Ucwaningo lukhombisa ukuthi abantu abadala ababalelwa ezigidini ezingama-537 emhlabeni jikelele banesifo sikashukela sohlobo 2, futhi lelo nani liyakhuphuka. Amazinga aphezulu kashukela egazini abangelwa isifo sikashukela angaholela ezimweni eziyingozi eziningi, kuhlanganise nesifo senhliziyo, ukulahlekelwa ukubona, ukwehluleka kwezinso, nezinye izinkinga ezinkulu zempilo. Konke lokhu kungasheshisa kakhulu ukuguga.
I-Tetrahydrocurcumin, etholakala ezimpandeni ze-turmeric, iboniswe ezifundweni zemitholampilo ukusiza ukunciphisa izici eziningi eziyingozi zohlobo lwe-2 yesifo sikashukela kanye noshukela wegazi ophansi kubantu abanesifo sikashukela noma i-prediabetes. Ukwelapha isifo sikashukela sohlobo 2 kungaba inselele ezigulini nakodokotela. Nakuba odokotela ngokuvamile betusa ukudla, ukuvivinya umzimba, kanye nemithi yokwelapha abantu abanesifo sikashukela sohlobo 2, ucwaningo lubonisa lokhoi-tetrahydrocurcumininganikeza ukwesekwa okwengeziwe.
• Ukumelana ne-insulin kanye nesifo sikashukela
Lapho sidla, ushukela wethu wegazi uyakhuphuka. Lokhu kubonisa ukuthi amanyikwe akhipha ihomoni ebizwa ngokuthi i-insulin, esiza amangqamuzana asebenzise i-glucose ukuze akhiqize amandla. Ngenxa yalokho, ushukela wegazi wehla futhi. Isifo sikashukela sohlobo 2 sibangelwa ukumelana ne-insulin ngoba amaseli awasabeli ngendlela evamile ehomoni. Izinga likashukela egazini lihlala liphakeme, isimo esibizwa nge-hyperglycemia. Amazinga aphezulu kashukela egazini angaholela ezinkingeni zesistimu, okuhlanganisa inhliziyo, isitsha segazi, izinso, iso, nokuphazamiseka kwesistimu yezinzwa, futhi kwandise ingozi yomdlavuza.
Ukuvuvukala kungase kube nomthelela ekumelaneni ne-insulin futhi kwandise i-hyperglycemia kubantu abanesifo sikashukela. [8,9] Amazinga aphezulu kashukela egazini abangela ukuvuvukala okwengeziwe, okusheshisa ukuguga futhi kwandise ingozi yezifo ezingapheli, njengesifo senhliziyo nomdlavuza. I-glucose eyeqile nayo idala ingcindezi ye-oxidative, engalimaza kakhulu amaseli nezicubu. Phakathi kwezinye izinkinga, ukucindezeleka okwenziwe nge-oxidative kungaholela ku:kunciphisa ukuthuthwa kweglucose kanye nokukhiqizwa kwe-insulin, ukulimala kwamaprotheni kanye ne-DNA, kanye nokwanda kwe-vascular permeability.
• Yiziphi Izinzuzo ZazoI-TetrahydrocurcuminKusifo sikashukela?
Njengesithako esisebenzayo ku-turmeric,I-Tetrahydrocurcuminkungasiza ukuvimbela ukukhula kwesifo sikashukela kanye nomonakalo esingawudala ngezindlela eziningi, okuhlanganisa:
1. Ukwenza kusebenze i-PPAR-γ, eyisilawuli se-metabolic esandisa ukuzwela kwe-insulin futhi sinciphise ukumelana ne-insulin.
2. Imiphumela yokulwa nokuvuvukala, kuhlanganise nokuvinjelwa kwama-molecule okubonisa okwandisa ukuvuvukala.
3. Ukusebenza okuthuthukisiwe nempilo yeseli ekhiqiza i-insulin.
4. Kuncishiswe ukwakheka kwemikhiqizo esezingeni eliphezulu ye-glycation futhi kwavimbela umonakalo ewudalayo.
5. Umsebenzi we-Antioxidant, onciphisa ukucindezeleka okwenziwe nge-oxidative.
6. Amaphrofayili e-lipid athuthukisiwe futhi anciphisa ezinye izimpawu zokungasebenzi kahle kwe-metabolic nesifo senhliziyo.
Kumamodeli ezilwane,i-tetrahydrocurcuminikhombisa ithemba ekusizeni ukuvimbela ukukhula kwesifo sikashukela kanye nokunciphisa ukumelana ne-insulin.
• Yiziphi Izinzuzo ZazoI-TetrahydrocurcuminKu-Cardiovascular?
Ucwaningo lwango-2012 olushicilelwe ku-International Journal of Pharmacology lwahlola imiphumela yei-tetrahydrocurcuminemasongweni e-aorta yegundane ukuze ubone ukuthi i-compound inezakhiwo ze-cardioprotective. Okokuqala, abacwaningi banweba izindandatho ze-aortic nge-carbachol, inhlanganisela eyaziwa ngokufaka i-vasodilation. Ngemuva kwalokho, amagundane ajovwa nge-homocysteine thiolactone (HTL) ukuvimbela i-vasodilation. [16] Ekugcineni, abacwaningi bajova amagundane nge-10 μM noma 30 μMi-tetrahydrocurcuminfuthi yathola ukuthi yenza i-vasodilation emazingeni afana ne-carbachol.
Ngokwalolu cwaningo, i-HTL ikhiqiza i-vasoconstriction ngokunciphisa inani le-nitric oxide emithanjeni yegazi futhi ikhulise ukukhiqizwa kwama-radicals mahhala. Ngakho-ke,i-tetrahydrocurcuminkumele kuthinte ukukhiqizwa kwe-nitric oxide kanye/noma ama-radicals mahhala ukuze kubuyiselwe i-vasodilation. Kusukelai-tetrahydrocurcumininezindawo eziqinile zokulwa ne-antioxidant, ingakwazi ukukhipha ama-radicals mahhala.
• Yiziphi Izinzuzo ZazoI-TetrahydrocurcuminNgeHypertension?
Nakuba umfutho wegazi ophakeme ungaba nezimbangela ezihlukahlukene, ngokuvamile uwumphumela wokuminyana ngokweqile kwemithambo yegazi, okuholela ekuncipheni kwemithambo yegazi.
Ocwaningweni lwango-2011, abacwaningi banikezei-tetrahydrocurcuminkumagundane ukubona ukuthi kuwuthinte kanjani umfutho wegazi. Ukuze benze ukungasebenzi kahle kwemithambo, abacwaningi basebenzise i-L-arginine methyl ester (L-NAME). Amagundane ahlukaniswa amaqoqo amathathu. Iqembu lokuqala lathola i-L-NAME, iqembu lesibili lathola i-tetrahydrocurcumin (50mg/kg isisindo somzimba) kanye no-L-NAME, kwathi iqembu lesithathu latholai-tetrahydrocurcumin(100mg/kg isisindo somzimba) kanye no-L-NAME.
Ngemuva kwamasonto amathathu omthamo wansuku zonke, i-i-tetrahydrocurcuminiqembu libonise ukwehla okukhulu komfutho wegazi uma kuqhathaniswa neqembu elithatha i-L-NAME kuphela. Iqembu elanikezwa umthamo ophezulu laba nomthelela ongcono kuneqembu elanikezwa umthamo ophansi. Abacwaningi bathi imiphumela emihle ibangelwei-tetrahydrocurcuminIkhono lokudala i-vasodilation.
Isikhathi sokuthumela: Oct-10-2024
