Epimedium(Horny Goat Weed) Extract- Icariin Inova Tariro Itsva muKurwisa Urothelial Cancer

Urothelial carcinoma ndeimwe yeanowanzo zivikanwa negomarara reweti, nebundu rekudzoka uye metastasis zviri zvinhu zvikuru zvekufungidzira. Muna 2023, inofungidzirwa kuti 168,560 zviitiko zvegomarara reurinary zvichaonekwa muUnited States, nekufa kwe32,590; 50% yezviitiko izvi ndeye urothelial carcinoma. Kunyangwe kuvepo kwemaitiro matsva ekurapa, akadai seplatinum-based chemotherapy uye PD1 antibody-based immunotherapy, inopfuura hafu yevarwere veurothelial carcinoma havasati vapindura kurapwa uku. Nokudaro, pane chido chekukurumidzira chekuongorora mishonga mitsva yekurapa kuvandudza kufungidzira kwevarwere veurothelial carcinoma.

Icariin(ICA), iyo inonyanya kushanda muEpimedium, ndeye tonic, aphrodisiac, uye anti-rheumatic yechinyakare mushonga weChinese. Kana yangopinzwa, ICA inogadziriswa ku icartin (ICT), iyo inobva yaita mhedzisiro yayo. ICA ine akawanda biological zviitiko, kusanganisira kudzora adaptive immune, kuve ne antioxidant zvivakwa, uye inhibiting bundu kufambira mberi. Muna 2022, Icaritin capsules ine ICT sechinhu chikuru chakagamuchirwa neChina National Medical Products Administration (NMPA) yekurapa kwekutanga kwepamusoro isingashande hepatocellular carcinoma. Mukuwedzera, yakaratidza kushanda kwakakosha mukuwedzera hupenyu hwese hwevarwere vane advanced hepatocellular carcinoma. ICT haingourayi zvakananga mabundu nekuita apoptosis uye autophagy, asi zvakare inogadzirisa bundu immune microenvironment uye inosimudzira anti-tumor immune immune. Nekudaro, iyo chaiyo nzira iyo ICT inodzora TME, kunyanya muurothelial carcinoma, haina kunyatsonzwisiswa.

Munguva pfupi yapfuura, vatsvakurudzi veDhipatimendi reUrology, Huashan Hospital, Fudan University yakabudisa nyaya ine musoro unoti "Icaritin inhibits kufambira mberi kwegomarara reurothelial nekudzvinyirira PADI2-mediated neutrophil infiltration uye neutrophil extracellular trap formation" mumagazini Acta Pharm Sin B. Chidzidzo chacho chakaratidza Sin B. kutiicariinzvakanyanya kuderedza kupararira kwebundu uye kufambira mberi uku ichidzivisa neutrophil kupinda uye NET synthesis, zvichiratidza kuti ICT inogona kunge iri itsva NETs inhibitor uye mushonga mutsva weurothelial carcinoma.

Tumor kudzokorora uye metastasis ndizvo zvikonzero zvikuru zvekufa muurothelial carcinoma. Mune bundu microenvironment, negative regulatory molecules uye akawanda immune cell subtypes anodzvanyirira antitumor immune. Iyo inoputika microenvironment, inobatanidza neutrophils uye neutrophil extracellular traps (NETs), inosimudzira tumor metastasis. Nekudaro, parizvino hapana mishonga inorambidza neutrophils neNETs.

Muchidzidzo ichi, vatsvakurudzi vakaratidza kekutanga kutiicariin, mutsara wekutanga wekurapa kwepamusoro uye isingarapike hepatocellular carcinoma, inogona kuderedza NETs inokonzerwa nekuzviuraya neNETosis uye kudzivirira neutrophil infiltration mu tumor microenvironment. Mechanistically, ICT inosungira uye inodzivisa kutaura kwePADI2 mune neutrophils, nokudaro inhibiting PADI2-mediated histone citrullination. Mukuwedzera, ICT inodzivisa ROS chizvarwa, inhibits MAPK kusaina nzira, uye inodzvinyirira NET-induced tumor metastasis.

Panguva imwecheteyo, ICT inhibits tumor PADI2-mediated histone citrullination, nokudaro ichidzivisa kunyorwa kweneutrophil recruitment genes yakadai seGM-CSF uye IL-6. Nekudaro, kudzikisira kweIL-6 kutaura kunoumba yekudzora mhinduro loop kuburikidza neJAK2/STAT3/IL-6 axis. Kuburikidza neongororo yekudzokorodza yemasamples ekiriniki, vaongorori vakawana kuwirirana pakati peneutrophils, NETs, ​​UCa prognosis uye kutiza immune. ICT yakasanganiswa neimmune checkpoint inhibitors inogona kunge iine synergistic mhedzisiro.

Muchidimbu, chidzidzo ichi chakawana kutiicariinzvakanyanya kuderedza kupararira kwebundu uye kufambira mberi uku ichidzivisa neutrophil kupinda uye NET synthesis, uye neutrophils neNETs dzakatamba basa rekudzivirira mubundu immune microenvironment yevarwere vane urothelial carcinoma. Pamusoro pezvo, ICT yakasanganiswa ne-anti-PD1 immunotherapy ine synergistic mhedzisiro, zvichiratidza nzira yekurapa inogona kuitika kune varwere vane urothelial carcinoma.