Epimedium (Icyatsi cy'ihene y'ihene) Ikuramo- Icariin ihinduka ibyiringiro bishya mu kurwanya kanseri ya Urothelia

Kanseri ya Urothelia ni imwe muri kanseri ikunda kwibasira inkari, hamwe no kubyimba ibibyimba ndetse na metastasis bikaba ibintu byingenzi byerekana ibimenyetso. Mu 2023, muri Leta zunze ubumwe za Amerika hazasuzumwa abantu 168.560 barwaye kanseri y'inkari, hapfa abagera ku 32.590; hafi 50% by'izi ndwara ni kanseri ya urothelia. Nubwo haboneka uburyo bushya bwo kuvura, nka chimiotherapie ishingiye kuri platine na immunoterapi ya PD1 antibody, abarenga kimwe cya kabiri cy’abarwayi ba kanseri ya urothelia baracyitabira ubwo buvuzi. Niyo mpamvu, hakenewe byihutirwa gukora ubushakashatsi ku miti mishya yo kuvura kugira ngo hamenyekane neza abarwayi ba kanseri ya urothelia.

Icariin. Iyo bimaze kwinjizwa, ICA ihindurwamo icartin (ICT), hanyuma igakora ingaruka zayo. ICA ifite ibikorwa byinshi byibinyabuzima, harimo kugenzura ubudahangarwa bw’imihindagurikire y’ikirere, kugira imiti igabanya ubukana, no kubuza ikibyimba gutera imbere. Mu 2022, capsules ya Icaritin hamwe na ICT nkibikoresho byingenzi byemejwe n’ikigo cy’igihugu gishinzwe ubuvuzi bw’ibihugu by’Ubushinwa (NMPA) kugira ngo bivurwe ku murongo wa mbere w’indwara ya kanseri yanduye idakira. Byongeye kandi, byagaragaje akamaro gakomeye mu kuramba muri rusange abarwayi bafite kanseri ya hepatocellular yateye imbere. ICT ntabwo yica gusa ibibyimba itera apoptose na autophagy, ahubwo inagenga ibibyimba bikingira umubiri kandi ikanatera imbaraga zo kurwanya ibibyimba. Nyamara, uburyo bwihariye ICT igenga TME, cyane cyane muri kanseri ya urothelia, ntabwo byumvikana neza.

Vuba aha, abashakashatsi bo mu ishami rya Urology, ibitaro bya Huashan, muri kaminuza ya Fudan basohoye inkuru yise "Icaritin ibuza iterambere rya kanseri y’inkari mu guhagarika indwara ya neutrophil yifashishijwe na PADI2 yatewe no kwanduza imitego ya neutrophil idasanzwe" mu kinyamakuru Acta Pharm Sin B. Ubushakashatsi bwerekanye ibyoicariinbyagabanije cyane ikibyimba gukwirakwira no gutera imbere mugihe kibuza kwinjiza neutrophil na synthesis ya NET, byerekana ko ICT ishobora kuba inzitizi nshya ya NETs nubuvuzi bushya bwa kanseri ya urothelia.

Ibibyimba byongera kubaho hamwe na metastasis nimpamvu nyamukuru zitera urupfu muri kanseri ya urothelia. Muri microen ibidukikije yibibyimba, molekile mbi igenga hamwe na subtypes nyinshi z'umubiri zirinda ubudahangarwa bwa antitumor. Microen ibidukikije yangiza, ifitanye isano na neutrophile hamwe na neutrophil imitego idasanzwe (NETs), itera metastasis yibibyimba. Nyamara, kuri ubu nta biyobyabwenge bibuza cyane neutrophile na NET.

Muri ubu bushakashatsi, abashakashatsi berekanye bwa mbere koicariin, umurongo wa mbere wokuvura kanseri yindwara ya hepatocellular yateye imbere kandi idakira, irashobora kugabanya NET iterwa no kwiyahura kwa NETose kandi ikarinda neutrophil kwinjira muri microen ibidukikije. Muburyo bwa tekinike, ICT ihuza kandi ikabuza imvugo ya PADI2 muri neutrophile, bityo ikabuza citrullination ya PADI2-yunganirwa. Byongeye kandi, ICT ibuza ibisekuruza bya ROS, ibuza inzira ya MAPK yerekana inzira, kandi ikumira NET iterwa na metastasis.

Muri icyo gihe, ICT ibuza ikibyimba PADI2-yifashishijwe na histrone citrullination, bityo ikabuza kwanduza genes za neutrophil nka GM-CSF na IL-6. Na none, kugabanya imvugo ya IL-6 ikora uburyo bwo gutanga ibitekerezo binyuze muri JAK2 / STAT3 / IL-6. Binyuze mu bushakashatsi bwihuse bwakozwe ku ngero z’amavuriro, abashakashatsi basanze isano iri hagati ya neutrophile, NET, UCa prognoz no guhunga ubudahangarwa. ICT ihujwe nubudahangarwa bw'umubiri irashobora kugira ingaruka zifatika.

Muri make, ubu bushakashatsi bwasanze ibyoicariinbyagabanije cyane ikibyimba gukwirakwira no gutera imbere mugihe kibuza kwinjiza neutrophil na synthesis ya NET, kandi neutrophile na NET byagize uruhare runini mu gukumira ibibyimba bikingira indwara y’ibibyimba by’abarwayi bafite kanseri ya urothelia. Byongeye kandi, ICT ifatanije na anti-PD1 immunotherapie igira ingaruka zifatika, byerekana ingamba zishobora kuvura abarwayi bafite kanseri ya urothelia