I-Newgreen Ifektri yokuHamba i-Topotecan Hydrochloride i-99% ye-topotecan hydrochrocle
Ingcaciso yeMveliso
I-Topotecan Hydrochloride i-chemotherapy ichiza elisetyenziselwa ukunyanga iintlobo ezithile zomhlaza. Yindlela ye-hydrochloride ye-topotecan, i-topomosomerase inhibitor esebenza ngokuyintloko ngokuthengisisa umsebenzi we-DNA Topoisomerase i.
Amanqaku:
Xa usebenzisa i-topotecan, izigulana kufuneka ziphantsi kwesikhokelo sikagqirha, ngakumbi kwizigulana ezinesibindi kunye ne-FITYSFNY NOBUCHULE okanye ezinye iingxaki zempilo. Uvavanyo lwegazi rhoqo luyafuneka ngexesha lonyango ukubeka iliso kwimiphumo ebezingalindelekanga.
Ukuqukumbela, i-Topotecan Hydrochloride sisiyobisi esibalulekileyo se-anticiancer, ikakhulu sisetyenziselwa ukuphatha umhlaza we-ovari kunye nomhlaza omncinci weseli, kwaye unexabiso elifanelekileyo lekliniki.
Coa
| Izinto | Inkcazo | Iziphumo |
| Imbonakalo | I-off-white okanye umgubo omhlophe | Umgubo omhlophe |
| Ukuchongwa kwe-HPPC | Iyahambelana nereferensi I-StoE SPIA YOKUGQIBELA IXESHA | Ivumelana |
| Ukujikeleza okuthile | +20.0 .- + 22.0. | +21. |
| Izinyithi ezinzima | ≤ I-10ppm | <I-10ppm |
| PH | 7.5-8.5 | 8.0 |
| Ilahleko yokomisa | ≤ 1.0% | I-0.25% |
| Khokelela | ≤3PPM | Ivumelana |
| I-arsenic | ≤1ppm | Ivumelana |
| I-cadmium | ≤1ppm | Ivumelana |
| I-mercury | ≤0. I-1PPM | Ivumelana |
| Indawo yokunyibilika | I-250.0℃~ 265.0℃ | 254.7 ~ 255.8℃ |
| Intsalela kwi-ignition | ≤0. I-1% | I-0.03% |
| Hydrazine | ≤2ppm | Ivumelana |
| Unizi lolwapho kuyiwa khona | / | I-0.21G / ml |
| Ukuxinana | / | I-0.45g / ml |
| I-assay(I-Topotecan hydrochloride) | I-99.0% ~ 101.0% | 99.65% |
| I-aerobes iyonke | ≤1000cfu / g | <2cFU / g |
| Ukubumba kunye neminham | ≤100cfu / g | <2cFU / g |
| E.coli | Engalunganga | Engalunganga |
| Isalmonella | Engalunganga | Engalunganga |
| Ukugcinwa | Gcina kwindawo epholileyo neyomisa, gcina ukukhanya okuqinileyo. | |
| Ukuqukumbela | Bafanelekile | |
Umsebenzi
I-Topotecan Hydrochloride i-chemotherapy ichiza elisetyenziselwa ukunyanga iintlobo ezithile zomhlaza. Yinto engu-topoisomerase inhibitor enezi ndlela zilandelayo zesenzo sesenzo kunye nemisebenzi:
Umsebenzi:
I-1.topoomerase Thibition: I-Topotecan iphazamisa impindezelo yeDNA kunye nokukhutshelwa ngokuthintela umsebenzi we-topoissomerase i.
I-2.MOTITUMORI-Topotecan isetyenziselwa ukunyanga umhlaza we-ovarian, umhlaza omncinci weseli kunye neentlobo ezithile ze-lymphoma. Ingasetyenziselwa njengonyango lomgca wokuqala okanye njengonyango lomgca wesibini emva kolunye unyango lwasilela.
I-3.cell yomjikeloIziphumo ze-topotecan kumjikelo weseli ikakhulu zikwisigaba se-S kwiSigaba se-S kwi-SITE, esenza ukuba kubekho isiphumo sokubulala okubi kwiiseli zomhlaza kwindawo ethile yeseli.
Unyango lonyango: I-Topotecan inokusetyenziswa ngokudibeneyo kunye nezinye iziyobisi zeChemotherapy yokuphucula isiphumo se-Anti-Tumor kunye nokuphucula impendulo yonyango.
5.impawuKwezinye iimeko, ukusetyenziswa kwe-topotecan kunokunceda anciphise iimpawu ezinxulumene nomhlaza kunye nokuphucula umgangatho wobomi bomguli.
Amanqaku:
I-Topotecan inokubangela iziphumo ebezingalindelekanga, kubandakanya kodwa zingapheleli ekubambeni, ukugabha, ukudinwa, i-leukinia, njl. Njl njl.
Ukuqukumbela, i-topotecan hydrochloride sisiyobisi esisebenzayo se-anticer esibonisa iziphumo zayo ze-antitmusor ngokuyintloko ngokuyiphepha le-DNA Topoismomerase i.
Isicelo
I-Topotecan Hydrochloride i-chemotherapy ichiza elisetyenziselwa ukunyanga iintlobo ezithile zomhlaza. Ezi zinto zilandelayo zizicelo zayo eziphambili:
1.Ovarian Umhlaza: I-Topotecan ihlala isetyenziselwa ukuphatha umhlaza owuphindaphindiweyo ophindaphindiweyo, ngakumbi kwizigulana emva kolunye unyango (njengonyango lweplatinam-osekwe kwi-chefatherapy) lusilele. Ingasetyenziswa njengearhente enye okanye ngokudibeneyo kunye nezinye iziyobisi.
2.Soll Sung Wiler Wing: Eli chiza likwasetyenziswa kunyango lomhlaza omncinci weselula, ngokufuthi njengendlela yonyango lwesibini, ngakumbi xa isifo siphindaphindwe emva kokufumana i-chemotherapy yokuqala.
3.Ocler Cancers: Nangona i-topotecan isetyenziselwa umhlaza we-ovari kunye nomhlaza omncinci weseli, ikwafundiswa kukhethelwa ezinye iintlobo zomhlaza, ezinje ngomhlaza wesibeleko, kunye neentlobo ezithile ze-lymphoma.
Iimvavanyo ze-4.clines: I-topotecan nayo ivavanywa kwiimvavanyo zeklinikhi zomhlaza ohlukeneyo ukufundisisa ukusebenza kunye nokhuseleko ngeendlela ezahlukeneyo zonyango.
5.Comba unyango: Kwezinye iimeko, i-topotecan inokusetyenziswa ngokudibeneyo kunye namanye amachiza amathanga okanye amachiza okunyanga okujolisayo ukuphucula isiphumo sonyango.
Amanqaku:
Xa usebenzisa i-topotecan, izigulana kufuneka ziphantsi kwesikhokelo sikagqirha, ngakumbi kwizigulana ezinesibindi kunye ne-FITYSFNY NOBUCHULE okanye ezinye iingxaki zempilo. Uvavanyo lwegazi rhoqo luyafuneka ngexesha lonyango ukubeka iliso kwimiphumo ebezingalindelekanga.
Ukuqukumbela, i-Topotecan hydrochloride ixabisekile ixabiso elibalulekileyo kunyango lomhlaza, ngakumbi kulawulo lomhlaza ovusayo ophindaphindiweyo kunye nomhlaza omncinci weseli.
Iphakheji kunye nokuHanjiswa
