Newgreen Factory Supply Topotecan Hydrochloride High Quality 99% Topotecan Hydrochloride Powder
Fa'amatalaga o oloa
Topotecan Hydrochloride ose vaila'au chemotherapy e fa'aaoga muamua e togafitia ai ituaiga o kanesa. O le hydrochloride fomu o le topotecan, o le topoisomerase inhibitor e galue muamua e ala i le taofia o le gaioiga o le DNA topoisomerase I.
Fa'amatalaga:
Pe a faʻaaogaina Topotecan, e tatau i tagata gasegase ona i lalo o le taʻitaʻiga a se fomaʻi, aemaise lava mo tagata mamaʻi e le atoatoa le ate ma fatugaʻo poʻo isi faʻafitauli tau soifua maloloina. E mana'omia su'ega toto faifaipea i taimi o togafitiga e mata'ituina ai a'afiaga e ono tutupu mai.
I le fa'ai'uga, o le Topotecan Hydrochloride ose vaila'au fa'ama'i fa'ama'i taua, e masani ona fa'aaogaina e togafitia ai le kanesa o le ovarian ma le kanesa mama sela laiti, ma e taua tele le fa'aogaina o le falema'i.
COA
| Aitema | Fa'amatalaga | I'uga |
| Fa'aaliga | Pa'epa'e pa'epa'e pe pa'epa'e pa'epa'e | Pa'u Pa'epa'e |
| Fa'ailoga HPLC | Ia ogatasi ma le faasinomaga taimi maualuga o le taofiga o mea | Fa'atatau |
| Ta'amilosaga fa'apitoa | +20.0.-+22.0. | +21. |
| Metala mamafa | ≤ 10ppm | <10ppm |
| PH | 7.5-8.5 | 8.0 |
| Ma'imau ile fa'amago | ≤ 1.0% | 0.25% |
| Ta'ita'i | ≤3ppm | Fa'atatau |
| Arsenic | ≤1ppm | Fa'atatau |
| Cadmium | ≤1ppm | Fa'atatau |
| Mercury | ≤0. 1ppm | Fa'atatau |
| Liu liusuavai | 250.0℃~265.0℃ | 254.7~255.8℃ |
| Toega ile mu | ≤0. 1% | 0.03% |
| Hydrazine | ≤2ppm | Fa'atatau |
| Fa'atosina tele | / | 0.21g/ml |
| Tapped density | / | 0.45g/ml |
| Su'ega(Topotecan Hydrochloride） | 99.0%~ 101.0% | 99.65% |
| E taulia le aerobes atoa | ≤1000CFU/g | <2CFU/g |
| Maliu & Faafefete | ≤100CFU/g | <2CFU/g |
| E.coli | Le lelei | Le lelei |
| Salmonella | Le lelei | Le lelei |
| Teuina | Teu i se nofoaga malulu & fa'agogo, fa'amama le malamalama malosi. | |
| Fa'ai'uga | Agavaa | |
Galuega
Topotecan Hydrochloride ose vaila'au chemotherapy e fa'aaoga muamua e togafitia ai ituaiga o kanesa. O le topoisomerase inhibitor fa'atasi ai ma faiga fa'apitoa o gaioiga ma galuega:
Galuega:
1.Topoisomerase inhibition: Topotecan e faʻalavelave i le DNA replication ma transcription e ala i le taofia o le gaioiga o le topoisomerase I. O lenei faʻalavelave e taʻitaʻia ai le motusia o filifili DNA, ma puipuia ai le faʻateleina o sela o le kanesa.
2. Gaoioiga Antitumor: Topotecan e masani ona faʻaaogaina e togafitia ai le kanesa ovarian, kanesa mama sela laiti ma nisi ituaiga o lymphoma. E mafai ona fa'aaogaina e fai ma togafitiga muamua po'o se togafitiga lona lua pe a uma ona le manuia isi togafitiga.
3.Cell taamilosaga specificity: O le aafiaga o Topotecan i le taamilosaga o le sela e masani ona tupu i le vaega S ma le vaega G2, lea e i ai se aafiaga malosi o le fasioti tagata i sela o le kanesa i se tulaga faapitoa o le tuputupu ae o sela.
4.Combination togafitiga: Topotecan e mafai ona faʻaaogaina faʻatasi ma isi vailaʻau chemotherapy e faʻaleleia ai le aʻafiaga o le tumor ma faʻaleleia le tali atu o le maʻi.
5. Fa'asalaina Fa'ailoga: I nisi tulaga, o le faʻaaogaina o le Topotecan e mafai ona fesoasoani e faʻamalolo faʻamaʻi e fesoʻotaʻi ma le kanesa ma faʻaleleia le lelei o le olaga o le tagata maʻi.
Fa'amatalaga:
Topotecan e mafai ona mafua ai nisi o aʻafiaga, e aofia ai ae le gata i le nausea, puaʻi, vaivai, leukopenia, ma isi. A faʻaaogaina lenei vailaʻau, e manaʻomia le mataʻituina ma le puleaina o tagata gasegase i lalo o le taʻitaʻiga a le fomaʻi.
I le faaiuga, Topotecan Hydrochloride o se vailaʻau faʻamaʻi faʻamaʻi e faʻaaogaina ona aʻafiaga faʻamaʻi e ala i le taofiofia o le DNA topoisomerase I.
Fa'atatauga
Topotecan Hydrochloride ose vaila'au chemotherapy e fa'aaoga muamua e togafitia ai nisi ituaiga o kanesa. O ona fa'aoga autu nei:
1. Ovarian kanesa: Topotecan e masani ona faʻaaogaina e togafitia ai le kanesa ovarian faifaipea, aemaise lava i gasegase pe a maeʻa isi togafitiga (pei o le platinum-based chemotherapy) ua le manuia. E mafai ona faʻaaogaina e fai ma sui e tasi pe faʻatasi ma isi vailaʻau.
2. kanesa mama sela laiti: O lenei vaila'au o lo'o fa'aaogaina fo'i i le togafitia o le kanesa o le mama sela laiti, e masani lava o se filifiliga lona lua o togafitiga, aemaise lava pe a toe fo'i le fa'ama'i pe a uma le chemotherapy muamua.
3. Isi Kanesa: E ui o le Topotecan e masani ona faʻaaogaina mo le kanesa o le ovarian ma le kanesa o le mama sela laiti, o loʻo suʻesuʻeina foi i nisi o suʻesuʻega faʻapitoa mo isi ituaiga o kanesa, e pei o le kanesa o le manava, kanesa pancreatic, ma nisi ituaiga o lymphoma.
4.Clinical tofotofoga: Topotecan o loʻo iloiloina foʻi i suʻesuʻega faʻapitoa mo kanesa eseese e suʻesuʻe ai lona aoga ma le saogalemu i togafitiga eseese.
5. Togafitiga Tuufaatasi: I nisi tulaga, Topotecan e mafai ona faʻaaogaina faʻatasi ma isi vailaʻau chemotherapy poʻo vailaʻau faʻapitoa e faʻaleleia ai le togafitiga.
Fa'amatalaga:
Pe a faʻaaogaina Topotecan, e tatau i tagata gasegase ona i lalo o le taʻitaʻiga a se fomaʻi, aemaise lava mo tagata mamaʻi e le atoatoa le ate ma fatugaʻo poʻo isi faʻafitauli tau soifua maloloina. E mana'omia su'ega toto faifaipea i taimi o togafitiga e mata'ituina ai a'afiaga e ono tutupu mai.
I le faaiuga, Topotecan Hydrochloride e taua tele le aoga i togafitiga o le kanesa, aemaise i le puleaina o le kanesa ovarian faifaipea ma le kanesa o le mama sela laiti.
afifi & Tiliva
