I-Newgreen Factory Supply Topotecan Hydrochloride High Quality 99% Topotecan Hydrochloride Powder
Incazelo Yomkhiqizo
I-Topotecan Hydrochloride umuthi we-chemotherapy osetshenziswa ngokuyinhloko ukwelapha izinhlobo ezithile zomdlavuza. Kuwuhlobo lwe-hydrochloride lwe-topotecan, i-topoisomerase inhibitor esebenza ngokuyinhloko ngokuvimbela umsebenzi we-DNA topoisomerase I.
Amanothi:
Uma usebenzisa i-Topotecan, iziguli kufanele zibe ngaphansi kokuqondisa kukadokotela, ikakhulukazi ezigulini ezinokukhubazeka kwesibindi nezinso noma ezinye izinkinga zempilo. Ukuhlolwa kwegazi okuvamile kuyadingeka ngesikhathi sokwelashwa ukuze kuqashwe imiphumela emibi engase ibe khona.
Sengiphetha, i-Topotecan Hydrochloride iyisidakamizwa esibalulekile se-anticancer, esisetshenziselwa ikakhulukazi ukwelapha umdlavuza wesibeletho kanye nomdlavuza omncane wamaphaphu wamangqamuzana, futhi inenani elibalulekile lesicelo somtholampilo.
I-COA
| Izinto | Imininingwane | Imiphumela |
| Ukubukeka | Impushana emhlophe noma emhlophe | Impushana Emhlophe |
| I-HPLC Identification | Ngokuhambisana nereferensi isikhathi sokugcina isiqongo esiyinhloko | Kuyavumelana |
| Ukuzungezisa okuqondile | +20.0.-+22.0. | +21. |
| Izinsimbi ezinzima | ≤ 10ppm | <10ppm |
| PH | 7.5-8.5 | 8.0 |
| Ukulahlekelwa ekomisweni | ≤ 1.0% | 0.25% |
| Ukuhola | ≤3ppm | Kuyavumelana |
| I-Arsenic | ≤1ppm | Kuyavumelana |
| I-Cadmium | ≤1ppm | Kuyavumelana |
| I-Mercury | ≤0. 1 ppm | Kuyavumelana |
| Iphoyinti lokuncibilika | 250.0℃~265.0℃ | 254.7~255.8℃ |
| Izinsalela ekushiseni | ≤0. 1% | 0.03% |
| IHydrazine | ≤2ppm | Kuyavumelana |
| Ukuminyana ngobuningi | / | 0.21g/ml |
| Ukuminyana okuthenjiwe | / | 0.45g/ml |
| Isivivinyo(I-Topotecan Hydrochloride） | 99.0%~ 101.0% | 99.65% |
| Izibalo eziphelele ze-aerobes | ≤1000CFU/g | <2CFU/g |
| Isikhunta & Imvubelo | ≤100CFU/g | <2CFU/g |
| E.coli | Okubi | Okubi |
| I-Salmonella | Okubi | Okubi |
| Isitoreji | Gcina endaweni epholile neyomile, vikela ukukhanya okuqinile. | |
| Isiphetho | Ufanelekile | |
Umsebenzi
I-Topotecan Hydrochloride umuthi we-chemotherapy osetshenziswa ngokuyinhloko ukwelapha izinhlobo ezithile zomdlavuza. Kuyi-topoisomerase inhibitor enalezi zindlela ezilandelayo zesenzo nemisebenzi:
Umsebenzi:
1.Ukuvimbela i-Topoisomerase: I-Topotecan iphazamisa ukuphindaphinda kwe-DNA nokulotshwa ngokuvimbela umsebenzi we-topoisomerase I. Lokhu kuvimbela kuholela ekuqhekekeni kwamaketanga e-DNA, ngaleyo ndlela kuvimbele ukwanda kwamangqamuzana omdlavuza.
2.Umsebenzi we-Antitumor: I-Topotecan isetshenziswa kakhulu ukwelapha umdlavuza wesibeletho, umdlavuza wamaphaphu amancane kanye nezinhlobo ezithile ze-lymphoma. Ingasetshenziswa njengokwelashwa komugqa wokuqala noma njengokwelashwa komugqa wesibili ngemva kokuba ezinye izindlela zokwelapha zehlulekile.
3.Ukucaciswa komjikelezo weseli: Umphumela we-Topotecan kumjikelezo weseli uyenzeka ikakhulukazi esigabeni se-S kanye nesigaba se-G2, okwenza kube nomthelela oqinile wokubulala kumaseli omdlavuza esigabeni esithile sokwanda kwamaseli.
4.Ukwelashwa okuhlangene: I-Topotecan ingasetshenziswa ngokuhambisana nezinye izidakamizwa ze-chemotherapy ukuze kuthuthukiswe umphumela wokulwa nesimila futhi kuthuthukiswe impendulo yokwelashwa kwesiguli.
5.Yehlisa Izimpawu: Kwezinye izimo, ukusetshenziswa kwe-Topotecan kungasiza ukukhulula izimpawu ezihlobene nomdlavuza futhi kuthuthukise izinga lempilo yesiguli.
Amanothi:
I-Topotecan ingase ibangele eminye imiphumela engemihle, kuhlanganise kodwa ingagcini nje ngokuba isicanucanu, ukuhlanza, ukukhathala, i-leukopenia, njll. Lapho usebenzisa lesi sidakamizwa, iziguli kudingeka ziqashwe futhi zilawulwe ngaphansi kokuqondisa kukadokotela.
Sengiphetha, i-Topotecan Hydrochloride iyisidakamizwa esisebenzayo sokulwa nomdlavuza esibonisa imiphumela yaso ye-antitumor ikakhulukazi ngokuvinjwa kwe-DNA topoisomerase I.
Isicelo
I-Topotecan Hydrochloride umuthi we-chemotherapy osetshenziswa ngokuyinhloko ukwelapha izinhlobo ezithile zomdlavuza. Okulandelayo yizinhlelo zayo eziyinhloko:
1.Umdlavuza wesibeletho: I-Topotecan ivame ukusetshenziselwa ukwelapha umdlavuza we-ovarian ophindaphindayo, ikakhulukazi ezigulini ngemva kokuba ezinye izindlela zokwelapha (ezifana ne-platinum-based chemotherapy) zihlulekile. Ingasetshenziswa njenge-ejenti eyodwa noma ihlanganiswe nezinye izidakamizwa.
2.Umdlavuza wamaphaphu omncane: Lesi sidakamizwa siphinde sisetshenziswe ekwelapheni umdlavuza wamaphaphu omncane, ngokuvamile njengendlela yokwelapha yomugqa wesibili, ikakhulukazi uma isifo siphindela emuva ngemva kokwelashwa ngamakhemikhali kokuqala.
3.Amanye AmaCancer: Nakuba i-Topotecan ngokuyinhloko isetshenziselwa umdlavuza wesibeletho kanye nomdlavuza wengqamuzana omncane wamaphaphu, iyacwaningwa futhi kwezinye izivivinyo zomtholampilo zezinye izinhlobo zomdlavuza, njengomdlavuza womlomo wesibeletho, umdlavuza we-pancreatic, nezinhlobo ezithile ze-lymphoma.
4.Izilingo zomtholampilo: I-Topotecan nayo iyahlolwa ezivivinyweni zokwelashwa ukuze kutholakale imidlavuza ehlukahlukene ukuze kufundwe ukusebenza kwayo nokuphepha ezinkethweni ezihlukene zokwelapha.
5.I-Combination Therapy: Kwezinye izimo, i-Topotecan ingasetshenziswa ngokuhlanganiswa nezinye izidakamizwa ze-chemotherapy noma imithi yokwelapha ehlosiwe ukuze kuthuthukiswe umphumela wokwelapha.
Amanothi:
Uma usebenzisa i-Topotecan, iziguli kufanele zibe ngaphansi kokuqondisa kukadokotela, ikakhulukazi ezigulini ezinokukhubazeka kwesibindi nezinso noma ezinye izinkinga zempilo. Ukuhlolwa kwegazi okuvamile kuyadingeka ngesikhathi sokwelashwa ukuze kuqashwe imiphumela emibi engase ibe khona.
Sengiphetha, i-Topotecan Hydrochloride inenani elibalulekile lesicelo ekwelapheni umdlavuza, ikakhulukazi ekulawulweni komdlavuza we-ovarian ophindelelayo kanye nomdlavuza wamaphaphu omncane.
Iphakheji Nokulethwa
