Yakanyanya Kuchena Metformin CAS 657-24-9 Metformin Mugadziri
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Metformin: Mushonga une simba wekurapa chirwere cheshuga
1. Chii chinonzi metformin?
Biguanides inowanikwa muuswa hwembudzi (Galega Officinalis), chirimwa chave chichishandiswa mumishonga yechivanhu kwemazana emakore. Iyo pharmacological action yechirimwa pachayo inoenderana negoatine (Isoamylene guanidine). Phenformin, Buformin, uye metformin ese akagadzirwa nemakemikari uye ane maviri guanidine mamorekuru. Metformin mushonga wemukanwa unoshandiswa zvakanyanya kurapa Type 2 chirwere cheshuga. Ndecheboka remishonga inonzi biguanides uye inonzi ndiyo yekutanga kurapwa kwechirwere cheshuga.
2.Metformin inoshanda sei?
Basa guru reMetformin nderekudzikisa huwandu hweshuga inogadzirwa nechiropa uye kuita kuti masero emuviri anzwe kugadzikana kune insulin. Iyo inonyatso kudzikisa mazinga ehuga uye inobatsira kugadzirisa mhinduro yemuviri kune insulin.
Metformin inogadzirisa shuga yeropa zvakanyanya nekudzivisa kubuda kweshuga yechiropa. Metformin inonyanya kuvimba ne organic cationic transporter 1 (OCT 1) kuti ipinde muhepatocytes, uyezve inodzivisa zvishoma mitochondrial breathing chain complex 1, zvichiita kuti intracellular ATP ideredze uye kuwedzera mazinga eAMP. Isu tose tinoziva kuti kuderera kweATP uye kuwedzera kwe AMP muchitokisi kunodzivisa zvakananga gluconeogenesis uye kuderedza kutendeuka kweglycerol kuva glucose.
Iyo yakawedzera AMP/ATP reshiyo inokonzerwa nemetformin zvakare inoita iyo AMPK siginecha nzira, iyo inhibits synthesis yemafuta uye inowedzera kunzwa kwemuviri kune insulin.
3. Ndezvipi zvinobatsira zve metformin?
Metformin inopa akawanda mabhenefiti kune vanhu vane chirwere cheshuga:
1) Kudzora shuga yeropa: Nekudzikisa kugadzirwa kweshuga muchiropa uye nekuvandudza insulin senitivity, metformin inobatsira kudzora mazinga ehuga uye kudzivirira kuti isakwira zvakanyanya kana kuderera.
2) Kutarisira uremu: Metformin inowanzoita kuti uremu huremu huve pakati nepakati muvanhu vane chirwere cheshuga. Inoita izvi nekuderedza kudya, kuwedzera manzwiro ekuzara, uye kubatsira kupinza muglucose uye zvitoro zvemafuta zvesimba.
3) Kudzivirirwa kweMwoyo: Zvidzidzo zvinoratidza kuti metformin inogona kuderedza njodzi yechirwere chemoyo, sechirwere chemoyo uye sitiroko, muvanhu vane chirwere cheshuga.
4) Polycystic ovary syndrome (PCOS): Pamusoro pekurapa chirwere cheshuga, metformin inoshandiswa kurapa PCOS, chirwere chehomoni chinokanganisa vakadzi. Inobatsira kudzora kutenderera kwekuenda kumwedzi, inoderedza insulin kuramba, uye inobatsira mukubereka.
4.Metformin inogona kushandiswa kupi?
Metformin inonyanya kushandiswa kurapa chirwere cheshuga chechipiri. Inogona kushandiswa yoga kana kusanganiswa nemimwe mishonga yemuromo antidiabetic kana pamwe chete ne insulin therapy, zvichienderana nezvinodiwa nemunhu. Metformin inoratidzwa kuti ishandiswe muvanhu vachangobva kuongororwa uye kune vanhu vane nguva refu yekudzora chirwere cheshuga. Muchidimbu, metformin mushonga une simba unoshandiswa zvakanyanya kurapa chirwere cheshuga 2 uye PCOS. Iine mabhenefiti akadai sekudzora shuga yeropa, huremu manejimendi, kudzivirira kwemoyo, uye PCOS zororo rechiratidzo. Nekuda kwekushanda kwayo uye kushandiswa kwakapararira, metformin yave chishandiso chakakosha mukubatsira vanhu kurarama hupenyu hune hutano vachinyatso gadzirisa mamiriro avo.
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