Tsvagiridzo inoratidza kuti vanhu vakuru vanosvika 537 miriyoni pasi rese vane Type 2 chirwere cheshuga, uye nhamba iyi iri kuwedzera. Huwandu hweshuga muropa hunokonzerwa nechirwere cheshuga hunogona kutungamirira kumamiriro ezvinhu ane ngozi akawanda, anosanganisira chirwere chemwoyo, kurasikirwa nekuona, kutadza kushanda zvakanaka kweitsvo, uye mamwe matambudziko makuru ehutano. Zvose izvi zvinogona kukurumidzisa kukwegura.
Tetrahydrocurcumin, yakabva kune turmeric midzi, yakaratidzwa mune zvidzidzo zvekliniki kubatsira kuderedza njodzi dzakawanda dzechirwere cheshuga 2 uye kuderedza shuga yeropa kune vanhu vane chirwere cheshuga kana prediabetes. Kurapa chirwere cheshuga chechipiri kunogona kunetsa kune vese varwere uye vanachiremba. Kunyange vanachiremba vachiwanzokurudzira kudya, kurovedza muviri, uye mishonga yekurapa vanhu vane chirwere cheshuga chechipiri, tsvakurudzo inoratidza izvozvotetrahydrocurcumininogona kupa rumwe rubatsiro.
• Insulin Resistance Uye Chirwere cheshuga
Patinodya, shuga yedu yemuropa inokwira. Izvi zvinoratidza kuti pancreas kuburitsa hormone inonzi insulin, iyo inobatsira masero kushandisa glucose kugadzira simba. Somugumisiro, shuga yeropa inodonha zvakare. Type 2 chirwere cheshuga chinokonzerwa ne insulin kusanzwa nekuti maseru haadavire sezvaajaira kuhormone. Mwero yeshuga yeropa inoramba ichikwira, chirwere chinonzi hyperglycemia. Kukwira kweshuga yeropa kunogona kutungamirira kumatambudziko ehurongwa, kusanganisira mwoyo, tsinga yeropa, itsvo, ziso, uye kusagadzikana kwehutano hwehutano, uye kuwedzera njodzi yekenza.
Kuzvimba kunogona kuita kuti insulin isarambe uye kuwedzera hyperglycemia muvanhu vane chirwere cheshuga. [8,9] Mazinga ehuga epamusoro anokonzera kuwedzera kwekuputika, iyo inokurumidza kukwegura uye inowedzera njodzi yezvirwere zvisingaperi, zvakadai sechirwere chemwoyo uye kenza. Yakawandisa glucose inokonzeresa oxidative kusagadzikana, iyo inogona kukuvadza zvakanyanya maseru uye tishu. Pakati pemamwe matambudziko, oxidative kusagadzikana kunogona kutungamirira kune:yakaderera kutakura kweglucose uye insulin secretion, protein uye DNA kukuvadzwa, uye yakawedzera vascular permeability.
• Ndezvipi ZvakanakiraTetrahydrocurcuminIn Diabetes ?
Sechinhu chinoshanda mu turmeric,Tetrahydrocurcumininogona kubatsira kudzivirira kukura kwechirwere cheshuga uye kukuvadzwa kwainogona kukonzera nenzira dzakati wandei, kusanganisira:
1. Kushanda kwePPAR-γ, iyo inogadzirisa metabolic inowedzera insulin senzwi uye inoderedza insulin kushorwa.
2. Anti-inflammatory effects, kusanganisira inhibition yezviratidzo zvemamorekuru anowedzera kuzvimba.
3. Kuvandudzwa kwebasa uye hutano hwe insulin-secreting cell.
4. Yakaderedzwa kugadzirwa kwepamusoro glycation end products uye kudzivirira kukuvadzwa kwazvinokonzeresa.
5. Antioxidant basa, iyo inoderedza oxidative kusagadzikana.
6. Kuvandudza lipid profiles uye kuderedza zvimwe zviratidzo zvekusashanda kwemetabolism uye chirwere chemwoyo.
Mune mhando dzemhuka,tetrahydrocurcumininoratidza chivimbiso mukubatsira kudzivirira kukura kwechirwere cheshuga uye kuderedza insulini kuramba.
• Ndezvipi ZvakanakiraTetrahydrocurcuminMune Cardiovascular?
Chidzidzo che2012 chakabudiswa muInternational Journal of Pharmacology chakaongorora mhedzisiro yetetrahydrocurcuminpambeva aortic zvindori kuona kana komboni yacho ine cardioprotective properties. Kutanga, vatsvakurudzi vakatambanudza zvindori zveaortic ne carbachol, komisheni inozivikanwa nekukonzera vasodilation. Zvadaro, mbeva dzakabayiwa nehomocysteine thiolactone (HTL) kurambidza vasodilation. [16] Pakupedzisira, vatsvakurudzi vakabaya mbeva pamwe ne10 μM kana 30 μM yetetrahydrocurcuminuye akawana kuti yakakonzera vasodilation pamatanho akafanana necarbachol.
Maererano neongororo iyi, HTL inogadzira vasoconstriction nekuderedza huwandu hwenitric oxide mumidziyo yeropa uye kuwedzera kugadzirwa kwemahara radicals. Naizvozvo,tetrahydrocurcumininofanira kukanganisa kugadzirwa kwe nitric oxide uye / kana mahara radicals kuitira kudzorera vasodilation. Kubvatetrahydrocurcuminine yakasimba antioxidant zvimiro, inogona kukwanisa kuchenesa mahara radicals.
• Ndezvipi ZvakanakiraTetrahydrocurcuminMune Hypertension?
Kunyange zvazvo high blood pressure inogona kuva nezvikonzero zvakasiyana-siyana, inowanzova mugumisiro wekunyanya kuvharwa kwemidziyo yeropa, izvo zvinotungamirira mukuderedza mitsipa yeropa.
Muchidzidzo che2011, vaongorori vakapatetrahydrocurcuminkune mbeva kuti vaone kuti yakanganisa sei BP. Kuita kuti vascular dysfunction, vatsvakurudzi vakashandisa L-arginine methyl ester (L-NAME). Mbeva dzakakamurwa kuita mapoka matatu. Boka rekutanga rakagamuchira L-NAME, boka rechipiri rakagamuchira tetrahydrocurcumin (50mg/kg uremu hwemuviri) uye L-NAME, uye boka rechitatu rakagamuchira.tetrahydrocurcumin(100mg/kg uremu hwemuviri) uye L-NAME.
Mushure memavhiki matatu ekudhakwa kwezuva nezuva, thetetrahydrocurcuminboka rakaratidza kuderera kukuru kweropa richienzaniswa neboka raingotora L-NAME. Boka rakapiwa muyero wepamusoro rakava nemigumisiro iri nani pane boka rakapiwa mushonga wakaderera. Vatsvakurudzi vakati zvibereko zvakanaka zvakakonzerwatetrahydrocurcuminkugona kukonzera vasodilation.
Nguva yekutumira: Oct-10-2024
