• YiniI-Tudca(TaurodeOxyCholic Acid)?
Isakhiwo:I-Tudca isifinyezo se-taurodeoxycholic acid.
Umthombo:I-Tudca iyingxenye yemvelo ekhishwe kwi-bile yenkomo.
Indlela yokwenza isenzo:I-Tudca iyi-acid bile ekhulisa uketshezi lwe-bile acid emathunjini, ngaleyo ndlela isize i-bile acid ukuze imunwe kangcono emathunjini. Ngaphezu kwalokho, i-Tudca ingaphinde futhi inciphise ukubuyisa kabusha kwe-bile acid emathunjini, ngaleyo ndlela kwandise ukusakazwa kwawo emzimbeni.
Isicelo: I-TudcaIsetshenziselwa ikakhulukazi ukwelapha i-Coolangitis yaseBilliary Coolangitis (PBC) nesifo esingesilo atshwala ngokunamafutha + (nafld).
• Yini i-UDCA (i-ursodeoxycholic acid)?
Isakhiwo:I-UDCA yisifinyezo se-ursodeoxycholic acid.
Umthombo:I-UDCA iyindawo yemvelo ekhishwe kusuka ku-bile bile.
Indlela yokwenza isenzo:I-UDCA iyafana ekwakheni i-acid yomzimba uqobo, ngakho-ke ingathatha indawo noma inikeze i-bile acid entula phansi umzimba. I-UDCA inemiphumela eminingi emathunjini, kufaka phakathi ukuvikela isibindi, ukulimala kokuvuvukala kanye nokulwa no-oxidation.
Isicelo:I-UDCA isetshenziselwa ikakhulukazi ukwelapha ama-cholangitis angamabanga aphansi (i-PBC), ama-cholesterol amatshe +
• Uyini umehluko phakathiI-Tudcakanye ne-UDCA ekusebenzeni kahle?
Yize bobabili i-tudca ne-UDCA babe nemiphumela yokuvikela isibindi yesibindi, izindlela zabo zingahluka. I-Tudca isebenza ikakhulukazi ngokwandisa uketshezi lwama-bale acid emathunjini, kuyilapho i-UDCA ifana nesakhiwo se-bile acid futhi ingathatha indawo noma isengeze i-bale acid engekho emzimbeni.
Zombili zingasetshenziswa ukwelapha izifo ezihlukene zesibindi, kepha zingakhombisa imiphumela noma izinzuzo ezihlukile ekwelapheni izifo ezithile. Isibonelo, i-Tudca ingasebenza kakhulu ekwelashweni kwe-cholangitis eyinhloko ye-cholangitis (PBC).
Ngamafuphi, bobabili i-Tudca ne-UDCA bayizidakamizwa ezisebenzayo, kepha kukhona umehluko emithonjeni yabo, izindlela zokwenza, kanye nesilinganiso sohlelo lokusebenza. Uma ucubungula usebenzisa le mithi, kunconywa ukuthi abonane nodokotela ngezeluleko neziqondiswa ezengeziwe.
NokhoI-TudcaFuthi i-UDCA yomabili ama-bile acid, izinhlaka zazo ze-molecular zihlukile kancane. Ngokukhethekile, i-Tudca yakhiwa i-molecule ye-bile acid kanye ne-molecule ye-taurine ehlanganiswe ngesibopho se-amide, ngenkathi i-UDCA iyi-molecule elula elula ye-bile acid.
Ngenxa umehluko esakhiweni samangqamuzana, uTudca no-UDCA nabo banemiphumela ehlukene emzimbeni womuntu. I-Tudca isebenza kangcono kune-UDCA ekuqondiseni ukuthuthwa kwe-renal, ukuvikela isibindi, nokuqinisa izinso. Ngaphezu kwalokho, i-Tudca nayo inemiphumela ye-antioxidant futhi inemiphumela eminingi yemithi efana nemiphumela enjengeSemula, i-antiaxiety, kanye nemiphumela ye-antibacterial.
I-Tudca(TaurodeOxycholic acid) ne-UDCA (ursoxycholic acid) yizo zombili izinhlobo ze-bile acid, futhi zombili izinto zemvelo zikhishwe esibindini.
I-UDCA iyingxenye eyinhloko ye-Beather bile. Ikuthuthukisa kakhulu umsebenzi wesibindi ngokwandisa imfihlo kanye ne-excretion ye-bile acid, ngaleyo ndlela kunciphisa ukugcwala kwe-bile acid. Umsebenzi wayo oyinhloko ukwelapha izifo ze-choletatic ezifana ne-cirrhosis, cholelithiasis, njll. Ngaphezu kwalokho, futhi kuyasiza ukwehlisa amazinga we-cholesterol.
I-Tudcainhlanganisela ye-taurine ne-bile acid. Kungathuthukisa futhi umsebenzi wesibindi, kepha indlela yawo yokusebenza yehlukile kulokho kwe-UDCA. Kungakhulisa umthamo we-antioxidant wesibindi futhi uvikele isibindi kusuka kumonakalo omkhulu wamahhala. Ngaphezu kwalokho, kuyasiza ukuthuthukisa ukuzwela kwe-insulin, amazinga kashukela wegazi aphansi, futhi inemiphumela ye-anti-tumor.
Ngokuvamile, i-UDCA neTudca bobabili abavikeli abahle besibindi, kepha izindlela zabo ezithile zesenzo zihlukile futhi zilungele izifo ezahlukahlukene kanye nabantu. Uma udinga ukusebenzisa lezi zidakamizwa ezimbili, kungcono ukuzisebenzisa ngaphansi kokuholwa ngudokotela ukugwema ukuphendula okunzima.
Isikhathi Sokuthumela: Dec-09-2024
