YiniKhefulela kabusha?
I-Resveratrol iyingxenye yemvelo etholakala ezitshalweni ezithile, izithelo, newayini elibomvu. Kungokweqembu lamakhompiyutha abizwa ngokuthi ama-polyphenols, asebenza njengama-antioxidants futhi ayaziwa ngezinzuzo zawo zezempilo. I-Resveratrol ichithe ikakhulukazi esikhunjeni samagilebhisi abomvu futhi kube yindaba yezifundo eziningi ngenxa yemiphumela yayo engaba khona ezicini ezahlukahlukene zempilo.
Olunye ucwaningo lubonisa ukuthi i-resveratrol ingahle ibe nezinzuzo ezingaba khona zempilo yenhliziyo, ngoba ingasiza ukuxhasa imithambo yegazi enempilo nokusakazwa. Ngokwengeziwe, sekufundwa ngemali yayo engaba khona yokulwa nokuvuvukala kanye nezakhiwo ze-antioxidant, ezingaba nemiphumela yezinqubo zempilo kanye nokuguga.
I-resveratrol ibuye yaphenywa ngeqhaza layo elingaba khona ekusekeleni impilo yezempilo yobuchopho kanye nomsebenzi wokuqonda, kanye nemiphumela yayo kwi-metabolism kanye nezinzuzo ezingaba khona zokulawulwa kwesisindo.
Izakhiwo ezingokomzimba nezamakhemikhali zeReveratrol
I-resveratrol (3-4'-5-Trihydroxystilbene) yi-non-flavonoid polyphenol compact. Igama lamakhemikhali lingu-3,4 ', 5-Trihydroxy-1,2--diphHylethylene (3,4--2-4, 5-TrihydroxyStilbene), ifomula yalo yamangqamuzana i-C14H12O3, kanye nesisindo sayo samangqamuzana angama-228.25.
I-reserveratror emsulwa ivela njengomhlophe ukukhanyisa i-powder ephuzi, i-odorless, insoluble emanzini, futhi kalula kalula kuma-sol solvents ezifana ne-ether, chloroform, i-methanol, i-ethanol, i-acetone kanye ne-ethyl acetate. Iphuzu lokuncibilika lingu-253-255 ° C, futhi izinga lokushisa elingaphansi lingu-261 ° C. Kungaphenduka bomvu ngezixazululo ze-alkaline njengamanzi ammonia, futhi kungasabela nge-Ferric Chloride-Potassium Ferrocyanide. Le mpahla ingasetshenziswa ukukhomba i-resveratrol.
I-Natural Reveratrol inezinhlaka ezimbili, i-CIS kanye ne-Trans. Ikhona ikakhulukazi e-trans acforvation ngokwemvelo. Lezi zinhlaka ezimbili zingahlanganiswa ne-glucose ukwakha i-CIS kanye ne-Trans reserterrol glycosides. I-Gy- and Trans-resveratrol glycosides ingakhipha i-resveratrol ngaphansi kwesenzo se-glycosidase emathunjini. Ngaphansi kokukhanya kwe-ultraviolet, i-trans-resveratrol ingaguqulwa ibe yi-CIS-isomers.
Indlela yokulungiselela
Indlela yokukhishwa kwezitshalo zemvelo
Amagilebhisi, ama-knotweed kanye namantongomane asetshenziswa njengezinto ezingavuthiwe ukuze akhiphe futhi ahlukanise kabusha i-crude reveratrol, bese zikuhlanza. Ubuchwepheshe obukhulu bokukhishwa kwe-crude extraction bubandakanya ukukhishwa kwe-organic solvent, ukukhishwa kwe-alkaline kanye nokukhishwa kwe-enzyme. Izindlela ezintsha ezinjengokukhishwa okusizwa nge-microwave, ukukhishwa kwe-co2 supercritical kanye nokukhishwa okusizwa nge-ultrasonic nakho kuyasetshenziswa. Inhloso yokuhlanzwa ikakhulukazi ukuhlukanisa ama-CIS- kanye nama-imomers we-trans-amasomers eReveratrol kanye ne-resveratrol kusuka ku-crude reserverrol ukuthola i-trans-reververatrol. Izindlela ezijwayelekile zokuhlanza zifaka i-Chromatography, i-Silica Gel Colem Chromatography, i-chromatography ye-chromatography emncane, i-chrmoppography ephezulu yokusebenza kwe-chromatography, njll.
Indlela ye-Synthesis
Kusukela kokuqukethwe kwekhefulela kabushaEzitshalweni ziphansi kakhulu kanti izindleko zokukhishwa ziphezulu, ukusetshenziswa kwamakhemikhali, okuphilayo, genetic ubunjiniyela nezinye izindlela ukuthola kabusha i-resveratror sekuyindlela ebaluleke kakhulu kwinqubo yayo yokuthuthuka. Ukusabela kwe-Perkin, ukusabela kwe-hech, kanye nokusabela kwama-hormer avuthiwe ngezindlela ezivuthiwe zamakhemikhali zokuvumelanisa kabusha kabusha, ngezindleko ezingama-55,2%, ezingama-70%, kanye nama-35.7% ngokulandelana. Ubuchwepheshe bezobunjiniyela bezakhi zofuzo busetshenziselwa ukulawula noma ukuthuthukisa indlela ye-biosynthesis ye-BIOSYNTES ye-resveratrol ukuthola izingqinamba zezitshalo eziphezulu; Izindlela ezinjengokusebenzisa i-mutagenesis ukukhetha imigqa yamaseli ephezulu ingakhuphula isivuno se-resveratrol nge-1.5 ~ 3.0 Times.
Yini inzuzo yeKhefulela kabusha?
I-Resveratrol ibilokhu iyisihloko socwaningo ngenxa yezinzuzo zayo zezempilo ezingaba khona. Ezinye zezinzuzo ezingaba khona zeReveratrol zifaka:
1.anti-ageng
Ngo-2003, uHarvard University uSolwazi David Sinclair nethimba lakhe bathola ukuthi iReveratrol ithola ukuthi i-acertarol isebenze i-acetylase futhi yandise isikhathi sokuphila kwemvubelo, eyabangela ukukhuphuka ngocwaningo lwe-resveratrol. UWiiTZ et al. Kutholakale ukuthi i-resveratrol ingasebenza njengesishodi esinamandla solwazi lokuthula imininingwane yokubuyiselwa kwemininingwane 2 homolog1 (i-sirt1), ingalingisa impendulo elwa nokuguga kwemikhawulo yekhalori (cr), futhi ibambe iqhaza ekulawulweni kwesilinganiso sokuphila kwezinto eziphilayo. . UCr ungumnukane oqinile we-sirt1 futhi angakhuphula ukubonakaliswa kwe-sirt1 ezithweni nezicubu ezifana nengqondo, inhliziyo, amathumbu, izinso, izicubu zomzimba kanye namafutha. U-Cr angadala izinguquko ezibonakalayo ezibambezela ukuguga futhi anwebe isikhathi sokuphila, okubaluleke kakhulu okunganwetshwa ngo-50%. . Ucwaningo luqinisekisile ukuthi i-resveratrol inganweba isikhathi sempilo yemvubelo, ama-nematode, izimpukane zezithelo kanye nezinhlanzi eziphansi.
I-2.anti-Tumos, Anti-Cancer
I-Resveratrol inemiphumela ebalulekile ekuvinjezelwe kumaseli ahlukene emithilamu afana ne-mouse hepatocellular carcinoma, umdlavuza webele, umdlavuza wekal, umdlavuza wekoloni, umdlavuza wesisu, kanye ne-leukemia. Ezinye izazi zikuqinisekisile ukuthi i-resveratrol inomphumela omkhulu obucayi kuma-melanoma amaseli nge-MTT indlela futhi agele i-Cytometry.
Kunemibiko yokuthi i-resveratrol ingathuthukisa i-radiotherapy yomdlavuza futhi iphume ngempumelelo imiphumela yamaseli we-cancer stem. Kepha kuze kube manje, ngenxa yobunzima bendlela yokulwa ne-resveratrorol anti-tlam, abacwaningi abakafinyeleli ekuvumelaneni ngenqubo yakhe yesenzo.
3.Prevent and Phatha isifo senhliziyo
Izifundo ze-Epidemiological zithole ukuthi into ethi "French Paradoox" yithi abantu baseFrance badla inani elikhulu lamafutha nsuku zonke, kepha ukufela kwezifo zenhliziyo kuphansi kakhulu kunamanye amazwe aseYurophu. Le nto ingahle ihlose ukusetshenziswa kwayo kwansuku zonke kwamawayini amakhulu. , futhi i-resveratrol ingaba yinto yayo eyingqayizivele yokuvikela. Ucwaningo lukhombisa ukuthi i-resveratrol ingalawula amazinga we-cholesterol ama-cholesterol ngokubopha ama-estrogen emzimbeni womuntu, ngaleyo ndlela avimbela ukuvela kwezifo zegazi, futhi anciphise ingozi yokugula kwenhliziyo, futhi anciphise ingozi yesifo senhliziyo emzimbeni womuntu. Ingozi yesifo se-vascular.
I-4.Antioxidant ukwesekwa:Khefulela kabushaIzenzo njenge-antioxidant, isiza ukuvikela amaseli kumonakalo oxidative monated kubangelwa ama-radicals wamahhala. Lokhu kungahle kube nemiphumela yezinqubo zempilo kanye nokuguga.
I-6. Impilo yobuchopho: Ucwaningo luhlole inhloso engaba khona ye-resveratrol ekusekeleni impilo yezempilo yobuchopho nomsebenzi wokuqonda, ngezifundo ezithile eziphakamisa izakhiwo zezinzwa.
7.Metabolism kanye nokuphathwa kwesisindo: I-resveratror iye yaphenywa ngemiphumela yayo engaba khona ku-metabolism neqhaza layo ekusekeleni ukuphathwa kwesisindo okunempilo.
Yini ukusetshenziswa kweKhefulela kabusha?
I-Resveratrol inezicelo ezahlukahlukene futhi isetshenziswa emikhakheni ehlukene ngenxa yezinzuzo zayo ezingaba khona. Ezinye izinhlelo zokusebenza zeReveratrol zifaka:
1. Izithasiselo zokudla: I-Resveratrol isetshenziswa kakhulu ezithandweni zokudla, zivame ukuthengiswa ngezakhiwo zayo ezingaba khona nezakhiwo zokuguga.
2. Imikhiqizo ye-Skincare: I-resveratrol ifakiwe kwemikhiqizo ethile ye-skincare ngenxa yezakhiwo zayo ze-antioxidant, ezingasiza ukuvikela isikhumba kusuka ekulimaleni kwemvelo nokusekelwa kwempilo yesikhumba yonke.
I-3. Ukudla okusebenzayo kanye neziphuzo ezisebenzayo: I-resveratrol kwesinye isikhathi ingezwa ekudleni okusebenzayo kanye neziphuzo, njengeziphuzo zamandla nemikhiqizo yokudla egxile empilweni, ukuhlinzeka ngezinzuzo zezempilo ezigxile kakhulu.
I-4. Ucwaningo Nentuthuko: I-resveratror iyaqhubeka nokuba yindaba yocwaningo lwesayensi, ngezifundo eziqhubekayo ezihlola ukusetshenziswa kwayo ezimweni zayo ezingaba khona ezimweni ezahlukahlukene zezempilo kanye nemiphumela yayo ekugugeni, imetabolism, kanye nenhlala-kahle yonke.
Yini okuphansi kwe-resveratrol?
Ngenkathi i-resveratrorol ifundelwe izinzuzo zayo zezempilo, kubalulekile ukucubungula okungaphansi kwemikhawulo noma ukulinganiselwa okuhambisana nokusetshenziswa kwayo. Okunye ukucatshangelwa maqondana nokuphansi kweReveratrol kufaka phakathi:
1. I-Bioavalability elinganiselwe Lokhu kungathinta ukusebenza kwayo ekukhiqizeni imiphumela efiselekayo yezempilo.
2 Lokhu kungenza kube yinselele ukuthi abathengi banqume umthamo ofanele kanye nekhwalithi yomkhiqizo.
3. Ukusebenzisana okungaba khona: I-resveratrol ingaxhumana nemithi ethile noma izimo zempilo. Kubalulekile ukuthintana nochwepheshe wezokunakekelwa kwempilo ngaphambi kokusebenzisa i-resveratrol, ikakhulukazi uma uthatha eminye imishanguzo noma unezinto ezikhathazayo zezempilo.
4. Ukulinganiselwa Kocwaningo: Ngenkathi ezinye izifundo zikhombisile imiphumela ethembisayo, kudingeka ucwaningo oluthe xaxa ukuze uqonde ngokugcwele imiphumela yesikhathi eside, umthamo ofanele, kanye nezingozi ezingaba khona ezihambisana nokungezelelwa kwe-reserter.
Njenganoma iyiphi inzuzo, kungakuhle ukuthi usondele ekusetshenzisweni kweReveratrol ngokuqapha futhi ngaphansi kokuholwa nguchwepheshe wezokunakekelwa kwempilo, ikakhulukazi uma unezinto ezikhathazayo zezempilo noma ukuthatha eminye imishanguzo.
Imibuzo ehlobene nayo ungayithanda:
Obani okufanele bagwemekhefulela kabusha?
Abantu abathile kufanele baqaphele noma bagweme i-resveratrol, ikakhulukazi ngefomu lokugxilisa elinqunyelwe. Kungcono ukuthi la maqembu alandelayo abonisane nochwepheshe wezokunakekelwa kwempilo ngaphambi kokusebenzisa i-resveratrol:
1. Abesifazane abakhulelwe noma ukuncelisa abesifazane
2
3. Labo abanezimo ezibucayi bama-hormone
4. Abantu abanezimo zesibindi: Ezinye izifundo ziphakamise ukuthi imithamo ephezulu ye-resveratror ingahle ibe nemiphumela esibindini. Abantu abanezimo zesibindi noma abaphuza imithi ethinta isibindi kufanele basebenzise i-resveratrol ngokuqapha futhi ngaphansi kokuqashwa kwezokwelashwa.
Njenganoma iyiphi isengezo, kubalulekile ukuthi uthintane nochwepheshe wezokunakekelwa kwempilo ngaphambi kokusebenzisa i-resveratrol, ikakhulukazi uma unezinto ezikhathazayo zezempilo, uphuza imishanguzo, noma unesimo sezempilo.
Ngabe i-resveratrol yenzani esikhunjeni?
I-Resveratrol ikholelwa ukuthi inikela ngezinzuzo eziningana ezingaba khona zesikhumba, eziholele ekufakweni kwayo emikhiqizweni ye-skincare. Eminye imiphumela ye-resveratrol esikhunjeni ingafaka:
1. Ukuvikelwa kwe-Antioxidant: I-Resveratrol isebenza njenge-antioxidant, isiza ukungathathi hlangothi ama-radicals mahhala futhi yehlise ukucindezelwa okuxakile esikhunjeni. Lokhu kungavikela isikhumba ngomonakalo wezemvelo, njengemisebe ye-UV nokungcola.
2
3. Imiphumela yokulwa nokuvuvukala: I-resveratrorol ifundelwe izakhiwo zayo zokulwa nokuvuvukala, ezingasiza ukuthambisa nokuthulisa isikhumba, ikakhulukazi kubantu abanesikhumba esibucayi noma esisebenzayo.
4. Ukuqhakambisa kwesikhumba: Abanye ucwaningo lubonisa ukuthi i-resveratrol ingafaka isandla ekukhanyiseni kwesikhumba nakusihlwa ukuphuma kwethoni yesikhumba, okunciphisa ukubukeka kwe-hyperpigmentation.
Yikuphi ukudla okuphezulu kakhulu ku-resveratrol?
Ukudla okuphezulu kakhulu ku-resveratrol kufaka phakathi:
1 Kodwa-ke, kubalulekile ukusebenzisa utshwala ngokulinganisela, futhi eminye imithombo ye-resveratrol ingathandwa ngabaphuza abangaphuzi.
2
3. Ama-Blueberries: Ama-Blueberries ayaziwa ngokuqukethwe kwawo kwe-antioxidant, futhi aqukethe futhi kabusha, yize ngamanani amancane aqhathaniswa namagilebhisi abomvu namantongomane.
I-4. Ama-Cranberry: AmaCranberry angomunye umthombo we-resveratrol, enikeza inani elithile le-compound.
I-5 Chocolate emnyama: Ezinye izinhlobo zeshokolethi emnyama ziqukethe i-resveratrol, enikeza indlela emnandi yokufaka le nhlanganisela ekudleni.
Kulungile ukuthatha i-resterrol nsuku zonke?
Isinqumo sokuthatha kabusha kabusha nsuku zonke kufanele senziwe ngokubonisana nochwepheshe wezokunakekelwa kwempilo, ikakhulukazi uma ubheka ukusekelwa kwe-resertorol. Ngenkathi i-resveratrorol ngokuvamile ithathwa njengephephile uma idliwa kumanani atholakala ngokudla, ukuphepha kanye nezinzuzo ezingaba khona zokungezelwa kabusha kwansuku zonke zingahluka ngokuya ngesimo sempilo yomuntu ngamunye, izimo zezokwelapha ezikhona, neminye imishanguzo.
Ingabe i-resveratrol inobuthi esibindini?
I-Resveratrol ifundelwe imiphumela yayo engaba khona esibindini, futhi ngenkathi icatshangelwa ukuthi iphephile lapho kusetshenziswa amanani atholakala ngokudla, kunobufakazi obuthile bokuthola imiphumela ephezulu. Ezinye izifundo ziveze ukuthi imithamo ephezulu yeReveratrorol ingaholela ekuphuzeni kwesibindi ezimweni ezithile.
Kubalulekile ukuqaphela ukuthi ucwaningo ngalesi sihloko luyaqhubeka, futhi amandla okuba nobuthi besibindi angathonywa yizici ezinjengethabo, isikhathi sokusebenzisa, kanye nezimo zempilo ngayinye. Njenganoma iyiphi inzuzo, kungcono ukuthintana nochwepheshe wezokunakekelwa kwempilo ngaphambi kokusebenzisa i-resveratrol, ikakhulukazi uma unezinto ezikhathazayo zezempilo noma ukuthatha eminye imishanguzo engathinta umsebenzi wesibindi.
Ngabe i-resveratroroli imbi ngezinso?
Kunobufakazi obulinganiselwe bokuphakamisa ukuthi i-resveratrol imbi kakhulu izinso. Kodwa-ke, njenganoma iyiphi inzuzo, kubalulekile ukuthi ubhekane nokusetshenziswa kwayo ngokuqapha, ikakhulukazi uma unezimo ezikhona zezinso noma uphuza imishanguzo engathinta umsebenzi wezinso. Kungcono ukuthintana nochwepheshe wezokunakekelwa kwempilo ukunquma ukuthi ukusekelwa kwe-resveratrol kufanelekile ngezidingo zakho zezempilo, ikakhulukazi uma unezinto ezikhathazayo ngomthelela wayo ongaba khona empilweni yempilo yezinso.
Okungahambelani nekhefulela kabusha?
Lapho ucubungula ukungezelelwa kwe-reserterrol, kubalulekile ukuthi wazi ngokuxhumana okungenzeka nezinye izinto. Ukucatshangelwa kokungahlangani ne-resveratrol kufaka phakathi:
1. Imithi yokunciphisa igazi: i-resveratror ingaba nezindawo ezinempilo eziphilayo, ngakho-ke kubalulekile ukusebenzisa ukuqaphela lapho uthatha uReveratrorol eceleni kwemithi yokunciphisa igazi, ngoba kungakhulisa ubungozi bokopha.
2. Ezinye izithasiselo ze-antioxidant: Ngenkathi ama-antioxidants ngokuvamile anenzuzo, ethatha imithamo ephezulu yezithasiselo eziningi ze-antioxidant ngasikhathi sinye kungenzeka kube nemiphumela engahlosiwe. Kungcono ukuthintana nochwepheshe wezokunakekelwa kwempilo ngaphambi kokuhlanganisa i-resveratrol nezinye izithasiselo ze-antioxidant.
I-3. Imithi ethile: I-resveratrol ingasebenzisana nemithi ethile, kufaka phakathi lezo zifanela isibindi. Kubalulekile ukuxoxa ngokubambisana okubangelwa yi-HealthCare Professional, ikakhulukazi uma uthatha eminye imithi.
Njenganoma iyiphi isengezo, kubalulekile ukufuna ukuholwa kuchwepheshe wezokunakekelwa kwempilo ukunquma ukusetshenziswa okufanele kakhulu kwe-resveratrol kususelwa kwisimo sempilo yomuntu ngamunye kanye nokuxhumana okungenzeka nezinye izinto.
Ngingakwazi ukusebenzisa i-Vitamin C nge-resveratrol?
Yebo, ngokujwayelekile ungasebenzisa i-Vitamin C nge-resveratrol. Eqinisweni, okunye ukucwaninga kusikisela ukuthi ukuhlanganisa kabusha kabusha nge-Vitamin C kungakhulisa imiphumela ye-antioxidant yazo zombili izinhlanganisela. UVitamin C uyi-antioxidant eyaziwayo engahlehlulela izinzuzo ezingaba khona zeReveratrol. Kodwa-ke, njenganoma iyiphi inhlanganisela yesengezo, kungcono ukuthintana nochwepheshe wezokunakekelwa kwempilo ukuqinisekisa ukuthi inhlanganisela ilungele izidingo zakho zezempilo kanye nokuxoxa nganoma yikuphi ukusebenzisana noma ukucatshangelwa okungaba khona.
Isikhathi sePosi: Sep-09-2024
