Epimium (Ihene ya Horny Weed) Ibikururwa- Icariin bihinduka ibyiringiro bishya mu kurwanya kanseri ya Uroteliya

Urothethema wa Uroteoma nimwe mu kanserizo rusange, hamwe na pumence renerrence na metastasis ari ibintu bikomeye cyane. Muri 2023, umubare w'abagera kuri 168.560 ba kanseri y'inkari zizasuzumwa muri Amerika, abantu bagera kuri 32.590; Hafi ya 50% yizi manza ni Urotema ya Uroteoma. Nubwo haboneka uburyo bushya bwo kuvura, nka chimiotherapie na plimotherapy na pd1 antibotherapy, abarenga kimwe cya kabiri cyabarwayi ba Uroteliya ntibucyasubiza ubwo buvuzi. Kubwibyo, hakenewe byihutirwa gukora iperereza ku bakozi bashya ba barara mu rwego rwo kunoza prognose y'abarwayi ba Karcinoma.

Icariin. Igihe kimaze gufatwa, IA ni Metabolized kuri Icearti (ICT), noneho noneho igira ingaruka. ICA ifite ibikorwa byinshi bifatika, harimo kugenzura ubudahangarwa bwo kurwanya imihindagurikireli, ufite imitungo ya Antioxident, kandi ikabuza gutera inshyi. Muri 2022, Ictaritin Capsules hamwe na ICT nk'ibintu nyamukuru byemejwe n'ubushinwa ubuyobozi bw'ubuvuzi bw'igihugu (NMPA) bwo kuvura umurongo wa mbere wa hepatooma. Byongeye kandi, yerekanaga akamaro kanini mugukura muri rusange kubaho kwabarwayi hamwe na hepatollilall ya hescinoma. ICT ntabwo yica ibibyimba bitaziguye gusa bitera Apoptose na Autophagy, ariko kandi agenga ibibyimba bidafite imibiri kandi biteza imbere igisubizo cyo kurwanya ibibyimba. Ariko, uburyo bwihariye bwa ICT bugenga TME, cyane cyane muri Carcinoma ya Urotedamu, ntabwo byumvikana neza.

Vuba aha, abashakashatsi bo mu ishami rya Urologiya, muri kaminuza ya Hudan, yashyize ahagaragara ikiganiro cyiswe "Icaritin Kubuza Iterambere rya Karomusiyo na NeutrophilicariinKugabanya cyane ibibyimba byakwirakwijwe no gutera imbere mugihe bibuza Neutrophil Vestisration na Synthesis, byerekana ko ICT ishobora kuba inshundura nshya kandi ivuza karudiyoli nshya.

Ikibyimba cya Repurrence na Metastasis niyo mpamvu nyamukuru itera urupfu muri Carcinoma ya Uroteliya. Muri ikibyimba cya mikororuma, molekile mbi hamwe na empleps yo hejuru yumudahangarwa ahagarikwa ubudahangarwa bwa arnetumity. Microseniment Microengoilment, ifitanye isano na neutrophile na neutrophil intera ngororamubiri ya neutroproli (inshundura), biteza imbere ikibyimba Metastasis. Ariko, kuri ubu nta biyobyabwenge bibuza neutrofils na nets.

Muri ubu bushakashatsi, abashakashatsi bagaragaje bwa mbere ibyoicariin, kuvura umurongo wa mbere wa carcinoma yateye imbere kandi udashobora kugabanya inshundura zatewe na susis yo kwiyahura no gukumira uruzitiro rwa neutrophil muri ticorvinonment. Metlacestique, ICT ihuza kandi ibuza imvugo ya Padi2 muri Netrofile, bityo ibuza padi. Byongeye kandi, inzabu icumu ku gisekuru, kibuza ikarita y'Ibimenyetso, kandi bikabihagarika intoki ya net yatewe na net yashishikarije.

Muri icyo gihe, ICT ibuza ikibyimba cya Padiri2 yashyize ahagaragara, bityo ikabuza inyandiko ya serivise ya Neutrophil yo gushaka ibyuma bya Neutrophil nka GM-CSF na IL-6. Na none, amakimbirane ya IL-6 imvugo yerekana ibitekerezo bishinzwe kugenzura unyuze muri Jak2 / status3 / il-6 axis. Binyuze mu bushakashatsi bwasubitswe ku ngero z'ubuvuzi, abashakashatsi basanze ihumure hagati ya neutrophiles, inshundura, uca prognose ndetse no guhunga. ICT ihujwe nubururu ntibubiri bushobora kugira ingaruka.

Muri make, ubu bushakashatsi bwabonye ibyoicariinKugabanya cyane ibibyimba byakwirakwijwe no gutera imbere mugihe bibuza Neutrophil incuro na Synthesis, na netrophiles yakinnye uruhare rubujije muri ikibyimba cyindwara zijimye za uroteyoma. Byongeye kandi, ICT ihuriweho na Anti-PD1 Immyundorapy ifite ingaruka zidafite ubuhanga, itanga ingamba zishobora kuvura abarwayi bafite Uroteoma