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ICoenzyme Q10 – Isiguquli saMandla seMitochondria yeSelula

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Yintoni iCoenzyme Q10?

I-Coenzyme Q10 (i-Coenzyme Q10, i-CoQ10), eyaziwa ngokuba yi-Ubiquinone (UQ) kunye ne-Coenzyme Q (CoQ), i-coenzyme ekhoyo kuzo zonke izinto eziphilayo ze-eukaryotic ezenza ukuphefumula kwe-aerobic. I-benzoquinone i-fat-soluble compound kunye nesakhiwo esifana ne-vitamin K. Q imele iqela le-quinone, kwaye i-10 imele inani le-isoprene eqhotyoshelwe kumsila wayo. Ikakhulu yenziwe kwi-membrane yangaphakathi ye-mitochondria, kwaye inxalenye encinci inokufumaneka ngokutya, njengenyama yenkomo, amaqanda, intlanzi enamafutha, amantongomane, iiorenji, i-broccoli kunye nezinye iziqhamo kunye nemifuno.

I-Coenzyme Q10 isasazwa ngokubanzi emzimbeni womntu kwaye ikhona kumalungu ahlukeneyo, izicubu, iinxalenye ze-subcellular kunye ne-plasma, kodwa umxholo wayo uyahluka kakhulu. Ubuninzi boxinzelelo buphezulu kwizicubu kunye namalungu anjengesibindi, intliziyo, izintso kunye ne-pancreas. Umsebenzi ophambili kukuqhuba iiseli zomntu ukuvelisa amandla. I-Coenzyme Q10 ibandakanyeka kakhulu kwi-mitochondrial oxidative phosphorylation kunye nenkqubo yokuvelisa i-ATP, ilawula indawo ye-cell redox, ithwala ii-electron ezincitshisiweyo kwi-vesicle okanye ngaphandle kweseli ngexesha lenkqubo yokungena kwe-electron membrane, kwaye ithatha inxaxheba ekwenziweni kweproton gradient I-membrane yangaphakathi kunye ne-plasma membrane. Inokukhawulezisa ukuvuselelwa kweeseli kwaye ikhuthaze ukusebenza kweeseli, ngaloo ndlela ikhuthaza kakhulu amandla eeseli ukufunxa izondlo. Ukongeza izithako ze-coenzyme Q10 kwiimveliso zokhathalelo lwesikhumba zinokunceda ngokufanelekileyo iiseli zolusu ukuba zifunxe ezinye izondlo kwiimveliso zokhathalelo lwesikhumba, kwaye zineziphumo ezigcina impilo ezifana nokukhawulezisa imetabolism kunye nokucothisa ukuguga.

Njengemveliso yezempilo, i-coenzyme Q10 inemisebenzi yokukhusela intliziyo, ukwandisa amandla, kunye nokuphucula ukugonywa. Ifanelekile kubadlali bezemidlalo, abasebenzi beengqondo eziphezulu, kunye nokuzinzisa kunye nokubuyiselwa kwezigulane ezinesifo senhliziyo, isifo sikashukela, njl.

IiPropati zoMzi kunye nezeMichiza yeCoenzyme Q10

Imbonakalo yeCoenzyme Q10:I-crystalline powder ephuzi okanye i-orenji-yellow; ayinavumba kwaye ayinancasa; ukubola ngokulula kukukhanya.

Umbala:ukukhanya orenji ukuya kumnyama orenji

Indawo yokunyibilika:49-51℃

Indawo yokubilisa:715.32℃

Ubuninzi:0.9145 g/cm3

Isalathiso seRefractive:1.4760

Iimeko zokugcina:Inokugcinwa kwiqondo lobushushu begumbi ixesha elifutshane, ngokukhethekileyo kwi-−20 ℃ yokugcina ixesha elide.

Ukunyibilika:Inyibilika ngokulula kwiklorofomu.

Uvakalelo:ukuzwela kwezithombe

Uzinzo:Izinzile, kodwa zivakalelwa kukukhanya okanye ubushushu, azihambelani nee-oxidants ezinamandla.

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Ukusasazwa kweCoenzyme Q10KuMzimba woMntu

I-Coenzyme Q10 ifumaneka ngokubanzi kwiimbumba zeeseli, ngakumbi kwiinwebu ze-mitochondrial, kwaye isasazwa kakhulu entliziyweni, emiphungeni, kwisibindi, kwizintso, kwi-spleen, pancreas kunye ne-adrenal glands. Umxholo womzimba wonke weCoenzyme Q10 yi-500 ~ 1500mg kuphela, kodwa idlala indima ebalulekileyo. ICoenzyme Q10 iphezulu kakhulu entliziyweni, kwizintso, isibindi kunye nezihlunu. Ngelo xesha, i-95% ye-Coenzyme Q10 emzimbeni womntu ikhona ngendlela ye-ubiquinol (eyehlisiwe i-Ubiquinol), kodwa ingqondo kunye nemiphunga ayibandakanywa. Kucingelwa ukuba kungenxa yoxinzelelo oluphezulu lwe-oxidative kwezi zicubu zimbini, ezenza i-ubiquinol ibe yi-ubiquinone ene-oxidized (i-Ubiquinone ene-oxidized).

Ngokuhla kweminyaka, umxholo weCoenzyme Q10 emzimbeni womntu uya kuncipha ngokuthe ngcembe. Ukuthatha iminyaka eyi-20 njengomgca oqhelekileyo, kwiminyaka eyi-80, ukuthotywa kwendalo kweCoenzyme Q10 kwiindawo ezahlukeneyo zomzimba womntu: isibindi: 83.0%; izintso: 65.3%; imiphunga: 51,7%; intliziyo: 42.9%. Ngoko ke, kuyamkelwa ngokubanzi ukuba intliziyo lilungu elifuna kakhulu i-coenzyme Q10 supplementation, okanye ukuba ezininzi iintlungu zentliziyo yabantu abadala zivela ngenxa yokungabikho kwe-coenzyme Q10.

Ziziphi iiNzuzo zeCoenzyme Q10?

Ezinye zezibonelelo ezinokubakho ze-CoQ10 ziquka:

1. Ukuphucula impilo yentliziyo:I-CoQ10 ibonakaliswe ukuxhasa impilo yentliziyo ngokunceda ekuphuculeni imveliso yamandla kwi-heart muscle, kunye nokusebenza njenge-antioxidant yokukhusela uxinzelelo lwe-oxidative.

2. Ukwanda kwemveliso yamandla:I-CoQ10 ibandakanyeka kwimveliso ye-adenosine triphosphate (ATP), eyona mthombo wamandla ophambili kwiiseli. Ukongezwa nge-CoQ10 kunokunceda ukwandisa amanqanaba amandla, ngakumbi kubantu abanamanqanaba aphantsi e-CoQ10.

3. Iimpawu zeAntioxidant:I-CoQ10 inceda ekunciphiseni ii-radicals zamahhala kunye nokunciphisa umonakalo we-oxidative emzimbeni, onokunceda ukukhusela kwizifo ezingapheliyo kunye nokuxhasa impilo yonke.

4. Iziphumo zokuchasa ukuguga ezinokubakho:Olunye uphando lubonisa ukuba i-CoQ10 inokuba nemiphumo yokuchasana nokuguga ngenxa yokukwazi ukukhusela iiseli kumonakalo we-oxidative kunye nokuxhasa ukuveliswa kwamandla eselula.

5. Inkxaso kubasebenzisi be-statin:Amayeza eStatin, aqhele ukumiselwa ukunciphisa i-cholesterol, anokuphelisa amanqanaba e-CoQ10 emzimbeni. Ukongezwa nge-CoQ10 kunokunceda ukunciphisa iziphumo ebezingalindelekanga zokusetyenziswa kwe-statin, ezinje ngeentlungu zemisipha kunye nobuthathaka.

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Yintoni Izicelo ZeCoenzyme Q10?

I-Coenzyme Q10 (CoQ10) inezicelo ezininzi ngenxa yeenzuzo zayo zempilo. Ezinye zezicelo eziphambili ze-CoQ10 ziquka:

1. Impilo yentliziyo:I-CoQ10 ihlala isetyenziselwa ukuxhasa impilo yentliziyo, ngakumbi kubantu abanesifo senhliziyo, uxinzelelo lwegazi oluphezulu, okanye ezinye iimeko zentliziyo. Inokunceda ukuphucula imveliso yamandla kwimisipha yentliziyo kwaye isebenze njenge-antioxidant yokukhusela uxinzelelo lwe-oxidative.

2. Iziphazamiso zeMitochondrial:I-CoQ10 ngamanye amaxesha isetyenziswa njengesongezelelo kubantu abanengxaki ye-mitochondrial, njengoko idlala indima ebalulekileyo kwimveliso yamandla ngaphakathi kwe-mitochondria.

3. I-myopathy eyenziwa yiStatin:I-CoQ10 supplementation ngamanye amaxesha iyacetyiswa kubantu abathatha amayeza e-statin ukunciphisa i-cholesterol, njengoko i-statins inokuphelisa amanqanaba e-CoQ10 emzimbeni. Ukongezwa nge-CoQ10 kunokunceda ukunciphisa iintlungu zemisipha kunye nobuthathaka obuhambelana nokusetyenziswa kwe-statin.

4. Ukuchasana nokuguga kunye nempilo yolusu:I-CoQ10 isetyenziswa kwezinye iimveliso ze-skincare ngenxa yeempawu zayo ze-antioxidant, ezinokunceda ukukhusela ulusu kumonakalo we-oxidative kunye nokuxhasa impilo yolusu luphela.

5. Uthintelo lweMigraine:Olunye uphando lubonisa ukuba ukuxhaswa kwe-CoQ10 kunokunceda ukunciphisa ukuphindaphinda kunye nobukhulu be-migraines, nangona uphando oluninzi lufunekayo ukuze kuqinisekiswe ukusebenza kwayo kule njongo.

6. Yenza umthambo:I-CoQ10 inokunceda ukuphucula ukusebenza komthambo kunye nokubuyisela ngokuxhasa ukuveliswa kwamandla kunye nokunciphisa uxinzelelo lwe-oxidative kwimisipha.

Coenzyme q10 Umxholo ekutyeni okuqhelekileyo

Umxholo weCoenzyme Q10 ngekhilogram yokutya (mg)

Ukutya

Umxholo we-CoQ10

Ukutya

Umxholo we-CoQ10

Iisardadi

33.6

Umbona

6.9

Saury

26.8

irayisi emdaka

5.4

Intliziyo yehagu

25.6

Ispinatshi

5.1

Isibindi senyama yehagu

25.1

Imifuno eluhlaza

3.2

Intlanzi emnyama

25.1

Imbewu yokudlwengulwa

2.7

Inyama yehagu

24.7

Iminqathe

2.6

Islamoni

22.5

Ilethasi

2.5

Imackerel

21.8

Iitumato

2.5

Yenkomo

21.2

IKiwifruit

2.4

Inyama yehagu

16.1

Isileri

2.3

Amandongomane

11.3

Iitapile eziswiti

2.3

Ibrokholi

10.8

Iiorenji

2.3

Amatsheri

10.7

Isityalo seqanda

2.3

Irhasi

10.6

Ii-ertyisi

2.0

Iimbotyi zesoya

7.3

Ingcambu yeLotus

1.3

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Imibuzo eNxulumeneyo onokuthi ubenomdla kuyo:

Zintoni iziphumo ezisecaleni zeCoenzyme Q10?

I-Coenzyme Q10 (CoQ10) ngokuqhelekileyo ithathwa njengekhuselekile kubantu abaninzi xa ithathwa kwiidosi ezifanelekileyo. Nangona kunjalo, abanye abantu banokuba neziphumo ebezingalindelekanga ezingephi. Oku kunokubandakanya:

1. Imiba yokwetyisa:Abanye abantu banokufumana iimpawu ezithambileyo zesisu esinjengesicaphucaphu, urhudo, okanye isisu esibuhlungu xa bethatha izongezo ze-CoQ10.

2. Ukuphuthelwa:Kwezinye iimeko, ukuxhaswa kwe-CoQ10 kuye kwadibaniswa nobunzima bokulala okanye ukulala, ngakumbi xa kuthathwa ngokuhlwa.

3. Ukwalana:Nangona kunqabile, abanye abantu banokungadibani ne-CoQ10 kwaye banokufumana iimpawu ezinje ngerhashalala, ukurhawuzelelwa, okanye ukuphefumla nzima.

4. Ukusebenzisana namayeza:I-CoQ10 inokunxibelelana namayeza athile, afana ne-blood thinners kunye namayeza oxinzelelo lwegazi oluphezulu. Kubalulekile ukubonisana nengcali yezempilo phambi kokuba uthathe i-CoQ10 ukuba ukuwo nawaphi na amayeza.

Kubalulekile ukuqaphela ukuba uninzi lwabantu luyinyamezela kakuhle i-CoQ10, kwaye iziphumo ebezingalindelekanga ezimandundu zinqabile. Nangona kunjalo, njengaso nasiphi na isongezelelo, kuyacetyiswa ukuba udibane nomboneleli wezempilo ngaphambi kokuba uqalise ukuxhaswa kwe-CoQ10, ngakumbi ukuba unayo naziphi na iimeko zempilo eziphantsi okanye uthatha amayeza.

Ngaba kufuneka uthathe i-CoQ10 yonke imihla?

Isigqibo sokuthatha i-Coenzyme Q10 (CoQ10) imihla ngemihla kufuneka isekelwe kwiimfuno zempilo yomntu kunye neengcebiso zengcali yezempilo. I-CoQ10 iveliswa ngokwemvelo emzimbeni kwaye ifumaneka ngokutya okuthile. Nangona kunjalo, njengoko abantu bekhula okanye kwiimeko ezithile zempilo, imveliso yendalo yomzimba ye-CoQ10 inokwehla.

Kubantu abacinga nge-CoQ10 supplementation, kubalulekile ukudibana nomboneleli wezempilo ukuze abone idosi efanelekileyo kunye nokuphindaphinda ngokusekwe kwimeko yempilo yomntu, ukusilela okunokwenzeka, kunye naziphi na iimeko zonyango ezikhoyo. Kwezinye iimeko, uchwepheshe wezempilo unokuncoma ukuthatha i-CoQ10 imihla ngemihla, ngelixa kwezinye iimeko, ishedyuli eyahlukileyo ye-dosing inokufaneleka ngakumbi.

Ngubani ongakwaziyo ukuthatha i-CoQ10?

Abantu abathile kufuneka balumke okanye baphephe ukuthatha iCoenzyme Q10 (CoQ10) ngaphandle kokubonisana nochwepheshe bezempilo. Oku kunokubandakanya:

1. Abasetyhini abakhulelweyo okanye abancancisayo:Nangona i-CoQ10 ngokuqhelekileyo ithathwa njengekhuselekile, kukho uphando oluncinci malunga nokhuseleko lwayo ngexesha lokukhulelwa kunye nokuncelisa. Ke ngoko, kuyacetyiswa ukuba abasetyhini abakhulelweyo okanye abancancisayo badibane nomboneleli wezempilo ngaphambi kokusebenzisa i-CoQ10.

2. Abantu abasebenzisa amayeza okunciphisa igazi:I-CoQ10 inokunxibelelana namayeza e-anticoagulant afana ne-warfarin (Coumadin) okanye iziyobisi ze-antiplatelet ezifana ne-aspirin. Kubalulekile ukuba umntu ngamnye kula mayeza afune iingcebiso zonyango phambi kokuba aqalise ukongeza kwi-CoQ10.

3. Abantu abaneemeko zonyango ezikhoyo:Abantu abaneemeko ezithile zonyango, ezifana nesifo sesibindi, isifo sezintso, okanye isifo seswekile, kufuneka badibane nomboneleli wezempilo ngaphambi kokuba bathathe i-CoQ10, njengoko inokusebenzisana namayeza asetyenziselwa ukulawula ezi meko.

4. Abo banezinto abaziwayo:Abantu abayaziyo i-allergies kwi-CoQ10 okanye iikhompawundi ezinxulumeneyo kufuneka bakuphephe ukusetyenziswa kwayo.

Ziziphi iimpawu zokufunaCoQ10?

Iimpawu zokufuna ukuxhaswa kwe-Coenzyme Q10 (CoQ10) azisoloko zithe tye, njengoko zinobuqili kwaye zinokudibana neempawu zeemeko ezahlukeneyo zempilo. Nangona kunjalo, ezinye iimpawu ezinokubonisa ukusilela kwi-CoQ10 ziquka:

1. Ukudinwa kunye namanqanaba asezantsi amandla:I-CoQ10 idlala indima ebalulekileyo kwimveliso yamandla eselula. Ke ngoko, ukudinwa okuzingisileyo kunye namanqanaba aphantsi amandla anokuba luphawu lokusilela kwe-CoQ10.

2. Ubuthathaka bemisipha kunye neentlungu:Ukusilela kwe-CoQ10 kunokufaka isandla kubuthathaka bemisipha, iintlungu, kunye neecramps, njengoko ibandakanyeka kwimveliso yamandla ngaphakathi kweeseli zemisipha.

3. Uxinzelelo lwegazi oluphezulu:Olunye uphando lubonisa ukuba amanqanaba aphantsi e-CoQ10 anokudibaniswa noxinzelelo lwegazi oluphezulu, kwaye ukuxhaswa kunokunceda ukuxhasa impilo ye-cardiovascular.

4. Isifo seentsini:I-CoQ10 ibandakanyeka ekugcineni izicubu zentsini ezisempilweni, kwaye ukunqongophala kunokuba negalelo kwisifo seentsini okanye iingxaki zeperiodontal.

5. Ukuqaqanjelwa yintloko:Olunye uphando lubonise ukuba ukuxhaswa kwe-CoQ10 kunokunceda ukunciphisa ukuphindaphinda kunye nobunzima be-migraines, ebonisa ukuba amanqanaba aphantsi e-CoQ10 anokuba negalelo kwi-migraines kwabanye abantu.

Kuthatha ixesha elingakanani ukubona izibonelelo?

Ixesha elithathayo ukubona izibonelelo zeCoenzyme Q10 (CoQ10) zinokuhluka ngokuxhomekeka kwimeko yempilo yomntu, imeko ethile yezempilo ijongiwe, kunye ne-dosage ye-CoQ10 esetyenziswayo. Kwezinye iimeko, abantu banokufumana inzuzo ngokukhawuleza, ngelixa kwezinye iimeko, kunokuthatha ixesha elide ukuqaphela nayiphi na imiphumo.

Kwiimeko ezithile ezifana nokungaphumeleli kwentliziyo okanye uxinzelelo lwegazi oluphezulu, kunokuthatha iiveki ezininzi ukuya kwiinyanga zokuxhaswa kwe-CoQ10 engaguqukiyo ukujonga ukuphuculwa kweempawu. Kwelinye icala, abantu abathatha i-CoQ10 ngenkxaso yamandla ngokubanzi okanye njenge-antioxidant banokuqaphela izibonelelo ezinjengokonyuka kwamanqanaba amandla okanye ukuphuculwa kwentlalo-ntle ngexeshana elifutshane, mhlawumbi kwiiveki ezimbalwa.


Ixesha lokuposa: Sep-19-2024