Wararkii ugu dambeeyay ee dhanka dawooyinka, hydroxypropyl beta-cyclodextrin ayaa u soo baxday sidii xarun rajo leh oo loogu talagalay gaarsiinta daroogada. Horumarkan cilmi ahaan adag wuxuu awood u leeyahay inuu wax ka beddelo habka dawooyinka loo maareeyo loona nuugo jirka. Hydroxypropyl beta-cyclodextrin waa nooc wax laga beddelay oo cyclodextrin ah, oo ah nooc ka mid ah molecule ee loo yaqaan awoodda uu u leeyahay in uu ku duubo oo uu milmo daawooyinka, taas oo ka dhigaysa mid la heli karo. Horumarkani waxa uu hayaa balan qaad weyn oo lagu hagaajinayo waxtarka iyo badbaadada daawooyinka kala duwan.
Soo Bandhigidda Codsiyada Ballanqaadka ah eeHydroxypropyl Beta-CyclodextrinIsku xirka wararka Sayniska:
Daraasadaha sayniska ayaa muujiyay waxtarka hydroxypropyl beta-cyclodextrin si kor loogu qaado milanka iyo xasilloonida dawooyinka biyaha ku milma liidata. Horumarkaani wuxuu saameyn weyn ku leeyahay warshadaha dawooyinka, maadaama ay horseedi karto sameynta dawooyin hufan oo la isku halayn karo. Iyadoo la wanaajinayo bioavailability ee daawooyinka, hydroxypropyl beta-cyclodextrin waxay suurtogal u tahay inay yaraato qiyaasta loo baahan yahay ee daawooyinka qaarkood, yaraynta khatarta waxyeellada xun iyo hagaajinta u hoggaansanaanta bukaanka.
Intaa waxaa dheer, isticmaalka hydroxypropyl beta-cyclodextrin ee hababka gudbinta daroogada ayaa muujisay natiijooyin rajo leh oo kor loogu qaadayo awood-siinta daawooyinka ee caqabadaha noolaha, sida xannibaadda dhiigga-maskaxda. Tani waxay furaysaa fursado cusub oo loogu talagalay daawaynta ciladaha neerfaha iyo xaaladaha kale ee u baahan in daroogada la beegsado habka dhexe ee neerfayaasha. Adkeysiga sayniska ee ka dambeeya natiijooyinkan ayaa hoosta ka xariiqaya kartida hydroxypropyl beta-cyclodextrin si ay wax uga qabato caqabadaha muddada dheer ee horumarinta iyo bixinta daroogada.
Codsiga hydroxypropyl beta-cyclodextrin ee qaababka dawooyinka ayaa sidoo kale lagu taageeray muuqaalkeeda badbaadada ee wanaagsan. Cilmi-baaris ballaaran ayaa muujisay is-waafajinta noole iyo sunta hoose ee xaruntan, taasoo ka dhigaysa ikhtiyaar macquul ah oo loo isticmaalo hababka kala duwan ee gudbinta daroogada. Caddayntan sayniseed waxay sii xoojinaysaa awoodda hydroxypropyl beta-cyclodextrin oo ah tignoolajiyada ciyaarta beddeleysa ee dhinaca dawooyinka.
Gabagabadii, horumarradii ugu dambeeyay ee ka faa'iidaysiga hydroxypropyl beta-cyclodextrin ee gaarsiinta daawadu waxay ka dhigan tahay horumar la taaban karo oo hore loogu qaaday cilmi-baarista dawooyinka. Daraasadaha cilmiyaysan ee adag ee taageeraya waxtarka, badbaadada, iyo kala duwanaanshiyaha xaruntan ayaa muujinaya awooddeeda si ay u wanaajiso waxtarka daawooyinka iyo ballaarinta fursadaha bixinta daroogada la beegsaday. Iyadoo cilmi baaris dheeraad ah iyo horumarin ay sii socoto, hydroxypropyl beta-cyclodextrin waxay diyaar u tahay inay door muhiim ah ka qaadato qaabeynta mustaqbalka tignoolajiyada gudbinta daroogada.
Waqtiga boostada: Jul-30-2024
