Ifu ya N-Acetylneuraminic Ifu Yumushinga Nicyatsi N-Acetylneuraminic aside
Ibisobanuro ku bicuruzwa
Acide N-acetylneuraminic (NANA, Neu5Ac) nikintu kinini kigize glycoconjugates, nka glycolipide, glycoproteine, na proteoglycans (sialoglycoproteine), itanga ibimenyetso biranga guhuza ibice bya glycosilated. Neu5Ac ikoreshwa mu kwiga ibinyabuzima byayo, metabolism no gufata muri vivo no muri vitro. Neu5Ac irashobora gukoreshwa mugutezimbere nanocarrier.
COA
| Ibintu | Ibisobanuro | Ibisubizo | |
| Kugaragara | Ifu yera | Ifu yera | |
| Suzuma |
| Pass | |
| Impumuro | Nta na kimwe | Nta na kimwe | |
| Ubucucike Buke (g / ml) | ≥0.2 | 0.26 | |
| Gutakaza Kuma | ≤8.0% | 4.51% | |
| Ibisigisigi kuri Ignition | ≤2.0% | 0.32% | |
| PH | 5.0-7.5 | 6.3 | |
| Ugereranije uburemere bwa molekile | <1000 | 890 | |
| Ibyuma biremereye (Pb) | ≤1PPM | Pass | |
| As | ≤0.5PPM | Pass | |
| Hg | ≤1PPM | Pass | |
| Kubara Bagiteri | 0001000cfu / g | Pass | |
| Colon Bakillus | ≤30MPN / 100g | Pass | |
| Umusemburo & Mold | ≤50cfu / g | Pass | |
| Indwara ya bagiteri | Ibibi | Ibibi | |
| Umwanzuro | Ihuze n'ibisobanuro | ||
| Ubuzima bwa Shelf | Imyaka 2 iyo ibitswe neza | ||
Imikorere
1. Kunoza ubwenge bwumwana no kwibuka
Acide N-Acetylneuraminic nikintu gikomeye cyubaka ganglioside mubwonko. Ibiri muri acide ya sialic mumyanya myakura ikubye inshuro 20 iyindi selile. Kuberako ihererekanyamakuru ryubwonko hamwe nogutwara imitsi yimitsi bigomba kugerwaho binyuze muri synaps, kandi aside N-Acetylneuraminic nintungamubiri zubwonko zikora mubwonko bwakorewe mubwonko hamwe na synaps, bityo aside N-Acetylneuraminic irashobora guteza imbere iterambere ryubwonko nubwenge. Ubushakashatsi bwerekanye ko kongera aside ya N-Acetylneuraminic mu mafunguro yonsa bizongera ibirimo aside -N-Acetylneuraminic mu bwonko bw’umwana, kandi urwego rwo kwerekana imiterere ya gen zijyanye no kwiga narwo ruziyongera, bityo bizamura ubushobozi bwo kwiga no kwibuka. Ku bana, ibirimo aside N-Acetylneuraminic ni 25% gusa y’amata yonsa.
2. Kurwanya guta umutwe
Acide N-Acetylneuraminic igira ingaruka zo gukingira no guhagarika ingirabuzimafatizo. Nyuma ya protease iherereye hejuru yimitsi ya selile nervice ihujwe na aside N-Acetylneuraminic, ntishobora guteshwa agaciro na protease idasanzwe. Indwara zimwe na zimwe zifata ubwonko, nka démée kare ya senile na schizofrenia, bizagabanya aside N-Acetylneuraminic iri mu maraso cyangwa mu bwonko, kandi nyuma yo gukira imiti ivura ibiyobyabwenge, aside aside -N-Acetylneuraminic izasubira mu buryo busanzwe, byerekana ko aside N-Acetylneuraminic yitabira. muburyo bwo guhinduranya ingirabuzimafatizo.
3. Kurwanya kumenyekana
Hagati ya molekile na selile, hagati ya selile na selile, no hagati ya selile nisi yo hanze, aside N-Acetylneuraminic irangiye urunigi rwisukari irashobora kuba urubuga rwo kumenyekanisha cyangwa guhisha urubuga rwo kumenyekanisha. Acide N-Acetylneuraminic ifitanye isano n’iherezo rya glycoside ikoresheje imiyoboro ya glycoside irashobora gukumira neza ahantu hamwe na hamwe hagaragara ibimenyetso bya antigenic ndetse n’ibimenyetso byerekana hejuru y’akagari, bityo bikarinda izo sakaride kutamenyekana no guteshwa agaciro na sisitemu y’umubiri ikikije umubiri.
Porogaramu
1. Irashobora gukoreshwa nkintungamubiri.
2. N-Acetylneuraminic aside igira uruhare runini mu kongera imirire nka glyconutrient. Igenga poroteyine yamaraso igice cyubuzima, aside, kutabogama kwuburozi butandukanye, ingirabuzimafatizo hamwe no kurinda lysis glycoprotein. Irashobora gukoreshwa nk'inyongera y'ibiryo.
3. Acide N-Acetylneuraminic irashobora gukoreshwa nka reagent yo gutangira guhuza ibinyabuzima bikomoka ku binyabuzima. Irashobora gukoreshwa nk'amavuta yo kwisiga.
Gupakira & Gutanga
