Njengoba siguga, ukusebenza kwezitho zomuntu kancane kancane kuyancipha, okuhlobene eduze nokwanda kwezifo ze-neurodeergenerative. Ukungasebenzi kahle kwe-Mitochondrial kubhekwa njengenye yezinto ezibalulekile kule nqubo. Muva nje, ithimba labacwaningi lika-Ajay Kumar ovela e-Indian Institute of Integrated Traditional Chinese and Western Medicine lishicilele umphumela obalulekile wocwaningo ku-ACS Pharmacology & Translational Science, eveza indlelai-crocetinibambezela ukuguga kobuchopho nomzimba ngokwenza ngcono amazinga wamandla eselula.
I-Mitochondria "yizimboni zamandla" kumaseli, anesibopho sokukhiqiza iningi lamandla adingwa amaseli. Ngokukhula kweminyaka, ukwehla kokusebenza kwamaphaphu, i-anemia, kanye nokuphazamiseka kwe-microcirculatory kuholela ekungeneni komoyampilo okwanele ezicutshini, okubangela i-hypoxia engapheli kanye nokungasebenzi kahle kwe-mitochondrial, ngaleyo ndlela kukhuthaze ukuqhubeka kwezifo ze-neurodegenerative. I-Crocetin iyinhlanganisela yemvelo enamandla okuthuthukisa umsebenzi we-mitochondrial. Lolu cwaningo luhlose ukuhlola imiphumela ye-crocetin emsebenzini we-mitochondrial kumagundane asebekhulile kanye nemiphumela yawo yokulwa nokuguga.
●KuyiniI-Crocetin?
I-Crocetin iyi-apocarotenoid dicarboxylic acid yemvelo etholakala embalini ye-crocus kanye nezithelo zayo ze-glycoside, i-crocetin, ne-Gardenia jasminoides. Yaziwa nangokuthi i-crocetic acid.[3][4] Yakha amakristalu abomvu ngezitini anephuzu lokuncibilika elingu-285 °C.
Isakhiwo samakhemikhali se-crocetin sakha umnyombo omaphakathi we-crocetin, isakhi esibhekele umbala wesafroni. I-Crocetin ivame ukukhishwa ngokwentengiso esithelweni se-gardenia, ngenxa yezindleko eziphezulu zesafroni.
●KanjaniI-CrocetinUkuthuthukisa Amandla Eselula ?
Abacwaningi basebenzise amagundane amadala e-C57BL/6J. Amagundane asebekhulile ahlukaniswe ngamaqembu amabili, iqembu elilodwa lathola ukwelashwa kwe-crocetin izinyanga ezine, kanti elinye iqembu lasebenza njengeqembu elilawulayo. Amakhono okuqonda nemoto amagundane ahlolwe ngokuhlolwa kokuziphatha okufana nokuhlolwa kwenkumbulo yendawo kanye nokuhlolwa kwendawo evulekile, futhi indlela yokusebenza ye-crocetin yahlaziywa ngezifundo ze-pharmacokinetic kanye nokulandelana okuphelele kwe-transcriptome. Ukuhlaziywa kokuhlehla kwe-Multivariate kwasetshenziselwa ukulungisa izinto ezididayo ezifana nobudala nobulili ukuze kuhlolwe imiphumela ye-crocetin emisebenzini yengqondo neyengqondo yamagundane.
Imiphumela yabonisa ukuthi ngemva kwezinyanga ezinei-crocetinukwelashwa, ukuziphatha kwenkumbulo kanye nekhono lemoto lamagundane kwathuthukiswa kakhulu. Iqembu lokwelapha lenze kangcono ekuhlolweni kwenkumbulo yendawo, lathatha isikhathi esincane ukuthola ukudla, lahlala engalweni ebanjwa isikhathi eside, futhi lanciphisa inani lezikhathi elingena ngalo engalweni engabanjwanga ngephutha. Ekuhlolweni kwendawo evulekile, amagundane eqenjini eliphethwe i-crocetin ayesebenza kakhulu, futhi ahambisa ibanga nesivinini.
Ngokulandelanisa yonke i-transcriptome ye-hippocampus yegundane, abacwaningi bathola lokhoi-crocetinukwelashwa kubangele izinguquko eziphawulekayo ekukhulumeni kwezakhi zofuzo, okuhlanganisa ukulawulwa kokuvezwa kwezakhi zofuzo ezihlobene njenge-BDNF (i-brain-derived neurotrophic factor).
Ucwaningo lwe-Pharmacokinetic lubonise ukuthi i-crocetin inokugxila okuphansi ebuchosheni futhi akukho ukunqwabelana, okubonisa ukuthi iphephile uma kuqhathaniswa. I-crocetin ithuthukise ngempumelelo ukusebenza kwe-mitochondrial futhi yandisa amazinga wamandla eselula kumagundane asebekhulile ngokwandisa ukusakazwa komoyampilo. Ukusebenza okuthuthukisiwe kwe-mitochondrial kusiza ukubambezela inqubo yokuguga yobuchopho nomzimba futhi kwandise isikhathi sokuphila samagundane.
Lolu cwaningo lukhombisa lokhoi-crocetiningabambezela kakhulu ukuguga kobuchopho nomzimba futhi yandise isikhathi sokuphila kumagundane asebekhulile ngokuthuthukisa ukusebenza kwe-mitochondrial nokwandisa amazinga wamandla eselula. Izincomo eziqondile zimi kanje:
Yengeza i-crocetin ngokulinganisela: Kubantu asebekhulile, ukugcwalisa i-crocetin ngokulinganisela kungase kusize ukuthuthukisa amakhono okuqonda nemisipha futhi kubambezele inqubo yokuguga.
Ukuphathwa kwezempilo okuphelele: Ngaphezu kokwengeza i-crocetin, kufanele futhi ugcine ukudla okunempilo, ukuvivinya umzimba okuvamile kanye nekhwalithi yokulala enhle ukuze ukhuthaze impilo yonke.
Naka ukuphepha: Nakubai-crocetinibonisa ukuphepha okuhle, kusadingeka ukuthi unake umthamo lapho ufaka futhi ukwenze ngaphansi kokuqondisa kukadokotela noma isazi sokudla okunempilo.
●NEWGREEN Supply Crocetin /Crocin /Saffron Extract
Isikhathi sokuthumela: Oct-23-2024
