Njengoko sikhula, umsebenzi wamalungu omntu uye uwohloka ngokuthe ngcembe, nto leyo ehambelana ngokusondeleyo nokwanda kwezifo ze-neurodeergenerative. Ukungasebenzi kweMitochondrial kuthathwa njengenye yezinto eziphambili kule nkqubo. Kutshanje, iqela lophando lika-Ajay Kumar ovela kwiZiko laseIndiya le-Indian Institute of Integrated Traditional Chinese kunye ne-Western Medicine lipapashe isiphumo esibalulekileyo sophando kwi-ACS Pharmacology kunye neSayensi yokuGuqulela, etyhila indlela esetyenziswa ngayo.crocetinilibazisa ingqondo kunye nokuguga komzimba ngokuphucula amanqanaba amandla eselula.
IMitochondria "ziifektri zamandla" kwiiseli, ezinoxanduva lokuvelisa uninzi lwamandla afunwa ziiseli. Ngokukhula, ukuncipha kokusebenza kwemiphunga, i-anemia, kunye nokuphazamiseka kwe-microcirculatory kukhokelela ekuboneleleni kweoksijini eyaneleyo kwiithishu, ezibangela i-hypoxia engapheliyo kunye nokungasebenzi kakuhle kwe-mitochondrial, ngaloo ndlela kukhuthaze ukuqhubela phambili kwezifo ze-neurodeergenerative. I-Crocetin iyikhompawundi yendalo enamandla okuphucula umsebenzi we-mitochondrial. Olu phononongo lujolise ekuphononongeni imiphumo ye-crocetin kumsebenzi we-mitochondrial kwiigundane ezikhulileyo kunye nemiphumo yokuchasana nokuguga.
●YintoniCrocetin?
I-Crocetin yi-apocarotenoid yendalo ye-dicarboxylic acid efumaneka kwintyatyambo yecrocus kunye ne-glycoside yayo, i-crocetin, kunye neziqhamo ze-Gardenia jasminoides. Ikwabizwa ngokuba yi-crocetic acid. [3] [4] Yenza iikristale ezibomvu zezitena ezinendawo yokunyibilika ye-285 °C.
Ukwakhiwa kweekhemikhali ze-crocetin zenza i-core core ye-crocetin, i-compound ejongene nombala we-safron. I-Crocetin idla ngokukhutshwa ngokurhweba kwisiqhamo se-gardenia, ngenxa yexabiso eliphezulu lesafron.
●NjaniCrocetinUkunyusa amandla eSelula ?
Abaphandi basebenzise iigundane ezidala ze-C57BL / 6J. Iigundane ezikhulileyo zahlulwa zibe ngamaqela amabini, elinye iqela lafumana unyango lwe-crocetin kwiinyanga ezine, kwaye elinye iqela lasebenza njengeqela lokulawula. Izakhono zokuqonda kunye neemoto zeempuku zavavanywa ngovavanyo lokuziphatha olufana novavanyo lwememori yendawo kunye novavanyo lwendawo evulekileyo, kwaye indlela yokusebenza ye-crocetin yahlalutywa ngezifundo ze-pharmacokinetic kunye nolandelelwano olupheleleyo lwe-transcriptome. Uhlalutyo lwe-multivariate regression lusetyenziselwa ukulungelelanisa izinto eziphazamisayo ezifana nobudala kunye nesini ukuvavanya imiphumo ye-crocetin kwimisebenzi yokuqonda kunye neemoto zeegundane.
Iziphumo zabonisa ukuba emva kweenyanga ezinecrocetinunyango, indlela yokuziphatha kwimemori kunye nokukwazi ukuhamba kweempuku kuphuculwe kakhulu. Iqela lonyango lenze ngcono kuvavanyo lwenkumbulo yendawo, lathatha ixesha elincinci lokufumana ukutya, lahlala kwingalo ebanjwe ixesha elide, kwaye lanciphisa inani lamaxesha angena ngalo ingalo engabanjwanga ngempazamo. Kuvavanyo lwebala elivulekileyo, iigundane kwiqela le-crocetin-treatment lalisebenza ngakumbi, kwaye zahamba umgama kunye nesantya.
Ngokulandelanisa yonke i-transcriptome ye-hippocampus ye-mouse, abaphandi bafumanisa ukubacrocetinunyango lubangele utshintsho olubalulekileyo kwi-gene expression, kubandakanywa nokulawulwa kokubonakaliswa kwezakhi zofuzo ezinxulumene ne-BDNF (i-brain-derived neurotrophic factor).
Izifundo ze-Pharmacokinetic zibonise ukuba i-crocetin ine-concentrations ephantsi kwingqondo kwaye akukho qoqo, ebonisa ukuba ikhuselekile. I-crocetin iphucule ngempumelelo umsebenzi we-mitochondrial kunye nokwandisa amanqanaba amandla eselula kwiimpuku ezisele zikhulile ngokunyusa ukusasazwa kweoksijini. Ukuphuculwa komsebenzi we-mitochondrial kunceda ukucothisa inkqubo yokuguga kwengqondo kunye nomzimba kunye nokwandisa ixesha lokuphila kweempuku.
Olu phononongo lubonisa ukubacrocetininokulibazisa kakhulu ingqondo kunye nokuguga komzimba kwaye yandise ixesha lokuphila kwiimpuku ezisele zikhulile ngokuphucula ukusebenza kwe-mitochondrial kunye nokunyusa amanqanaba amandla eselula. Izindululo ezithile zezi zilandelayo:
Yongeza i-crocetin ngokumodareyitha: Kubantu abadala, ukongeza i-crocetin ngokumodareyitha kunokunceda ukuphucula amandla okuqonda kunye nemoto kunye nokulibazisa inkqubo yokuguga.
Ulawulo lwezempilo olubanzi: Ukongeza ekongezeni i-crocetin, kufuneka kwakhona ugcine ukutya okunempilo, ukuzivocavoca umzimba rhoqo kunye nomgangatho omhle wokulala ukukhuthaza impilo yonke.
Nika ingqalelo ukhuseleko: Nangonacrocetinibonisa ukhuseleko olulungileyo, kusafuneka ubeke ingqalelo kwi-dosage xa uncedisa kwaye ukwenze phantsi kwesikhokelo sikagqirha okanye isondlo.
● I-NEWGREEN Unikezelo lweCrocetin / iCrocin / iSaffron Extract
Ixesha lokuposa: Oct-23-2024
