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Incazelo Yomkhiqizo
I-Famotidine iyi-H2 receptor antagonist, esetshenziselwa ikakhulukazi ukwelapha izifo ezihlobene ne-gastric acid. Ivimbela ama-histamine H2 receptors kumaseli e-gastric parietal, inciphisa ukukhishwa kwe-asidi esiswini, futhi ngaleyo ndlela ikhulule izimpawu ezibangelwa i-asidi yesisu ngokweqile. Okulandelayo yisingeniso esinemininingwane ye-Famotidine:
Izici Eziyinhloko kanye Nemisebenzi
1.Indlela: I-Famotidine ivimbela ukukhishwa kwe-asidi yesisu futhi yehlise i-asidi esiswini ngokukhetha ukuphikisana nama-H2 receptors kumaseli e-gastric parietal.
2.Izinkomba:
- I-Gastroesophageal Reflux Disease (GERD): Isetshenziselwa ukudambisa izimpawu ezibangelwa i-acid reflux, njengesilungulela kanye ne-acid regurgitation.
I-Peptic ulcer: isetshenziselwa ukwelapha isilonda esiswini kanye nesilonda se-duodenal futhi ikhuthaze ukuphulukiswa kwesilonda.
-Ukuvinjelwa Kwezifo Ezihlobene Ne-Gastric Acid: Ezimweni ezithile, i-Famotidine ingase isetshenziselwe ukuvimbela ukuphazamiseka okuhlobene ne-gastric acid okubangelwa imithi efana ne-NSAID.
3. Ifomu lomthamo:I-Famotidine ivame ukutholakala iwuhlobo lwamaphilisi omlomo nemijovo, futhi iziguli zingayithatha ngokweseluleko sikadokotela.
4.Ukusabela Okubi:I-Famotidine ngokuvamile ibekezelelwa kahle, kodwa eminye imiphumela emibi ingase ibe khona, njengekhanda elibuhlungu, isiyezi, isifo sohudo noma ukuqunjelwa.
5. Izinyathelo zokuqapha zokusetshenziswa:Lapho zisebenzisa i-Famotidine, iziguli kufanele zazise odokotela bazo uma zinezinye izinkinga zempilo noma zisebenzisa eminye imithi ukuze zigweme ukusebenzisana kwezidakamizwa okungenzeka.
Fingqa
I-Famotidine iyi-H2 receptor antagonist ephumelelayo, esetshenziselwa ikakhulukazi ukwelapha izifo ezihlobene ne-asidi esiswini, njengesifo se-reflux ye-gastroesophageal kanye nezilonda ze-peptic. Ngokunciphisa ukukhishwa kwe-asidi yesisu, i-Famotidine ingakhulula izimpawu ezihlobene futhi ikhuthaze ukuphulukiswa. Uma uyisebenzisa, kufanele ulandele imiyalelo kadokotela ukuze uqinisekise ukuphepha nokusebenza.
I-COA
| Izinto | Imininingwane | Imiphumela |
| Ukubukeka | Impushana emhlophe noma emhlophe | Impushana Emhlophe |
| I-HPLC Identification | Ngokuhambisana nereferensi isikhathi sokugcina isiqongo esiyinhloko | Kuyavumelana |
| Ukuzungezisa okuqondile | +20.0.-+22.0. | +21. |
| Izinsimbi ezinzima | ≤ 10ppm | <10ppm |
| PH | 7.5-8.5 | 8.0 |
| Ukulahlekelwa ekomisweni | ≤ 1.0% | 0.25% |
| Ukuhola | ≤3ppm | Kuyavumelana |
| I-Arsenic | ≤1ppm | Kuyavumelana |
| I-Cadmium | ≤1ppm | Kuyavumelana |
| I-Mercury | ≤0. 1 ppm | Kuyavumelana |
| Iphoyinti lokuncibilika | 250.0℃~265.0℃ | 254.7 ~ 255.8℃ |
| Izinsalela ekushiseni | ≤0. 1% | 0.03% |
| IHydrazine | ≤2ppm | Kuyavumelana |
| Ukuminyana ngobuningi | / | 0.21g/ml |
| Ukuminyana okuthenjiwe | / | 0.45g/ml |
| I-Assay (Famotidine) | 99.0%~ 101.0% | 99.65% |
| Izibalo eziphelele ze-aerobes | ≤1000CFU/g | <2CFU/g |
| Isikhunta & Imvubelo | ≤100CFU/g | <2CFU/g |
| E.coli | Okubi | Okubi |
| I-Salmonella | Okubi | Okubi |
| Isitoreji | Gcina endaweni epholile neyomile, vikela ukukhanya okuqinile. | |
| Isiphetho | Ufanelekile | |
Umsebenzi
I-Famotidine iyi-H2 receptor antagonist, esetshenziselwa ikakhulukazi ukwelapha izifo ezihlobene ne-gastric acid. Isebenza ngokuvimbela ama-histamine H2 receptors emangqamuzaneni e-gastric parietal, ukunciphisa ukukhishwa kwe-asidi esiswini. Lokhu okulandelayo yimisebenzi esemqoka ye-Famotidine:
1.Yehlisa ukukhishwa kwe-asidi esiswini:I-Famotidine inciphisa kakhulu ukukhishwa kwe-asidi yesisu ngokuphikisana nama-H2 receptors, esiza ekudambiseni izimpawu ezibangelwa i-asidi yesisu eyeqile.
2. Ukwelashwa kwesifo se-reflux ye-gastroesophageal (GERD):I-Famotidine ingasetshenziselwa ukwelapha isifo se-reflux ye-gastroesophageal, ekhulula isilungulela kanye nokungakhululeki okubangelwa i-gastric acid reflux.
3. Ukwelashwa kwe-peptic ulcer:I-Famotidine isetshenziselwa ukwelapha isilonda esiswini kanye nesilonda se-duodenal, ukukhuthaza ukuphulukiswa kwesilonda, nokunciphisa ingozi yokuphinda.
4. Ukuvimbela ukukhishwa kwe-asidi yesisu ngemuva kokuhlinzwa:Ngemva kokuhlinzwa okuthile, i-Famotidine ingasetshenziswa ukuvimbela ukukhishwa kwe-asidi yesisu ngokweqile nokunciphisa ingozi yezinkinga zangemva kokuhlinzwa.
5.Yehlisa izimpawu ezihlobene ne-asidi yesisu:I-Famotidine ingasiza ekudambiseni izimpawu ezibangelwa i-asidi esiswini, njengobuhlungu besisu, ukungagayeki kahle nokuqunjelwa.
Ukusetshenziswa
I-Famotidine ivamise ukutholakala isesimweni samaphilisi omlomo noma imijovo, futhi umthamo othize kanye nemvamisa yokusetshenziswa kufanele kulungiswe ngokusekelwe eselulekweni sikadokotela wakho.
Ukusabela Okubi
I-Famotidine ngokuvamile ibekezelelwa kahle, kodwa eminye imiphumela emibi ingase ibe khona, njengekhanda elibuhlungu, isiyezi, isifo sohudo, noma ukuqunjelwa.
Ekuphetheni, i-Famotidine iyi-H2 receptor antagonist ephumelelayo, ikakhulukazi esetshenziselwa ukwelapha izifo ezihlobene ne-acid esiswini, ukusiza iziguli ukukhulula izimpawu nokukhuthaza ukuphulukiswa. Uma uyisebenzisa, kufanele ulandele imiyalelo kadokotela ukuze uqinisekise ukuphepha nokusebenza.
Isicelo
Ukusetshenziswa kwe-Famotidine kugxile kakhulu ekwelapheni izifo ezihlobene ne-asidi yesisu, kufaka phakathi izici ezilandelayo:
1. I-Gastroesophageal Reflux Disease (GERD):I-Famotidine isetshenziselwa ukukhulula izimpawu ezibangelwa i-acid reflux, njengesilungulela, ukuphindaphinda kwe-asidi, nobuhlungu besifuba. Ikhulula lezi zimpawu ngokunciphisa ukukhishwa kwe-asidi esiswini.
2.Peptic ulcer:I-Famotidine isetshenziselwa ukwelapha isilonda esiswini kanye nesilonda se-duodenal, esiza ukukhuthaza ukuphulukiswa kwezilonda kanye nokukhulula ubuhlungu obuhambisanayo nokungakhululeki.
3. Ukuvimbela izifo ezihlobene ne-asidi esiswini:I-Famotidine ingasetshenziselwa ukuvimbela izifo ezihlobene ne-asidi esiswini ezibangelwa izidakamizwa ezifana nezidakamizwa ezingezona ukuvuvukala (ama-NSAID), ikakhulukazi ezigulini ezisengozini enkulu.
4.Zollinger-Ellison syndrome:I-Famotidine ingasetshenziswa futhi ekwelapheni lesi sifo esingajwayelekile, esidala ukugcwala ngokweqile kwe-asidi esiswini.
5.Ukuphathwa kwe-asidi yesisu ngemuva kokuhlinzwa:Ngemva kokuhlinzwa okuthile, i-Famotidine ingasetshenziswa ukulawula ukukhishwa kwe-asidi esiswini futhi kuncishiswe ingozi yezinkinga zangemva kokuhlinzwa.
Ukusetshenziswa
I-Famotidine ivamise ukunikezwa ngendlela yamaphilisi omlomo. Iziguli kufanele zizithathe ngokweseluleko sikadokotela wazo. Umthamo kanye nemvamisa yokusetshenziswa kuzohluka kuye ngesimo esithile.
Amanothi
Lapho zisebenzisa i-Famotidine, iziguli kufanele zazise odokotela bazo uma zinezinye izinkinga zempilo noma zisebenzisa eminye imithi ukuze zigweme ukusebenzisana kwezidakamizwa okungenzeka. Ngaphezu kwalokho, nakuba i-Famotidine ingakwazi ukulawula ngempumelelo ukukhishwa kwe-asidi esiswini, iziguli kufanele zifune usizo lwezokwelapha uma izimpawu ziqhubeka noma ziba zimbi.
Ekuphetheni, i-Famotidine iyinhlangano ephumelelayo ye-H2 receptor antagonist esetshenziswa kabanzi ekwelapheni izifo ezihlobene ne-gastric acid, esiza iziguli ukukhulula izimpawu nokukhuthaza ukuphulukiswa. Kufanele isetshenziswe ngaphansi kokuqondisa kukadokotela ukuze kuqinisekiswe ukuphepha nokusebenza ngempumelelo.
Iphakheji Nokulethwa
