• YiniI-Lycopene ?
I-Lycopene iyi-carotenoid yemvelo, etholakala kakhulu ezithelweni nasemifino efana notamatisi. Isakhiwo sayo samakhemikhali siqukethe i-11 conjugated double bond kanye ne-2 non-conjugated double bond, futhi inomsebenzi oqinile we-antioxidant.
I-Lycopene ingavikela isidoda ku-ROS, ngaleyo ndlela ithuthukise ukuhamba kwesidoda, ivimbele i-prostate hyperplasia, i-prostate cancer cell carcinogenesis, inciphise izehlakalo zesibindi esinamafutha, i-atherosclerosis nesifo senhliziyo, ithuthukise ukuzivikela komuntu, futhi inciphise ukulimala kwesikhumba okubangelwa ukukhanya kwe-ultraviolet.
Umzimba womuntu awukwazi ukuhlanganisa i-lycopene ngokwawo, futhi ungangenwa kuphela ngokudla. Ngemva kokumuncwa, igcinwa ikakhulukazi esibindini. Ingabonakala ku-plasma, i-seminal vesicles, i-prostate nezinye izicubu.
• Yiziphi Izinzuzo ZazoI-LycopeneUkulungiselela Ukukhulelwa Kwabesilisa?
Ngemuva kokusebenza kwe-RAGE, ingabangela ukusabela kwamaseli futhi iholele ekukhiqizeni i-ROS, ngaleyo ndlela ithinte umsebenzi wesidoda. Njenge-antioxidant eqinile, i-lycopene ingacisha umoya-mpilo we-singlet, isuse i-ROS, futhi ivimbele ama-sperm lipoprotein ne-DNA ekubeni i-oxidized. Ucwaningo luye lwabonisa ukuthi i-lycopene inganciphisa izinga le-receptor for advanced glycation end products (RAGE) esidodeni somuntu, ngaleyo ndlela ithuthukise ukuhamba kwesidoda.
Okuqukethwe kwe-Lycopene kuphezulu kumasende amadoda anempilo, kodwa aphansi kwabesilisa abangazali. Ucwaningo lwezokwelapha luye lwathola ukuthi i-lycopene ingathuthukisa ikhwalithi yesidoda sowesilisa. Abesilisa abangenanzalo abaneminyaka engu-23 kuya ku-45 bacelwa ukuba baphuze i-lycopene ngomlomo kabili ngosuku. Ezinyangeni eziyisithupha kamuva, ukugxiliswa kwesidoda sabo, ukusebenza kanye nokuma kwabo kwahlolwa futhi. Izingxenye ezintathu kwezine zamadoda zazithuthukise kakhulu ukuhamba kwesidoda kanye ne-morphology, futhi ukugxila kwesidoda kwaba ngcono kakhulu.
• Yiziphi Izinzuzo ZazoI-LycopeneNge-Prostate Yesilisa ?
1. I-Prostatic Hyperplasia
I-Prostatic hyperplasia yisifo esivamile emadodeni, futhi eminyakeni yamuva nje, izinga lezigameko liye lehla kakhulu. Izimpawu zomzila womchamo ophansi (ukuphuthuma komchamo/ukuchama njalo/ukuchama okungaphelele) yizimpawu zomtholampilo eziyinhloko, ezithinta kakhulu izinga lempilo yeziguli.
I-Lycopeneingavimbela ukwanda kwamangqamuzana e-prostate epithelial, ikhuthaze i-apoptosis kuzicubu ze-prostate, ikhuthaze ukuxhumana kwe-intercellular gap junction ukuvimbela ukuhlukana kwamaseli, futhi inciphise ngempumelelo amazinga ezici ezivuthayo ezifana ne-interleukin IL-1, IL-6, IL-8 kanye ne-tumor necrosis. isici (TNF-α) ukusebenzisa imiphumela elwa nokuvuvukala.
Izivivinyo zemitholampilo zithole ukuthi i-lycopene ingathuthukisa i-prostate hyperplasia kanye nesakhiwo se-muscle esibushelelezi sesinye kubantu abakhuluphele futhi ikhulule izimpawu zomgudu womchamo ophansi wabesilisa. I-Lycopene inomphumela omuhle wokwelapha nokuthuthukisa izimpawu ze-urinary tract tract ezibangelwa i-prostate hypertrophy ne-hyperplasia, ehlobene nemiphumela eqinile ye-antioxidant ne-anti-inflammatory ye-lycopene.
2. Umdlavuza Wendlala Yendlala Yesinye
Kunezincwadi eziningi zezokwelapha ezisekela lokhoi-lycopeneekudleni kwansuku zonke kudlala indima ebalulekile ekuvimbeleni umdlavuza wendlala yesinye, futhi ukuthathwa kwe-lycopene kuhlotshaniswa kabi nengozi yomdlavuza wendlala yesinye. Indlela yayo kukholakala ukuthi ihlobene nokuthinta ukuvezwa kwezakhi zofuzo namaprotheni ahlobene nesimila, ukuvimbela ukwanda kwamangqamuzana omdlavuza nokunamathela, kanye nokwenza ngcono ukuxhumana phakathi kwamaseli.
Ukuhlola umphumela we-lycopene ngesilinganiso sokusinda kwamangqamuzana omdlavuza wendlala yesinye: Ezivivinyweni zezokwelapha, i-lycopene yasetshenziswa ukwelapha imigqa yamaseli omdlavuza womuntu we-prostate DU-145 kanye ne-LNCaP.
Imiphumela yabonisa lokhoi-lycopeneibe nomthelela omkhulu wokuvimbela ekwandeni kwamaseli e-DU-145, futhi umphumela wokuvimbela ubonakale ku-8μmol/L. Umphumela ovimbelayo we-lycopene kuyo wawuhlotshaniswa kahle nomthamo, futhi izinga eliphezulu lokuvinjelwa lingafinyelela ku-78%. Ngesikhathi esifanayo, ingavimbela ngokuphawulekayo ukwanda kwe-LNCaP, futhi kukhona ubudlelwano obusobala bomphumela womthamo. Izinga eliphezulu lokuvinjelwa ezingeni lika-40μmol/L lingafinyelela ku-90%.
Imiphumela ibonisa ukuthi i-lycopene ingavimbela ukwanda kwamangqamuzana e-prostate futhi inciphise ingozi yamangqamuzana omdlavuza we-prostate abe umdlavuza.
Isikhathi sokuthumela: Nov-20-2024
