Epimedium (Weed Riyaha Horny) Oo Laga Soo Saaray- Icariin Oo Noqday Rajo Cusub Oo La Dagaalanka Kansarka Urothelial

Kansarka urothelial waa mid ka mid ah kansarka kaadi mareenka ee ugu badan, oo leh soo noqoshada buro iyo metastasis oo ah arrimo waaweyn oo saadaaliya. 2023, qiyaastii 168,560 xaaladood oo kansarka kaadida ah ayaa laga ogaan doonaa gudaha Mareykanka, iyadoo ku dhawaad ​​32,590 ay u dhinteen; ku dhawaad ​​50% kiisaskan waa kansarka kaadi mareenka. Inkasta oo la heli karo doorashooyin cusub oo daaweyn ah, sida kiimoterabiga ku salaysan platinum iyo PD1 ee difaaca jirka ku salaysan, in ka badan kala badh bukaannada kansarka kaadi mareenka ayaan weli ka jawaabin daaweyntan. Sidaa darteed, waxaa jira baahi degdeg ah oo loo baahan yahay in la baaro wakiilada cusub ee daaweynta si loo hagaajiyo saadaasha bukaanka kansarka kaadiheysta.

Icariin(ICA), walaxda ugu muhiimsan ee firfircoon ee Epimedium, waa tonic, aphrodisiac, iyo dawo dhaqameed Shiinees ah oo ka-hortagga laabotooyinka. Marka la dhuuqo, ICA waxay metabolized u noqotaa icartin (ICT), taas oo markaa saameynteeda yeelata. ICA waxay leedahay hawlo badan oo bayooloji ah, oo ay ku jiraan nidaaminta difaaca la qabsiga, yeelashada sifooyinka antioxidant, iyo joojinta horumarka burada. 2022, kaabsoosha Icaritin oo leh ICT oo ah walaxda ugu muhiimsan waxaa ansixiyay Maamulka Alaabada Caafimaadka Qaranka ee Shiinaha (NMPA) daaweynta safka koowaad ee kansarka hepatocellular aan shaqaynayn. Intaa waxaa dheer, waxay muujisay waxtarka weyn ee sii dheereynta guud ahaan badbaadada bukaanada qaba kansarka hepatocellular sare. ICT ma aha oo kaliya inay si toos ah u disho burooyinka iyada oo keenaysa apoptosis iyo autophagy, laakiin sidoo kale waxay nidaamisaa unugyada difaaca jirka ee buro waxayna kor u qaadaa jawaab celinta difaaca burada. Si kastaba ha ahaatee, habka gaarka ah ee ICT ay u maamusho TME, gaar ahaan kansarka kaadi mareenka, si buuxda looma fahmin.

Dhawaan, cilmi-baarayaal ka socda Waaxda Urology, Huashan Hospital, Fudan University ayaa daabacday maqaal cinwaankeedu yahay "Icaritin wuxuu joojiyaa horumarka kansarka kaadi mareenka iyada oo la xakameynayo PADI2-dhexdhexaadinta neutrophil neutrophil iyo neutrophil formation trap extracellular" ee joornaalka Acta Pharm Sin B. Daraasadda ayaa shaaca ka qaaday. inicariinwaxay si aad ah u yaraysay faafinta burada iyo horumarka iyada oo la joojinayo dhexgalka neutrophils iyo NET synthesis, taas oo muujinaysa in ICT ay noqon karto NETs-horjooge cusub iyo daaweyn cusub oo loogu talagalay kansarka kaadi mareenka.

Soo noqoshada burada iyo metastasisyada ayaa ah sababaha ugu weyn ee dhimashada kansarka kaadi mareenka. Unugyada yaryar ee buro, unugyo-hoosaadyo xunxun iyo unugyo hoosaadyo badan oo difaaca waxay xakameeyaan difaaca antitumor. Microenvironment bararka, oo la xidhiidha neutrophils iyo neutrophils extracellular traps (NETs), waxay kor u qaadaan metastasis-ka burada. Si kastaba ha ahaatee, hadda ma jiraan daawooyin si gaar ah u joojiya neutrophils iyo NETs.

Daraasaddan, cilmi-baarayaashu waxay muujiyeen markii ugu horreysay inicariin, daawaynta safka hore ee kansarka hepatocellular ee horumarsan oo aan laga bogsan karin, waxay yarayn kartaa NET-yada ay sababto isdilka NETosis waxayna ka hortagtaa galitaanka neutrophil ee buro microenvironment. Farsamo ahaan, ICT waxay ku xidhaa oo joojisaa muujinta PADI2 ee neutrophils, taas oo ka hortagaysa PADI2-dhexdhexaadinta citrullination histone. Intaa waxaa dheer, ICT waxay joojisaa jiilka ROS, waxay joojisaa dariiqa calaamadaynta MAPK, waxayna xakameysaa metastasis-ka burada ee NET.

Isla mar ahaantaana, ICT waxay joojisaa burada PADI2-dhexdhexaadinta histone citrullination, taas oo joojinaysa qorista hiddo-wadaha qoritaanka neutrophil sida GM-CSF iyo IL-6. Taa baddalkeeda, hoos u dhigista odhaahda IL-6 waxay samaysaa wareegga jawaab celinta sharciyeed iyada oo loo marayo dhidibka JAK2/STAT3/IL-6. Iyadoo loo marayo daraasad dib-u-eegis ah oo ku saabsan shaybaarada kiliinikada, cilmi-baarayaashu waxay heleen xiriir ka dhexeeya neutrophils, NETs, ​​UCa prognosis iyo badbaadada difaaca. ICT oo ay weheliso ka-hortagayaasha isbaarada difaaca ayaa laga yaabaa inay yeeshaan saameyn isku-dhafan.

Isku soo wada duuboo, daraasaddan ayaa lagu ogaadayicariinsi aad ah u yareeyey faafidda iyo horumarka burada iyada oo la joojinayo dhexgalka neutrophils iyo NET synthesis, iyo neutrophils iyo NETs waxay door ka ciyaaraan doorka xakameynaya unugyada difaaca jirka ee bukaanka bukaanka qaba kansarka kaadiheysta. Intaa waxaa dheer, ICT oo lagu daray anti-PD1 immunotherapy waxay leedahay saameyn isku-dhafan, taasoo soo jeedinaysa istaraatiijiyad daweyn oo suurtagal ah bukaannada qaba kansarka kaadiheysta.