Sezvo isu tichikura, basa remitezo yemunhu zvishoma nezvishoma rinodzikira, izvo zvine hukama nekuwedzera kwezviitiko zvezvirwere zveurourodegenerative. Mitochondrial dysfunction inoonekwa sechimwe chezvinhu zvakakosha mukuita uku. Munguva pfupi yadarika, timu yekutsvagisa yaAjay Kumar kubva kuIndia Institute of Integrated Traditional Chinese uye Western Medicine yakaburitsa yakakosha tsvagiridzo muACS Pharmacology & Translational Sayenzi, ichiburitsa mashandisirwo ayo.crocetinkunonotsa huropi nekuchembera kwemuviri nekuvandudza maserura esimba.
Mitochondria ndiwo "mafekitori emagetsi" mumasero, ane mutoro wekugadzira rakawanda resimba rinodiwa nemasero. Nezera, kuderera kwekushanda kwemapapu, kupererwa neropa, uye microcirculatory kusagadzikana zvinotungamira mukushaikwa kweokisijeni kumatishu, zvichikonzera chisingaperi hypoxia uye kuwedzera mitochondrial dysfunction, nekudaro zvichikurudzira kufambira mberi kwezvirwere zveurourodegenerative. Crocetin isanganiswa yechisikigo ine mukana wekuvandudza mitochondrial basa. Ichi chidzidzo chine chinangwa chekuongorora mhedzisiro ye crocetin pane mitochondrial basa mumakonzo akura uye ayo anopesana nekuchembera mhedzisiro.
● ChiiCrocetin?
Crocetin is natural apocarotenoid dicarboxylic acid inowanikwa muruva recrocus pamwe chete ne glycoside, crocetin, uye Gardenia jasminoides michero. Iyo inozivikanwa zvakare se crocetic acid. [3] [4] Inoumba zvidhinha zvitsvuku makristasi ane nzvimbo yekunyunguduka ye285 °C.
Iyo kemikari chimiro checrocetin inoumba iyo yepakati musimboti we crocetin, komisheni inokonzeresa ruvara rwesafoni. Crocetin inowanzo kutorwa mukutengesa kubva gardenia muchero, nekuda kwekudhura kwesafoni.
● Anoita SeiCrocetinKuwedzera Simba reSerura ?
Vatsvakurudzi vakashandisa mazera eC57BL/6J mbeva. Mbeva dzakwegura dzakakamurwa kuva mapoka maviri, rimwe boka rakagamuchira crocetin kurapwa kwemwedzi mina, uye rimwe boka rakashanda seboka rinodzora. Iko kugona kwekuziva uye mota yemakonzo kwakaongororwa nemaitiro ekuedza senge spatial ndangariro bvunzo uye yakavhurika bvunzo bvunzo, uye maitiro echiito checrocetin akaongororwa nezvidzidzo zvepharmacokinetic uye yakazara transcriptome sequencing. Multivariate regression analysis yakashandiswa kugadzirisa kuvhiringidza zvinhu zvakadai sezera uye zvepabonde kuongorora migumisiro ye crocetin pakuziva uye motokari mabasa emakonzo.
Zvigumisiro zvakaratidza kuti mushure memwedzi mina yecrocetinkurapwa, maitiro ekurangarira uye kugona kwemota yemakonzo zvakavandudzwa zvakanyanya. Boka rekurapa rakaita zviri nani muyedzo yespatial memory test, rakatora nguva shoma yekutsvaga chikafu, rakagara muruwoko rwechirauro kwenguva refu, uye rakaderedza nhamba yenguva dzavakapinda ruoko rusina chirauro nekukanganisa. Muyedzo yevhu rakavhurika, mbeva muboka rakabatwa necrocetin dzaive dzakanyanya kushanda, uye dzakafamba kure nekumhanya.
Nekuteedzera iyo yese transcriptome yembeva hippocampus, vaongorori vakawana izvozvocrocetinkurapwa kwakakonzera kuchinja kukuru mukutaura kwemajini, kusanganisira kukwidziridzwa kwekutaura kwemajini ane hukama akadai seBDNF (brain-derived neurotrophic factor).
Pharmacokinetic zvidzidzo zvakaratidza kuti crocetin ine yakaderera yakadzika muuropi uye hapana kuunganidza, zvichiratidza kuti yakachengeteka. crocetin yakabudirira kuvandudza mitochondrial basa uye yakawedzera masero esimba mazinga mumakonzo akwegura nekuwedzera kupararira kweokisijeni. Kuvandudzwa kwemitochondrial basa kunobatsira kunonoka kuchembera kwehuropi nemuviri uye kuwedzera hupenyu hwembeva.
Chidzidzo ichi chinoratidza izvozvocrocetininogona kunonoka zvakanyanya kuchembera kwehuropi uye kwemuviri uye kuwedzera hupenyu mumakonzo akura nekuvandudza mitochondrial basa uye kuwedzera masero emasimba masimba. Mazano chaiwo ndeaya anotevera:
Supplement crocetin mumwero: Kune vakweguru, kuwedzera crocetin zvine mwero kunogona kubatsira kuvandudza kugona kwekuziva uye mota uye kunonoka kuchembera.
Hutano hwakakwana hwehutano: Pamusoro pekuwedzera crocetin, iwe unofanirwawo kuchengetedza kudya kune hutano, kugara uchisimbisa muviri uye kunaka kwekurara kusimudzira hutano hwese.
Chenjerera kuchengetedzeka: Kunyangwecrocetininoratidza kuchengetedzeka kwakanaka, iwe uchiri kufanira kutarisisa kuyerwa kana uchiwedzera uye uzviite uchitungamirwa nachiremba kana nyanzvi yezvekudya.
● NEWGREEN Supply Crocetin /Crocin /Saffron Extract
Nguva yekutumira: Oct-23-2024
