• Yintoni iI-TUDCA( Taurodeoxycholic Acid ) ?
Ulwakhiwo:I-TUDCA sisishunqulelo se-taurodeoxycholic acid.
Umthombo:I-TUDCA yimbumba yendalo ekhutshwe kwinyongo yenkomo.
Indlela yokwenza:I-TUDCA yi-asidi ye-bile eyandisa ukumanzi kwe-bile acid emathunjini, ngaloo ndlela inceda i-bile acid ukuba ifakwe ngcono emathunjini. Ukongeza, i-TUDCA inokunciphisa ukubuyiswa kwakhona kwe-bile acid emathunjini, ngaloo ndlela inyusa ukujikeleza kwayo emzimbeni.
Isicelo: I-TUDCAisetyenziselwa ikakhulu ukunyanga i-primary biliary cholangitis (PBC) kunye nesifo sesibindi esinamafutha angenalo utywala + (NAFLD).
• Yintoni i-UDCA (Ursodeoxycholic Acid) ?
Ulwakhiwo:I-UDCA sisishunqulelo se-ursodeoxycholic acid.
Umthombo:I-UDCA yimbumba yendalo ekhutshwe kwi-bile yebhere.
Indlela yokwenza:I-UDCA iyafana kulwakhiwo kwi-asidi ye-bile yomzimba, ngoko inokutshintsha okanye yongeze i-asidi ye-bile engekhoyo ngumzimba. I-UDCA ineempembelelo ezininzi emathunjini, kubandakanywa nokukhusela isibindi, i-anti-inflammatory, kunye ne-anti-oxidation.
Isicelo:I-UDCA isetyenziselwa ikakhulu ukunyanga isifo se-primary biliary cholangitis (PBC), amatye e-cholesterol +, i-cirrhosis, isifo se-non-alcoholic fatty (NAFLD) kunye nezinye izifo.
• Nguwuphi umahluko phakathiI-TUDCAkunye ne-UDCA esebenzayo ?
Nangona zombini i-TUDCA kunye ne-UDCA zineempembelelo zokukhusela isibindi, iindlela zabo zinokwahluka. I-TUDCA isebenza ikakhulu ngokunyusa ubumanzi be-bile acids emathunjini, ngelixa i-UDCA ifana nesakhiwo somzimba we-bile acid kwaye inokutshintsha okanye yongeze i-bile acid engekhoyo emzimbeni.
Zombini zingasetyenziselwa ukunyanga izifo ezahlukahlukeneyo zesibindi, kodwa zinokubonisa iziphumo ezahlukeneyo okanye iingenelo kunyango lwezifo ezithile. Ngokomzekelo, i-TUDCA inokusebenza ngakumbi kunyango lwe-primary biliary cholangitis (PBC).
Isishwankathelo, zombini i-TUDCA kunye ne-UDCA ngamachiza asebenzayo, kodwa kukho ukungafani kwimithombo yabo, iindlela zokwenza, kunye nobubanzi besicelo. Ukuba ucinga ukusebenzisa la machiza, kuyacetyiswa ukuba udibane nodokotela ukuze ufumane iingcebiso ezithe ngqo kunye nesikhokelo.
NangonaI-TUDCAkunye ne-UDCA zombini i-bile acids, izakhiwo zabo ze-molecular zihluke kancinane. Ngokukodwa, i-TUDCA yenziwe ngemolekyuli ye-bile acid kunye ne-taurine molekyuli edityaniswe yi-amide bond, ngelixa i-UDCA iyimolekyuli nje ye-bile acid.
Ngenxa yokwahlukana kwesakhiwo se-molecular, i-TUDCA kunye ne-UDCA nayo ineempembelelo ezahlukeneyo kumzimba womntu. I-TUDCA isebenze ngakumbi kune-UDCA ekulawuleni ukuthuthwa kwezintso, ukukhusela isibindi, kunye nokomeleza izintso. Ukongeza, i-TUDCA nayo ineempembelelo ze-antioxidant kwaye ineziphumo ezininzi ze-pharmacological ezifana ne-sedation, i-antianxiety, kunye ne-antibacterial effects.
I-TUDCA(i-taurodeoxycholic acid) kunye ne-UDCA (i-ursoxycholic acid) zombini iindidi ze-bile acid, kwaye zombini zizinto zendalo ezikhutshwe kwisibindi.
I-UDCA iyona nxalenye ephambili yenyongo yebhere. Ikakhulu iphucula ukusebenza kwesibindi ngokunyusa ukukhuselwa kunye nokukhutshwa kwe-asidi ye-bile, ngaloo ndlela inciphisa ukuxinwa kwe-bile acid. Umsebenzi wayo oyintloko kukunyanga izifo ze-cholestatic ezifana ne-cirrhosis, i-cholelithiasis, njl. Ukongeza, inceda ekunciphiseni amanqanaba e-cholesterol.
I-TUDCAyindibaniselwano ye-taurine kunye ne-bile acid. Iyakwazi nokuphucula ukusebenza kwesibindi, kodwa indlela yokusebenza kwayo ihluke kwi-UDCA. Isenokuphucula amandla esibindi okulwa ne-antioxidant kwaye ikhusele isibindi ekonakalisweni kwasimahla. Ukongeza, inceda ekuphuculeni ubuntununtunu be-insulin, amanqanaba asezantsi eswekile yegazi, kwaye ineempembelelo ezichasene ne-tumor.
Ngokubanzi, i-UDCA kunye ne-TUDCA zombini zikhusela isibindi ezilungileyo, kodwa iindlela zabo zokwenza izinto zahlukile kwaye zifanelekile kwizifo ezahlukeneyo kunye nabemi. Ukuba udinga ukusebenzisa la mayeza mabini, kungcono ukuwasebenzisa phantsi kolwalathiso lukagqirha ukuphepha ukusabela okubi.
Ixesha lokuposa: Dec-09-2024
