Ekuthuthukisweni okudabukisayo, ososayensi baye bathola amandla e-matrine, isakhi semvelo esitholakala empandeni yesitshalo i-Sophora flavescens, ekulweni nomdlavuza. Lokhu kutholakala kuphawula intuthuko enkulu emkhakheni we-oncology futhi kunamandla okuguqula ukwelashwa komdlavuza.
YiniUmatine?
I-Matrine sekuyisikhathi eside isetshenziswa emithini yendabuko yamaShayina ngezindawo zayo zokulwa nokuvuvukala kanye nezokulwa nomdlavuza. Kodwa-ke, izindlela zayo ezithile zokwenza azikatholakali kuze kube manje. Abacwaningi basanda kwenza ucwaningo olubanzi lokuvula izindlela zamangqamuzana lapho i-matrine iveza khona imiphumela yokulwa nomdlavuza.
Ngophenyo lwabo, ososayensi bathole ukuthi i-matrine inezinto ezinamandla zokulwa nokwanda kanye ne-pro-apoptotic, okusho ukuthi ingavimbela ukukhula kwamangqamuzana omdlavuza futhi ibangele ukufa kwamangqamuzana awo ahleliwe. Lesi senzo esimbaxambili senza u-matrine abe yikhandidethi elithembisayo lokuthuthukiswa kwezindlela zokwelapha ezinomdlavuza.
Ngaphezu kwalokho, ucwaningo luye lwabonisa lokhoumatineingavimbela ukufuduka nokuhlasela kwamangqamuzana omdlavuza, okuyizinqubo ezibalulekile ekusakazekeni komdlavuza. Lokhu kusikisela ukuthi i-matrine ingase ingaphumeleli nje kuphela ekwelapheni izimila eziyinhloko kodwa futhi nasekuvimbeleni i-metastasis, inselele enkulu ekulawulweni komdlavuza.
Ngaphezu kwemiphumela yayo eqondile kumangqamuzana omdlavuza, i-matrine itholakale ishintsha i-tumor microenvironment, icindezela ukwakheka kwemithambo yegazi emisha ebalulekile ekukhuleni kwesimila. Le mpahla elwa ne-angiogenic ithuthukisa futhi amandla ka-matrine njenge-ejenti ebanzi yokulwa nomdlavuza.
Ukutholakala kwamandla ka-matrine okulwa nomdlavuza kuye kwavusa isasasa emphakathini wesayensi, njengoba abacwaningi manje sebegxile ekuqhubekeni nokuhlola izinhlelo zayo zokwelapha. Izivivinyo zemitholampilo ziyaqhubeka ukuze kuhlolwe ukuphepha nokusebenza ngempumelelo kokwelashwa okusekelwe emanzini ezigulini ezinomdlavuza, okunikeza ithemba lokuthuthukiswa kwemithi yokwelapha yomdlavuza emisha nethuthukisiwe.
Sengiphetha, isambulo sesika matrineizakhiwo zokulwa nomdlavuza zimelela ingqopha-mlando ebalulekile empini eqhubekayo yokulwa nomdlavuza. Ngezindlela zayo zokwenza izinto eziningi kanye nemiphumela ethembisayo yokwelashwa, i-matrine inesithembiso esikhulu njengesikhali sesikhathi esizayo ekulweni nalesi sifo esibhubhisayo. Njengoba ucwaningo kule ndawo luqhubeka nokuvela, amandla ka-matrine ekuguquleni ukwelashwa komdlavuza angeke aqiniswe.
Isikhathi sokuthumela: Sep-02-2024
