Njengoko sineminyaka esidala, ukusebenza kwamalungu abantu ngokuthe ngcembe krakra, ehambelana ngokusondeleyo nemeko ezandisiweyo zezifo ze-neurodegenegenelitionation. I-MitochondInd AMSSTUTONS ithathelwa ingqalelo njengenye yezona zinto ziphambili kule nkqubo. Kutshanje, iqela lophando le-Ajay Kumar kwiZiko laseIndiya laseIndiya leSizwe kunye neNtshona lipapasha iziphumo ezibalulekileyo zophando kwi-ACS phamacology kunye neCaltal Science, ityhila indlela aphocrocetinUkulibaziseka kwengqondo kunye nokwaluphala komzimba ngokuphucula amanqanaba eeselfowuni.
I-mitochondria "ziifektri zamandla" kwiiseli, ezinoxanduva lokuvelisa amandla amaninzi afunekayo ngeeseli. Ngobudala, ukunciphisa umsebenzi, i-anemia, kunye ne-microcirculator ikhokelela ekunikezelweni kwe-thesygen, kubangela ukungasebenzi kakuhle kwe-tisyvendlial kunye ne-thnocking engapheliyo ye-mitochond, ngaloo ndlela ikhuthaza ukuqhubela phambili kwezifo ze-neurodegenege. I-crocetin yindawo yendalo enokubakho ukuphucula umsebenzi we-mitochond. Olu phononongo lujolise ekuphoseni iziphumo ze-cracetin kumsebenzi we-mitochondIntonce kwi-mice ye-aged kunye neziphumo zawo zokuthathwa gadalala.
● YintoniCrocetin?
I-crocetin yi-Apocarotenoid ye-ApocarxID ye-Apocarboxylic acid efumaneka kwi-crocus ntyatyambo kunye ne-glycoside yayo, i-crocetin, neGadia Jasminaides. Ikwabizwa ngokuba yi-crocetic acid. [3] [4] Yenza ii-crystals ezibomvu ze-Brick kunye nendawo yokunyibilika ye-285 ° C.
Isakhiwo sekhemikhali se-cracetin senza eyona nto iphambili kwi-cracetin, iqula elinoxanduva lombala wesafron. I-cracetin idla ngokukhutshwa kwezorhwebo ukusuka kwisiqhamo seGadia, ngenxa yendleko eziphezulu zesafron.
● Kukwenza njaniCrocetinUkonyusa amandla?
Abaphandi basebenzise i-C57bl / 6Jice mice. Iimpuku zabalupheleyo zahlulwa zangamaqela amabini, elinye iqela lafumana unyango lwe-crocetin kwiinyanga ezine, kwaye elinye iqela lasebenza njengeqela lolawulo. Ingqondo kunye nezakhono zeempuku zavavanywa ngokuvavanywa kweendlela zokuziphatha ezinjengokuvavanywa kwememori yendawo kunye novavanyo oluvulekileyo lwendawo, kwaye indlela yesenzo esivulekileyo se-crametin sahlalutywa yi-pharmaconkinic kwaye iyonke Uhlalutyo lweRever vistremiate lweRegivaruet lwalusetyenziselwa ukuhlengahlengisa izinto ezibadala njengakwiminyaka yobudala kunye nesini ukuvavanya iziphumo ze-crocetin kwimisebenzi yengqondo kunye nemoto yeempuku.
Iziphumo zibonise ukuba emva kweenyanga ezine zecrocetinUnyango, indlela yokuziphatha kwememori kunye namandla eempuku zaziphuculwe kakhulu. Iqela lonyango lenze ngcono kuvavanyo lweememori zendawo, ithathe ixesha elincinci ukufumana ukutya, ihlale kwingalo esisileyo, kwaye inciphise inani lamaxesha abangena kwingalo engafakwanga ngempazamo. Kuvavanyo lwentsimi evulekileyo, iimpuku kwiqela eliphathwayo kwi-cracetin zazisebenza ngakumbi, zaza zashukumela umgama omkhulu kunye nesantya.
Ngokulandelelana yonke i-Techchtoptome ye-hippocampis yemouse, abaphandi bayifumanise loo ntocrocetinUnyango lwabangela utshintsho olukhulu kwinkcazo yesifo, kubandakanya ukupakishwa kwentetho yemfuza enxulumene ne-BDNF (i-neurotrophic ye-neurotrophic).
Izifundo ze-pharmacokinetic zibonisile ukuba i-crocetin inoxinzelelo olusezantsi kwingqondo kwaye akukho luqokelelo, ebonisa ukuba ikhuselekile. I-crocetin iphuculwe ukusebenza ngokuphuculweyo komsebenzi we-mitochondals kwaye yanda amanqanaba eeselfowuni kwiimpuku ezindala ngokwanda kweoksijini. Ukuphuculwa komsebenzi we-mitochondIals kunceda ukuthoba inkqubo yokugugaka kwengqondo kunye nomzimba kwaye ugobe ixesha lokuphila kweempuku.
Olu phando lubonisa ukubacrocetinUnokulibazisa ubukho bengqondo kunye nokwaluphala komzimba kwaye kwandise ixesha lokuphila kwiimpuku ezilupheleyo ngokuphucula ukusebenza kweMitochonduls kunye nokwanda kwamanqanaba endlela yeselula. Iingcebiso ezithile zezi zilandelayo:
Isongezelelo kwi-cracetin ngokumodareyitha: kuba abantu abalupheleyo, ukuxhamla i-cracetin ngokumodareyitha kunokunceda ukuphucula ubuchule bokuqonda kunye nobuchule beemoto kwaye balibazise inkqubo yokwaluphala.
Ulawulo lwezempilo olubanzi: Ukongeza ukongeza i-cracetin, kuya kufuneka ugcine ukutya okusempilweni, ukusebenzisa ngokwasemzimbeni rhoqo kunye nomgangatho olungileyo wokulala ukuphakamisa impilo.
Nikela ingqalelo kukhuseleko: NangonacrocetinIbonisa ukhuseleko oluhle, kusafuneka unikele ingqalelo kumthamo wokufumana umthamo xa uyongeze kwaye uyenze phantsi kwesikhokelo sikagqirha okanye umlo.
● I-Newgrean youlelo kwi-cracetin / clcin / saffron ikhupha
Ixesha leposi: Oct-23 ukuya kwi-2024
