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Mosebetsi:

1. E ntlafatsa lefu la mala

Ho ile ha fumanoa hore phello ea polysaccharide ka mafu a ka mpeng e ne e bonahala haholo-holo likarolong tse tharo tse latelang: (1) Polysaccharide e bile le phello ea ho tlosa Helicobacter pylori, e thibela ho ata ha Helicobacter pylori le ho thibela ho tlama ha eona ka mucosa ea gastric; (2) E na le phello ea ho sireletsa mucosa ea ka mpeng le ho phekola seso sa ka mpeng, 'me e na le phello e ntle ea phokotso ea joala le lithethefatsi tse bakoang ke kotsi ea mucosal ea mala le seso se sa foleng sa ka mpeng; (3) Fucoidan e na le phello e khahlanong le kankere ea mala, e ka thibela ho ata ha lisele tsa kankere ea mala, ea fokotsa litla-morao tsa chemotherapy, le ho ntlafatsa boleng ba bophelo ba bakuli.

2. Tšusumetso ea anticoagulant

Fucoidan e na le mesebetsi e mengata ea likokoana-hloko, empa ts'ebetso ea eona ea anticoagulant ke eona e ithutoang ka ho fetisisa. Boithuto bo bontšitse hore li-polysaccharides tse ntšitsoeng ho algae e fapaneng ea Marine e sootho li na le likhato tse fapaneng tsa ts'ebetso ea anticoagulant. Ka mohlala, li-polysaccharides tse tsoang 'me li bontšitse tekanyo e phahameng ea mosebetsi oa anticoagulant, le mosebetsi oa anticoagulant oa' me e ne e le halofo ea pele, empa hoo e ka bang ha ho na mosebetsi oa anticoagulant.

3. Phello ea antithrombotic

Mohlaleng oa liteko oa liphoofolo tse phelang, polysaccharide ea fucoidan e na le phello e thibelang ho thrombosis ea venous le arterial thrombosis. Rocha et al. o fumane hore polysaccharide e ne e se na ts'ebetso ea anticoagulant ka har'a vitro, empa e bontšitse phello e hlakileng ea antithrombotic ka mokhoa oa phoofolo ea ho etsa thrombosis ea venous, 'me phello e ne e itšetlehile ka nako, e fihla holimo ka mor'a 8h ea tsamaiso. Mosebetsi oa anticoagulant oa polysaccharide mohlomong o ne o amana le ho susumetsa tlhahiso ea heparin sulfate ka lisele tsa endothelial.

4. Tšusumetso ea kokoana-hloko

Liphuputso li bonts'itse hore li-polysaccharides tse sulfated (ho kenyeletsoa le fucoidan polysaccharides) li bonts'a ts'ebetso ea antiviral ka har'a vivo le in vitro. Hayashi et al. o ithutile phello ea ts'ireletso ea fucoidan ho herpes simplex virus (HSV). Ba fumane hore fucoidan e ka sireletsa litoeba ho tsoa tšoaetsong ea HSV, mme a supa hore fucoidan e ka thibela ts'oaetso ea HSV ka ho thibela ka kotloloho ho ikatisa ha kokoana-hloko le ho ntlafatsa ts'ebetso ea ts'ireletso ea 'mele ea tlhaho le e fumanoeng. Ka nako e ts'oanang, ho ile ha boela ha fumanoa hore polysaccharide e bontšitse mosebetsi oa antiviral khahlanong le HSV-1 le HSV-2. Hidari et al. e tlalehile hore fucoidan e ka thibela ts'oaetso ea mofuta oa "dengue virus" ea mofuta oa 2 (DEN2), mme e bontšitse hore fucoidan e tlama likaroloana tsa DEN2 mme e sebelisana le sephutheloana sa eona sa glycoprotein. Ha e na phello e tobileng ea passivation ho li-virions, 'me mochine oa eona oa antiviral ke ho thibela ho thehoa ha kokoana-hloko ea cytiocyte ka ho thibela ho ata ha kokoana-hloko.

5. Phello e khahlanong le hlahala

Fucoidan e nkuoa e le moemeli oa tlhaho o thibelang mofets'e, mme ts'ebetso ea eona ea anti-tumor e tlalehiloe le ho feta. Alekseyenko et al. o ithutile tšebetso e khahlanong le hlahala ea fucoidan ho litoeba tse nang le Lewis lung adenocarcinoma, mme a fepa fucoidan ka tekanyo ea 10mg/kg ho litoeba, e leng se ileng sa fella ka ts'ebetso e leka-lekaneng e khahlanong le hlahala le phello ea anti-tumor metastasis. Liphuputso tse ling li fumane hape hore sekhahla sa thibelo ea hlahala ea fucoidan ho liphoofolo tse 5 tse nang le S180 sarcoma e ne e le 30%, 'me sarcoma ea liphoofolo tse peli e ile ea kokobela ka ho feletseng. Sejaneng sa petri se nang le lisele tsa mofets'e tse ka bang 10,000 tse tšoaroang ka algae polysaccharides ea tlhaho e fumanoeng ho kelp, karolo ea 50 lekholong ea lisele tsa mofetše e shoele kamora lihora tse 24, mme hoo e ka bang lisele tsohle tsa mofets'e li ile tsa shoa kamora lihora tse 72. Hyun et al. e fumane hore polysaccharide ea algae ea majoe e ka thibela haholo kholo ea lisele tsa kankere ea colon ea HCT-15. Kamora ho phekoloa ha mohala oa lisele tsa HCT-15 le rock algae polysaccharide, liketsahalo tsa apoptotic tse kang ho robeha ha DNA, chromosome aggregation, le keketseho ea lisele tsa subdiploid karolong ea G1 e ile ea hlaha.

6. Liphello tsa Antioxidant

Palo e kholo ea liteko tsa in vitro e bontšitse hore polysaccharide ea algae ea majoe e na le ts'ebetso ea bohlokoa ea antioxidant, ke mofuta oa antioxidant ea tlhaho, 'me e ka thibela ka katleho lefu le bakoang ke li-radicals tsa mahala. Costa et al. e ile ea ntšoa li-polysaccharides tsa sulfate ho tsoa ho mefuta ea 11 ea limela tsa leoatleng tsa tropike, tseo kaofela li neng li e-na le ts'ebetso ea antioxidant, bokhoni ba ho etsa li-chelate tse nang le ferrous le matla a ho fokotsa matla, 5 ea eona e nang le matla a ho tlosa li-radicals tsa hydroxyl, 'me 6 ea eona e na le matla a ho tlosa peroxy radicals. Micheline et al. e tlaleha hore li-polysaccharides tse tsoang ho algae li ka thibela ho thehoa ha hydroxyl radical le superoxide radical.

7. Mosebetsi oa ho itšireletsa mafung

Fucoidan e na le mesebetsi e mengata ea 'mele ea ho itšireletsa mafung, e kenyelletsang ts'ebetso e khahlanong le ho tlatsana, karabelo e khahlanong le ho ruruha le liphello tsa immunomodulatory. Tissot et al. e netefalitse hore polysaccharide ea fucoite e ka thibela protheine e tlatselletsang serum e tloaelehileng ea motho, ka hona e thibela ho qhibiliha ha lisele tse khubelu tsa mali tse bakoang ke ts'ebetso ea motlatsi, le ho thibela ts'ebetso ea motlatsi ka ho thibela mohato oa pele oa tsela ea khale ea ts'ebetso (ho kenyeletsoa). karolo ya pele ya tlatsetso, karolo ya bobedi le karolo ya bone). Yang et al. e fumane hore fucoidan e ka thibela ka mokhoa o ikhethileng polelo ea inducible nitric oxide synthase liseleng tsa ho ruruha mme e na le ts'ebetso e khahlanong le ho ruruha. Mizuno et al. e sebelisitse tsamaiso ea co-culture ea intestinal epithelial Caco-2 lisele le macrophage RAW264.7 ho hlahloba phello e khahlanong le ho ruruha ea lijo, 'me liphello li bontšitse hore polysaccharide ea S. japonicum e ka susumetsa tlhahiso ea tumor necrosis factor.α ho RAW264.7, kahoo e thibela polelo ea mRNA ea interleukin liseleng tsa Caco-2.

8. Ntlafatsa boleng ba peō ea botona

Tsamaiso ea fucoidan e ka ntlafatsa boleng ba peo le bongata ka ho ntlafatsa metabolites ea mali le microbiota ea mala. Bafuputsi ba fumane hore kamora ho tsamaisoa ka li-polysaccharides tsa leoatleng, maemo a polelo a liphatsa tsa lefutso tse amanang le spermatogenesis a ile a eketseha haholo litekong tsa litoeba. Ka nako e ts'oanang, ho ne ho e-na le kamano e ntle pakeng tsa intestinal microbiota le metabolites ea mali. Ka ho laola tse peli, polysaccharide ea fucoite e ntlafalitse metabolites ea testis, ea eketsa tšireletso ea antioxidant, 'me ea laola boemo ba polelo ea liphatsa tsa lefutso tse amanang le lisele tsa likokoana-hloko, kahoo e tlatsetsa ho spermatogenesis le ntlafatso ea boleng.