I-Berberine : Imizuzu emi-5 Yokufunda Ngezinzuzo zayo Zezempilo

● Yiziphi Izinzuzo Zezempilo Ze-Berberine?

1.I-Antioxidant

Ngaphansi kwezimo ezijwayelekile, umzimba womuntu ugcina ibhalansi phakathi kwama-antioxidants nama-prooxidants. Ukucindezeleka kwe-oxidative kuyinqubo eyingozi engase ibe umlamuleli obalulekile wokulimala kwesakhiwo samangqamuzana, ngaleyo ndlela ibangele izifo ezihlukahlukene ezifana nesifo senhliziyo, umdlavuza, izifo zezinzwa nesifo sikashukela. Ukukhiqizwa ngokweqile kwezinhlobo ze-oxygen esebenzayo (i-ROS), ngokuvamile ngokukhuthazwa ngokweqile kwe-NADPH ngama-cytokines noma ngochungechunge lwezokuthutha lwe-electron mitochondrial kanye ne-xanthine oxidase, kungaholela ekucindezelekeni kwe-oxidative. Ukuhlolwa kubonise ukuthi i-berberine metabolites kanye ne-berberine ibonisa umsebenzi omuhle kakhulu wokukhipha u-OH, ocishe ulingane ne-antioxidant enamandla vitamin C. Ukuphathwa kwe-berberine kumagundane anesifo sikashukela kungaqapha ukwanda komsebenzi we-SOD (superoxide dismutase) kanye nokuncipha kwe-MDA (a umaka we-lipid peroxidation) amazinga [1]. Eminye imiphumela ikhombisa ukuthi umsebenzi wokukhipha udoti we-berberine usondelene kakhulu nomsebenzi wayo we-ferrous ion chelating, futhi iqembu le-C-9 hydroxyl le-berberine liyingxenye ebalulekile.

2.Anti-isimila

Kube nemibiko eminingi ngomphumela wokulwa nomdlavuza wei-berberine. Ucwaningo oluhlukahlukene eminyakeni yamuva lubonise ukuthi i-berberine ibaluleke kakhulu ekwelapheni i-adjuvant yezifo zomdlavuza ezinzima ezifana nomdlavuza we-ovarian, umdlavuza we-endometrial, umdlavuza wesibeletho, umdlavuza webele, umdlavuza wamaphaphu, umdlavuza we-colorectal, umdlavuza wezinso, umdlavuza wesinye kanye nomdlavuza we-prostate. [2]. I-Berberine ingavimbela ukwanda kwamangqamuzana e-tumor ngokusebenzisana nezinhloso nezindlela ezihlukahlukene. Ingashintsha ukubonakaliswa kwama-oncogenes kanye nezakhi zofuzo ezihlobene ne-carcinogenesis ukuze kuzuzwe injongo yokulawula umsebenzi wama-enzyme ahlobene ukuze kuvinjwe ukwanda.

3.Ukwehlisa Igazi Lipids Nokuvikela Isistimu Yenhliziyo

I-Berberine idlala indima ebalulekile ekwelapheni izifo zenhliziyo nemithambo yegazi futhi inezinhlobonhlobo zezicelo. I-Berberine ifinyelela injongo ye-anti-arrhythmia ngokunciphisa izehlakalo zokushaywa kwe-ventricular ngaphambi kwesikhathi futhi ivimbele ukuvela kwe-tachycardia ye-ventricular. Okwesibili, i-dyslipidemia iyingozi enkulu yesifo senhliziyo, ebonakala ngamazinga aphakeme e-cholesterol ephelele, i-triglycerides, kanye ne-low-density lipoprotein cholesterol (LDL), kanye namazinga ehla e-high-density lipoprotein (HDL), kanye ne-berberine ingagcina i-high-density lipoprotein (HDL) ukuzinza kwalezi zinkomba. I-hyperlipidemia yesikhathi eside iyimbangela ebalulekile yokwakheka kwama-atherosclerotic plaque. Kubikwa ukuthi i-berberine ithinta ama-receptors e-LDL kuma-hepatocytes ukunciphisa amazinga e-serum cholesterol ku-hepatocytes. Akugcini lapho,i-berberineinomphumela omuhle we-inotropic futhi isetshenziselwe ukwelapha ukuhluleka kwenhliziyo ehlangene.

4.Yehlisa Ushukela Wegazi Futhi Ilawula I-Endocrine

Isifo sikashukela i-mellitus (DM) isifo sokuphazamiseka kwe-metabolic esibonakala ngokukhuphuka kwamazinga kashukela egazini (hyperglycemia) okubangelwa ukungakwazi kwamangqamuzana e-pancreatic B ukukhiqiza i-insulin eyanele, noma ukulahlekelwa ukusabela kwezicubu eziqondiwe ngempumelelo ku-insulin. Umphumela we-hypoglycemic we-berberine watholakala ngengozi ngeminyaka yawo-1980 ekwelapheni iziguli ezinesifo sikashukela esihudo.

Ucwaningo oluningi luye lwabonisa lokhoi-berberineyehlisa ushukela wegazi ngalezi zindlela ezilandelayo:

● Ivimbela i-glucose oxidation ye-mitochondrial futhi ivuselele i-glycolysis, kamuva yandise umzimba we-glucose;
● Yehlisa amazinga e-ATP ngokuvimbela ukusebenza kwe-mitochondrial esibindini;
● Ivimbela umsebenzi we-DPP 4 (i-serine protease etholakala yonke indawo), ngaleyo ndlela ihlukanise ama-peptide athile asebenza ukukhulisa amazinga e-insulin lapho kukhona i-hyperglycemia.
● I-Berberine inomphumela onenzuzo ekuthuthukiseni ukumelana ne-insulin kanye nokusetshenziswa kwe-glucose ezicutshini ngokunciphisa i-lipids (ikakhulukazi i-triglycerides) namazinga anamafutha angenayo i-plasma.

Isifinyezo

Namuhla,i-berberineingahlanganiswa ngokwenziwa futhi iguqulwe ngezindlela zobunjiniyela bekristalu. Inezindleko eziphansi kanye nobuchwepheshe obuphambili. Ngokuthuthukiswa kocwaningo lwezokwelapha kanye nokujula kocwaningo lwamakhemikhali, i-berberine ngokuqinisekile izobonisa imiphumela eminingi yokwelapha. Ngakolunye uhlangothi, i-berberine ayizuzanga nje kuphela imiphumela ephawulekayo ocwaningweni lwendabuko lwemithi elwa namagciwane, i-antiviral, anti-inflammatory, anti-tumor, anti-diabetes, kanye nokwelashwa kwezifo zenhliziyo nemithambo ye-cerebrovascular, kodwa futhi nomklamo wayo wobunjiniyela bekristalu nokuhlaziywa kwe-morphological. bathole ukunakwa okukhulu. Ngenxa yokusebenza kwayo okuphawulekayo kanye nemiphumela ephansi enobuthi nemiphumela engemihle, inamandla amakhulu ekusetshenzisweni komtholampilo futhi inamathemba abanzi. Ngokuthuthuka kwebhayoloji yamangqamuzana, indlela ye-pharmacological ye-berberine izocaciswa kusukela kuzinga lamaselula ngisho namazinga e-molecular and target, okuhlinzeka ngesisekelo sethiyori esithe xaxa sokusetshenziswa kwayo emtholampilo.

● Ukunikezela nge-NEWGREENI-Berberine/Liposomal Berberine Powder/Capsules/Tablets