• Yintoni iI-Lycopene ?
I-Lycopene yi-carotenoid yendalo, efumaneka kakhulu kwiziqhamo kunye nemifuno efana neetumato. Ubume bayo beekhemikhali buqukethe i-11 conjugated bond bonds kunye ne-2 non-conjugated bonds double, kwaye inomsebenzi onamandla we-antioxidant.
I-Lycopene inokukhusela isidoda kwi-ROS, ngaloo ndlela iphucula i-sperm motility, inhibiting prostate hyperplasia, i-prostate cancer cell carcinogenesis, ukunciphisa iziganeko zesibindi esinamafutha, i-atherosclerosis kunye nesifo senhliziyo, ukuphucula ukukhuseleka komntu, kunye nokunciphisa umonakalo wesikhumba obangelwa ukukhanya kwe-ultraviolet.
Umzimba womntu awukwazi ukwenza i-lycopene ngokwawo, kwaye unokungeniswa kuphela ngokutya. Emva kokufunxa, igcinwa ikakhulu esibindini. Ingabonwa kwi-plasma, i-seminal vesicles, i-prostate kunye nezinye izicubu.
• Ziziphi iiNzuzoI-LycopeneUkulungiselela Ukukhulelwa kwaMadoda?
Emva kokusebenza kwe-RAGE, inokubangela ukuphendulwa kweeseli kwaye ikhokelele ekuveliseni i-ROS, ngaloo ndlela ichaphazela umsebenzi wesidoda. Njenge-antioxidant eyomeleleyo, i-lycopene inokucima i-oksijini eyodwa, isuse i-ROS, kwaye ithintele i-sperm lipoproteins kunye ne-DNA ekubeni i-oxidized. Uphononongo lubonise ukuba i-lycopene inokunciphisa inqanaba le-receptor ye-advanced glycation end products (RAGE) kwisidoda somntu, ngaloo ndlela iphucula i-sperm motility.
Umxholo we-Lycopene uphezulu kumasende amadoda aphilileyo, kodwa aphantsi kumadoda angenanzala. Izifundo zeklinikhi zifumanise ukuba i-lycopene inokuphucula umgangatho wesidoda sendoda. Amadoda angamadlolo aneminyaka engama-23 ukuya kwengama-45 acelwa ukuba athathe i-lycopene ngomlomo kabini ngemini. Kwiinyanga ezintandathu kamva, ukugxininiswa kwamadlozi, umsebenzi kunye nokumila kwawo kwaphinda kwajongwa kwakhona. Iikota ezintathu zamadoda ziye zaphucula kakhulu i-sperm motility kunye ne-morphology, kwaye ukugxilwa kwesidoda kwaphuculwa kakhulu.
• Ziziphi iiNzuzoI-LycopeneKwiProstate yaMadoda ?
1. I-Prostatic Hyperplasia
I-Prostatic hyperplasia sisifo esiqhelekileyo kumadoda, kwaye kwiminyaka yamuva nje, izinga leziganeko liye lehla ngokukhawuleza. Iimpawu ezisezantsi zokuchama (ukungxamiseka komchamo / ukuchama rhoqo / ukuchama okungaphelelanga) zezona zibonakaliso eziphambili zeklinikhi, ezichaphazela kakhulu umgangatho wobomi bezigulane.
I-Lycopeneinokuthintela ukwanda kweeseli ze-prostate epithelial, ikhuthaze i-apoptosis kwizicubu ze-prostate, ivuselele unxibelelwano lwe-intercellular gap junction ukukhusela ukwahlukana kweeseli, kunye nokunciphisa ngokufanelekileyo amanqanaba ezinto ezivuthayo ezifana ne-interleukin IL-1, IL-6, IL-8 kunye ne-tumor necrosis. factor (TNF-α) ukwenza iziphumo ezichasayo.
Ulingo lwezonyango lufumanise ukuba i-lycopene inokuphucula i-prostate hyperplasia kunye ne-bladder smooth muscle shape shape kubantu abatyebe kakhulu kwaye ithomalalise iimpawu ze-urinary tract tract. I-Lycopene inesiphumo esihle sonyango kunye nokuphuculwa kweempawu ze-urinary eziphantsi zamadoda ezibangelwa yi-prostate hypertrophy kunye ne-hyperplasia, ehambelana ne-antioxidant enamandla kunye ne-anti-inflammatory effects ye-lycopene.
2. Umhlaza weProstate
Zininzi iincwadi zonyango ezixhasa okoi-lycopeneekutyeni kwemihla ngemihla kudlala indima ephambili ekuthinteleni umhlaza wedlala lobudoda, kwaye ukuthathwa kwe-lycopene kuhambelana kakubi nomngcipheko womhlaza wedlala lesinyi. Indlela yayo kukholelwa ukuba inxulumene nokuchaphazela ukubonakaliswa kwemfuza enxulumene nethumba kunye neeproteni, inqanda ukwanda kweeseli zomhlaza kunye nokunamathela, kunye nokuphucula unxibelelwano phakathi kwe-intercellular.
Uvavanyo lwesiphumo se-lycopene kwizinga lokusinda kweeseli zomhlaza wedlala lesinyi kubantu: Kuvavanyo lwezonyango lwezonyango, i-lycopene yayisetyenziselwa ukunyanga imigca yeseli yomhlaza wedlala lesinyi DU-145 kunye ne-LNCaP.
Iziphumo zabonisa ukubai-lycopeneibe nempembelelo enkulu yokuthintela ukwanda kweeseli ze-DU-145, kwaye umphumo wokuthintela ubonwe kwi-8μmol / L. Impembelelo yokuthintela i-lycopene kuyo yayihambelana ngokufanelekileyo kunye nedosi, kwaye izinga eliphezulu lokuthintela lingafikelela kwi-78%. Kwangaxeshanye, inokuthintela ngokubonakalayo ukwanda kwe-LNCaP, kwaye kukho ubudlelwane obucacileyo bedosi. Umlinganiselo ophezulu wokuthintela kwinqanaba le-40μmol / L linokufikelela kwi-90%.
Iziphumo zibonisa ukuba i-lycopene inokuthintela ukwanda kweeseli ze-prostate kunye nokunciphisa umngcipheko weeseli zomhlaza we-prostate zibe ngumhlaza.
Ixesha lokuposa: Nov-20-2024
