Qalabka Cusub ee Warshada Topotecan Hydrochloride Tayada Sare 99% Topotecan Hydrochloride Powder
Sharaxaada Alaabta
Topotecan Hydrochloride waa dawada kiimikaad ee loo isticmaalo daawaynta noocyada kansarka qaarkood. Waa qaabka hydrochloride ee topotecan, topoisomerase inhibitor ka shaqeeya marka hore isagoo joojinaya dhaqdhaqaaqa DNA topoisomerase I.
Xusuusin:
Marka la isticmaalayo Topotecan, bukaanku waa inay hoos yimaadaan hagidda dhakhtarka, gaar ahaan bukaanka qaba cillad beerka iyo kelyaha ama dhibaatooyinka kale ee caafimaadka. Tijaabooyin dhiig oo joogto ah ayaa loo baahan yahay inta lagu jiro daawaynta si loola socdo waxyeelada suurtagalka ah.
Gebagebadii, Topotecan Hydrochloride waa dawo muhiim ah oo ka hortagga kansarka, oo inta badan loo isticmaalo daawaynta kansarka ugxansidaha iyo kansarka sambabada unugyada yaryar, waxayna leedahay qiime caafimaad oo muhiim ah.
COA
| Walxaha | Tilmaamaha | Natiijooyinka |
| Muuqashada | Cad-cad ama budo cad | Budada Cad |
| Aqoonsiga HPLC | waafaqsan tixraaca walaxda ugu sarreysa waqtiga haynta | waafaqsan |
| Wareegid gaar ah | + 20.0…-+22.0. | +21 |
| Biraha culus | ≤ 10pm | <10pm |
| PH | 7.5-8.5 | 8.0 |
| Luminta qalajinta | ≤ 1.0% | 0.25% |
| Hogaamin | ≤3pm | waafaqsan |
| Arsenic | ≤1pm | waafaqsan |
| Cadmium | ≤1pm | waafaqsan |
| Meerkuri | ≤0. 1pm | waafaqsan |
| barta dhalaalaysa | 250.0℃~265.0℃ | 254.7 ~ 255.8℃ |
| Hadhaaga dabka | ≤0. 1% | 0.03% |
| Hydrazine | ≤2pm | waafaqsan |
| Cufnaanta weyn | / | 0.21g/ml |
| cufnaanta la taabtay | / | 0.45g/ml |
| Qiimayn(Topotecan Hydrochloride) | 99.0% ~ 101.0% | 99.65% |
| Wadarta aerobes ayaa tirinaya | ≤1000CFU/g | <2CFU/g |
| Caaryada & Khamiirka | ≤100CFU/g | <2CFU/g |
| E.coli | xun | xun |
| Salmonella | xun | xun |
| Kaydinta | Ku kaydi meel qabow oo qallajisa, ka fogee iftiinka xooggan. | |
| Gabagabo | U qalma | |
Shaqada
Topotecan Hydrochloride waa dawada kiimikaad ee loo isticmaalo daawaynta noocyada kansarka qaarkood. Waa topoisomerase inhibitor oo leh hababka soo socda ee gaarka ah ee ficilka iyo hawlaha:
Shaqada:
1. Joojinta Topoisomerase: Topotecan waxay faragelisaa dib-u-celinta DNA-da iyo qoraalka iyada oo la joojinayo dhaqdhaqaaqa topoisomerase I. Ka-hortaggani wuxuu keenayaa jebinta silsiladaha DNA, taas oo ka hortagaysa faafitaanka unugyada kansarka.
2.Hawlgalka antitumorTopotecan waxaa inta badan loo isticmaalaa in lagu daweeyo kansarka ugxan-sidaha, kansarka sambabada unugyada yaryar iyo noocyada qaarkood ee lymphoma. Waxaa loo isticmaali karaa daawaynta safka koowaad ama daawaynta safka labaad ka dib marka daawaynta kale ay guul darreysato.
3.Cilmiga wareegga unugyada: Saamaynta Topotecan ee wareegga unugga waxay inta badan ku dhacdaa marxaladda S iyo marxaladda G2, taas oo ka dhigaysa inay saameyn xooggan ku yeelato unugyada kansarka ee marxalad gaar ah oo fidinta unugyada.
4.Daawaynta isku dhafka ah: Topotecan waxaa loo isticmaali karaa in lagu daro daawooyinka kale ee kiimoterabiga si kor loogu qaado saameynta ka hortagga burooyinka iyo hagaajinta jawaabta daaweynta bukaanka.
5.Calamadaha ka saarXaaladaha qaarkood, isticmaalka Topotecan waxay kaa caawin kartaa yaraynta calaamadaha kansarka iyo hagaajinta tayada nolosha bukaanka.
Xusuusin:
Topotecan waxaa laga yaabaa inay keento waxyeelooyin qaar, oo ay ku jiraan laakiin aan ku xaddidnayn lallabbo, matag, daal, leukopenia, iwm. Marka la isticmaalayo daawadan, bukaanku waxay u baahan yihiin in la kormeero oo la maareeyo iyada oo la raacayo hagida dhakhtarka.
Gebogebadii, Topotecan Hydrochloride waa dawada ka hortagga kansarka oo wax ku ool ah taas oo keenta saameynteeda antitumor ugu horrayn iyada oo la joojinayo DNA topoisomerase I.
Codsiga
Topotecan Hydrochloride waa dawada kiimikaad ee loo isticmaalo daawaynta noocyada kansarka qaarkood. Kuwa soo socda waa codsiyadooda ugu waaweyn:
1. kansarka ugxansidahaTopotecan waxaa caadi ahaan loo isticmaalaa in lagu daweeyo kansarka ugxan-sidaha ee soo noqnoqda, gaar ahaan bukaannada ka dib marka daawaynta kale (sida kiimoterabiga platinum-ku-salaysan) ay guul-darraystaan. Waxaa loo isticmaali karaa hal wakiil ama lagu daro daroogooyinka kale.
2. kansarka sanbabada unug yarDaawadan waxaa sidoo kale loo isticmaalaa daawaynta kansarka sambabada unugyada yaryar, sida caadiga ah sida ikhtiyaarka daawaynta ee safka labaad, gaar ahaan marka cudurku soo noqdo ka dib daaweynta kemotherabi ee bilowga ah.
3.Kansarada kaleIn kasta oo Topotecan loo isticmaalo kansarka ugxan-sidaha iyo kansarka sambabada unugyada yaryar, waxa kale oo lagu daraaseeyaa tijaabooyinka bukaan-socodka qaarkood ee noocyada kale ee kansarka, sida kansarka ilmo-galeenka, kansarka ganaca, iyo noocyada qaarkood ee lymphoma.
4.Clinical tests: Topotecan ayaa sidoo kale lagu qiimeeyaa tijaabooyinka bukaan-socodka ee kansarrada kala duwan si loo barto waxtarkeeda iyo badbaadada fursadaha daaweynta kala duwan.
5.Daawaynta Isku-dhafka ahXaaladaha qaarkood, Topotecan waxaa laga yaabaa in lagu daro daawooyinka kale ee kiimoterabiga ama dawooyinka daawaynta ee bartilmaameedka ah si kor loogu qaado saamaynta daweynta.
Xusuusin:
Marka la isticmaalayo Topotecan, bukaanku waa inay hoos yimaadaan hagidda dhakhtarka, gaar ahaan bukaanka qaba cillad beerka iyo kelyaha ama dhibaatooyinka kale ee caafimaadka. Tijaabooyin dhiig oo joogto ah ayaa loo baahan yahay inta lagu jiro daawaynta si loola socdo waxyeelada suurtagalka ah.
Gebogebadii, Topotecan Hydrochloride waxay leedahay qiime codsi oo muhiim ah daaweynta kansarka, gaar ahaan maaraynta kansarka ugxan-sidaha ee soo noqnoqda iyo kansarka sambabada unugyada yaryar.
Xidhmada & Bixinta
