Terbinafine Hydrochloride High Purity API Material CAS 78628-80-5
Product Description
Terbinafine Hydrochloridemushonga unorwisa fungal unoshandiswa kurapa zvirwere zvakasiyana siyana. Iyo inowanzo muchimiro chemapiritsi kana makirimu. terbinafine hydrochloride mushonga unoshanda weantifungal unoshandiswa kurapa hosha dzakasiyana siyana. Ingave iri kugadzirisa hutachiona hwetsoka kana fungal chipikiri, mushonga uyu unoshanda nekutadzisa kugadzirwa kweergosterol uye unopa ese epamusoro uye emuromo sarudzo dzekushandisa kuti zvive nyore uye zvinobudirira.
COA
| ZVINHU | STANDARD | TEST RESULT |
| Assay | 99% | Conforms |
| Color | Upfu chena | Conforms |
| Kunhuwa | Hapana kunhuhwirira kwakakosha | Conforms |
| Chikamu saizi | 100% inopfuura 80mesh | Conforms |
| Kurasikirwa pakuomeswa | ≤5.0% | 2.35% |
| Residue | ≤1.0% | Conforms |
| Heavy metal | ≤10.0ppm | 7ppm |
| As | ≤2.0ppm | Conforms |
| Pb | ≤2.0ppm | Conforms |
| Mushonga wezvipembenene wasara | Negative | Negative |
| Yese plate count | ≤100cfu/g | Conforms |
| Yeast & Mold | ≤100cfu/g | Conforms |
| E.Coli | Negative | Negative |
| Salmonella | Negative | Negative |
| Mhedziso | Ita zvinoenderana neSpecification | |
| Storage | Yakachengetwa munzvimbo Inotonhorera & Yakaoma, Ramba Kure Nechiedza Chakasimba uye Kupisa | |
| Sherufu hupenyu | 2 years pakachengetwa zvakanaka | |
Function
1.Terbinafine hydrochloride inogadzirwa allyla antifungal. Iyo ine lipophilic yakanyanya muchimiro uye inowanzo kuunganidza muganda, zvipikiri, uye mafuta tishu.
2.Terbinafine · HCl nhengo ye allyl class ye antifungals, yakawanikwa iine inhibitor chaiyo ye ergosterol synthesis kuburikidza ne squalene epoxidase inhibition. Squalene epoxidase ienzyme inoburitswa nedermatophyte fungi kuti iparadze Squalene, iyo inovhiringa sero membrane basa uye kuumbwa kwemadziro.
3.Terbinafine hydrochloride ine fungicidal effect paganda fungi uye inhibitory effect paCandida albicans. Inokodzera ganda uye zvipikiri zvirwere zvinokonzerwa nepamusoro-soro fungi, senge ringworm, ringworm yemuviri, ringworm yefemur, ringworm yetsoka, ringworm yepikiri uye Candida albicans utachiona hweganda hunokonzerwa neTrichophyton rubrum, Microsporum canis. uye Flocculus epidermidis.
Application
Terbinafine hydrochloride ichena yakanaka yecrystalline poda inonyungudika zvakasununguka mumethan uye dichlorome, inonyungudika mu ethanol, uye inonyungudika zvishoma mumvura. Kufanana nedzimwe allylamines, terbinafine inhibits ergosterol synthesis nekudzivisa squalene epoxidase,
enzyme iyo chikamu cheiyo fungal cell membrane synthesis nzira. Nekuti terbinafine inodzivirira kushandurwa kwesqualene kuita lanosterol, ergosterol haigone kugadzirwa. Izvi zvinofungidzirwa kushandura cell membrane permeability, zvichikonzera fungal cell lysis.
1. Terbinafine Hcl inonyanya kushanda paboka redermatophyte refungi.
2. Sekirimu ye1% kana hupfu, inoshandiswa pamusoro pezvirwere zveganda zvepamusoro sejock itch (tinea cruris),
rutsoka rwemutambi (tinea pedis), uye mamwe marudzi emakonye (tinea corporis). Terbinafine cream inoshanda mukati mehafu yenguva inodiwa
nemamwe antifungal.
3. Oral 250mg mapiritsi anowanzo kunyorerwa kurapwa kwe onychomycosis, fungal chipikiri chirwere, kazhinji nedermatophyte.
kana Candida marudzi. Fungal zvipikiri zvirwere zviri pakadzika pasi pembambo mu cuticle kune iyo topically inoshandiswa kurapwa
haikwanise kupinda muhuwandu hwakakwana. Mahwendefa anogona, kashoma, kukonzera hepatotoxicity, saka varwere vanonyeverwa nezveizvi uye
inogona kuongororwa nekuongororwa kwekushanda kwechiropa. Dzimwe nzira dzekutonga nemuromo dzakadzidzwa.
4. Terbinafine inogona kukurudzira kana kuwedzera subacute cutaneous lupus erythematosus. Vanhu vane lupus erythematosus vanofanira
tanga wakurukura nachiremba wavo njodzi dzinogona kuitika vasati vatanga kurapwa.
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