I-epimdium (i-horny yebhokhwe yebhokhwe) i-caricarin iba yithemba elitsha lokulwa nomhlaza we-UROTIT

URothelial Carcnoma ngomnye womhlaza oqhelekileyo oqhelekileyo, kunye ne-tumor yokuphinda-phinda kunye ne-metastasis ukuba zezona zibalulekileyo. Ngo-2023, kuqikelelwa ukuba amatyala ayi-168,560 womhlaza wovukori ovuthayo aya kufunyaniswa eUnited States, malunga nokufa kwabantu abangama-32 590; Malunga ne-50% yezi meko yi-urotheial carcinoma. Ngaphandle kokufumaneka kwezinto ezitsha zonyango, ezinje ngeplatinam-esekwe kwi-chemotherapy kunye ne-PD1 i-PD1 ye-Antion, ngaphezulu kwesiqingatha se-Urothelial CarCintomoma zingabaphenduli kunyango. Ke ngoko, kukho isidingo esingxamisekileyo sokuphanda iiarhente ezintsha zonyango ukuphucula imeko ye-Urothelial Carcnoma.

I-icarin. Nje ukuba ungene, i-ICA ​​ifumeke kwi-ICACarn (ICT), ethintela imiphumo. I-ICA inemisebenzi emininzi yebhayiloji, kubandakanya nokulawula ukungaziphathi kakuhle, ukuba neepropathi ze-antioxidant, kunye nokuvula ukuqhubela phambili kwe-tumor. Ngo-2022, iicaphurini ze-Icaritin nge-ICC njengesona sithako siyintloko samkelwa nguLawulo lweeMveliso zoNyango lweSizwe (i-NMPA) kunyango lodidi lokuqala lwe-hepatozlar ye-Hopatoz. Ukongeza, ibonise ukusebenza kakuhle ekusebenziseni ukusinda kwezigulana ezikwi-hepatocellinal ye-capatosoma. I-ICT ayizukubulala ngokuthe ngqo amathumba ngokufumana i-Apoptosis kunye ne-Autophagy, kodwa ilawula i-micronvisvialviorovialvisvialhloisiles kunye nempendulo yomkhuhlane we-anti-tumine. Nangona kunjalo, indlela ethile ye-ICT ilawula apho i-ICT ilawula i-TME, ngakumbi e-Urothelial CarCinoma, ayiqondwa ngokupheleleyo.

Kutshanje, abaphandi abavela kwiSebe le-Urology, iYunivesithi yaseHuashan, i-sudan yapapasha inqaku elinomdlalo we-Uroftial ngokucinezelwa kwe-Iroftial Trap yoMnxeba we-Uroftial ngokucinezela i-Arban Trap Therm B. Isifundo sivelei-icarinKunciphile kakhulu i-tumor eshukumisayo kunye nokuqhubela phambili ngelixa ithintelwe i-neutrophil yokungenisa i-netrophil ingena kwi-ICT inokuba yi-Itsitor entsha kunye nonyango olutsha lwe-Urothelial CarCinoma.

Ukuphinda-phinda kunye ne-metastasis zezona zinto zibangela ukufa e-Urothelial CarCinoma. Kwi-tumor microDhisvialvionvialviesvialvionsvialvionsvialviesvialvorvaintsis, iimolekyuli ezimbi ezikhoyo kunye namajoni amaninzi esuti omzimba The inflammatory microenvironment, associated with neutrophils and neutrophil extracellular traps (NETs), promotes tumor metastasis. Nangona kunjalo, akukho ziziyobisi zithintele ngqo i-neutrophils kunye neminatha.

Kolu phononongo, abaphandi babonisa okokuqalai-icarin, Unyango lomgca wokuqala lwe-capatorallullar ehamba phambili nenganyangekiyo, inokunciphisa iminatha ebangelwa yi-netosis ye-netosis kunye nokuthintela ukungangeni kwe-neutrophil ukungenisa i-micronvicevicrove. Umatshini, i-ICT ubophelele kwaye uthintele intetho yePadi2 kwi-neutrophils, ngaloo ndlela kuthintelayo i-pala2 ithethwe nge-rounenetine. Ukongeza, ukuthintela iRos isizukulwana, thintela i-Mapk Translationy, kwaye icinezela i-Itral ye-Itral ye-Itroo.

Kwangelo xesha, i-ICT ithintela i-tumor padi2-ithethwe i-rouneting rounetone, ngokwenza oko ikhupha i-neutrophil yemfuza yokufumana i-GM-CSF kunye ne-IL-6. Emva koko, ukuphosa i-Il-6 i-Il-6 i-Il-6 ibonisa intetho ye-Loop yengxelo elawulayo nge-jak2 / i-Stat3 / il-6 axis. Ngokusebenzisa iisampulu zeklinikhi, abaphandi bafumana unxibelelwano phakathi kwe-neutrophils, iminatha, i-UCA ye-UCA ye-UCA i-prognosis kunye ne-Coune. I-ICT edityanisiweyo ye-Infitint ye-Onming ye-Onligition inokuba nefuthe elilinganayo.

Ngesishwankathelo, olu phononongo lufunyelei-icarinKunciphile kakhulu i-tumor eshukumayo kunye nokuqhubela phambili ngelixa ithintelwe i-neutrophil engenanzi kunye ne-neutrophils kunye neminatha idlale indima yophawu lwezigulana ezine-tumilheal carcinoma. Ukongeza, i-ICT edibeneyo ne-Anti-PD1 i-Immunotherapy inesicwangciso esiliqili, iphakamisa isicwangciso esinokubakho sonyango kwizigulana ezine-Urothelial Carcnoma