• YiniI-TUDCA(Taurodeoxycholic Acid) ?
Isakhiwo:I-TUDCA isifinyezo se-taurodeoxycholic acid.
Umthombo:I-TUDCA iyinhlanganisela yemvelo ekhishwe enyongweni yenkomo.
Indlela Yesenzo:I-TUDCA iyi-asidi ye-bile eyandisa uketshezi lwe-bile acid emathunjini, ngaleyo ndlela isiza i-bile acid ukuthi imunceke kangcono emathunjini. Ngaphezu kwalokho, i-TUDCA inganciphisa ukumuncwa kabusha kwe-bile acid emathunjini, ngaleyo ndlela ikhulise ukujikeleza kwayo emzimbeni.
Isicelo: I-TUDCAisetshenziswa kakhulu ukwelapha i-primary biliary cholangitis (PBC) kanye ne-non-alcoholic fatty liver disease+ (NAFLD).
• Iyini i-UDCA (Ursodeoxycholic Acid) ?
Isakhiwo:I-UDCA isifinyezo se-ursodeoxycholic acid.
Umthombo:I-UDCA iyinhlanganisela yemvelo ekhishwe enyongweni yebhere.
Indlela yokwenza:I-UDCA iyafana ngesakhiwo ne-bile acid yomzimba, ngakho-ke ingabuyisela noma yengezele i-bile acid entula umzimba. I-UDCA inemiphumela eminingi emathunjini, okuhlanganisa ukuvikela isibindi, i-anti-inflammatory, kanye ne-anti-oxidation.
Isicelo:I-UDCA isetshenziselwa kakhulu ukwelapha i-primary biliary cholangitis (PBC), i-cholesterol stones+, i-cirrhosis, isifo sesibindi esinamafutha angenalo utshwala (NAFLD) nezinye izifo.
• Uyini umehluko phakathiI-TUDCAkanye ne-UDCA iyasebenza?
Nakuba kokubili i-TUDCA ne-UDCA inemiphumela yokuvikela isibindi, izindlela zabo zingase zihluke. I-TUDCA isebenza ikakhulukazi ngokukhuphula ukugcwala kwe-bile acid emathunjini, kuyilapho i-UDCA ifana nesakhiwo se-bile acid yomzimba futhi ingafaka esikhundleni noma yengezele i-bile acid engenawo umzimba.
Zombili zingasetshenziswa ukwelapha izifo ezihlukahlukene zesibindi, kodwa zingase zibonise imiphumela ehlukene noma izinzuzo ekwelapheni izifo ezithile. Isibonelo, i-TUDCA ingase isebenze kangcono ekwelapheni i-primary biliary cholangitis (PBC).
Kafushane, kokubili i-TUDCA ne-UDCA imithi esebenzayo, kodwa kunomehluko othile emithonjeni yawo, izindlela zokwenza, kanye nobubanzi bokusetshenziswa. Uma ucabangela ukusebenzisa le mithi, kunconywa ukuthi uthintane nodokotela ukuze uthole iseluleko esiqondile kanye nesiqondiso.
NakubaI-TUDCAkanye ne-UDCA womabili ama-bile acid, izakhiwo zawo zamangqamuzana zihluke kancane. Ngokukhethekile, i-TUDCA yakhiwe nge-molecule ye-bile acid kanye ne-taurine molecule ehlanganiswe yi-amide bond, kuyilapho i-UDCA iyi-molecule ye-bile acid elula.
Ngenxa yomehluko wesakhiwo samangqamuzana, i-TUDCA ne-UDCA nayo inemiphumela ehlukene emzimbeni womuntu. I-TUDCA iphumelela kakhulu kune-UDCA ekulawuleni ukuthuthwa kwezinso, ekuvikeleni isibindi, nasekuqiniseni izinso. Ngaphezu kwalokho, i-TUDCA nayo inemiphumela yokulwa ne-antioxidant futhi inemiphumela eminingi yezekhemisi njenge-sedation, antianxiety, nemiphumela yokulwa namagciwane.
I-TUDCA(i-taurodeoxycholic acid) kanye ne-UDCA (ursoxycholic acid) zombili izinhlobo ze-bile acid, futhi zombili ziyizinto zemvelo ezikhishwe esibindini.
I-UDCA iyingxenye eyinhloko ye-bile bile. Ngokuyinhloko ithuthukisa ukusebenza kwesibindi ngokwandisa ukukhishwa kanye nokuphuma kwe-bile acid, ngaleyo ndlela yehlise ukugcwala kwe-bile acid. Umsebenzi wayo oyinhloko ukwelapha izifo ze-cholestatic ezifana ne-cirrhosis, i-cholelithiasis, njll Ngaphezu kwalokho, kusiza futhi ukwehlisa amazinga e-cholesterol.
I-TUDCAiyinhlanganisela ye-taurine ne-bile acid. Ingase futhi ithuthukise ukusebenza kwesibindi, kodwa indlela yayo yokusebenza ihlukile kuleyo ye-UDCA. Ingathuthukisa amandla esibindi e-antioxidant futhi ivikele isibindi ekulimaleni kwama-radical mahhala. Ngaphezu kwalokho, kusiza ukuthuthukisa ukuzwela kwe-insulin, ukwehlisa amazinga kashukela egazini, futhi kunemiphumela elwa ne-tumor.
Ngokuvamile, i-UDCA ne-TUDCA zombili ziyizivikeli ezinhle zesibindi, kodwa izindlela zazo ezithile zokwenza zihlukile futhi zifanele izifo ezihlukahlukene kanye nenani labantu. Uma udinga ukusebenzisa lezi zidakamizwa ezimbili, kungcono ukuzisebenzisa ngaphansi kokuqondiswa udokotela ukuze ugweme ukusabela okubi.
Isikhathi sokuthumela: Dec-09-2024
