YiniI-azelaic acid?
I-Azelaic Acid i-DicarBoxylic acid ngokwemvelo esetshenziswa kabanzi ekunakekelweni kwesikhumba nokwelapha izimo ezahlukahlukene zesikhumba. Inama-antibacterial, anti-inflammatory kanye ne-keratin elawula izakhiwo futhi ivame ukusetshenziselwa ukwelapha izinkinga zesikhumba ezinjenge-acne, rosacea kanye ne-hyperpigmentation.
Izakhiwo ezingokomzimba nezamakhemikhali ze-azelaic acid
1. Isakhiwo samakhemikhali nezakhiwo
Isakhiwo samakhemikhali
Igama lamakhemikhali: i-azelaic acid
Ifomula yamakhemikhali: c9h16o4
Isisindo Molecular: 188.22 g / mol
Isakhiwo: I-Azelaic Acid iyi-dicarboxylic acid eqonde ngqo.
Izakhiwo ze-2.Physical
Ukubukeka: I-Azelaic Acid ngokuvamile ivela njenge-White Crystalline Powder.
I-Solubinity: Inyakazisa kancane emanzini kepha incane kakhulu kuma-solvents ezi-organic njenge-ethanol ne-preylene glycol.
Iphoyinti elincibilikayo: Cishe i-106-108 ° C (223-226 ° F).
3. Indlela Yokusebenza
I-antibacterial: I-a antibacterial: i-azelaic acid ivimbela ukukhula kwamagciwane, ikakhulukazi umnikelo we-provibacterium acnes, okungumnikelo osemqoka oya e-Acne.
Ukulwa nokuvuvukala: Kunciphisa ukuvuvukala ngokuvimbela ukukhiqizwa kwama-cytokines avuvukala.
Ukulawulwa Kwe-Keratinization: I-Azelaic Acid isiza ngokwejwayelekile ukuchitheka kwesikhumba sesikhumba esifile, kuvinjelwe ama-pores ahlanganisiwe nokwakhiwa kwama-comedones.
I-Tyrosinase Vising: Ivimbela i-Enzyme Tyrosinase, ebandakanyeka ekukhiqizeni i-melanin, ngaleyo ndlela kusiza ukunciphisa i-hyperpigmentation ne-melasma.
Yini izinzuzo zeI-azelaic acid?
I-Azelaic Acid iyinhlangano ehlukahlukene ye-dicarboxylic acid esetshenziswa kabanzi ekunakekelweni kwesikhumba nokwelashwa kwezinkinga ezahlukahlukene zesikhumba. Nazi izinzuzo eziphambili ze-azelaic acid:
1. Phawula izinduna
- Umphumela we-antibacterial
- Umphumela wokulwa nokuvuvukala: kunganciphisa impendulo yokuvuvukala kwesikhumba futhi kudambise ukubomvu, ukuvuvukala nobuhlungu.
- I-Keratin elawula: i-azelaic acid isiza ngokwejwayelekile ukuchithwa kwamangqamuzana esikhumba afile, kuvinjelwe ama-pores kanye nokwakheka kwezinduna.
2. Ukwelashwa kweRosacea
- Yehlisa ukubomvu: i-azelaic acid yehlisa ngempumelelo ukubomvu nokuvuvukala okuhlotshaniswa noRosacea.
- Umphumela we-antibacterial: Kuvimbela ukukhula kwamagciwane ahlobene neRosos bese kunciphisa ubungozi bokutheleleka kwesikhumba.
3. Thuthukisa i-pigmentation
- Umphumela Wempilo
- Ithoni Yesikhumba: Imiphumela ejwayelekile yokusetshenziswa kwezwi lesikhumba, kunciphisa amabala amnyama kanye ne-pigmentation engalingani.
4. Umphumela we-Antioxidant
- Ukuvikelwa kwama-radicals wamahhala: I-Azelaic Acid inezindawo ze-antioxidant ezithinta ama-radicals wamahhala futhi zinciphise ukulimala kwengcindezi esikhunjeni.
- Ukulwa nama-anti: ngokunciphisa umonakalo wamahhala we-radical, i-azelaic acid isiza ukukhula kwesikhumba futhi kunciphise ukubukeka kwemigqa emihle nemibimbi.
I-5H)
- Yehlisa i-pigmentation: i-azelaic acid iphatha ngempumelelo i-hyperpigmentation ngemuva kokuvuvukala, okuvame ukwenzeka ngemuva kwezimo zomqubuko noma ezinye izimo zokuvuvukala.
- Khuthaza ukulungiswa kwesikhumba: Kukhuthaza ukuvuselelwa nokulungiswa kwamaseli esikhumba futhi kusheshise ukuphelelwa yi-pigmentation.
6. Ilungele isikhumba esibucayi
- Mnene futhi engacasuli: i-azelaic acid ngokuvamile ibekezelelwa kahle futhi ilungele izinhlobo zesikhumba esibucayi.
- NonMedogenic: Akukaqedi ama-pores futhi kufanelekile isikhumba esithambekele emqubeni.
7. Phatha ezinye izifo zesikhumba
- I-Keratosis Pilaris: I-Azelaic Acid ingasiza ekunciphiseni isikhumba esinolaka, esiphakanyisiwe esihambisana ne-keratosis Pilaris.
- Ezinye izifo zesikhumba sokuvuvukala: Futhi inemiphumela ethile yokwelapha kwezinye izifo zesikhumba okuvuvukala njenge-eczema ne-psoriasis.
Yini ukusetshenziswa kweI-azelaic acid?
1. Phawula izinduna: amalungiselelo aphezulu
- Ama-Acne Creams nama-gels: I-Azelaic Acid isetshenziswa kakhulu kumalungiselelo we-toporical ukwelapha izinduna ezinokulinganisela. Kuyasiza ukunciphisa inani lezilonda zezinduna futhi kuvimbela ukwakheka kwabasha.
- Ukwelashwa okuhlanganisiwe: kuvame ukusetshenziswa ngokubambisana nezinye izindlela zokwelapha ezifana neBenzioyl Peroxide noma i-redinoic acid ukuthuthukisa ukusebenza kahle.
2. Ukwelashwa kweRosacea: Amalungiselelo okulwa nokuvuvukala
- Ama-Rosacea Creams nama-Gels: i-azelaic acid yehlisa ngempumelelo ukubomvu nokuvuvukala okuhlotshaniswa noRosacea futhi kuvame ukusetshenziswa kumalungiselelo aphezulu abhekiswe ngqo eRosacea.
- Abaphathi besikhathi eside: Ilungele ukuphathwa isikhathi eside kweRosacea, isiza ukugcina isimo esizinzile sesikhumba.
3. Thuthukisa i-pigmentation: Imikhiqizo yamhlophe
- Okhilimu obukhali nama-serums: I-Azelaic Acid isiza ukunciphisa i-pigmentation ne-melasma ngokuvimbela umsebenzi we-tyrosinase kanye nokunciphisa ukukhiqizwa kwe-melanin.
- Ithoni Yesikhumba: Imiphumela ejwayelekile yokusetshenziswa kwezwi lesikhumba, kunciphisa amabala amnyama kanye ne-pigmentation engalingani.
I-4. I-Antioxidant kanye nokulwa nokuguga: Umkhiqizo wokunakekelwa kwesikhumba we-antioxidants
- Amakhilimu alwa nama-anti nama-serums: Izici ze-antioxidant ze-azelaic acid zenza kube yisithako esibalulekile kwimikhiqizo yokunakekelwa kwesikhumba elwa nokuguga, isiza ukunciphisa ukulimala kwamahhala kwesikhumba futhi yehlise ukuguga kwesikhumba.
- Ukunakekelwa kwesikhumba kwansuku zonke: Kulungele ukunakekelwa kwesikhumba kwansuku zonke, okuhlinzeka ngokuvikelwa kwe-antioxidant kanye nokugcina isikhumba siphilile.
I-5
- Ukulungisa okhilimu kanye nama-serums: i-azelaic acid iyasebenza ekwelapheni i-hyperpigmentation ngemuva kokuvuvukala futhi ivame ukusetshenziswa kumakhilimu wokulungisa nama-serums ukusiza ukusheshisa ukulahleka kwe-hyperpigmentation.
- Ukulungiswa kwesikhumba: khuthaza ukuphishelwa kabusha nokulungiswa kwamaseli esikhumba futhi usheshise ukuphenya kwe-pigmentation.
6. Phatha ezinye izifo zesikhumba
I-Keratosis Pilaris
- Imikhiqizo Yesimo seKeratin: i-azelaic acid ingasiza ekunciphiseni isikhumba esinolaka, esiphakanyisiwe esihambisana ne-keratosis Pilaris futhi sivame ukusetshenziswa emikhiqizweni ye-keratin conditioning.
- Isikhumba Sokushelelayo: Kuthuthukisa Ukushelela Kwesikhumba Nokuthambisa, Ukuthuthukisa Ukuthungwa kwesikhumba.
Ezinye izifo zesikhumba sokuvuvukala
- I-Eczema ne-Psoriasis: I-Azelaic Acid nayo inemiphumela ethile yokwelapha kwezinye izifo zesikhumba sokuvuvukala ezinjenge-eczema ne-psoriasis, futhi ivame ukusetshenziswa kumalungiselelo ahlobene nawo.
7. Ukunakekelwa kwesikhumba: Imikhiqizo yokulwa nokuvuvukala kanye ne-antibacterial
- Imikhiqizo ye-SCCAP Care: Izakhiwo ze-azelaic ze-anti-acurmatory kanye ne-antibacterial zenza zilungele ukusetshenziswa emikhiqizweni yokunakekelwa kwesikhumba ukusiza ukunciphisa ukuvuvukala kwesikhumba kanye nokutheleleka.
- Impilo Ye-Scalp: Ithuthukisa impilo ye-scalp futhi inciphise i-dandruff kanye ukulunywa.
Imibuzo Ehlobene Ungathakazelela:
Iyakwenzai-azelaic acidube nemiphumela emibi?
I-AZLEIC Acid ingaba nemiphumela emibi, yize imvamisa iyabekezelelwa kakhulu ngabantu abaningi. Imiphumela emibi imvamisa imnene futhi ithambekele ekunciphiseni ngokuqhubeka kokusetshenziswa. Nayi eminye imiphumela emibi kanye nokucatshangelwa:
1. Imiphumela emibi ejwayelekile
Ukucasuka kwesikhumba
- Izimpawu: ukucasuka okuncane, ukubomvu, ukulunywa, noma umuzwa ovuthayo endaweni yesicelo.
- Abaphathi: Lezi zimpawu zivame ukuncipha njengoba isikhumba sakho sivumelana nokwelashwa. Uma ukucasuka kuqhubeka, kungadingeka ukuthi unciphise imvamisa yesicelo noma uthintane nomhlinzeki wezokunakekelwa kwempilo.
Ukoma nokukhonkotha
- Izimpawu: ukomisa, ukufiphala, noma ukuncipha kwesikhumba.
- Abaphathi: Sebenzisa i-moisturizer emnene yokudambisa ukoma nokugcina i-hydration yesikhumba.
2. Imiphumela emincane evamile evamile
Ukusabela kwe-hypersensiticitivity
- Izimpawu: ukulunywa kanzima, ukuqubuka, ukuvuvukala, noma okhalweni.
- Abaphathi: yeka ukusetshenziswa ngokushesha bese uthintana nomhlinzeki wezokunakekelwa kwempilo uma uhlangabezana nanoma yiziphi izimpawu zokusabela komzimba.
Ukwanda kokuzwela kwelanga
- Izimpawu: Ukwanda kokuzwela elangeni, okuholela ekushisweni kwelanga noma ekulimaleni kwelanga.
- Abaphathi: Sebenzisa i-sunscreen ye-suncreen ebanzi nsuku zonke futhi uvikele ukuvezwa kwelanga isikhathi eside.
3. Imiphumela emibi engavamile
Ukusabela okukhulu kwesikhumba
- Izimpawu: Ubomvu obukhulu, ukukhala, noma ukukhonkotha okukhulu.
- Abaphathi: yeka ukusetshenziswa bese ufuna izeluleko zezokwelashwa uma uhlangabezana nokusabela kwesikhumba okukhulu.
4. Ukuqapha kanye nokucatshangelwa
Ukuhlolwa kwe-Patch
- Isincomo: Ngaphambi kokusebenzisa i-azelaic acid, yenza ukuhlolwa kwe-patch endaweni encane yesikhumba ukubheka noma yikuphi ukusabela okunzima.
Ukwethulwa kancane kancane
- Isincomo: Uma umusha ku-azelaic acid, qala ngokugxila okuphansi futhi kancane kancane wandise imvamisa yesicelo ukuvumela isikhumba sakho ukuthi silungiselele.
Ukuxoxisana
- Isincomo: Thintana nodokotela wesikhumba noma umhlinzeki wezempilo ngaphambi kokuqala i-azelaic acid, ikakhulukazi uma unesikhumba esibucayi noma usebenzisa ezinye izithako ze-skincare ezisebenzayo.
5. Kukhethekile abantu abakhethekile
Ukukhulelwa nokuncelisa
- Ezokuphepha: I-Azelaic Acid icatshangelwa ukuthi iphephile ukusetshenziswa ngesikhathi sokukhulelwa nokuncelisa, kepha kungcono kakhulu ukubonakalisa umhlinzeki wezokunakekelwa kwempilo ngaphambi kokuqala noma yiluphi lokwelashwa okusha ngaphambi kokuqala noma yiluphi lokwelashwa okusha.
Isikhumba Esibucayi
- Ukucatshangelwa: Abantu abanesikhumba esibucayi kufanele basebenzise i-azelaic acid ngokuqapha futhi bangazuza ekwakhiweni okwenzelwe isikhumba esibucayi.
Kuthatha isikhathi esingakanani ukubona imiphumelai-azelaic acid?
Isikhathi esithatha isikhathi sokubona imiphumela kusuka ku-azelaic acid ingahlukahluka, kepha ukuthuthuka kokuqala kuvame ukubonwa kungakapheli amasonto amabili kuya kwayi-4 ukuthola izinduna, namasonto amane kuya kwayi-8 ukuze i-hyperpigmentation ne-melasma. Imiphumela ebaluleke kakhulu ngokuvamile yenzeka ngemuva kwamasonto ayi-8 kuye kwayi-12 ukusetshenziswa okungaguquki. Izici ezinjengokuqoqwa kwe-azelaic acid, imvamisa yesicelo, izici zesikhumba ngazinye, kanye nobunzima besimo esiphathwayo kungathonya ukusebenza kanye nejubane lemiphumela. Ukusetshenziswa njalo nokungaguquki, kanye nezenzo ezihambisanayo ze-skincare, kungasiza ukufeza imiphumela engcono kakhulu.
Izici Imiphumela Yokuthonya
Ukugxila kwe-azelaic acid
Ukugxila Okuphezulu: Imikhiqizo enokugxila okuphezulu kwe-azelaic acid (isib., 15% kuya ku-20%) kungakhiqiza imiphumela esheshayo futhi ebonakalayo.
Ukugxila okuphansi: Imikhiqizo enokugxila okuphansi ingathatha isikhathi eside ukukhombisa imiphumela ebonakalayo.
Imvamisa yesicelo
Ukusetshenziswa Okungaguquki
Ukusetshenziswa Okungahambelani: Isicelo esingajwayelekile singabambezela imiphumela ebonakalayo futhi sinciphise ukusebenza kahle.
Izici zomuntu ngamunye
Uhlobo lwesikhumba: Uhlobo lwesikhumba ngasinye kanye nesimo kungathonya ukuthi imiphumela ngokushesha ibonwa ngokushesha kangakanani. Isibonelo, abantu abanamathoni esikhumba alula angabona imiphumela ngokushesha okukhulu kuqhathaniswa nalawo anamathoni wesikhumba amnyama.
Ubunzima besimo: Ubulukhuni besikhumba selaphakelwe bungathinta nesikhathi esidingayo ukubona imiphumela. Izimo ezimnene zingaphendula ngokushesha kunezimo ezinzima kakhulu.
Ungasebenzisa nini i-azelaic acid, ekuseni noma ebusuku?
I-Azelaic Acid ingasetshenziswa zombili ekuseni nasebusuku, kuya ngenqubo yakho ye-skincare nezidingo ezithile. Uma kusetshenziswe ekuseni, landela njalo nge-sunscreen ukuvikela isikhumba sakho ekulimaleni kwe-UV. Ukuyisebenzisa ebusuku kungathuthukisa ukulungiswa kwesikhumba futhi kunciphise ukusebenzisana nezinye izithako ezisebenzayo. Ngezinzuzo eziphezulu, abanye abantu bakhetha ukusebenzisa i-azelaic acid emabili ekuseni nobusuku, kepha kubalulekile ukuqapha impendulo yesikhumba sakho bese ulungisa ngokufanele. Njalo faka i-azelaic acid ngemuva kokuhlanza futhi ngaphambi kokuthambisa, futhi ubheke ukuthi ifinyelela kanjani kwirejimeko yakho ye-skincare ukufeza imiphumela emihle kakhulu.
Okungahambelani nei-azelaic acid?
I-Azelaic Acid iyisithako se-skincare esiguquguqukayo futhi esivame ukubekezelela kahle, kepha kubalulekile ukuba ukhumbule ukuthi kuhlangana kanjani nezinye izithako ezisebenzayo kwinqubo yakho ye-skincare. Ukuxuba izithako ezithile kungaholela ekucasukeni, kuncishiswe ukusebenza ngempumelelo, noma eminye imiphumela engafuneki. Nayi eminye imihlahlandlela kulokho ongakuhlanganisi ne-azelaic acid:
1. Ama-exfoliants aqinile
Alpha hydroxy acid (ahas)
- Izibonelo: Glycolic acid, i-lactic acid, imendiki acid.
- Isizathu: Ukuhlanganisa i-azelaic acid ngama-ahas aqinile kungakhulisa ubungozi bokucasuka, ubomvu kanye nokukhonkotha. Zombili zingabandakanyi, futhi ukuzisebenzisa ndawonye kungaba zinokhahlo kakhulu ngesikhumba.
I-Beta Hydroxy Acids (Bhas)
- Izibonelo: i-salicylic acid.
- Isizathu: Kuyafana no-Ahasi, ama-Bhas nawo axoxa. Ukuzisebenzisa ngokubambisana ne-azelaic acid kungaholela ekuxolishweni ngokweqile nasekukeni kwesikhumba.
2. Ama-retinoids
- Izibonelo: I-retinol, i-retinaldehyde, tretinoin, adapalene.
- Isizathu: Ama-retinoids anezithako ezinamandla ezingadala ukoma, ukukhonkotha, nokucasuka, ikakhulukazi lapho kwethulwa kuqala. Ukuhlanganisa nabo nge-azelaic acid kungandisa le miphumela emibi.
3. Benziyl peroxide
Isisusa
- Ukucasuka: IBenzoyl Peroxide yisithako esiqinile sokulwa nezinduna esingadala ukoma nokucasuka. Ukuyisebenzisa eceleni kwe-azelaic acid kungakhulisa ubungozi bokucasuka kwesikhumba.
- Ukusebenza kahle okuncishisiwe: I-Benzoyl Peroxide ingaphinde futhi i-oxidize nezinye izithako ezisebenzayo, ngokunciphisa ukusebenza kwazo.
4. Vitamin C (Ascorbic Acid)
Isisusa
- Amanqamu we-PH: Vitamin C (Ascorbic Acid) idinga i-PH ephansi ukuze isebenze, ngenkathi i-azelaic acid isebenza kangcono kakhulu ku-pH ephakeme kancane. Ukuzisebenzisa ndawonye kungahlehlisa ukusebenza kwezithako zombili.
- Ukucasulwa: Ukuhlanganisa lezi zithako ezimbili ezinamandla kungakhulisa ubungozi bokucasuka, ikakhulukazi ngesikhumba esibucayi.
5. Niacinamide
Isisusa
- Ukuxhumana okungaba khona: ngenkathi i-niacinamide ngokuvamile ibekezelelwa kahle futhi ingasetshenziswa ngezithako eziningi ezisebenzayo, abanye abantu bangathola ukucasulwa lapho behlanganisa nge-azelaic acid. Lokhu akuyona umthetho wendawo yonke, kepha yinto okufanele iqaphele.
6. Ezinye Izivumelwano Ezinamandla
Izibonelo
- I-Hydroquinone, i-kojic acid, nezinye izinhlaka ezikhanyisa isikhumba.
- Isizathu: Ukuhlanganisa ama-actives amaningi anamandla okuhloswe ngawo ukuphatha i-hyperpigmentation kungakhulisa ubungozi bokucasuka futhi kungenzeka kungathuthukise ukusebenza ngempumelelo.
Ungakufaka kanjaniI-azelaic acidNgokuphepha:
Enye indlela wenase
- Isu: Uma ufuna ukusebenzisa i-azelaic acid eceleni kwamanye ama-actives anamandla, cabanga ngokushintshana kwabo. Isibonelo, sebenzisa i-azelaic acid ekuseni kanye nama-retinoids noma ama-ahas / bhas ebusuku.
Ukuhlolwa kwe-Patch
- Isincomo: Njalo yenza isivivinyo se-patch lapho wethula isithako esisha esisebenzayo kwinqubo yakho ukuze uhlole noma yikuphi ukusabela okunzima.
Qala kancane
- Isu: Yethula kancane i-azelaic acid kancane kancane, kusukela ngokuhlushwa okuphansi kanye nokuvamisa okuzayo njengoba isikhumba sakho sakha ukubekezelelana.
Thintana nodokotela we-dermatologist
- Isincomo: Uma ungaqiniseki ngokuthi ungafaka kanjani i-avelaic acid kwinqubo yakho, thintana nodokotela wesikhumba wezeluleko ezenziwe ngezifiso.
Isikhathi sePosi: Sep-21-2024
