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Ingcaciso yeMveliso
I-Pranlukast lichiza lomlomo elichasene ne-aleji elisetyenziswa ikakhulu ukunyanga izifo ezibangelwa kukwalana, ngakumbi i-rhinitis ye-allergies kunye ne-asthma. Yinto ekhethiweyo ye-leukotriene receptor antagonist enokuthi ithintele ngokufanelekileyo imiphumo ye-leukotrienes, ngaloo ndlela inciphisa ukusabela kwe-allergies kunye nokuvuvukala.
Iimpawu eziphambili kunye neMisebenzi
1. Inkqubo:I-Pranlukast ikhetha ukulwa ne-CysLT1 receptors, inqanda ukuxinana kwendlela yomoya, ukukhutshwa kwe-mucus kunye nokunyuka kwe-vascular permeability okubangelwa yi-leukotrienes (efana ne-cysteine leukotrienes), ngaloo ndlela inciphisa iimpawu ezibangelwa yi-allergies kunye nokuhlaselwa kwesifuba.
2. Iimpawu:
-I-rhinitis ye-Aleji:Isetyenziselwa ukuthomalalisa iimpawu ezifana nokuxinana kweempumlo, impumlo ebalekayo, ukuthimla, njl.
- Umbefu:Njengonyango olongezelelweyo lwe-asthma, inceda ukulawula iimpawu ze-asthma kunye nokunciphisa ukuphindaphinda kohlaselo.
3. Ifomu yomthamo:I-Pranlukast idla ngokufumaneka ngokohlobo lweepilisi zomlomo, ezinokuthi izigulana zizithathe ngokwengcebiso kagqirha.
Ukuqukumbela, i-Pranlukast lichiza elisebenzayo elichasayo, elisetyenziswa ikakhulu ukunyanga i-rhinitis ye-allergies kunye ne-asthma, enciphisa ukusabela kunye nokudumba ngokuchasa i-leukotriene receptors. Xa uyisebenzisa, kufuneka ulandele isikhokelo sikagqirha ukuqinisekisa ukhuseleko kunye nokusebenza.
I-COA
Izinto | Iinkcukacha | Iziphumo |
Imbonakalo | Ngaphandle-mhlophe okanye umgubo omhlophe | Umgubo oMhlophe |
Ukuchongwa kwe-HPLC | Iyangqinelana nereferensi ixesha lokugcinwa kwento ephambili | Iyahambelana |
Ukujikeleza okuthe ngqo | +20.0.-+22.0. | +21. |
Iintsimbi ezinzima | ≤ 10ppm | <10ppm |
PH | 7.5-8.5 | 8.0 |
Ilahleko ekomisweni | ≤ 1.0% | 0.25% |
Inkokeli | ≤3ppm | Iyahambelana |
Arsenic | ≤1ppm | Iyahambelana |
I-Cadmium | ≤1ppm | Iyahambelana |
IMercury | ≤0. 1ppm | Iyahambelana |
Indawo yokunyibilika | 250.0℃~265.0℃ | 254.7 ~ 255.8℃ |
Intsalela ekutshisweni | ≤0. 1% | 0.03% |
IHydrazine | ≤2ppm | Iyahambelana |
Unizi lolwapho kuyiwa khona | / | 0.21g/ml |
Uxinaniso olucofaziweyo | / | 0.45g/ml |
Uvavanyo (Pranlukast) | 99.0%~ 101.0% | 99.62% |
Ubalo lwe-aerobes iyonke | ≤1000CFU/g | <2CFU/g |
Umngundo kunye negwele | ≤100CFU/g | <2CFU/g |
E.coli | Ibi | Ibi |
Salmonella | Ibi | Ibi |
Ugcino | Gcina kwindawo epholileyo kunye neyomileyo, gcina ukukhanya okuqinileyo. | |
Ukuqukumbela | Ufanelekile |
Umsebenzi
I-Pranlukast lichiza lomlomo elichasene ne-aleji elisetyenziswa ikakhulu ukunyanga i-asthma kunye ne-rhinitis ye-alergic. Yinto ekhethiweyo ye-leukotriene receptor antagonist evimbela ngokufanelekileyo imiphumo ye-leukotrienes, ngaloo ndlela inciphisa iimpawu ezinxulumene nokungahambi kakuhle kunye ne-asthma. Le ilandelayo yimisebenzi ephambili yePranlukast:
1. Isiphumo sokuchasa ukudumba:I-Pranlukast inceda ukulawula iimpawu ze-asthma ngokuthintela iziphumo ze-leukotrienes kunye nokunciphisa impendulo yokuvuvukala kwiindlela zomoya.
2. Phucula umsebenzi wokuphefumla:Ngokunciphisa ukuxinwa kunye nokuvuvukala kweendlela zomoya, i-Pranlukast inokuphucula umsebenzi wokuphefumula wezigulane ze-asthma kunye nokunciphisa ukuvela kokuphefumla kunye nobunzima bokuphefumla.
3. Ukuphelisa iimpawu zokwaliwa:I-Pranlukast ikwasetyenziselwa ukunyanga i-rhinitis ye-allergies kwaye inokuphelisa iimpawu zokungalungelani ezifana nokuxinana kweempumlo, impumlo ephumayo, ukuthimla, njl.
4. UThintelo loHlaselo lwe-Asma:Ukusetyenziswa kwexesha elide le-Pranlukast kunokunceda ukukhusela ukuhlaselwa kwe-asthma, ngakumbi kwizigulana ezine-asthma ezibangelwa umthambo.
5. Ukusetyenziswa okudityanisiweyo namanye amachiza:I-Pranlukast ingasetyenziswa ngokudityaniswa namanye amachiza achasene ne-asthma (afana ne-corticosteroids ephefumlelweyo) ukunyusa isiphumo sonyango.
Ngamafutshane, umsebenzi ophambili wePranlukast kukukhulula iimpawu ze-asthma kunye ne-rhinitis ye-allergen kunye nokuphucula umgangatho wobomi bezigulane ngokuchasa i-leukotriene receptors. Xa uyisebenzisa, kufuneka ulandele isikhokelo sikagqirha ukuqinisekisa ukhuseleko kunye nokusebenza.
Isicelo
Ukusetyenziswa kwePranlukast kugxininise kakhulu kunyango lwezifo ezinxulumene nokwaliwa, kubandakanywa le miba ilandelayo:
1. I-rhinitis ekwaliwayo:I-Pranlukast isetyenziselwa ukuthomalalisa iimpawu ze-rhinitis ye-aleji ebangelwa yi-pollen, amangolwane, inkwethu yezilwanyana, njl. njl., ezifana nokuxinana kweempumlo, ukuvuza kweempumlo, ukuthimla kunye nokurhawuzelelwa kweempumlo. Iyanciphisa impendulo yokuvuvukala kwisigxina sempumlo ngokuchasa imiphumo ye-leukotrienes.
2. Umbefu:I-Pranlukast isetyenziswa njengonyango lokuncedisa kwi-asthma ukunceda ukulawula iimpawu ze-asthma kunye nokunciphisa ukuphindaphinda kunye nobunzima bokuhlaselwa kwe-asthma. Ingasetyenziswa ngokudityaniswa namanye amachiza achasene nesifuba somoya (afana ne-corticosteroids ephefumlelweyo kunye ne-bronchodilators) ukuqinisa isiphumo sonyango.
3. I-Bronchoconstriction ebangelwa kukuzilolonga:I-Pranlukast ingasetyenziselwa kwiimeko ezithile ukukhusela i-bronchoconstriction eyenziwa ngumzimba, ukunceda abagijimi kunye nabantu abakhutheleyo ukulawula iimpendulo zabo zomoya ngaphambi kokuzivocavoca.
4. Izigulo eziNgezigulo eziNgezingxaki:I-Pranlukast inokuqwalaselwa kwakhona njengenxalenye yerejimeni yonyango kulawulo lwezinye izifo ezingapheliyo zakwaliwa.
Ukusetyenziswa
I-Pranlukast idla ngokufumaneka ngendlela yeepilisi zomlomo, apho izigulane kufuneka zizithathe ngokwengcebiso yazo kagqirha, ngokuqhelekileyo kanye yonke imihla.
Amanqaku
Xa usebenzisa iPranlukast, izigulane kufuneka zixelele ugqirha wazo ukuba zinezinye iingxaki zempilo okanye zithatha amanye amayeza ukuphepha ukusebenzisana kweziyobisi okunokwenzeka. Ukongezelela, ngelixa i-Pranlukast inokunceda ukulawula ukungabikho komzimba kunye neempawu ze-asthma, ayenzelwanga unyango lokuhlaselwa kwe-asthma.
Ukuqukumbela, i-Pranlukast lichiza elisebenzayo elichasayo, elisetyenziswa ngokubanzi kunyango lwe-rhinitis ye-allergies kunye ne-asthma, inceda izigulane ukuphucula umgangatho wobomi babo. Xa uyisebenzisa, kufuneka ulandele isikhokelo sikagqirha ukuqinisekisa ukhuseleko kunye nokusebenza.