• YiniI-TUDCA ?
Ukuchayeka elangeni kuyimbangela enkulu yokukhiqizwa kwe-melanin. Imisebe ye-ultraviolet ekukhanyeni kwelanga ilimaza i-deoxyribonucleic acid, noma i-DNA, emangqamuzaneni. I-DNA eyonakele ingaholela ekulimaleni nasekuhlukanisekeni kolwazi lofuzo, futhi ibangele nokuguqulwa kwezakhi zofuzo ezimbi, noma ukulahlekelwa izakhi zofuzo ezicindezela isimila, okuholela ekuveleni kwezimila.
Kodwa-ke, ukuchayeka elangeni "akubi", futhi konke lokhu "kuyisikweletu" ku-melanin. Eqinisweni, ngezikhathi ezibucayi, i-melanin izokhishwa, ibambe ngokuphumelelayo amandla emisebe ye-ultraviolet, ivimbele i-DNA ukuba ingalimazi, ngaleyo ndlela inciphise umonakalo obangelwa imisebe ye-ultraviolet emzimbeni womuntu. Nakuba i-melanin ivikela umzimba womuntu emonakalweni we-ultraviolet, ingenza futhi isikhumba sethu sibe mnyama futhi sibe namabala. Ngakho-ke, ukuvimbela ukukhiqizwa kwe-melanin kuyindlela ebalulekile yokwenza isikhumba sibe mhlophe embonini yobuhle.
• Yiziphi izinzuzoI-TUDCAekwengezeni kwezemidlalo ?
Inzuzo eyinhloko ye-TUDCA impilo yesibindi nokusebenza okuthuthukisiwe. Ucwaningo luveza imiphumela emangazayo yokuncipha kwama-enzyme esibindi ngemuva kokufakwa kwe-TUDCA. Ama-enzyme esibindi aphakeme abonisa impilo embi nokusebenza kwesibindi, kuyilapho ama-enzyme esibindi aphansi abonisa impilo evamile yesibindi nokusebenza. Ukwengezwa nge-TUDCA kubonise ukunciphisa okuphawulekayo kuma-enzyme abalulekile esibindi, okumelela impilo yesibindi ethuthukisiwe.
Lokhu kuthuthukiswa kwempilo yesibindi yikhona okwenza i-TUDCA ibe nomthelela omkhulu kubasebenzisi bezinto ze-anabolic, ikakhulukazi izinto zomlomo ezinama-anabolic. Lezi zinto zingaba nomthelela omkhulu empilweni yethu yesibindi kanye nokusebenza, futhi ukuthatha izithasiselo zokusekela umjikelezo kuhlale kunconywa ngaphezu kokuhlolwa kwegazi okuvamile ukuqapha impilo. I-TUDCA ibhekwa njengenye yezithako zezempilo zesibindi ezihamba phambili ezitholakala namuhla.
I-TUDCAiyakwazi ukuvikela i-mitochondria ezingxenyeni zamaselula ngokuvamile ezingadala lokhu kuphazamiseka, ngaleyo ndlela ivimbele i-apoptosis. Lokhu ikwenza ngokuvimbela i-molecule ebizwa ngokuthi i-Bax ukuthi ingathuthwa iye ku-mitochondria. Lapho i-Bax idluliswa isuka ku-cytosol iye ku-mitochondria, iphazamisa ulwelwesi lwe-mitochondrial, oluqala lolu chungechunge lwezenzakalo. Ngokuvimba i-Bax nge-TUDCA, kuzovimbela ukuhlanganiswa kwe-membrane yeseli, okube sekuvimbela ukukhululwa kwe-cytochrome c, okubuye kuvimbele i-mitochondria ukuthi isebenze ama-caspases. I-TUDCA ivimbela ukufa kweseli ngokuvikela ulwelwesi lweseli lwe-mitochondrial.
I-TUDCA ivimbela ukufa kweseli ngokuvikela ulwelwesi lwe-mitochondrial lweseli ezintweni eziyingozi. Le nqubo kanye nokusabela komzimba yingakho ucwaningo lubheka izinzuzo zokwengeza i-TUDCA kubantu abanokuphazamiseka kwemizwa njengeziguli zika-Parkinson, i-Huntington's, i-Alzheimer's, ne-ALS. Imiphumela yalezi zifundo kanye nokusikisela kokuqala kuyajabulisa kakhulu. I-TUDCA ingaba nemiphumela emihle kakhulu ezifweni eziningi ezinkulu.
Ucwaningo luye lwabonisa nokuthi i-TUDCA ithuthukisa ukuzwela kwe-insulin kokubili kwemisipha nesibindi, futhi inomthelela omuhle empilweni yegilo.
• MaliniI-TUDCAkufanele kuthathwe?
Izinhlobonhlobo zemithamo iye yafundelwa izinzuzo ze-TUDCA. Ukuqala nge-10-13 mg ye-TUDCA yokwengeza ngosuku, iziguli ezinesifo sesibindi esingapheli zithole ukuncipha okuphawulekayo kwama-enzyme esibindi izinyanga ze-3. Imithamo efika ku-1,750 mg ngosuku iboniswe ukuthi inenzuzo yesifo sesibindi esinamafutha futhi ithuthukisa ukuzwela kwe-insulin yemisipha nesibindi. Izilwane ezihlolisisiwe zabonisa imithamo efika ku-4,000 mg (okulingana nomuntu) ibe nomthelela omuhle ekuvikelekeni kwe-neuroprotection ekulahlekeni kwenkumbulo okuhlobene neminyaka.
Naphezu kwalezi zilinganiso ezimbi kakhulu, phakathi kwe-500 mg ne-1,500 mg ngosuku kubonakala kuwumthamo ofanelekile wokukhiqiza imiphumela ye-TUDCA. Izithako zokudla eziningi zibonakala zenzelwe ukuqukatha i-100 - 250 mg ye-TUDCA ngokuphakwa ngakunye, okufanele ithathwe izikhathi eziningi ngosuku. Njengeziningi zalezi zithako, ucwaningo olwengeziwe luyadingeka ukuze uthole izinombolo ezithile.
• Kufanele niniI-TUDCAkuthathwe?
I-TUDCA ingathathwa nganoma yisiphi isikhathi sosuku, futhi ithathwa kangcono nokudla ukusiza ukumuncwa. Njengoba kushiwo ngenhla, izithako eziningi zithathwa ku-100 - 250 mg ngokukhonza ngakunye. Kunconywa ukuthi usakaze umthamo we-TUDCA usuku lonke, uyithathe 2, 3, 4 noma ngisho izikhathi ezi-5 ngosuku.
• Kuthatha isikhathi esingakanani ukuthi i-TUDCA isebenze?
I-TUDCA ayisebenzi ngobusuku obubodwa. Ucwaningo lubike imiphumela ehlukahlukene ye-TUDCA ngemuva kwe-1, 2, 3 noma ngisho nezinyanga ze-6 zokwengeza. Kusukela ocwaningweni olutholakalayo, kuphephile ukusho ukuthi okungenani izinsuku ezingama-30 (inyanga engu-1) yokwengeza ziyadingeka ukuze ubone ukuthuthukiswa kanye nezinzuzo. Kodwa-ke, ukusetshenziswa okuqhubekayo nesikhathi eside kuzoletha izinzuzo ezinkulu kakhulu ngokufaka i-TUDCA.
Isikhathi sokuthumela: Dec-06-2024
