Ubonelelo lweNewgreen Factory Topotecan Hydrochloride High Quality 99% Topotecan Hydrochloride Powder
Ingcaciso yeMveliso
I-Topotecan Hydrochloride liyeza le-chemotherapy elisetyenziselwa ikakhulu ukunyanga iintlobo ezithile zomhlaza. Yindlela ye-hydrochloride ye-topotecan, i-topoisomerase inhibitor esebenza ngokuyinhloko ngokuthintela umsebenzi we-DNA topoisomerase I.
Amanqaku:
Xa usebenzisa i-Topotecan, izigulane kufuneka zibe phantsi kolawulo lukagqirha, ngakumbi kwizigulane ezinesibindi kunye nokungasebenzi kakuhle kwezintso okanye ezinye iingxaki zempilo. Uvavanyo lwegazi rhoqo luyafuneka ngexesha lonyango ukujonga iziphumo ezinokwenzeka.
Ukuqukumbela, i-Topotecan Hydrochloride lichiza elibalulekileyo le-anticancer, elisetyenziswa ikakhulu ukunyanga umhlaza we-ovarian kunye nomhlaza wemiphunga omncinci weseli, kwaye inexabiso elibalulekileyo lesicelo seklinikhi.
I-COA
| Izinto | Iinkcukacha | Iziphumo |
| Imbonakalo | Ngaphandle-mhlophe okanye umgubo omhlophe | Umgubo oMhlophe |
| Ukuchongwa kwe-HPLC | Iyangqinelana nereferensi ixesha lokugcinwa kwento ephambili | Iyahambelana |
| Ukujikeleza okuthe ngqo | +20.0.-+22.0. | +21. |
| Iintsimbi ezinzima | ≤ 10ppm | <10ppm |
| PH | 7.5-8.5 | 8.0 |
| Ilahleko ekomisweni | ≤ 1.0% | 0.25% |
| Inkokeli | ≤3ppm | Iyahambelana |
| Arsenic | ≤1ppm | Iyahambelana |
| I-Cadmium | ≤1ppm | Iyahambelana |
| IMercury | ≤0. 1ppm | Iyahambelana |
| Indawo yokunyibilika | 250.0℃~265.0℃ | 254.7~255.8℃ |
| Intsalela ekutshisweni | ≤0. 1% | 0.03% |
| IHydrazine | ≤2ppm | Iyahambelana |
| Unizi lolwapho kuyiwa khona | / | 0.21g/ml |
| Uxinaniso olucofaziweyo | / | 0.45g/ml |
| Isivavanyi(Topotecan Hydrochloride） | 99.0%~ 101.0% | 99.65% |
| Ubalo lwe-aerobes iyonke | ≤1000CFU/g | <2CFU/g |
| Umngundo kunye negwele | ≤100CFU/g | <2CFU/g |
| E.coli | Ibi | Ibi |
| Salmonella | Ibi | Ibi |
| Ugcino | Gcina kwindawo epholileyo kunye neyomileyo, gcina ukukhanya okuqinileyo. | |
| Ukuqukumbela | Ufanelekile | |
Umsebenzi
I-Topotecan Hydrochloride liyeza le-chemotherapy elisetyenziselwa ikakhulu ukunyanga iintlobo ezithile zomhlaza. Yi-topoisomerase inhibitor enezi ndlela zilandelayo zokwenza kunye nemisebenzi:
Umsebenzi:
1.Uthintelo lweTopoisomerase: I-Topotecan iphazamisa ukuphindaphinda kwe-DNA kunye nokubhala ngokuthintela umsebenzi we-topoisomerase I. Olu thintelo lukhokelela ekuqhekekeni kwamaketanga e-DNA, ngaloo ndlela kuthintela ukwanda kweeseli zomhlaza.
2.Umsebenzi we-Antitumor: I-Topotecan isetyenziselwa ukunyanga umhlaza we-ovarian, umhlaza omncinci we-cell lung kunye neentlobo ezithile ze-lymphoma. Ingasetyenziswa njengonyango lodidi lokuqala okanye njengonyango lodidi lwesibini emva kokuba olunye unyango lungaphumelelanga.
3.Umjikelo weSeli ezichanekileyo: Impembelelo ye-Topotecan kwi-cell cycle iyenzeka ikakhulu kwisigaba se-S kunye ne-G2, eyenza ibe nefuthe elinamandla lokubulala kwiiseli zomhlaza kwisigaba esithile sokunyuka kweeseli.
4.Unyango oludibeneyo: I-Topotecan ingasetyenziselwa kunye namanye amachiza e-chemotherapy ukunyusa i-anti-tumor effect kunye nokuphucula impendulo yonyango yesigulane.
5.Nceda Iimpawu: Kwezinye iimeko, ukusetyenziswa kweTopotecan kunokunceda ukukhulula iimpawu ezinxulumene nomhlaza kunye nokuphucula umgangatho wobomi besigulane.
Amanqaku:
I-Topotecan inokubangela ezinye iziphumo, kubandakanywa kodwa kungaphelelanga kwisicaphucaphu, ukuhlanza, ukukhathala, i-leukopenia, njl. Xa usebenzisa eli chiza, izigulane kufuneka zibekwe esweni kwaye zilawulwe phantsi kwesikhokelo sikagqirha.
Ukuqukumbela, iTopotecan Hydrochloride lichiza elisebenzayo le-anticancer elisebenzisa iziphumo zalo ze-antitumor ikakhulu ngokuthintelwa kwe-DNA topoisomerase I.
Isicelo
I-Topotecan Hydrochloride liyeza le-chemotherapy elisetyenziselwa ikakhulu ukunyanga iintlobo ezithile zomhlaza. Ezi zilandelayo zezona ziphambili izicelo:
1.Umhlaza wesibeleko: I-Topotecan isetyenziswa ngokuqhelekileyo ukunyanga umhlaza we-ovarian ophindaphindiweyo, ngakumbi kwizigulane emva kokuba ezinye iindlela zonyango (ezifana ne-platinum-based chemotherapy) ziye zahluleka. Ingasetyenziswa njenge-arhente enye okanye idityaniswe namanye amachiza.
2.Umhlaza wemiphunga yeeseli ezincinci: Eli chiza likwasetyenziswa kunyango lomhlaza weseli emiphunga encinci, ngokuqhelekileyo njengokhetho lonyango lodidi lwesibini, ngakumbi xa isifo siphinda sibuyela emva kwechemotherapy yokuqala.
3.Ezinye iiCancer: Nangona i-Topotecan isetyenziselwa ngokukodwa umhlaza we-ovarian kunye nomhlaza omncinci we-cell lung, iphinda ifundwe kwezinye iimvavanyo zekliniki kwezinye iintlobo zomhlaza, ezifana nomhlaza wesibeleko, umhlaza we-pancreatic, kunye neentlobo ezithile ze-lymphoma.
4. Ulingo lwezonyango: I-Topotecan iphinda ivavanywe kulingo lwezonyango kwiintlobo zomhlaza ezahlukeneyo ukufunda ukusebenza kwayo kunye nokhuseleko kwiinketho zonyango ezahlukeneyo.
5.Unyango oludibeneyo: Kwezinye iimeko, i-Topotecan ingasetyenziselwa kunye namanye amachiza e-chemotherapy okanye amachiza onyango ekujoliswe kuyo ukuphucula umphumo wonyango.
Amanqaku:
Xa usebenzisa i-Topotecan, izigulane kufuneka zibe phantsi kolawulo lukagqirha, ngakumbi kwizigulane ezinesibindi kunye nokungasebenzi kakuhle kwezintso okanye ezinye iingxaki zempilo. Uvavanyo lwegazi rhoqo luyafuneka ngexesha lonyango ukujonga iziphumo ezinokwenzeka.
Ukuqukumbela, i-Topotecan Hydrochloride inexabiso elibalulekileyo lesicelo kunyango lomhlaza, ngakumbi kulawulo lomhlaza we-ovarian ophindaphindiweyo kunye nomhlaza wamaphaphu omncinci.
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