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Ingcaciso yeMveliso
I-Famotidine ngumchasi we-H2 we-receptor, ngokukodwa isetyenziselwa ukunyanga izifo ezinxulumene ne-asidi yesisu. Ivimbela i-histamine H2 receptors kwiiseli ze-parietal zesisu, inciphisa ukukhuselwa kwe-asidi yesisu, kwaye ngaloo ndlela ikhulula iimpawu ezibangelwa yi-asidi ye-gastric. Oku kulandelayo sisingeniso esicacileyo seFamotidine:
Iimpawu eziphambili kunye neMisebenzi
1.Inkqubo: I-Famotidine inqanda ukukhutshwa kwe-asidi ye-gastric kunye nokunciphisa i-asidi esiswini ngokukhetha ngokuchasayo i-H2 receptors kwiiseli ze-parietal zesisu.
2.Imiqondiso:
- I-Gastroesophageal Reflux Disease (GERD): Isetyenziselwa ukukhulula iimpawu ezibangelwa yi-acid reflux, njenge-heartburn kunye ne-acid regurgitation.
Isilonda sePeptic: sisetyenziselwa ukunyanga isilonda esiswini kunye nesilonda se-duodenal kunye nokukhuthaza ukuphiliswa kwesilonda.
-Ukuthintelwa kweengxaki ezinxulumene ne-Gastric Acid-Related Disorders: Kwiimeko ezithile, i-Famotidine ingasetyenziselwa ukukhusela izifo ezinxulumene ne-gastric acid ezibangelwa ngamayeza afana ne-NSAID.
3.Ifomu yomthamo:I-Famotidine idla ngokufumaneka kwiipilisi zomlomo kunye neenaliti, kwaye izigulane zinokuyithatha ngokwengcebiso kagqirha.
4.Iimpendulo ezingalunganga:I-Famotidine ixhatshazwa ngokufanelekileyo, kodwa ezinye iziphumo zecala zinokuthi zenzeke, njengentloko, isiyezi, isifo sohudo okanye ukuqhina.
5.Imiqathango yokusetyenziswa:Xa usebenzisa iFamotidine, izigulana kufuneka zazise oogqirha bazo ukuba zinezinye iingxaki zempilo okanye zithatha amanye amayeza ukuphepha ukusebenzisana kweziyobisi.
Shwankathela
I-Famotidine ngumchasi osebenzayo we-H2 we-receptor, ngokukodwa isetyenziselwa ukunyanga izifo ezinxulumene ne-asidi yesisu, ezifana nesifo se-reflux ye-gastroesophageal kunye nezilonda ze-peptic. Ngokunciphisa ukukhutshwa kwe-asidi yesisu, i-Famotidine inokukhulula iimpawu ezinxulumene nokukhuthaza ukuphilisa. Xa uyisebenzisa, kufuneka ulandele imiyalelo kagqirha ukuqinisekisa ukhuseleko kunye nokusebenza.
I-COA
Izinto | Iinkcukacha | Iziphumo |
Imbonakalo | Ngaphandle-mhlophe okanye umgubo omhlophe | Umgubo oMhlophe |
Ukuchongwa kwe-HPLC | Iyangqinelana nereferensi ixesha lokugcinwa kwento ephambili | Iyahambelana |
Ukujikeleza okuthe ngqo | +20.0.-+22.0. | +21. |
Iintsimbi ezinzima | ≤ 10ppm | <10ppm |
PH | 7.5-8.5 | 8.0 |
Ilahleko ekomisweni | ≤ 1.0% | 0.25% |
Inkokeli | ≤3ppm | Iyahambelana |
Arsenic | ≤1ppm | Iyahambelana |
I-Cadmium | ≤1ppm | Iyahambelana |
IMercury | ≤0. 1ppm | Iyahambelana |
Indawo yokunyibilika | 250.0℃~265.0℃ | 254.7 ~ 255.8℃ |
Intsalela ekutshisweni | ≤0. 1% | 0.03% |
IHydrazine | ≤2ppm | Iyahambelana |
Unizi lolwapho kuyiwa khona | / | 0.21g/ml |
Uxinaniso olucofaziweyo | / | 0.45g/ml |
Uvavanyo (Famotidine) | 99.0%~ 101.0% | 99.65% |
Ubalo lwe-aerobes iyonke | ≤1000CFU/g | <2CFU/g |
Umngundo kunye negwele | ≤100CFU/g | <2CFU/g |
E.coli | Ibi | Ibi |
Salmonella | Ibi | Ibi |
Ugcino | Gcina kwindawo epholileyo kunye neyomileyo, gcina ukukhanya okuqinileyo. | |
Ukuqukumbela | Ufanelekile |
Umsebenzi
I-Famotidine ngumchasi we-H2 we-receptor, ngokukodwa isetyenziselwa ukunyanga izifo ezinxulumene ne-asidi yesisu. Isebenza ngokuthintela i-histamine H2 receptors kwiiseli ze-parietal zesisu, ukunciphisa ukukhutshwa kwe-asidi yesisu. Le ilandelayo yimisebenzi ephambili yeFamotidine:
1.Yehlisa ukukhutshwa kweasidi esiswini:I-Famotidine iyanciphisa kakhulu i-asidi ye-asidi yesisu ngokuchasa i-H2 receptors, inceda ukukhulula iimpawu ezibangelwa yi-asidi yesisu.
2.Ukunyangwa kwesifo se-reflux ye-gastroesophageal (GERD):I-Famotidine ingasetyenziselwa ukunyanga isifo se-reflux ye-gastroesophageal, ukukhulula isitshisa kunye nokungahambi kakuhle okubangelwa yi-gastric acid reflux.
3. Ukunyangwa kwesilonda esiswini:I-Famotidine isetyenziselwa ukunyanga isilonda sesisu kunye nesilonda se-duodenal, ukukhuthaza ukuphulukiswa kwesilonda, kunye nokunciphisa umngcipheko wokuphindaphinda.
4. Ukuthintela ukukhuselwa kweasidi yesisu emva kokusebenza:Emva kotyando oluthile, i-Famotidine ingasetyenziselwa ukukhusela ukukhutshwa kwe-asidi ye-gastric ngokugqithiseleyo kunye nokunciphisa umngcipheko weengxaki zasemva kokuhlinzwa.
5.Yehlisa iimpawu ezinxulumene neasidi esiswini:I-Famotidine inokunceda ukukhulula iimpawu ezibangelwa yi-asidi yesisu, njengeentlungu zesisu, ukungahambi kakuhle kunye nokuqunjelwa.
Ukusetyenziswa
I-Famotidine idla ngokufumaneka ngendlela yeepilisi zomlomo okanye iinaliti, kwaye idosi ethile kunye nezihlandlo zokusetyenziswa kufuneka zihlengahlengiswe ngokusekelwe kwiingcebiso zikagqirha wakho.
Iimpendulo Ezibi
I-Famotidine ixhatshazwa ngokufanelekileyo, kodwa ezinye iziphumo zecala zinokuthi zenzeke, njengentloko, isiyezi, isifo sohudo, okanye ukuqhina.
Ukuqukumbela, i-Famotidine ingumchasi osebenzayo we-H2 we-receptor, ngokukodwa isetyenziselwa ukunyanga izifo ezinxulumene ne-asidi yesisu, ukunceda izigulane zinciphise iimpawu kunye nokukhuthaza ukuphilisa. Xa uyisebenzisa, kufuneka ulandele imiyalelo kagqirha ukuqinisekisa ukhuseleko kunye nokusebenza.
Isicelo
Ukusetyenziswa kweFamotidine kugxile ikakhulu kunyango lwezifo ezinxulumene ne-asidi yesisu, kubandakanya le miba ilandelayo:
1. Isifo seGastroesophageal Reflux (GERD):I-Famotidine isetyenziselwa ukukhulula iimpawu ezibangelwa yi-acid reflux, ezifana ne-heartburn, ukubuyisela i-asidi, kunye neentlungu zesifuba. Ikhulula ezi zimpawu ngokunciphisa imfihlo ye-asidi yesisu.
2.Peptic ulcer:I-Famotidine isetyenziselwa ukunyanga isilonda esiswini kunye nesilonda se-duodenal, inceda ukukhuthaza ukuphiliswa kwezilonda kunye nokunciphisa intlungu kunye nokungahambi kakuhle.
3. Ukuthintelwa kwezifo ezinxulumene ne-asidi yesisu:I-Famotidine ingasetyenziselwa ukuthintela izifo ezinxulumene ne-asidi yesisu ezibangelwa ngamachiza afana neziyobisi ezingekho phantsi kwe-anti-inflammatory (NSAIDs), ngakumbi kwizigulane ezinobungozi obukhulu.
4.Isifo seZollinger-Ellison:I-Famotidine ingasetyenziselwa ukunyanga esi sifo sinqabileyo, esibangela ukukhuselwa ngokugqithiseleyo kwesisu esiswini.
5.Ulawulo lwe-asidi yesisu emva kokusebenza:Emva kotyando oluthile, i-Famotidine ingasetyenziselwa ukulawula ukukhutshwa kwe-asidi yesisu kunye nokunciphisa umngcipheko weengxaki ze-postoperative.
Ukusetyenziswa
I-Famotidine idla ngokunikezelwa ngendlela yeepilisi zomlomo. Izigulane kufuneka zithathe ngokwengcebiso kagqirha wazo. Idosi kunye nokuphindaphinda kokusetyenziswa kuya kwahluka ngokuxhomekeke kwimeko ethile.
Amanqaku
Xa usebenzisa iFamotidine, izigulana kufuneka zazise oogqirha bazo ukuba zinezinye iingxaki zempilo okanye zithatha amanye amayeza ukuphepha ukusebenzisana kweziyobisi. Ukongezelela, nangona i-Famotidine inokulawula ngokufanelekileyo ukukhutshwa kwe-asidi yesisu, izigulane kufuneka zifune unyango ukuba iimpawu ziqhubeka okanye ziba nzima.
Ekugqibeleni, i-Famotidine i-H2 i-receptor antagonist esebenzayo esetyenziswa ngokubanzi kunyango lwezifo ezinxulumene ne-asidi yesisu, inceda izigulane zinciphise iimpawu kunye nokukhuthaza ukuphilisa. Kufuneka isetyenziswe phantsi kwesikhokelo sogqirha ukuqinisekisa ukhuseleko kunye nokusebenza.