• YiniTetrahydrocurcumin ?
I-Rhizoma Curcumae Longae yi-rhizoma eyomile ye-curcumae longa l. Isetshenziswa kabanzi njengokudla kombala kanye nephunga. Ukwakheka kwalo kwamakhemikhali ikakhulukazi kubandakanya i-curcumin namafutha aguqukayo, ngaphandle kwama-saccharides kanye nezinti. Curcumin (cur), njenge-polyphenol yemvelo esiteshini se-curcuma, kukhonjiswe ukuthi ube nemiphumela ehlukahlukene yemithi, kufaka phakathi ukuvuvukala kwezikhathi, ukuvikelwa kwama-antio-fibrosis, ukuvimba kwezifo ze-anti-tlame, ukuvikela isifo se-alzheimer (isikhangiso).
I-Curcumin ihlanganiswe ngokushesha emzimbeni zibe yizihlanganisi ze-glucuronic acid, ama-dihydrocurcumin, i-tetrahydrocurcumin, kanye ne-hexahydrocurcumin, kanye ne-hexahydrocurcumin, yona eguqulwa yaba yiTetrahyDrocurcumin. Ucwaningo lokuhlola lukuqinisekisile ukuthi i-curcumin inokuqina okungafanele (bheka i-photodecompation), i-solubility yamanzi ampofu kanye ne-bioavailability ephansi. Ngakho-ke, i-tetrahydrocumcumin yayo ephambili ye-metabolic emzimbeni iye yaba yindawo yokucwaninga ekhaya nasemazweni aphesheya eminyakeni yamuva.
Tetrahydrocurcumin(Thc), njengoba i-metabolite esebenza kakhulu futhi eyinhloko ye-curcumin ekhiqizwa ngesikhathi se-metabolism yayo eVivo, ingahlukaniswa ne-cytoplasm yamathumbu amancane nesibindi ngemuva kokuphathwa kwe-curcumin kumuntu noma igundane. Ifomula ye-molecular i-C21h26o6, isisindo samangqamuzana singu-372.2, ubuningi ngu-1.222, futhi iphuzu lokuncibilika lingu-95 ℃ -97 ℃.
• Yini izinzuzo zeTetrahydrocurcuminEkunakekelweni kwesikhumba?
1. Umphumela ekukhiqizeni i-melanin
I-Tetrahydrocurcumin inganciphisa okuqukethwe kwe-melanin kumaseli we-B16F10. Lapho kunikezwe i-tetrahydrocurcumin (25, 50, 100, 200μmol / l) yasungulwa, okuqukethwe kwe-melanin kwehle kusuka ku-100% kuya ku-74.34%, ama-34.37%, ama-21.40%, ngokulandelana.
I-Tetrahydrocurcumin ingavimbela umsebenzi we-tyrosinase kumaseli we-B16F10. Lapho ukugcwala okuhambisanayo kwe-tetrahydrocurcumin (100 no-200μmol / l) kwanikezwa amaseli, umsebenzi we-introsinase we-intracellular wehle waya ku-84.51% no-83.38%, ngokulandelana.
2. Anti-Photo Paling
Sicela ubheke umdwebo wegundane elingezansi: I-CTRL (Ukulawula), UV (UVA + UVB), THC (UVA + UVB + thc Thc / KG, incibilike ku-0.5% Sodium Carboxymethyl celtulose). Izithombe zesikhumba ngemuva kwamagundane ama-KM ngamaviki ayi-10 ngemuva kokwelashwa kwe-THC eqokiwe kanye ne-UVA irradiation. Amaqembu ahlukene anemisebe ye-UVA Flux efanayo ekukhuleni okukhanyayo ahlolwe nge-Bissett Score. Amanani avezwayo ukuphambuka okujwayelekile (n = 12 / iqembu). * P <0.05, ** P
Ukusuka ekubukekeni, uma kuqhathaniswa neqembu elijwayelekile lokulawula, isikhumba seqembu lokulawula imodeli sasinzima, esibonakalayo, u-Ulceration, imibimbi yajula futhi yaqina, ihambisana nento ejwayelekile yokushintsha kwesikhumba. Qhathanisa neqembu lokulawula imodeli, isilinganiso sokulimala kwetetrahydrocurcuminIqembu le-100 mg / kg laliphansi kakhulu kunaleso seqembu elilawulayo lemodeli, futhi akukho scab kanti u-Erythema atholwe esikhunjeni, kuphela imigqa emincane nemibimbi emihle ebonwe.
3.I-antioxidant
I-Tetrahydrocurcumin ingakhuphula izinga le-sod, lehlile izinga L-LDH futhi likhuphule izinga le-GSH-PX kumaseli we-hacat.
Scavenging radicals yamahhala ye-DPPH
Le khasitetrahydrocurcuminIsixazululo sihlanjululwe ngo-10, 50, 80, 100, 200, 400, 800, izikhathi eziyi-1600 nge-1600 ngokulandelana, futhi isixazululo sesampula sahlanganiswa kahle nesixazululo esingu-0.1Mmol / l DPPH ngesilinganiso esingu-1: 5. Ngemuva kokuphendula ekulweni negumbi lokushisa lama-30min, inani lokuheha lalinqunywa ku-517nm. Umphumela ukhonjiswa esithombeni:
4. Vimbela ukuvuvukala kwesikhumba
Ucwaningo lokuhlola lubonise ukuthi ukwelashwa kwamacensi kwamagundane kwaqashelwa ngokuqhubekayo izinsuku eziyi-14, lapho kusetshenziswa i-thc-slns gel ngokulandelana, ijubane lokupholisa izinxeba kanye nokulawulwa okuhle kwakuyi-thc-slns gel>
Thc> ukulawula okuhle.
Ngezansi kunezithombe eziyizimele zemodeli yegundane elibunjiwe kanye nokuqashelwa kwe-histopathological, A1 no-A6 ekhombisa isikhumba esijwayelekile, i-A4 no-A8 ekhombisa izilawuli ezinhle, kanti u-A5 no-A10 ekhombisa ukungabi nalutho kwe-lipid nanoparticles (SLN), ngokulandelana.
• Ukusetshenziswa kweTetrahydrocurcuminEzimonyo
Imikhiqizo yokunakekelwa kwe-1.Skin:
Imikhiqizo elwa nokuguga:Kusetshenziswe kumakhilimu alwa nokuguga nama-serums okusiza ukunciphisa imibimbi nemigqa emihle futhi athuthukise ukuqina kwesikhumba.
Imikhiqizo yakwaWhitening:Ingezwe kuma-exiting amhlophe kanye nokhilimu ukusiza ukuthuthukisa ithoni engalingani kwesikhumba nezindawo.
Imikhiqizo ye-2.anti-inflammatory:
Isetshenziswa emikhiqizweni yokunakekelwa kwesikhumba ebucayi efana nokhilimu opholisayo nokulungisa ukunciphisa ukuncipha nokucasuka.
Imikhiqizo ye-3.Cleaning:
Ngeza kubahlanza kanye nama-exfoliants okusiza ukuhlanza isikhumba futhi unikeze izinzuzo zokulwa nama-antibacterial ukuvikela izinduna.
Imikhiqizo ye-4.Sunscreen:
Isebenza njenge-antioxidant ukuthuthukisa ukusebenza kahle kwesikrini se-sunnscreen futhi kuvikeleke isikhumba emisebeni ye-UV.
5.Faka imaski:
Kusetshenziswe kumaski ahlukahlukene wobuso ukuhlinzeka ukondliwa okujulile nokulungisa, ukuthuthukisa ukuthungwa kwesikhumba.
TetrahydrocurcuminKusetshenziswa kabanzi kwezimonyo, ukumboza ukunakekelwa kwesikhumba, ukuhlanza, ukuvikelwa kwelanga kanye nezinye izinkambu. Ithandwa nge-antioxidant yayo, anti-inflammatory nemiphumela yamhlophe.
Isikhathi sePosi: Oct-10-2024
