Uphando lubonisa ukuba malunga ne-537 yezigidi zabantu abadala kwihlabathi jikelele banesifo seswekile se-2, kwaye elo nani liyenyuka. Amanqanaba aphezulu eswekile yegazi abangelwa sisifo seswekile angakhokelela kwiimeko ezininzi ezinobungozi, kuquka nesifo senhliziyo, ukulahlekelwa ngumbono, ukungaphumeleli kwezintso, kunye nezinye iingxaki zempilo. Konke oku kunokukukhawulezisa kakhulu ukuguga.
Tetrahydrocurcumin, ephuma kwingcambu ye-turmeric, iboniswe kwizifundo zeklinikhi zokunceda ukunciphisa imingcipheko emininzi yesifo sikashukela sohlobo lwe-2 kunye nokunciphisa ushukela wegazi kubantu abanesifo sikashukela okanye i-prediabetes. Ukunyanga isifo seswekile se-2 kunokuba ngumngeni kuzo zombini izigulane kunye noogqirha. Ngelixa oogqirha ngokuqhelekileyo bencoma ukutya, ukuzivocavoca, kunye namayeza okunyanga abantu abanesifo seswekile se-2, uphando lubonisa ukubatetrahydrocurcumininokubonelela ngenkxaso eyongezelelweyo.
• Ukumelana ne-insulin kunye nesifo seswekile
Xa sisitya, iswekile yegazi iyenyuka. Oku kuthetha ukuba udakada ukhuphe incindi yedlala ebizwa ngokuba yi-insulin, enceda iiseli zisebenzise iswekile ukuvelisa amandla. Ngenxa yoko, iswekile yegazi iyehla kwakhona. Udidi lwesi-2 lweswekile lubangelwa kukunganyangeki kwe-insulin kuba iiseli aziphenduli ngokuqhelekileyo kwihomoni. Izinga leswekile yegazi lihlala liphezulu, imeko ebizwa ngokuba yi-hyperglycemia. Amanqanaba aphezulu eswekile yegazi angakhokelela kwiingxaki zenkqubo, kuquka intliziyo, isitya segazi, izintso, iliso, kunye nokuphazamiseka kwenkqubo ye-nervous, kunye nokwandisa umngcipheko womhlaza.
Ukudumba kunokuba negalelo ekunganyangekiyo kwe-insulin kunye nokwandisa i-hyperglycemia kubantu abanesifo seswekile. [8,9] Amanqanaba aphezulu eshukela egazi abangela ukuvuvukala okungaphezulu, okukhawulezisa ukuguga kunye nokwandisa umngcipheko wezifo ezingapheliyo, ezifana nesifo senhliziyo kunye nomhlaza. I-glucose engaphezulu nayo ibangela uxinzelelo lwe-oxidative, olunokonakalisa kakhulu iiseli kunye nezicubu. Phakathi kwezinye iingxaki, uxinzelelo lwe-oxidative lunokukhokelela ku:ukunciphisa ukuthuthwa kwe-glucose kunye ne-insulin secretion, iprotheni kunye ne-DNA umonakalo, kunye nokunyuka kwe-vascular permeability.
• Ziziphi iiNzuzoTetrahydrocurcuminKwisifo seswekile ?
Njengesithako esisebenzayo kwi-turmeric,Tetrahydrocurcumininokunceda ukukhusela ukuphuhliswa kwesifo seswekile kunye nomonakalo onokuthi ubangele ngeendlela ezininzi, kuquka:
1. Ukusetyenziswa kwe-PPAR-γ, okuyi-regulator ye-metabolic eyandisa ukuvakalelwa kwe-insulin kunye nokunciphisa ukuxhathisa kwe-insulin.
2. Iimpembelelo ezichasayo, kubandakanywa ukuvinjelwa kweemolekyuli ezibonisa ukuvuvukala.
3. Ukuphuculwa komsebenzi kunye nempilo yeseli ekhupha i-insulin.
4. Ukwakhiwa okuncitshisiweyo kweemveliso zokuphela kwe-glycation kunye nokuthintela umonakalo obangelwayo.
5. Umsebenzi we-Antioxidant, onciphisa uxinzelelo lwe-oxidative.
6. Ukuphuculwa kweeprofayili ze-lipid kunye nokunciphisa abanye abamakishi be-metabolic dysfunction kunye nesifo senhliziyo.
Kwimizekelo yezilwanyana,tetrahydrocurcuminibonisa isithembiso ekuncedeni ukukhusela ukuphuhliswa kwesifo sikashukela kunye nokunciphisa ukuxhathisa kwe-insulin.
• Ziziphi iiNzuzoTetrahydrocurcuminKwi-Cardiovascular?
Uphononongo luka-2012 olupapashwe kwi-International Journal of Pharmacology luvavanye iziphumo zetetrahydrocurcuminkumakhonkco e-aorta ye-mouse ukubona ukuba i-compound ineempawu ze-cardioprotective. Okokuqala, abaphandi bahlambulula amakhonkco e-aortic kunye ne-carbachol, i-compound eyaziwa ngokubangela i-vasodilation. Emva koko, iimpuku zafakwa i-homocysteine thiolactone (HTL) ukuthintela i-vasodilation. [16] Ekugqibeleni, abaphandi batofa iimpuku nokuba yi-10 μM okanye i-30 μM yetetrahydrocurcuminkwaye yafumanisa ukuba yenza i-vasodilation kumanqanaba afana ne-carbachol.
Ngokutsho kolu phononongo, i-HTL ivelisa i-vasoconstriction ngokunciphisa inani le-nitric oxide emithanjeni yegazi kunye nokwandisa ukuveliswa kwee-radicals zamahhala. Ngoko ke,tetrahydrocurcuminkufuneka kuchaphazele ukuveliswa kwe-nitric oxide kunye / okanye i-radicals yamahhala ukwenzela ukubuyisela i-vasodilation. Ukusukela okotetrahydrocurcuminineepropathi ezinamandla zokulwa ne-antioxidant, inokukwazi ukutshabalalisa iiradicals zasimahla.
• Ziziphi iiNzuzoTetrahydrocurcuminKuxinzelelo lwegazi ?
Nangona uxinzelelo lwegazi oluphezulu lunokuba nezizathu ezahlukahlukeneyo, ludla ngokuba ngumphumo wokuxinana ngokugqithiseleyo kwemithambo yegazi, nto leyo ekhokelela ekucuthekeni kwemithambo yegazi.
Kuphononongo luka-2011, abaphandi baniketetrahydrocurcuminukuya kwiimpuku ukubona ukuba ichaphazele uxinzelelo lwegazi. Ukubangela ukungasebenzi kakuhle kwe-vascular, abaphandi basebenzise i-L-arginine methyl ester (L-NAME). Iimpuku zohlulwa zangamaqela amathathu. Iqela lokuqala lifumene i-L-NAME, iqela lesibini lifumene i-tetrahydrocurcumin (50mg / kg ubunzima bomzimba) kunye ne-L-NAME, kwaye iqela lesithathu lifumenetetrahydrocurcumin(100mg/kg ubunzima bomzimba) kunye L-NAME.
Emva kweeveki ezintathu zedosi yemihla ngemihla, itetrahydrocurcuminiqela libonise ukunciphisa okukhulu kwixinzelelo lwegazi xa kuthelekiswa neqela elithatha kuphela i-L-NAME. Iqela elinikwe idosi ephezulu linesiphumo esingcono kuneqela elinikwe umthamo ophantsi. Abaphandi bathi iziphumo ezintle zibangelwa kokotetrahydrocurcuminUkukwazi ukwenza i-vasodilation.
Ixesha lokuposa: Oct-10-2024
