I-Itraconazole Yebanga Lemithi Yebanga Le-Traconazole Intengo Ye-Antifungal Itraconazole
Incazelo Yomkhiqizo
I-Itraconazoleiyi-oral-active triazole antifungal ekhonjiswe ukusetshenziswa ekwelapheni i-mycoses yangasese, yangasese neye-systemic. Ezigulini ezingenawo amandla omzimba kanye ne-AIDS, i-itraconazole ikhonjiswe ukuthi yehlisa kakhulu izehlakalo zokubuyela emuva kwe-cryptococcal meningitis.
I-COA
| IZINTO | IZINGA | UMPHUMELA WOKUHLOLA |
| Isivivinyo | 99% Itraconazole | Kuyavumelana |
| Umbala | Impushana emhlophe | Conforms |
| Iphunga | Alikho iphunga elikhethekile | Conforms |
| Usayizi wezinhlayiya | I-100% idlula i-80mesh | Conforms |
| Ukulahlekelwa ekomisweni | ≤5.0% | 2.35% |
| Izinsalela | ≤1.0% | Kuyavumelana |
| Insimbi enzima | ≤10.0ppm | 7 ppm |
| As | ≤2.0ppm | Conforms |
| Pb | ≤2.0ppm | Conforms |
| Izinsalela zezibulala-zinambuzane | Okubi | Okubi |
| Inani lepuleti eliphelele | ≤100cfu/g | Kuyavumelana |
| Imvubelo & Isikhunta | ≤100cfu/g | Kuyavumelana |
| E.Coli | Okubi | Okubi |
| I-Salmonella | Okubi | Okubi |
| Isiphetho | Vumelanisa ne-Specification | |
| Isitoreji | Igcinwe Endaweni Epholile Neyomile, Zigcine Kude Nokukhanya Okuqinile Nokushisa | |
| Impilo yeshelufu | Iminyaka emi-2 lapho igcinwe kahle | |
Umsebenzi
1) I-Itraconazole inomsebenzi omningi kune-fluconazole (kodwa hhayi obubanzi njenge-voriconazole noma i-posaconazole). Ikakhulukazi, iyasebenza ngokumelene ne-Aspergillus engeyona i-fluconazole.
2) Iphinde ibekelwe izifo zesistimu, njenge-aspergillosis, candidiasis, ne-cryptococcosis.
3) I-Itraconazole nayo isanda kuhlolwa njenge-ejenti elwa nomdlavuza ezigulini ezine-basal cell carcinoma.
Isicelo
1.I-Itraconazole iyi-clotrimazole yokwenziwa yokwenziwa, iyi-ejenti yokwenziwa ye-antifungal ebanzi. I-spectrum yayo ye-antimicrobial kanye ne-antimicrobial mechanism ifana ne-clotrimazole, kodwa inomsebenzi oqinile we-antibacterial ngokumelene ne-Aspergillus.
2.I-Itraconazole inomphumela wayo wokulwa nesikhunta ngokushintsha ulwelwesi lwamangqamuzana esikhunta lukwazi ukungeneka ngomsebenzi we-antibacterial ngokumelene namagciwane esikhunta angaphandle najulile. I-spectrum yayo ye-antibacterial ibanzi futhi inamandla kune-ketoconazole, ikwazi ukuvimbela ukuhlanganiswa kwe-ergosterol ye-fungal cell membrane, ngaleyo ndlela idlala umphumela we-antifungal.
3.I-Itraconazole ilungele ukwelashwa kwe-Dermatophytes (i-Trichophyton, i-Microsporum, i-Flocculent Epidermophyton), Imvubelo [Cryptococcus neoformans, Pityrosporum, Candida (kuhlanganise ne-Candida albicans, i-Candida glabrata kanye ne-candida krusei)], i-Aspergillus, i-Histococcus neoformans, i-Histococcus, i-Histococcus, i-Histococcus, i-Histococcus, i-Histococcus, i-Histococcus, i-Histococcus, i-Histococcus, i-Histococcal i-scheckii, i-Hormodendrum, i-Cladosporium, i-Blastomyces dermatitidis kanye nezinhlobo ezahlukene zezinye izinhlobo zemvubelo nesikhunta. I-Itraconazole ayikwazi ukuvimbela ukukhula kwe-Rhizopus ne-Mucor.
Imikhiqizo ehlobene
Imboni ye-Newgreen iphinde inikeze ama-amino acid njengokulandelayo:
Iphakheji Nokulethwa
