Eminyakeni yakamuva,NMN, osekudume umhlaba wonke, sekuseshweni olushisayo oluningi kakhulu. Kungakanani okwaziyo nge-NMN? Namuhla, sizogxila ekwethuleni i-NMN, ethandwa yiwo wonke umuntu.
● YiniNMN?
I-NMN ibizwa nge-β-Nicotinamide Mononucleotide, noma i-NMN ngamafuphi. I-NMN inama-diastereomer amabili: α kanye no-β. Ucwaningo luthole ukuthi uhlobo lwe-β kuphela lwe-NMN olunomsebenzi webhayoloji. Ngokwesakhiwo, i-molecule yakhiwe i-nicotinamide, i-ribose, ne-phosphate.
I-NMN ingenye yezandulela ze-NAD+. Ngamanye amazwi, umthelela oyinhloko we-NMN utholakala ngokuguqulelwa ku-NAD+. Njengoba sikhula, izinga le-NAD+ emzimbeni womuntu liyehla kancane kancane.
Ku-2018 Aging Biology Research Compilation, izindlela ezimbili ezibalulekile zokuguga komuntu zafingqwa:
1. Ukulimala okubangelwa ukucindezeleka kwe-oxidative (izimpawu zibonakala njengezifo ezihlukahlukene)
2. Amazinga anciphile e-NAD+ kumaseli
Inani elikhulu lezimpumelelo ezifundweni ku-NAD+ ocwaningweni lokulwa nokuguga olwenziwa ososayensi abaphambili emhlabeni basekela isiphetho sokuthi ukwanda kwamazinga e-NAD+ kungathuthukisa ikhwalithi yezempilo ezicini eziningi futhi kubambezele ukuguga.
● Ziyini Izinzuzo ZezempiloNMN?
1.Khulisa okuqukethwe kwe-NAD+
I-NAD+ iyinto ebalulekile yokugcina ukusebenza komzimba. Ikhona kuwo wonke amaseli futhi ibamba iqhaza ezinkulungwaneni zokusabela komzimba emzimbeni. Ngaphezu kwama-enzyme angama-500 emzimbeni womuntu adinga i-NAD+.
Kusukela kulesi sibalo, siyabona ukuthi izinzuzo zokwengeza i-NAD+ ezithweni ezahlukahlukene zifaka phakathi ukuthuthukisa impilo yobuchopho nohlelo lwezinzwa, isibindi nezinso, imithambo yegazi, inhliziyo, izicubu ze-lymphatic, izitho zokuzala, amanyikwe, izicubu ze-adipose, nemisipha.
Ngo-2013, ithimba labacwaningi eliholwa nguSolwazi David Sinclair we-Harvard Medical School libonise ngokuhlolwa ukuthi ngemva kokuphathwa ngomlomo kwe-NMN isonto elilodwa, izinga le-NAD+ kumagundane anezinyanga ezingu-22 lakhula, kanye nezinkomba ezibalulekile ze-biochemical ezihlobene ne-homeostasis ye-mitochondrial kanye. ukusebenza kwemisipha kwabuyiselwa esimweni samagundane amancane alingana nezinyanga ezingu-6 ubudala.
2. Yenza kusebenze amaprotheni e-SIR
Ucwaningo eminyakeni engu-20 edlule luthole ukuthi ama-Sirtuins adlala indima enkulu yokulawula cishe yonke imisebenzi yamangqamuzana, ethinta izinqubo zomzimba ezifana nokuvuvukala, ukukhula kwamangqamuzana, isigqi se-circadian, i-energy metabolism, umsebenzi we-neuronal kanye nokumelana nokucindezeleka.
Ama-Sirtuin avame ukubizwa ngokuthi umndeni wamaprotheni wesikhathi eside, okuwumndeni wamaphrotheni e-deacetylase ancike ku-NAD+.
Ngo-2019, uSolwazi Kane AE woMnyango Wezofuzo eHarvard Medical School nabanye bathola lokhoNMNisandulela esibalulekile sokwenziwa kwe-NAD+ emzimbeni. Ngemuva kokuthi i-NMN ikhulise izinga le-NAD + kumaseli, imiphumela yayo eminingi enenzuzo (njengokuthuthukisa imetabolism, ukuvikela isimiso senhliziyo nemithambo yegazi, njll.) ifinyelelwa ngokuvula i-Sirtuins.
3. Lungisa umonakalo we-DNA
Ngaphezu kokuthinta umsebenzi we-Sirtuins, izinga le-NAD+ emzimbeni liphinde libe yi-substrate ebalulekile ye-enzyme yokulungisa i-DNA PARPs (i-poly ADP-ribose polymerase).
4. Ukuthuthukisa umzimba
I-Metabolism iqoqo lokuhlangana kwamakhemikhali okugcina impilo ephilayo, evumela ukuthi zikhule futhi zizalane, zigcine ukwakheka kwazo, futhi zisabele emvelweni. I-Metabolism yinqubo lapho izinto eziphilayo zishintshana ngokuqhubekayo izinto namandla. Uma selimile, ukuphila kwento ephilayo kuzophela. USolwazi u-Anthony waseNyuvesi yaseCalifornia nethimba lakhe bathola ukuthi i-NAD+ metabolism isiphenduke indlela yokwelapha engaba ngcono yokuthuthukisa izifo ezihambisana nokuguga nokwandisa impilo nempilo yabantu.
5. Khuthaza ukuvuselelwa kwemithambo yegazi futhi ugcine ukunwebeka kwemithambo yegazi
Imithambo yegazi iyizicubu ezibalulekile zokuthutha umoya-mpilo nezakhamzimba, ukucubungula isikhutha nama-metabolites, nokulawula izinga lokushisa lomzimba. Njengoba sikhula, imithambo yegazi kancane kancane ilahlekelwa ukuguquguquka kwayo, ibe nzima, iminyene, futhi ibe mincane, okubangela "i-arteriosclerosis."
Ngo-2020, ucwaningo olwenziwa ngabanye abafundi be-PhD base-Zhejiang University of Technology e-China, kuhlanganise no-Sh, lwathola ukuthi ngemva kokuphathwa ngomlomoNMNkumagundane acindezelekile, izimpawu zokudangala zehliswa ngokukhuphuka kwamazinga e-NAD+, ukusebenzisa i-Sirtuin 3, kanye nokwenza ngcono i-mitochondrial energy metabolism ku-hippocampus nasemangqamuzaneni esibindi obuchopho bamagundane.
6. Vikela impilo yenhliziyo
Inhliziyo iyisitho esibaluleke kakhulu emzimbeni womuntu futhi ibalulekile ekugcineni ukusebenza kwenhliziyo. Ukwehla kwamazinga e-NAD + kuhlobene ne-pathogenesis yezifo ezahlukahlukene zenhliziyo. Inani elikhulu lezifundo eziyisisekelo liphinde labonisa ukuthi ukufaka i-coenzyme ngingazuza amamodeli wesifo senhliziyo.
7. Gcina impilo yobuchopho
Ukungasebenzi kahle kwe-neurovascular kungadala ukulimala komqondo kwangaphambi kwesikhathi kwemithambo kanye ne-neurodegenerative. Ukugcina ukusebenza kwe-neurovascular kubalulekile ekuvimbeleni izifo ze-neurodeergenerative.
Izici eziyingozi njengesifo sikashukela, umfutho wegazi ophakeme we-midlife, ukukhuluphala kwe-midlife, ukungawuvivinyi umzimba nokubhema konke kuhlotshaniswa nokuwohloka komqondo kwemithambo nesifo i-Alzheimer's.
8. Thuthukisa ukuzwela kwe-insulin
Ukuzwela kwe-insulin kuchaza izinga lokumelana ne-insulin. Ukuncipha kokuzwela kwe-insulin, kuyancipha izinga lokuwohloka koshukela.
Ukumelana ne-insulin kusho ukuncipha kokuzwela kwezitho ezihlosiwe ze-insulin esenzweni se-insulin, okungukuthi, isimo lapho umthamo ojwayelekile we-insulin ukhiqiza umphumela ophansi kunojwayelekile wezinto eziphilayo. Imbangela eyinhloko yesifo sikashukela sohlobo 2 ukukhiqizwa kwe-insulin ephansi kanye nokuzwela kwe-insulin okuphansi.
NMN, njengesengezo, kungasiza ekuthuthukiseni ukuzwela kwe-insulin ngokwandisa amazinga e-NAD+, ukulawula izindlela ze-metabolic, nokuthuthukisa ukusebenza kwe-mitochondrial.
9. Usizo ekulawuleni isisindo
Isisindo asithinti nje kuphela izinga lempilo nempilo, kodwa futhi siba yimbangela yezinye izifo ezingapheli. Ucwaningo luye lwabonisa ukuthi i-NAD precursor β-nicotinamide mononucleotide (NMN) ingahlehlisa eminye yemiphumela emibi yokudla okunamafutha aphezulu (HFD).
Ngo-2017, uSolwazi David Sinclair we-Harvard Medical School kanye nethimba labacwaningi abavela e-Australian Medical School baqhathanisa amagundane esifazane akhuluphele ayezivocavoca ku-treadmill amasonto angu-9 noma ajovwe nge-NMN nsuku zonke izinsuku ezingu-18. Imiphumela ibonise ukuthi i-NMN ibonakala inomphumela onamandla ku-metabolism yamafutha esibindi kanye nokuhlanganiswa kunokuzivocavoca.
●Ukuphepha kweNMN
I-NMN ibhekwa njengephephile ekuhlolweni kwezilwane, futhi imiphumela iyakhuthaza. Isamba sezinhlolo zomtholampilo zabantu eziyi-19 seziqalisiwe, ezi-2 zazo zishicilele imiphumela yokuhlola.
Ithimba labacwaningi abavela e-Washington University School of Medicine e-St. Louis lishicilele isihloko kumagazini wesayensi ophezulu "Isayensi", eveza imiphumela yokuhlolwa kokuqala komtholampilo womuntu emhlabeni, eqinisekisa izinzuzo ze-metabolic ze-NMN emzimbeni womuntu.
●NEWGREEN Supply NMN Powder/Capsules/Liposomal NMN
Isikhathi sokuthumela: Oct-15-2024
