Yini?I-Glabridin?
I-Glabridin iyi-flavonoid ekhishwe ezimpandeni ze-licorice (Glycyrrhiza glabra) futhi inezinhlobonhlobo zemisebenzi yebhayoloji kanye nezinzuzo zezempilo. I-glabridin yaziwa ngokuba mhlophe kwayo okunamandla, i-antioxidant kanye ne-anti-inflammatory properties futhi isetshenziswa kakhulu ekunakekelweni kwesikhumba nezimonyo.
I-Glycyrrhiza glabra L. isitshalo esingapheli esikhula eningizimu yeYurophu, e-Asia, nasesifundeni saseMedithera. Itshalwa kakhulu eRussia, Spain, Iran naseNdiya. Isitshalo se-G. glabra singamamitha angu-1-1.5 ubude, sinamaqabunga amancane aluhlaza okumnyama, izimbali eziphuzi, eziluhlaza okwesibhakabhaka, ne-violet, kanye ne-rhizome emnandi.
I-Glabridin ingenye ye-flavonoid eyinhloko ku-Glycyrrhiza glabra. Ibonisa umphumela oqinile we-anti-free radical oxidation ohlelweni lwe-cytochrome P450/NADPH oxidation, futhi ingavimbela kakhulu ama-radicals mahhala akhiqizwa ngesikhathi senqubo ye-metabolism emzimbeni ukuvimbela ama-biomacromolecules azwela i-oxidation (low-density lipoprotein LDL, DNA) kanye izindonga zamaseli ekonakalisweni yi-free radical oxidation. Lokhu kungavimbela futhi kuphathe izinguquko ezithile ze-pathological ezihlobene ne-free radical oxidation, njenge-atherosclerosis nokuguga kwamangqamuzana. Ngaphezu kwalokho, i-glabridin inomphumela othile wokwehlisa i-lipids yegazi nomfutho wegazi. Ucwaningo lwase-Italy luphinde lwaqinisekisa ukuthi i-Glabridin inomphumela wokucindezela ukudla, onganciphisa amafutha ngaphandle kokunciphisa isisindo. Ngemva kokuhlolwa okuphindaphindiwe, imiphumela eyinhloko imi kanje: 1. I-Whitening, inhibiting melanin; 2. Umphumela wokulwa nokuvuvukala; 3. Umphumela we-Antioxidant; 4. Amagciwane.
Izakhiwo zePhysical And Chemical ofI-Glabridin
1. Isakhiwo Samakhemikhali
Igama leKhemikhali: Glabridin
I-Chemical Formula: C20H20O4
Isisindo samangqamuzana: 324.37 g/mol
Izici Zesakhiwo: I-Glabridin iyinhlanganisela ye-flavonoid enesakhiwo esivamile somgogodla we-flavonoid. Iqukethe izindandatho ezimbili ezinephunga elimnandi (A no-B) ezixhunywe ibhuloho elinekhabhoni emithathu elakha indandatho yephiran evaliwe.
2. Izakhiwo Zomzimba
Ukubukeka: I-Glabridin ngokuvamile ivela njenge-crystalline powder emhlophe noma ephuzi.
Ukunyibilika:
Amanzi: Awancibiliki kahle emanzini.
I-Organic Solvents: Incibilika kuzincibilikisi eziphilayo njenge-ethanol, i-methanol, ne-propylene glycol.
Indawo Encibilika: Cishe ku-156-158°C (313-316°F).
Iphunga: I-Glabridin ngokuvamile ayinalo iphunga elihlukile.
3. Izakhiwo Zamakhemikhali
Ukuzinza: I-Glabridin izinzile uma kuqhathaniswa ngaphansi kwezimo ezivamile kodwa ingehlisa izinga lapho ichayeke ekukhanyeni, ekushiseni, noma ezimeni ezine-asidi. Kutuswa ukuyigcina endaweni epholile, eyomile, kude nelanga eliqondile.
Ukuzwela kwe-pH: I-Glabridin izwela izinguquko ze-pH futhi ingase yonakalise ezindaweni ezine-acidic kakhulu noma eziyisisekelo.
Ukusebenza kabusha: Njenge-flavonoid, i-glabridin ingabhekana nokusabela kwamakhemikhali okujwayelekile okuhlotshaniswa nezinhlanganisela ze-phenolic, njenge-oxidation nokuhlanganisa.
Yiziphi Izinzuzo ZazoI-Glabridin?
1. Isikhumba sibe mhlophe futhi sicwebezele
- Ukuvinjelwa kwe-Tyrosinase: I-Glabridin yaziwa kakhulu ngezindawo zayo zokwenza isikhumba sibe mhlophe. Ivimbela umsebenzi we-tyrosinase, i-enzyme ebalulekile ekukhiqizeni i-melanin, ngaleyo ndlela inciphise ukwakheka kwamabala amnyama kanye ne-hyperpigmentation.
- Ngisho Nebala Lesikhumba: Ngokunciphisa ukwakheka kwe-melanin, i-glabridin isiza ekuzuzeni ithoni yesikhumba elinganayo kanye nebala elikhanyayo.
2. Izakhiwo Ze-Antioxidant
- I-Free Radical Scavenging: I-Glabridin inezakhiwo eziqinile ze-antioxidant, ezisiza ekunciphiseni ama-radicals mahhala. Lokhu kunciphisa ukucindezeleka kwe-oxidative futhi kuvimbela ukulimala kwamaselula.
- I-Anti-Aging: Umsebenzi we-antioxidant we-glabridin usiza ekwehliseni izimpawu zokuguga, njengemigqa emihle, imibimbi, namabala obudala, ngokuvikela isikhumba emonakalweni we-oxidative.
3. Imithelela Eqeda Ukuvuvukala
- Ukunciphisa Ukuvuvukala: I-Glabridin ikhombisa izakhiwo zokulwa nokuvuvukala, ezisiza ekwehliseni ukuvuvukala kwesikhumba, ububomvu nokuvuvukala.
- Umphumela Opholile: Ingapholisa isikhumba esithukuthele futhi inenzuzo ezimeni ezifana nezinduna, i-eczema, ne-rosacea
4. Umsebenzi we-Antimicrobial
- Ukuvimbela Amagciwane: I-Glabridin ibonise izakhiwo ze-antimicrobial ngokumelene namagciwane ahlukahlukene kanye nesikhunta. Lokhu kwenza kube usizo ekuvimbeleni nasekwelapheni izifo zesikhumba.
- Ukwelashwa kwezinduna: Izakhiwo zayo zokulwa namagciwane kanye nezokuqeda ukuvuvukala zenza i-glabridin iphumelele ekwelapheni izinduna ngokunciphisa ukukhula kwamagciwane nokuvuvukala.
5. Ukuvikelwa kwe-UV
- Ukuvikela isithombe: I-Glabridin inganikeza izinga elithile lokuvikela emisebeni ye-UV. Kuyasiza ekwehliseni ukulimala kwesikhumba okubangelwa yi-UV, njengokushiswa yilanga nokuthwebula izithombe.
- I-Synergistic Effect: Uma isetshenziswa ngokuhambisana namanye ama-ejenti okuvikela ilanga, i-glabridin ingathuthukisa umphumela wokuvikela izithombe.
6. Ukwelapha Amanxeba
- Ikhuthaza Ukuphulukiswa: I-Glabridin ingakhuthaza ukuphulukiswa kwesilonda ngokunciphisa ukuvuvukala nokucindezeleka okwenziwe nge-oxidative, futhi ngokugqugquzela ukuvuselelwa kwamangqamuzana esikhumba.
- Ukunciphisa Izibazi: Kungasiza futhi ekwehliseni ukubukeka kwezibazi ngokukhuthaza ukuvuselelwa kwesikhumba okunempilo.
7. Ukunakekelwa Kwezinwele
- Impilo Yesikhumba: I-Glabridin's anti-inflammatory and antimicrobial properties ingazuza impilo ye-scalp, ukunciphisa inkwethu nokucasuka kwesikhumba.
- Ukukhula Kwezinwele: Ngokuthuthukisa impilo ye-scalp, i-glabridin ingase futhi ikhuthaze ukukhula kwezinwele okunempilo.
Yiziphi Izicelo ZeI-Glabridin?
Izimonyo kanye Skincare
1.Imikhiqizo Yesikhumba Esimhlophe
- Ama-Whitening Creams namaSerums: I-Glabridin iyisithako esiyinhloko emikhiqizweni eminingi yokucwenga kwesikhumba kanye nokukhanya ngenxa yekhono layo lokuvimbela umsebenzi we-tyrosinase nokunciphisa ukukhiqizwa kwe-melanin.
- I-Spot Treatments: Isetshenziswa ekwenziweni okuhloswe ngayo ukunciphisa amabala amnyama, i-hyperpigmentation, kanye nethoni yesikhumba engalingani.
2.Imikhiqizo Yokuguga
- Ama-Anti-Aging Creams and Lotions: Izakhiwo ze-antioxidant ze-glabridin zisiza ekwehliseni izimpawu zokuguga, njengemigqa emihle, imibimbi, namachashaza obudala.
- Izikhilimu zamehlo: Ngokuvamile zifakwa kokhilimu wamehlo ukunciphisa imibuthano emnyama nokukhukhumala.
3.Imikhiqizo Enqanda Ukuvuvukala Nepholile
- Ama-Gel and Creams apholile: Izakhiwo ze-Glabridin zokuqeda ukuvuvukala ziyenza ifaneleke emikhiqizweni eklanyelwe ukuthobisa isikhumba esicasuliwe noma esivuthayo.
- Ukwelashwa kwezinduna: Kusetshenziswa emikhiqizweni yokwelapha izinduna ukunciphisa ukuvuvukala nokukhula kwamagciwane.
4.Imikhiqizo Yokuvikela Ilanga
- Ama-sunscreens: I-Glabridin ingafakwa kuma-sunscreens ukuze inikeze ukuvikeleka okwengeziwe emonakalweni wesikhumba owenziwe yi-UV.
- Ukunakekelwa Kwangemva Kwelanga: Kusetshenziswa emikhiqizweni yangemuva kwelanga ukuze kuthobe futhi kulungiswe isikhumba esishiswe yilanga.
Ezemithi
1. Imithi yokwelapha
- Ama-Anti-Inflammatory Creams: Asetshenziswa emithini ye-topical ukwelapha izimo zesikhumba ezivuvukalayo njenge-eczema, i-psoriasis, ne-dermatitis.
- Amafutha Apholisa Amanxeba: Afakwe ekwakhiweni okuhloswe ngayo ukukhuthaza ukupholiswa kwesilonda kanye nokunciphisa ukwakheka kwezibazi.
2. Izithasiselo Zomlomo
- I-Antioxidant Supplements: Izakhiwo ze-Glabridin ze-antioxidant zikwenza kube isithako esibalulekile ezingxenyeni zomlomo ezihloswe ukunciphisa ukucindezeleka okwenziwe nge-oxidative nokukhuthaza impilo yonke.
- Ama-Immune Boosters: Asetshenziswa kwizithako eziklanyelwe ukuthuthukisa ukusebenza komzimba ngenxa yezakhiwo zayo zokulwa nokuvuvukala kanye ne-antimicrobial.
Ukunakekelwa Kwezinwele
1.Ukwelashwa Kwesikhumba
- Ama-Anti-Dandruff Shampoos: I-Glabridin's antimicrobial and anti-inflammatory properties iyenza iphumelele ekwelapheni inkwethu nokucasuka kwesikhumba.
- AmaSerum e-scalp: Asetshenziswa kumaserum ekhanda ukuze kuthuthukiswe indawo enempilo ye-scalp futhi okungenzeka akhuthaze ukukhula kwezinwele.
2.Ama-Hair Conditioner
- Ama-Conditioners kanye Nemaski Yezinwele: Kufakwe emikhiqizweni yokunakekelwa kwezinwele ukuhlinzeka ngokuvikelwa kwe-antioxidant futhi kuthuthukise impilo yezinwele.
Ukudla Neziphuzo
Ukudla Okusebenzayo
- Iziphuzo Zezempilo: I-Glabridin ingafakwa eziphuzweni zezempilo kanye neziphuzo ezisebenzayo ukuze inikeze izinzuzo ze-antioxidant ne-anti-inflammatory.
- Amabha Okudla Okunomsoco: Asetshenziswa ezindaweni zokudla okunempilo nokudla okulula okuhloselwe ukukhuthaza impilo nokuphila kahle.
Ucwaningo Nentuthuko
Ucwaningo Lwezempilo
- Ucwaningo Lomdlavuza: I-Glabridin icwaningwa ngezindawo zayo zokulwa nomdlavuza ezingase zibe khona, okuhlanganisa ikhono layo lokuvimbela ukukhula kwamangqamuzana omdlavuza futhi yenze i-apoptosis.
- Ucwaningo Lwezifo Ezingamahlalakhona: Luphenyelelwa izinzuzo zalo ezingaba khona ekulawuleni izifo ezingamahlalakhona ezifana nesifo sikashukela kanye nezifo zenhliziyo nemithambo yegazi ngenxa yezakhiwo zalo zokulwa nokuvuvukala kanye ne-antioxidant.
Imibuzo Ehlobene Ongaba Nentshisekelo Kuyo:
Kuthatha isikhathi esingakanani ukukhipha i-licoricei-glabridinukukhanyisa isikhumba?
Isikhathi esisithathayo ukuze kukhishwe i-licorice equkethe i-glabridin ukuze kukhanye isikhumba kungahluka kuye ngezinto ezimbalwa, okuhlanganisa ukugcwala kwe-glabridin emkhiqizweni, imvamisa yokusetshenziswa, uhlobo lwesikhumba somuntu, kanye nobukhulu be-hyperpigmentation. Nayi eminye imihlahlandlela ejwayelekile nokucatshangelwa:
1. Uhlaka Lwesikhathi Olujwayelekile
- Imiphumela Yasekuqaleni: Abanye abasebenzisi bangase baqale ukubona ukuthuthuka kokuqala kwethoni yesikhumba kanye nokuncipha kwe-hyperpigmentation phakathi kwamaviki angu-2 kuya kwangu-4 okusetshenziswa okungaguquki.
- Imiphumela Ebalulekile: Imiphumela ekhanyayo nebalulekile ekhanyisa isikhumba ngokuvamile ivela ngemva kwamaviki angu-8 kuya kwangu-12 okusetshenziswa njalo.
2. Izici Ezithonya Ukusebenza Ngempumelelo
Ukugxila kweGlabridin
- Ukugxila Okuphakeme: Imikhiqizo enezinga eliphezulu le-glabridin (isb., 0.5% kuya ku-1%) ingase ikhiqize imiphumela esheshayo necace kakhudlwana.
- Ukugxila Okuphansi: Imikhiqizo enezingqimba eziphansi ingase ithathe isikhathi eside ukukhombisa imiphumela ebonakalayo.
Imvamisa Yokufaka Isicelo
- Ukusetshenziswa Kwansuku zonke: Ukusebenzisa umkhiqizo kanye noma kabili ngosuku, njengoba kunconyiwe, kungathuthukisa ukusebenza kahle futhi kusheshise imiphumela.
- Ukusetshenziswa Okungahambisani: Ukusetshenziswa okungajwayelekile kungase kubambezele imiphumela ebonakalayo futhi kunciphise ukusebenza kahle konke.
Uhlobo Nesimo Sesikhumba
- Uhlobo Lwesikhumba: Abantu abanesikhumba esikhanyayo bangabona imiphumela ngokushesha uma kuqhathaniswa nalabo abanesikhumba esimnyama.
- Ubukhulu be-Hyperpigmentation: I-hyperpigmentation encane ingase iphendule ngokushesha ekwelapheni, kuyilapho izimo ezinzima kakhulu zingathatha isikhathi eside ukubonisa ukuthuthukiswa.
3. Umjikelezo Wokunakekelwa Kwesikhumba Ohambisanayo
- Ukuvikela Ilanga: Ukusebenzisa i-sunscreen nsuku zonke kubalulekile uma usebenzisa imikhiqizo ekhanyisa isikhumba ukuze ugweme ukuqhubeka nokushintsha umbala futhi uvikele isikhumba emonakalweni we-UV.
- Ukuswakama: Ukugcina isikhumba siswakeme kahle kungathuthukisa ukumuncwa nokusebenza ngempumelelo kwemikhiqizo equkethe i-glabridin.
- I-exfoliation: Ukukhishwa njalo kungasiza ukususa amangqamuzana esikhumba afile futhi kukhuthaze ukungena kwezithako ezisebenzayo, okungase kusheshise imiphumela.
4. Izifundo Zemitholampilo Nobufakazi
- Izifundo Zemitholampilo: Ezinye izifundo zomtholampilo zibonise ukuthi i-glabridin inganciphisa kakhulu i-hyperpigmentation futhi ithuthukise ithoni yesikhumba phakathi kwamasonto angu-8 kuya kwangu-12 wokusetshenziswa okungaguquki.
- Ubufakazi Bomsebenzisi: Abasebenzisi abaningi babika ukuthi babone ukuthuthuka okubonakalayo esikhumbeni sabo kanye nokuncipha kwamabala amnyama phakathi namaviki ambalwa kuya ezinyangeni ezimbalwa zokusetshenziswa okuvamile.
Iyini imiphumela emibi ye-i-glabridin?
I-Glabridin inezinhlobonhlobo zezinto eziphilayo kanye nezinzuzo zezempilo, kodwa kwezinye izimo, ukusebenzisa imikhiqizo equkethe i-glabridin kungase kubangele eminye imiphumela emibi. Okulandelayo yimiphumela emibi engaba khona kanye nezinyathelo zokuphepha ze-glabridin:
1. Ukucasuka Kwesikhumba kanye Ne-Allergic Reactionns
Ukucasuka Kwesikhumba
- Izimpawu: Ingase ihlanganise ububomvu, ukuvuvukala, ukulunywa, ukuluma, noma ukuzwa ukusha.
- Izimbangela: Ukuzwela kwesikhumba ku-glabridin noma ezinye izithako emkhiqizweni kungabangela ukucasuka okuncane kwesikhumba.
Ukusabela Okungezwani Nomzimba
- Izimpawu: Kungase kuhlanganise ukuqubuka, i-erythema, ukuvuvukala, noma ukulunywa okukhulu.
- Izimbangela: Ukungezwani ne-glabridin noma ezinye izithako emkhiqizweni, okungase kubangele ukungezwani komzimba.
2. Ukuzwela kwesithombe
- Ukwandisa Ukuzwela Emisebeni Yelanga: i-glabridin ingase ikhulise ukuzwela kwesikhumba ekukhanyeni kwelanga, okuholela ekushiseni kwelanga noma i-photosensitivity dermatitis.
- Ukuvimbela: Uma usebenzisa imikhiqizo equkethe i-glabridin, kunconywa ukusebenzisa i-sunscreen ebanzi futhi ugweme ukuchayeka elangeni isikhathi eside.
3. Imiphumela Yama-Hormonal
- Umsebenzi Ongaba khona We-Hormonal: Nakuba i-glabridin ngokuyinhloko ihloselwe ukusetshenziswa kwezihloko, izingxenye ezithile ze-licorice (njenge-glycyrrhizic acid) zaziwa ngokuba nemiphumela efana ne-steroid engase ithinte ibhalansi ye-hormone.
- Ukucabangela: Uma usebenzisa imikhiqizo equkethe i-glabridin ngobuningi isikhathi eside, kufanele unake ukubheka ukuthi zikhona yini izimpawu zokungalingani kwe-hormonal.
4. Ukusebenzisana Nezinye Izithako Zokunakekelwa Kwesikhumba
- Ukusebenzisana Okungenzeka: i-glabridin ingase ihlanganyele nezinye izithako ezisebenzayo (ezifana ne-vitamin C, i-retinol, njll.), ezithinta ukusebenza kwayo noma ukwandisa ingozi yemiphumela emibi.
- Isincomo: Uma usebenzisa imikhiqizo equkethe i-glabridin, kutuswa ukuba ugweme ukusetshenziswa kanyekanye kwezinye izithako ezisebenzayo eziqinile noma uthintane nodokotela wesikhumba ngaphambi kokusetshenziswa.
5. Imiphumela Yesistimu
- Ukumuncwa Okukhawulelwe:i-glabridinisetshenziswa kakhulu ukusetshenziswa kwangaphandle futhi inokumuncwa okuncane kwesistimu, ngakho imiphumela emibi yesistimu ayijwayelekile kakhulu.
- Ukuqapha: Uma uhlangabezana nanoma yikuphi ukungaphatheki kahle noma ukusabela okungavamile, kufanele uyeke ukuyisebenzisa ngokushesha futhi uxhumane nodokotela wakho.
6. Ukukhulelwa Nokuncelisa Ibele
- Ukukhathazeka Ngokuphepha: Okwamanje kunedatha elinganiselwe ngokuphepha kwe-glabridin kwabesifazane abakhulelwe nabancelisa ibele.
- Isincomo: Abesifazane abakhulelwe nabancelisayo kufanele babonane nodokotela wabo ngaphambi kokusebenzisa imikhiqizo equkethe i-glabridin.
Isikhathi sokuthumela: Sep-21-2024
