Njengoba sikhula, umsebenzi wezitho zabantu uwohloka kancane kancane, okuhlobene kakhulu nezigameko ezengeziwe zezifo ze-neurodegenerative. I-Mitochondrial Dysfunction ibhekwa njengenye yezinto ezibalulekile kule nqubo. Muva nje, ithimba lokucwaninga lase-Ajay Kumar elivela kwi-Indian Institute of Chinese Chinese Chinese Chinese kanye nentshonalanga yashicilela umphumela obalulekile wokucwaninga nge-ACS Pharmacology ne-Translational Science, eveza indlela laphoingcobekweniUkubambezeleka kobuchopho nokuguga komzimba ngokwenza ngcono amazinga wamandla amaselula.
I-Mitochondria iyi "Fakisi Energy Factories" kumaseli, abhekele ukukhiqiza iningi lamandla afunwa amaseli. Ngobudala, ukuncipha kwe-lung umsebenzi, i-anemia, kanye nokuphazamiseka kwe-microcircurrculatoratory kuholele ekuhlinzekeni komoya-mpilo ezicubu, kubangele i-hysfunction engapheli nokukhuthaza ukuqhubeka kwezifo ze-neurodegenerative. I-Crocetin yindawo yemvelo enamandla okuthuthukisa umsebenzi we-mitochondrial. Lolu cwaningo luhlose ukuhlola imiphumela ye-crocetin emsebenzini we-mitochondrial kumagundane asemdala nemiphumela yaso yokulwa nokuguga.
● YiniIngcobekweni?
I-Crocetin yi-apocarotenoid yemvelo ye-apocarotenoid acid etholakala kwizimbali ze-crocus kanye ne-glycoside yayo, i-crocetin, kanye ne-Gardicia Jasmiphoodes izithelo. Yaziwa nangokuthi i-acid ye-cropetic. [3] [4] Kwakha amakristalu abomvu wesitini ngephuzu lokuncibilika lika-285 ° C.
Isakhiwo samakhemikhali se-Crocetin sakha umnyombo ophakathi nendawo yeCrocetin, okuyikhompiyutha ebhekele umbala wesafroni. I-Crocetin imvamisa ikhishwe kwezentengiso kusuka ezitsheni zensimu, ngenxa yezindleko eziphakeme zesafroni.
● Kwenzeka kanjaniIngcobekweniUkukhulisa amandla amaselula?
Abaphenyi basebenzise i-Aged C57BL / 6J Mice. Amagundane adala ahlukaniswe ngamaqembu amabili, iqembu elilodwa lathola ukwelashwa kwe-crocetin izinyanga ezine, kanti elinye iqembu lasebenza njengeqembu elilawulayo. Amakhono amagundane namagundane ahlolwe ngokuhlolwa kokuziphatha okufana nokuhlolwa kwenkumbulo yendawo kanye nokuhlolwa kwensimu evulekile, futhi inqubo yokwenza iCrocetin yahlaziywa ngezifundo ze-Pharmacokinetic kanye nokulandelana kwayo okulandelayo. Ukuhlaziywa kokubuyiselwa kwe-multivariate kwasetshenziselwa ukujwayela izinto ezididayo ezinjengobudala kanye nobulili bokuhlola imiphumela ye-crosetin emisebenzini ye-Cronsitive and motor yamagundane.
Imiphumela ikhombisile ukuthi ngemuva kwezinyanga ezineingcobekweniUkwelashwa, indlela yokuziphatha yememori kanye nekhono lezimoto amagundane lathuthukiswa kakhulu. Iqembu lokwelashwa elenziwa kangcono ekuhlolweni kwememori yendawo, lithathe isikhathi esincane sokuthola ukudla, lahlala endaweni ehlonishwayo ende, futhi lanciphisa inani lezikhathi abafakenga ngephutha elingavinjelwe ngephutha. Esivivinyweni sensimu evulekile
Ngokulandelana okubhalwe phansi kwe-hippocampus yegundane, abacwaningi bakutholile lokhoingcobekweniUkwelashwa kubange izinguquko ezibalulekile e-Gene Expression, kufaka phakathi ukwahlukaniswa kokubonakaliswa kwezinhlobo ezihlobene njenge-BDNF (ubuchopho obususelwa ebuchosheni be-neurotrophic).
Izifundo ze-Pharmacokinetic zikhombisile ukuthi i-Crocetin inokugxila okuphansi ebuchosheni futhi akukho ukunqwabelana, okubonisa ukuthi iphephile kakhulu. I-Crocetin ethuthukiswe ngempumelelo yi-mitochondrial function kanye namazinga we-cellical energy asebekhulile amagundane asebekhulile ngokwandisa ukuphazamiseka komoya-mpilo. Umsebenzi we-Mitochondrial othuthukisiwe usiza ukwehlisa inqubo yokuguga kwengqondo nomzimba futhi wehlise isikhathi sokuphila kwamagundane.
Lolu cwaningo lukhombisa lokhoingcobekweniIngalibalisa kakhulu ubuchopho nokuguga komzimba futhi yandise isikhathi sokuphila kumagundane asebekhulile ngokwenza ngcono umsebenzi we-mitochondrial kanye nokwanda kwamazinga wamandla weselula. Izincomo ezithile zinjengokulandelayo:
Faka i-Crocetin ngokulinganisela: okwenzelwe asebekhulile, ukwengeza i-crocetin ngokulinganisela kungasiza ukuthuthukisa amakhono okuqonda kanye nezimoto futhi kubambezele inqubo yokuguga.
Ukuphathwa kwezempilo okuphelele: Ngaphezu kokungezelela iCrocetin, kufanele futhi ulondoloze ukudla okunempilo, ukuvivinya umzimba njalo kanye nekhwalithi enhle yokulala ukukhuthaza impilo yonke.
Naka ukuphepha: NomaingcobekweniIbonisa ukuphepha okuhle, usadinga ukunaka umthamo lapho ungezelela futhi ukwenze ngaphansi kokuholwa ngudokotela noma udokotela onempilo.
● I-NewGreen Supply Crocetin / Crocin / Saffron Extract
Isikhathi Sokuthumela: Oct-23-2024
