Icyatsi gishya gitanga ubuziranenge Bwiza bwa Algae Gukuramo Ifu ya Fucoidan 98%

Imikorere:

1. Kunoza indwara zo mu gifu

Byagaragaye ko ingaruka za polysaccharide ku ndwara zo mu gifu zagaragaye cyane cyane mu bintu bitatu bikurikira: (1) Polysaccharide yagize ingaruka zo gukuraho Helicobacter pylori, ibuza ikwirakwizwa rya pylori ya Helicobacter no kubuza guhuza na mucosa yo mu gifu; . .

2. Ingaruka zo kurwanya anticoagulant

Fucoidan ifite ibikorwa byinshi byibinyabuzima, ariko ibikorwa byayo birwanya anticoagulant nibyo byizwe cyane. Ubushakashatsi bwerekanye ko polysaccharide yakuwe muri algae zitandukanye zo mu nyanja zifite ibyiciro bitandukanye byibikorwa bya anticoagulant. Kurugero, polysaccharide ivuye kandi yerekanaga urwego rwo hejuru rwibikorwa bya anticoagulant, hamwe nigikorwa cyo kurwanya anticoagulant ya kandi yari kimwe cya kabiri cyibya mbere, ariko hafi ya byose ntabwo ari anticagulant.

3. Ingaruka ya antithrombotic

Muburyo bwubushakashatsi bwinyamaswa nzima, polysaccharide ya fucoidan igira ingaruka mbi kuri trombose yimitsi ndetse na arterial trombose. Rocha n'abandi. yasanze polysaccharide idafite ibikorwa bya anticagulant muri vitro, ariko yerekanye ingaruka zigaragara za antithrombotique muburyo bwinyamanswa zo gukora trombose yo mu mitsi, kandi ingaruka zaterwaga nigihe, zikagera kuri byinshi nyuma ya 8h yubuyobozi. Igikorwa cyo kurwanya anticoagulant ya polysaccharide birashoboka ko cyari gifitanye isano no gushimangira umusaruro wa heparin sulfate na selile endothelia.

4. Ingaruka za virusi

Ubushakashatsi bwerekanye ko polisikaride ya sulfate (harimo na fucoidan polysaccharide) yerekana ibikorwa bya virusi haba muri vivo ndetse no muri vitro. Hayashi n'abandi. yize ingaruka zo kwirinda fucoidan kuri herpes simplex virusi (HSV). Basanze fucoidan ishobora kurinda imbeba kwandura HSV, bagaragaza ko fucoidan ishobora kwirinda kwandura HSV ibuza kwanduza virusi no kongera imikorere y’ubudahangarwa bw'umubiri. Muri icyo gihe, byagaragaye kandi ko polysaccharide yerekanye ibikorwa bya virusi irwanya HSV-1 na HSV-2. Hidari n'abandi. yatangaje ko fucoidan ishobora guhagarika neza kwandura virusi ya dengue yo mu bwoko bwa 2 (DEN2), ikanerekana ko fucoidan ihuza uduce twa DEN2 kandi igakorana na glycoproteine. Ntabwo igira ingaruka zitaziguye kuri virusi, kandi uburyo bwayo bwo kurwanya virusi ni ukubuza kwanduza virusi cytiocytes mu kubuza kwanduza virusi.

5. Ingaruka zo kurwanya ibibyimba

Fucoidan ifatwa nkibintu bisanzwe birwanya kanseri, kandi ibikorwa byayo byo kurwanya ibibyimba byagaragaye cyane. Alekseyenko n'abandi. yize ku gikorwa cyo kurwanya ibibyimba bya fucoidan ku mbeba zirwaye Lewis ibihaha adenocarcinoma, kandi agaburira fucoidan ku gipimo cya 10mg / kg ku mbeba, bikavamo ibikorwa byo kurwanya ibibyimba bitagereranywa ndetse n'ingaruka zo kurwanya ibibyimba. Ubushakashatsi bumwe bwerekanye kandi ko igipimo cyo kubuza ikibyimba cya fucoidan ku nyamaswa 5 zirimo sarcoma ya S180 cyari 30%, naho sarcoma y’inyamaswa 2 irashira burundu. Mu isahani ya petri ingirabuzimafatizo zigera ku 10,000 zifata kanseri ya algae polysaccharide yakuwe muri kelp, 50 ku ijana by'uturemangingo twa kanseri twapfuye nyuma y'amasaha 24, kandi kanseri hafi ya zose zapfuye nyuma y'amasaha 72. Hyun n'abandi. yasanze polysaccharide ya algae yigitare ishobora kubuza cyane imikurire ya kanseri ya kanseri ya HCT-15. Nyuma yo kuvura umurongo wa selile HCT-15 hamwe na polygaccharide ya algae, ibintu bya apoptotique nko kumena ADN, guteranya chromosome, no kwiyongera kwa selile subdiploid mugice cya G1 byagaragaye

6. Ingaruka za Antioxydeant

Umubare munini wubushakashatsi bwa vitro bwerekanye ko polysaccharide ya algae yigitare ifite ibikorwa byingenzi birwanya antioxydeant, ni ubwoko bwa antioxydants karemano, kandi birashobora gukumira neza indwara ziterwa na radicals yubuntu. Costa n'abandi. yakuyemo polysaccharide ya sulfate mu moko 11 y’ibiti byo mu nyanja yo mu turere dushyuha, byose bikaba byari bifite ibikorwa bya antioxydeant, ubushobozi bwo gukora chelates ferrous no kugabanya ingufu, 5 muri zo zikaba zari zifite ubushobozi bwo gukuraho radicals hydroxyl, naho 6 muri zo zikaba zifite ubushobozi bwo gukuraho radicals peroxy. Micheline n'abandi. yatangaje ko polysaccharide iva muri algae ishobora kubuza ishingwa rya hydroxyl radical na superoxide radical.

7. Igikorwa cyo kwirinda

Fucoidan ifite ibikorwa byinshi byo kwirinda, harimo ibikorwa byo kurwanya kuzuzanya, kurwanya anti-inflammatory n'ingaruka zo gukingira indwara. Tissot n'abandi. yemeje ko polysaccharide ya fucoite ishobora kubuza poroteyine zuzuzanya muri serumu zisanzwe zabantu, bityo bikabuza iseswa ryintama zamaraso zitukura zatewe no gukora kwuzuzanya, no guhagarika ibikorwa byuzuzanya muguhagarika intambwe yambere yinzira ya classique ya classique (harimo igice cya mbere cyuzuzanya, igice cya kabiri nigice cya kane). Yang n'abandi. yasanze fucoidan ishobora guhitamo guhagarika imvugo ya synthase ya nitric oxyde ya selile mu ngirabuzimafatizo kandi ifite ibikorwa byo kurwanya inflammatory. Mizuno n'abandi. yakoresheje sisitemu yo guhuza imico ya epiteliyale yo mu mara Caco-2 na macrophage RAW264.7 kugirango isuzume ingaruka zo kurwanya indwara ziterwa nibiribwa, kandi ibisubizo byagaragaje ko polysaccharide ya S. japonicum ishobora gutera imbaraga kubyara ikibyimba cya nérosose.α muri RAW264.7, bityo bikabuza imvugo ya mRNA ya interleukin muri selile Caco-2.

8. Kunoza ubwiza bwintanga

Imiyoborere ya fucoidan irashobora kuzamura ubwiza bwintanga nubwinshi mugutezimbere metabolite yamaraso na mikorobe yo mara. Abashakashatsi basanze nyuma yo gutangwa na polysaccharide yo mu nyanja, urugero rwerekana imiterere ya gen zifitanye isano na spermatogenezi ziyongereye cyane mu gupima imbeba. Muri icyo gihe, habaye isano ryiza hagati ya microbiota yo munda na metabolite yamaraso. Mugutegeka byombi, polysaccharide ya fucoite yatezimbere metabolite ya testis, yongera kurinda antioxydeant, kandi igenzura urwego rwerekana imiterere ya genes zifitanye isano na selile mikorobe, bityo bikagira uruhare muri spermatogenezi no kuzamura ireme.