Newgreen Factory Supply Topotecan hydrochloride izinga eliphezulu lekhwalithi 99% Topotecan hydrochloride powder
Ukuchazwa Komkhiqizo
I-TopoteCan Hydrochloride umuthi we-chemotherapy osetshenziswa ngokuyinhloko ukwelapha izinhlobo ezithile zomdlavuza. Yindlela ye-hydrochloride ye-topotecan, inhibitor e-topoisomerase esebenza ngokuyinhloko ngokuvimbela umsebenzi we-DNA Topoisomerase I.
Amanothi:
Lapho usebenzisa i-TopoteCan, iziguli kufanele zibe ngaphansi kokuholwa ngudokotela, ikakhulukazi iziguli ezine-dysfunction yesibindi nangozinso noma ezinye izinkinga zempilo. Ukuhlolwa kwegazi njalo kuyadingeka ngesikhathi sokwelashwa ukuqapha imiphumela emibi okungenzeka.
Ekuphetheni, i-Topotecan Hydrochloride iyisidakamizwa esibalulekile seziphilayo, ikakhulukazi esisetshenziselwa ukwelapha umdlavuza we-ovari kanye nomdlavuza omncane wamaphaphu, futhi unenani lesicelo se-Clinical.
Coha
| Into | Ukucacisa | Umphumela |
| Ukubonakala | I-powder emhlophe noma emhlophe | Umhlophe we-powder |
| Ukukhonjwa kwe-HPLC | Kuyahambisana nesethenjwa Isikhathi sokugcina impahla | Kuvumelana |
| Ukujikeleza okuthile | +20.0 .- + 22.0. | +21. |
| Izinsimbi ezisindayo | ≤ 10ppm | <10ppm |
| PH | 7.5-8.5 | 8.0 |
| Ukulahleka kokuwomile | ≤ 1.0% | 0.25% |
| Hola | ≤3ppm | Kuvumelana |
| I-arsenic | ≤1ppm | Kuvumelana |
| Inhlamvu kaCadmium | ≤1ppm | Kuvumelana |
| Ucembekile | ≤0. 1ppm | Kuvumelana |
| Iphuzu elincibilikayo | 250.0℃~ 265.0℃ | 254.7 ~ 255.8℃ |
| Desidie ekulahliseni | ≤0. 1% | 0.03% |
| Intwayri | ≤2ppm | Kuvumelana |
| Ubuningi obuningi | / | 0.21g / ml |
| I-Fensity | / | 0.45g / ml |
| Ngalokho(Topotecan hydrochlorideIsihlehlukene | 99.0% ~ 101.0% | 99.65% |
| Inani eliphelele le-aerobes | ≤1000cFU / g | <2cFU / g |
| Isikhunta & imvubelo | ≤100cFU / g | <2cFU / g |
| E.coli | -Phikisayo | -Phikisayo |
| Salmonella | -Phikisayo | -Phikisayo |
| Ukubeka | Gcina endaweni epholile newomile, gcina ukukhanya okuqinile. | |
| Ukugcina | -Nokwazi | |
Sebenza
I-TopoteCan Hydrochloride umuthi we-chemotherapy osetshenziswa ngokuyinhloko ukwelapha izinhlobo ezithile zomdlavuza. Kuyinto inhibitor ye-topoisomerase enezindlela ezithile ezilandelayo zezenzo nemisebenzi:
Umsebenzi:
1.Topoisomerasehing Visition: I-topotecan ihlangana nokuphindaphinda kwe-DNA futhi okubhaliwe ngokuvimbela umsebenzi we-topoisomerase I. Lokhu kuvinjwa kuholela ekwakhekeni kwamaketanga we-DNA, ngaleyo ndlela kuvinjelwe ukwanda kwamaseli womdlavuza.
Umsebenzi we-2.antiItumor: I-TopoteCan isetshenziselwa ikakhulukazi ukwelapha umdlavuza we-ovarian, umdlavuza omncane wamaphutha weseli nezinhlobo ezithile ze-lymphoma. Ingasetshenziswa njengokwelashwa komugqa wokuqala noma njengokwelashwa komugqa wesibili ngemuva kokulashwa kwezinye izindlela zehlulekile.
Ukucaciswa komjikelezo we-3.Cell: Umphumela we-TopoteCan kumjikelezo weseli uvele ikakhulukazi esigabeni sesigaba kanye ne-G2, okwenza kube nomphumela wokubulala oqinile kumaseli womdlavuza esigabeni esithile samaseli esitokisini.
4.corapy therapy: I-TopoteCan ingasetshenziswa ngokuhlanganiswa neminye imishanguzo ye-chemotherapy ukuthuthukisa umphumela we-anti-fulam futhi uthuthukise impendulo yokwelashwa yesiguli.
Izimpawu ze-5.Relive: Kwezinye izimo, ukusetshenziswa kwe-TopoteCan kungasiza ukudambisa izimpawu ezihlobene nomdlavuza futhi kuthuthukise ikhwalithi yempilo yesiguli.
Amanothi:
I-TopoteCan ingahle ibangele imiphumela emibi, kufaka phakathi i-nausea, ukugabha, ukukhathala, ukukhathala iLeukopeneia, njll. Lapho usebenzisa lesi sidakamizwa, iziguli zidinga ukubhekelwa futhi ziphathwe ngaphansi kokuholwa ngudokotela.
Ekuphetheni, i-Topotecan Hydrochloride iyindlela ephumelelayo yezilwane eziphilayo ezinamandla amakhulu ane-antitumor yawo ngokuvinjwa kwe-DNA Topoisomerase I.
Isicelo
I-TopoteCan Hydrochloride umuthi we-chemotherapy osetshenziswa ngokuyinhloko ukwelapha izinhlobo ezithile zomdlavuza. Okulandelayo izicelo zalo eziphambili:
Umdlavuza we-1.ovarian: I-TopoteCan ivame ukusetshenziswa ukwelapha umdlavuza we-ovari aphindaphindwayo, ikakhulukazi ezigulini ngemuva kwezinye izindlela zokwelapha (njengePlatin-based Chemotherapy) yehlulekile. Ingasetshenziswa njenge-ejenti eyodwa noma inhlanganisela nezinye izidakamizwa.
2.Small cell luleng cancer: Lesi sidakamizwa siyasetshenziswa futhi ekwelashweni komdlavuza wamaphaphu amancane, imvamisa njengenketho yokwelashwa yomugqa wesibili, ikakhulukazi lapho isifo sibuye sibuye ngemuva kokuqala kwe-chemotherapy.
3.Ether Canchers: Yize i-topotecan esetshenziselwa umdlavuza we-ovarind kanye nomdlavuza omncane we-cell cell, kuyafundwa kwezinye izivivinyo zomtholampilo zezinye izinhlobo zomdlavuza, njengomdlavuza wesibeletho, umdlavuza wesibeletho, kanye nezinhlobo ezithile ze-lymphoma.
Izilingo ze-4.Climonical: I-TopoteCan nayo iyahlolwa ezivivinyweni zemitholampilo zomdlavuza ohlukahlukene ukutadisha ukusebenza kwayo nokuphepha kwayo ngezinketho ezahlukene zokwelashwa.
5----------BITNEAING THERAPY: Kwezinye izimo, i-topotecan ingahle isetshenziswe ngokuhlanganiswa neminye imishanguzo ye-chemotherapy noma izidakamizwa zokwelapha ezihlosiwe ukuze zithuthukise umphumela wokwelapha.
Amanothi:
Lapho usebenzisa i-TopoteCan, iziguli kufanele zibe ngaphansi kokuholwa ngudokotela, ikakhulukazi iziguli ezine-dysfunction yesibindi nangozinso noma ezinye izinkinga zempilo. Ukuhlolwa kwegazi njalo kuyadingeka ngesikhathi sokwelashwa ukuqapha imiphumela emibi okungenzeka.
Ekuphetheni, i-topotecan hydrochloride inenani elibalulekile lesicelo ekwelashweni komdlavuza, ikakhulukazi ekuphathweni komdlavuza we-ovarian okutshaliwe kanye nomdlavuza omncane weseli.
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