-terbinafine hydrochloride umuthi osebenzayo we-antifungal osetshenziselwa ukwelapha izifo ezihlukahlukene zesikhunta. Kungakhathaliseki ukuthi ukhuluma nonyawo lomsubathi noma izifo ezithinta izinzipho zesikhunta, lo muthi usebenza ngokuvimbela ukukhiqizwa kwe-ergosterol futhi unikeza izinketho zombili zohlelo lokusebenza lwezihloko nelomlomo ukuze kube lula nokusebenza.
I-COA
| IZINTO | IZINGA | UMPHUMELA WOKUHLOLA |
| Isivivinyo | 99% | Kuyavumelana |
| Umbala | Impushana emhlophe | Kuyavumelana |
| Iphunga | Alikho iphunga elikhethekile | Kuyavumelana |
| Usayizi wezinhlayiya | I-100% idlula i-80mesh | Kuyavumelana |
| Ukulahlekelwa ekomisweni | ≤5.0% | 2.35% |
| Izinsalela | ≤1.0% | Kuyavumelana |
| Insimbi enzima | ≤10.0ppm | 7 ppm |
| As | ≤2.0ppm | Kuyavumelana |
| Pb | ≤2.0ppm | Kuyavumelana |
| Izinsalela zezibulala-zinambuzane | Okubi | Okubi |
| Inani lepuleti eliphelele | ≤100cfu/g | Kuyavumelana |
| Imvubelo & Isikhunta | ≤100cfu/g | Kuyavumelana |
| E.Coli | Okubi | Okubi |
| I-Salmonella | Okubi | Okubi |
| Isiphetho | Vumelanisa ne-Specification | |
| Isitoreji | Igcinwe Endaweni Epholile Neyomile, Zigcine Kude Nokukhanya Okuqinile Nokushisa | |
| Impilo yeshelufu | Iminyaka emi-2 lapho igcinwe kahle | |
Umsebenzi
I-1.I-Terbinafine hydrochloride i-synthetic allyla antifungal. Ine-lipophilic kakhulu ngokwemvelo futhi ijwayele ukunqwabelana esikhumbeni, izinzipho, nezicubu ezinamafutha.
2.I-Terbinafine·HCl ilungu lesigaba se-Allyl lama-antifungals, itholwe iyisivimbeli esithile se-ergosterol synthesis nge-squalene epoxidase inhibition. I-squalene epoxidase iyi-enzyme ekhishwe isikhunta se-dermatophyte ukuze iphule i-Squalene, ephazamisa ukusebenza kolwelwesi lwamaseli kanye nokwakheka kodonga.
I-3.I-Terbinafine hydrochloride inomphumela we-fungicidal kusikhunta sesikhumba kanye nomphumela ovimbelayo kuma-Candida albicans. Ilungele izifo zesikhumba nezinzipho ezibangelwa isikhunta esingenasici, njengesibandamu, umbandamu womzimba, umbandamu we-femur, umbandamu wezinyawo, umbandamu wezinzipho kanye nokutheleleka kwesikhumba kwe-Candida albicans okubangelwa i-Trichophyton rubrum, i-Microsporum canis. kanye ne-Flocculus epidermidis.
Isicelo
I-Terbinafine hydrochloride iyimpushana ecwebezelayo emhlophe encibilika ngokukhululeka ku-methan ne-dichlorome, inyibilika ku-ethanol, futhi inyibilika kancane emanzini. Njengamanye ama-allylamines, i-terbinafine ivimbela ukuhlanganiswa kwe-ergosterol ngokuvimbela i-squalene epoxidase,
i-enzyme eyingxenye ye-fungal cell membrane synthesis pathway. Ngenxa yokuthi i-terbinafine ivimbela ukuguqulwa kwe-squalene ibe i-lanosterol, i-ergosterol ayikwazi ukuhlanganiswa. Lokhu kucatshangelwa ukuthi kushintsha ulwelwesi lwamaseli ukungena, okubangela ukubola kweseli fungal.
1. I-Terbinafine Hcl iphumelela kakhulu eqenjini le-dermatophyte lesikhunta.
2. Njengokhilimu ongu-1% noma impushana, isetshenziselwa izifo zesikhumba ezingaphandle njenge-jock itch (tinea cruris),
unyawo lomsubathi (tinea pedis), nezinye izinhlobo zezikelemu (tinea corporis). Ukhilimu we-Terbinafine usebenza cishe engxenyeni yesikhathi esidingekayo
nezinye izidakamizwa ze-antifungal.
3. Amaphilisi omlomo angama-250mg avame ukunikezwa ukwelashwa kwe-onychomycosis, ukutheleleka kwe-fungal nail, ngokuvamile nge-dermatophyte.
noma izinhlobo ze-Candida. Ukutheleleka kwe-fungal nail kutholakala ekujuleni kwe-nail ku-cuticle lapho kusetshenziswa khona ukwelapha
azikwazi ukungena ngamanani anele. Amaphilisi angase, ngokungajwayelekile, abangele i-hepatotoxicity, ngakho iziguli ziyaxwayiswa ngalokhu futhi
ingase igadwe ngokuhlolwa kokusebenza kwesibindi. Ezinye izindlela zokuphatha ngomlomo sezihloliwe.
4. I-Terbinafine ingase ihehe noma ikhulise i-lupus erythematosus ye-cutaneous. Abantu abane-lupus erythematosus kufanele
baqale baxoxe ngezingozi ezingase zibe khona nodokotela wabo ngaphambi kokuqala kokwelapha.
Imikhiqizo Ehlobene
Imboni ye-Newgreen iphinde inikeze ama-amino acid njengokulandelayo:
Iphakheji Nokulethwa
