• ChiiTUDCA(Taurodeoxycholic Acid) ?
Chimiro:TUDCA ndiyo chidimbu chetaurodeoxycholic acid.
Kwakabva:TUDCA musanganiswa wechisikigo wakatorwa munyongo yemombe.
Mechanism of Action:TUDCA i bile acid inowedzera kuyerera kwe bile acid muura, nokudaro ichibatsira bile acid kuti inyudzwe zvirinani muura. Uye zvakare, TUDCA inogona zvakare kuderedza kudzoreredzwa kwebile acid muura, nekudaro ichiwedzera kutenderera kwayo mumuviri.
Application: TUDCAinonyanya kushandiswa kurapa primary biliary cholangitis (PBC) uye isiri-doro fatty chiropa chirwere + (NAFLD).
Chii chinonzi UDCA (Ursodeoxycholic Acid) ?
Chimiro:UDCA ndiyo chidimbu che ursodeoxycholic acid.
Kwakabva:UDCA musanganiswa wechisikigo wakatorwa mubere bile.
Mechanism yekuita:UDCA yakafanana muchimiro kune yega bile acid yemuviri, saka inogona kutsiva kana kuwedzera bile acid inoshaikwa nemuviri. UDCA ine maitiro akawanda muura, kusanganisira kuchengetedza chiropa, anti-inflammatory, uye anti-oxidation.
Application:UDCA inonyanya kushandiswa kurapa primary biliary cholangitis (PBC), cholesterol matombo +, cirrhosis, isiri-doro fatty chiropa chirwere (NAFLD) nezvimwe zvirwere.
• Ndeupi musiyano uripoTUDCAuye UDCA inoshanda here?
Kunyange zvazvo zvose TUDCA neUDCA zvine zvidziviriro zvechiropa, maitiro avo anogona kunge akasiyana. TUDCA inoshanda zvakanyanya nekuwedzera kuyerera kwe bile acids muura, nepo UDCA yakafanana neyemuviri bile acid chimiro uye inogona kutsiva kana kuwedzera iyo bile acid inoshaikwa nemuviri.
Ose ari maviri anogona kushandiswa kurapa akasiyana ezvirwere zvechiropa, asi anogona kuratidza akasiyana mhedzisiro kana zvakanakira mukurapa kwezvimwe zvirwere. Semuenzaniso, TUDCA inogona kunyatsoshanda mukurapa kweprimary biliary cholangitis (PBC).
Muchidimbu, zvese TUDCA neUDCA mishonga inoshanda, asi pane misiyano mumatsime avo, nzira dzekuita, uye huwandu hwekushandisa. Kana uri kufunga kushandisa mishonga iyi, zvinokurudzirwa kuonana nachiremba kuti uwane mamwe mazano chaiwo uye mazano.
NyangweTUDCAuye UDCA ese ari bile acids, mamorekuru awo akasiyana zvishoma. Kunyanya, TUDCA inoumbwa nebile acid molecule uye taurine molecule inosungwa neamide bond, nepo UDCA ingori nyore bile acid molecule.
Nekuda kwemusiyano wekuumbwa kwemamorekuru, TUDCA neUDCA zvakare zvine maitiro akasiyana mumuviri wemunhu. TUDCA inoshanda zvakanyanya kupfuura UDCA mukugadzirisa kutakura kwetsvo, kuchengetedza chiropa, nekusimbisa itsvo. Uye zvakare, TUDCA zvakare ine antioxidant mhedzisiro uye ine akawanda emishonga mhedzisiro sedation, antianxiety, uye antibacterial mhedzisiro.
TUDCA(taurodeoxycholic acid) uye UDCA (ursoxycholic acid) ese ari maviri marudzi e bile acid, uye ese ari maviri zvinhu zvakasikwa zvakabviswa muchiropa.
UDCA ndicho chikamu chikuru chebere bile. Inonyanya kuvandudza kushanda kwechiropa nekuwedzera kuvharidzirwa uye kubuda kwe bile acid, nokudaro kuderedza kuwanda kwe bile acid. Basa rayo guru nderokurapa cholestatic zvirwere zvakadai se cirrhosis, cholelithiasis, etc. Mukuwedzera, inobatsirawo kuderedza cholesterol mazinga.
TUDCAmusanganiswa we taurine uye bile acid. Inogonawo kuvandudza kushanda kwechiropa, asi maitiro ayo ekuita akasiyana neaUDCA. Inogona kukwidziridza simba re antioxidant uye kudzivirira chiropa kubva pakukuvadzwa kwemahara radical. Mukuwedzera, inobatsira kuvandudza insulin senitivity, kuderedza mazinga ehuga, uye ine anti-tumor madhara.
Kazhinji, UDCA neTUDCA zvose zvakanaka zvinodzivirira chiropa, asi maitiro avo chaiwo akasiyana uye akakodzera zvirwere zvakasiyana uye vanhu. Kana iwe uchida kushandisa mishonga miviri iyi, zvakanakisisa kuishandisa pasi pekutungamirirwa kwachiremba kuti udzivise maitiro asina kunaka.
Nguva yekutumira: Zvita-09-2024
