Iphepha-intloko - 1

imveliso

Terbinafine Hydrochloride High Purity API Material CAS 78628-80-5

Inkcazelo emfutshane:

Igama leMveliso:Terbinafine Hydrochloride

Inkcazo yeMveliso:99%

Ubomi beShelf: 24months

Indlela yokuGcina: Indawo eyomileyo epholileyo

Imbonakalo:Umgubo omhlophe

Isicelo: Ukutya / iSongezelelo / iChemical / Cosmetic

Ukupakisha: 25kg / igubu; 1kg/foil Bag okanye njengemfuno yakho


Iinkcukacha zeMveliso

Inkonzo ye-OEM/ODM

Iithegi zeMveliso

Ingcaciso yeMveliso

I-Terbinafine Hydrochlorideliyeza le-antifungal elisetyenziselwa ukunyanga izifo ezahlukeneyo. Ngokuqhelekileyo ikwimo yeetafile okanye iikhrimu. I-terbinafine hydrochloride liyeza elisebenzayo le-antifungal elisetyenziselwa ukunyanga izifo ezahlukeneyo zokungunda. Nokuba ijongana nonyawo lomdlali okanye usulelo lwezinzipho zokungunda, eli yeza lisebenza ngokuthintela ukuveliswa kwe-ergosterol kwaye linikezela ngeendlela ezingezihloko kunye nezomlomo zokhetho ukuze kube lula kunye nokusebenza.

I-COA

IZINTO

UMGANGATHO

ISIPHUMO SOVAVANYO

Isivavanyi 99% Iyahambelana
Umbala Umgubo omhlophe Iyahambelana
Ivumba Akukho vumba likhethekileyo Iyahambelana
Ubungakanani besuntswana I-100% iphumelele i-80mesh Iyahambelana
Ilahleko ekomisweni ≤5.0% 2.35%
Intsalela ≤1.0% Iyahambelana
Intsimbi enzima ≤10.0ppm 7ppm
As ≤2.0ppm Iyahambelana
Pb ≤2.0ppm Iyahambelana
Intsalela yesitshabalalisi Ibi Ibi
Ubalo lweepleyiti lulonke ≤100cfu/g Iyahambelana
Igwele kunye noMngundo ≤100cfu/g Iyahambelana
E.Coli Ibi Ibi
Salmonella Ibi Ibi

Ukuqukumbela

Qhagamshelana neNgcaciso

Ugcino

Igcinwe kwindawo epholileyo kunye neyomileyo, zigcine kude nokukhanya okuqinileyo kunye nobushushu

Beka ubomi kwishelufa

Iminyaka emi-2 xa igcinwe ngokufanelekileyo

Umsebenzi

I-1.Terbinafine hydrochloride i-synthetic allyla antifungal. Ine-lipophilic kakhulu kwindalo kwaye ithande ukuqokelela eluswini, iinzipho, kunye nezicubu ezinamafutha.

2.Terbinafine ·HCl ilungu leklasi ye-Allyl ye-antifungals, ifunyenwe inhibitor ethile ye-ergosterol synthesis nge-squalene epoxidase inhibition. I-squalene epoxidase yi-enzyme ekhutshwe yi-dermatophyte fungi ukuze iphule i-Squalene, ephazamisana nomsebenzi we-cell membrane kunye ne-wall synthesis.

I-3.I-Terbinafine hydrochloride inefuthe le-fungicidal kwi-fungi yesikhumba kunye ne-inhibitory effect kwi-Candida albicans. Ilungele ukusuleleka kwesikhumba kunye nezikhonkwane ezibangelwa yifungi engaphezulu, efana ne-ringworm, intshulube yomzimba, intshulube ye-femur, i-ringworm yeenyawo, intshulube yesikhonkwane kunye nosulelo lwe-Candida albicans lwesikhumba olubangelwa yi-Trichophyton rubrum, i-Microsporum canis. kunye neFlocculus epidermidis.

Isicelo

I-Terbinafine hydrochloride ngumgubo omhlophe wekristale ococekileyo onyibilikayo ngokukhululekileyo kwi-methan kunye ne-dichlorome, enyibilikayo kwi-ethanol, kwaye inyibilika kancinane emanzini. Njengezinye ii-allylamines, i-terbinafine inqanda ukuhlanganiswa kwe-ergosterol ngokuthintela i-squalene epoxidase,

i-enzyme eyinxalenye ye-fungal cell membrane synthesis pathway. Ngenxa yokuba i-terbinafine ithintela ukuguqulwa kwe-squalene kwi-lanosterol, i-ergosterol ayinakwenziwa. Oku kucingelwa ukuba ukutshintsha inwebu yeseli permeability, okubangela fungal cell lysis.
1. I-Terbinafine Hcl isebenza kakhulu kwiqela le-dermatophyte yefungi.
2. Njenge-1% yekhrimu okanye umgubo, isetyenziselwa ukusuleleka kolusu oluphezulu olufana nejock itch (tinea cruris),

unyawo lwembaleki (tinea pedis), kunye nezinye iintlobo zombungu (tinea corporis). I-Terbinafine cream isebenza malunga nesiqingatha sexesha elifunekayo

ngamanye amayeza e-antifungal.

3. Amacwecwe omlomo angama-250mg ahlala emiselwe unyango lwe-onychomycosis, usulelo lwe-fungal nail, ngokuqhelekileyo yidermatophyte.

okanye iintlobo zeCandida. Usulelo lwezikhonkwane lwefungal lubekwe nzulu phantsi kwesikhonkwane kwi-cuticle apho unyango olusetyenziswa ngokwezihloko

azikwazi ukungena ngezixa ezaneleyo. Iipilisi zinokuthi, ngokungaqhelekanga, zibangele i-hepatotoxicity, ngoko izigulane ziyaxwayiswa ngale nto kwaye

inokujongwa ngovavanyo lokusebenza kwesibindi. Iindlela ezizezinye zolawulo lomlomo ziye zaphononongwa.

4. I-Terbinafine isenokubangela okanye yenza mandundu ngakumbi i-lupus erythematosus ye-cutaneous. Abantu abane lupus erythematosus kufuneka

baqale baxoxe ngeengozi ezinokwenzeka nogqirha wabo phambi kokuba baqalise ngonyango.

Iimveliso ezinxulumeneyo

Umzi-mveliso omtsha oluhlaza ukwabonelela ngeeAmino acids ngolu hlobo lulandelayo:

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