• Ke Eng?PQQ ?
PQQ, lebitso le felletseng ke pyrroloquinoline quinone. Joalo ka coenzyme Q10, PQQ le eona ke coenzyme ea reductase. Sebakeng sa li-supplement tsa lijo, hangata e hlaha e le tekanyo e le 'ngoe (ka mokhoa oa letsoai la disodium) kapa ka mokhoa oa sehlahisoa se kopantsoeng le Q10.
Tlhahiso ea tlhaho ea PQQ e tlase haholo. E fumaneha mobung le likokoana-hloko, limela le lisele tsa liphoofolo, joalo ka tee, natto, kiwifruit le PQQ le tsona li teng ka har'a lisele tsa motho.
PQQe na le mesebetsi e mengata ea 'mele. E ka khothaletsa mitochondria e ncha liseleng (mitochondria e bitsoa "limela tsa ho sebetsa matla a lisele"), e le hore lebelo la motsoako oa matla a sele le ka eketseha haholo. Ntle le moo, PQQ e netefalitsoe lithutong tsa liphoofolo le batho ho ntlafatsa boroko, maemo a tlase a k'holeseterole, ho fokotsa khatello ea oxidative, ho lelefatsa bophelo, ho khothaletsa ts'ebetso ea boko le ho imolla ho ruruha.
Ka 2017, sehlopha sa bafuputsi se entsoeng ke Moprofesa Hiroyuki Sasakura le ba bang ba Univesithi ea Nagoya Japane ba ile ba hatisa liphetho tsa bona tsa lipatlisiso koranteng ea "JOURNAL OF CELL SCIENCE". Coenzyme pyrroloquinoline quinone (PQQ) e ka lelefatsa bophelo ba li-nematode.
• Melemo ea Bophelo ke EfePQQ ?
PQQ e Khothalletsa Mitochondria
Phuputsong ea liphoofolo, bafuputsi Univesithing ea California ba fumane hore PQQ e ka khothalletsa tlhahiso ea mitochondria e phetseng hantle. Thutong ena, kamora ho nka PQQ bakeng sa libeke tse 8, palo ea mitochondria 'meleng e imenne habeli. Phuputsong e 'ngoe ea liphoofolo, liphetho li bonts'itse hore boits'ireletso ba mmele bo fokotsehile haholo mme palo ea mitochondria e fokotsehile ntle le ho nka PQQ. Ha PQQ e eketsoa hape, matšoao ana a ile a khutlisoa kapele.
Fokotsa ho ruruha le ho thibela ramatikiAntioxidant & Tšireletso ea methapo
Hangata batho ba hōlileng ba tšoenngoa ke ramatiki, eo le eona e leng sesosa sa bohlokoa se bakang kholofalo. Liphuputso li bontšitse hore kakaretso ea palo ea batho ba shoang ba nang le ramatiki ea ramatiki e phahame ka 40% ho feta ea baahi bohle. Ka hona, sechaba sa saense se 'nile sa batla ka mafolofolo litsela tsa ho thibela le ho imolla ramatiki. Phuputso e sa tsoa hatisoa koranteng ea Inflammation e bontša seoPQQe ka 'na ea e-ba mopholosi oa ramatiki eo bafuputsi ba' nileng ba e batla.
Tekong ea kliniki ea batho, bo-rasaense ba ile ba etsisa ho ruruha ha chondrocyte ka har'a tube ea teko, ba kenya PQQ sehlopheng se le seng sa lisele, 'me ha baa ka ba kenya sehlopha se seng. Liphetho li bonts'itse hore boemo ba li-enzyme tse nyenyefatsang tsa collagen (matrix metalloproteinases) sehlopheng sa li-chondrocyte tse sa kang tsa entoa ka PQQ bo eketsehile haholo.
Ka lithuto tsa in vitro le in vivo, bo-ramahlale ba fumane hore PQQ e ka thibela ho lokolloa ha lintlha tsa ho ruruha ka lisele tsa fibrotic synovial manonyeletso, ha e ntse e thibela ts'ebetso ea lintlha tsa nyutlelie tse bakang ho ruruha. Ka nako e ts'oanang, bo-ramahlale ba boetse ba fumane hore PQQ e ka fokotsa ts'ebetso ea li-enzyme tse ikhethileng (joalo ka matrix metalloproteinases), tse senyang mofuta oa 2 collagen manonyeletsong le ho senya manonyeletso.
Antioxidant & tšireletso ea methapo
Liphuputso li fumane seoPQQe na le phello e sireletsang methapo ea kutlo tšenyong ea neuronal ea rat midbrain le lefu la Parkinson le bakoang ke rotenone.
Ho se sebetse hantle ha mitochondrial le khatello ea oxidative ho bonahetse e le lisosa tse peli tse ka sehloohong tsa lefu la Parkinson (PD). Boithuto bo bonts'itse hore PQQ e na le phello e matla ea antioxidant mme e ka sireletsa khahlanong le cerebral ischemia ka ho hanela khatello ea oxidative. Karabelo ea khatello ea oxidative e nkuoa e le e 'ngoe ea litsela tsa bohlokoahali tse lebisang ho apoptosis ea sele. PQQ e ka sireletsa lisele tsa SH-SY5Y ho rotenone (neurotoxic agent) -e bakoang ke cytotoxicity. Bo-rasaense ba sebelisitse PQQ pretreatment ho thibela rotenone-induced cell apoptosis, ho khutlisa bokhoni ba membrane ea mitochondrial, le ho thibela tlhahiso ea mefuta ea oksijene e sebetsang ka har'a intracellular (ROS).
Ka kakaretso, lipatlisiso tse tebileng mabapi le karolo eaPQQ'meleng ho ka thusa batho ho thibela botsofali hamolemo.
• Phepelo E NCHAPQQPhofo /Capsules/Tablets/Gummies
Nako ea poso: Oct-26-2024
