I-TanshinoneⅡA 99% Umkhiqizi I-Newgreen TanshinoneⅡA Isithasiselo Sempushana esingu-99%
Incazelo Yomkhiqizo
I-Tanshinone, eyaziwa nangokuthi i-tanshinone ephelele, iyinhlanganisela ye-phenanthrenequinone encibilika ngamafutha enomphumela we-antibacterial ekhishwe emuthini wendabuko waseShayina u-Salvia miltiorrhiza (isitshalo seLamiaceae i-Salvia miltiorrhiza impande), okuhlukaniswa kuyo i-tanshinone I, tanshinone IIA, tanshinone IIB, cryptotanshinone, kanye ne-isocryptozolin. Kukhona ngaphezu kwe-10 tanshinone monomers kuhlanganisa i-tanshinone, phakathi kwayo i-5 monomers: i-cryptotanshinone, i-dihydrotanshinone II, i-hydroxytanshinone, i-methyl tanshinone, ne-tanshinone IIB, inemiphumela yokulwa namagciwane, kanye nemiphumela yokulwa nokuvuvukala nokupholisa. I-Tanshinone IIA sodium sulfonate, umkhiqizo we-sulfonated we-tanshinone IIA, uyancibilika emanzini. Ukuhlolwa komtholampilo kufakazele ukuthi kunemiphumela ebalulekile ekwelapheni i-angina pectoris ngemiphumela engemihle embalwa. Iwumuthi omusha wokwelapha isifo senhliziyo. I-Tanshinone inemisebenzi eminingi efana ne-antibacterial, anti-inflammatory, ukukhuthaza ukujikeleza kwegazi kanye nokukhuthaza ukuphulukiswa kwesilonda. Ayikho imiphumela emibi esobala ngemva kokusetshenziswa isikhathi eside.
I-Tanshinone IIAiyikristalu efana nenaliti ewolintshi-bomvu (EtOAc), mp 209～210 ℃. Incibilika kalula ku-ethanol, i-acetone, i-ether, i-benzene nezinye izincibilikisi eziphilayo, ezincibilika kancane emanzini.
I-COA
| Izinto | Imininingwane | Imiphumela | |
| Ukubukeka | I-Brown Powder | I-Brown Powder | |
| Isivivinyo |
| Dlula | |
| Iphunga | Lutho | Lutho | |
| Ukuminyana Okuxekethile(g/ml) | ≥0.2 | 0.26 | |
| Ukulahlekelwa Ekumisweni | ≤8.0% | 4.51% | |
| Izinsalela ekushiseni | ≤2.0% | 0.32% | |
| PH | 5.0-7.5 | 6.3 | |
| Isilinganiso sesisindo samangqamuzana | <1000 | 890 | |
| Izinsimbi Ezisindayo(Pb) | ≤1PPM | Dlula | |
| As | ≤0.5PPM | Dlula | |
| Hg | ≤1PPM | Dlula | |
| Ukubalwa Kwamagciwane | ≤1000cfu/g | Dlula | |
| I-Colon Bacillus | ≤30MPN/100g | Dlula | |
| Imvubelo & Isikhunta | ≤50cfu/g | Dlula | |
| Amagciwane e-Pathogenic | Okubi | Okubi | |
| Isiphetho | Vumelanisa nencazelo | ||
| Impilo yeshelufu | Iminyaka emi-2 lapho igcinwe kahle | ||
Umsebenzi
1. Thuthukisa isifo senhliziyo: I-Salvia miltiorrhiza ekhishwe inomphumela othile wokuvikela enhliziyweni nasemithanjeni yegazi, ingamelana ne-arrhythmia, imelana ne-arteriosclerosis, ithuthukise i-microcirculation, futhi isiza ekwelapheni okusizayo kwesifo senhliziyo;
2. Vimbela ukuhlanganiswa kweplatelet: Ukukhishwa kwe-Salvia miltiorrhiza kungavimbela umsebenzi we-coronary artery platelet, bese kuvinjelwa umsebenzi wokuhlanganisa i-platelet;
3. Yehlisa i-hyperlipidemia: Ukukhishwa kwe-Salvia miltiorrhiza kungavimbela umsebenzi wesistimu ye-fibrinolytic ngezinga elithile, futhi kubambe iqhaza ekwehliseni i-hyperlipidemia kanye nokusimamisa ukusha kwesibindi kokuqina.
Isicelo
1. Umphumela wokulwa namagciwane Ukuhlolwa kwe-In vitro kubonisa ukuthi i-tanshinone inomphumela onamandla wokulwa namagciwane ku-Staphylococcus aureus kune-berberine. Iphinde ibe nomthelela ovimbelayo kuhlobo lwe-Mycobacterium tuberculosis H37RV (izinga eliphansi kakhulu le-inhibitory lingafinyelela ngaphansi kuka-1.5 mg/mL) kanye nezinhlobo ezimbili ze-trichophyton.
2. Umphumela wokulwa nokuvuvukala: I-Tanshinone elawulwa yi-gavage kumagundane inomphumela ocacile wokulwa nokuvuvukala. Esigabeni sokuqala semodeli yokuvuvukala, sinomthelela omkhulu wokuvimbela ukwanda kwe-capillary permeability okubangelwa i-histamine; inomphumela ovimbelayo ekuvuvukeni kwamalunga okunamandla okubangelwa iqanda elimhlophe, i-carrageenan ne-dextran; inomphumela ovimbelayo ku-exudative formaldehyde peritonitis. umphumela.
3.Umphumela we-Anticoagulant Tanshinone unomphumela we-anticoagulant. Umphumela unamandla kunalowo we-protoethyl aldehyde.
Iphakheji Nokulethwa
