Kuphuhliso lomhlaba, izazinzulu ziye zafumanisa amandla e-matrine, ikhompawundi yendalo ephuma kwingcambu yesityalo iSophora flavescens, ekulweni nomhlaza. Oku kufunyanisiweyo kuphawula inkqubela phambili ebalulekileyo kwinkalo ye-oncology kwaye inamandla okuguqula unyango lomhlaza.
Yintoni naMatrine?
I-Matrine kudala isetyenziswa kumayeza emveli aseTshayina ngenxa yeempawu zayo zokuchasa ukudumba kunye nomhlaza. Nangona kunjalo, iindlela zayo zokusebenza ezithile zisahleli zinzima ukuza kuthi ga ngoku. Abaphandi basanda kuqhuba uphando olubanzi ukutyhila iindlela ze-molekyuli apho i-matrine yenza iziphumo zayo zokuchasana nomhlaza.
Ngophando lwabo, izazinzulu zifumanise ukuba i-matrine ineepropathi ezinamandla zokuchasa ukwanda kunye ne-pro-apoptotic, okuthetha ukuba inokuthintela ukukhula kweeseli zomhlaza kwaye ibangele ukufa kweeseli zabo ezicwangcisiweyo. Eli nyathelo libini lenza i-matrine ibe ngumviwa othembisayo kuphuhliso lwenoveli yonyango lomhlaza.
Ngapha koko, uphando lubonise ukubaimatrineinokuthintela ukufuduka kunye nokuhlasela kweeseli zomhlaza, eziziinkqubo ezibalulekileyo ekusasazeni umhlaza. Oku kuphakamisa ukuba i-matrine ayinakusebenza kuphela ekunyangeni amathumba aphambili kodwa nasekuthinteleni i-metastasis, umngeni omkhulu kulawulo lomhlaza.
Ukongeza kwiziphumo zayo ezithe ngqo kwiiseli zomhlaza, i-matrine ifunyenwe ukumodareyitha i-tumor microenvironment, icinezela ukwakheka kwemithambo yegazi emitsha eyimfuneko ekukhuleni kwethumba. Le propati ye-anti-angiogenic iphakamisa ngakumbi ukubanakho kwe-matrine njenge-arhente yokulwa nomhlaza.
Ukufunyaniswa kwamandla okuchasa umhlaza we-matrine kubangele uchulumanco kuluntu lwezenzululwazi, nabaphandi ngoku bagxile ekuphononongeni ngakumbi usetyenziso lwayo lonyango. Ulingo lwezonyango luyaqhuba ukuvavanya ukhuseleko kunye nokusebenza kakuhle konyango olusekelwe kwi-matrine kwizigulane ezinomhlaza, ezinikezela ngethemba lokuphuhliswa konyango olutsha noluphuculweyo lomhlaza.
Ukuqukumbela, isityhilelo sekwe matrineiipropathi ezichasene nomhlaza zibonisa isiganeko esibalulekileyo kwidabi eliqhubekayo lokulwa nomhlaza. Ngeendlela zayo ezininzi zokwenza kunye neziphumo ezithembisayo zangaphambili, i-matrine inesithembiso esikhulu njengesixhobo sexesha elizayo kumlo ochasene nesi sifo sitshabalalisayo. Njengoko uphando kule ndawo luqhubeka luqhubeka, amandla e-matrine ekuguquleni unyango lomhlaza alukwazi ukugqithiswa.
Ixesha lokuposa: Sep-02-2024
