Ufa Wogulitsa Chakudya Chochuluka Wa Pranlukast Ndi Mtengo Wabwino Kwambiri
Mafotokozedwe Akatundu
Pranlukast ndi mankhwala oletsa matupi a m'kamwa omwe amagwiritsidwa ntchito kwambiri pochiza matenda osagwirizana nawo, makamaka matupi awo sagwirizana rhinitis ndi mphumu. Ndiwosankha wa leukotriene receptor antagonist omwe amatha kulepheretsa zotsatira za leukotrienes, potero amachepetsa kuyabwa ndi kutupa.
Main Features ndi Ntchito
1. Njira:Pranlukast mosankha amatsutsana ndi zolandilira CysLT1, kuletsa kutsekeka kwa mpweya, kutuluka kwa ntchentche ndi kuchuluka kwa mitsempha yamagazi chifukwa cha ma leukotrienes (monga cysteine leukotrienes), potero amachepetsa zizindikiro za ziwengo ndi mphumu.
2. Zizindikiro:
- Matupi awo sagwirizana rhinitis:Amagwiritsidwa ntchito pochotsa zizindikiro monga kutsekeka kwa m'mphuno, mphuno, kutsekemera, etc. chifukwa cha mungu, nthata za fumbi, ndi zina zotero.
-Chifuwa:Monga chithandizo chothandizira mphumu, imathandizira kuwongolera zizindikiro za mphumu ndikuchepetsa kuchuluka kwa kuukira.
3. Fomu ya mlingo:Pranlukast nthawi zambiri imapezeka mu mawonekedwe a mapiritsi apakamwa, omwe odwala amatha kumwa molingana ndi malangizo a dokotala.
Pomaliza, Pranlukast ndi ogwira odana ndi matupi awo sagwirizana mankhwala, makamaka ntchito pofuna kuchiza matupi awo sagwirizana rhinitis ndi mphumu, amene amachepetsa thupi lawo siligwirizana ndi kutupa ndi antagonizing leukotriene zolandilira. Mukamagwiritsa ntchito, muyenera kutsatira malangizo a dokotala kuti muwonetsetse kuti ndinu otetezeka komanso ogwira mtima.
COA
| Zinthu | Zofotokozera | Zotsatira |
| Maonekedwe | Zoyera-zoyera kapena ufa woyera | Ufa Woyera |
| Chizindikiro cha HPLC | Mogwirizana ndi zomwe zanenedwa nthawi yosunga zinthu pachimake | Zimagwirizana |
| Kuzungulira kwachindunji | + 20.0.-+22.0. | + 21. |
| Zitsulo zolemera | ≤ 10ppm | <10ppm |
| PH | 7.5-8.5 | 8.0 |
| Kutaya pakuyanika | ≤ 1.0% | 0.25% |
| Kutsogolera | ≤3 ppm | Zimagwirizana |
| Arsenic | ≤1ppm | Zimagwirizana |
| Cadmium | ≤1ppm | Zimagwirizana |
| Mercury | ≤0. 1 ppm | Zimagwirizana |
| Malo osungunuka | 250.0 ℃ ~ 265.0 ℃ | 254.7 ~ 255.8 ℃ |
| Zotsalira pakuyatsa | ≤0. 1% | 0.03% |
| Hydrazine | ≤2 ppm | Zimagwirizana |
| Kuchulukana kwakukulu | / | 0.21g/ml |
| Kachulukidwe kachulukidwe | / | 0.45g/ml |
| Assay (Pranlukast) | 99.0% ~ 101.0% | 99.62% |
| Chiwerengero chonse cha ma aerobes | ≤1000CFU/g | <2CFU/g |
| Nkhungu & Yisiti | ≤100CFU/g | <2CFU/g |
| E.coli | Zoipa | Zoipa |
| Salmonella | Zoipa | Zoipa |
| Kusungirako | Sungani pamalo ozizira & owuma, sungani kuwala kolimba. | |
| Mapeto | Woyenerera | |
Ntchito
Pranlukast ndi mankhwala oletsa matupi amkamwa omwe amagwiritsidwa ntchito kwambiri pochiza mphumu ndi matupi awo sagwirizana rhinitis. Ndilosankha leukotriene receptor antagonist yomwe imalepheretsa zotsatira za leukotrienes, motero kuchepetsa zizindikiro zokhudzana ndi chifuwa ndi mphumu. Zotsatirazi ndi ntchito zazikulu za Pranlukast:
1. Anti-inflammatory effect:Pranlukast imathandizira kuwongolera zizindikiro za mphumu mwa kuletsa zotsatira za leukotrienes ndikuchepetsa kuyankha kotupa mumayendedwe apamlengalenga.
2. Kupititsa patsogolo ntchito ya kupuma:Pochepetsa kutsekeka ndi kutupa kwa mpweya, Pranlukast imatha kupititsa patsogolo kupuma kwa odwala mphumu ndikuchepetsa kupezeka kwa kupuma komanso kupuma movutikira.
3. Chepetsani zizindikiro za ziwengo:Pranlukast amagwiritsidwanso ntchito pochiza matupi awo sagwirizana ndi rhinitis ndipo amatha kuthetsa zizindikiro za ziwengo monga mphuno yamphuno, mphuno yothamanga, sneezing, etc.
4. Kupewa Matenda a Chifuwa:Kugwiritsa ntchito nthawi yayitali kwa Pranlukast kungathandize kupewa matenda a mphumu, makamaka kwa odwala omwe ali ndi mphumu yochita masewera olimbitsa thupi.
5. Kugwiritsa ntchito limodzi ndi mankhwala ena:Pranlukast itha kugwiritsidwa ntchito limodzi ndi mankhwala ena odana ndi mphumu (monga inhaled corticosteroids) kuti apititse patsogolo chithandizo.
Mwachidule, ntchito yaikulu ya Pranlukast ndi kuthetsa zizindikiro za mphumu ndi matupi awo sagwirizana rhinitis ndi kusintha umoyo wa odwala ndi antagonizing leukotriene zolandilira. Mukamagwiritsa ntchito, muyenera kutsatira malangizo a dokotala kuti muwonetsetse kuti ndinu otetezeka komanso ogwira mtima.
Kugwiritsa ntchito
Kugwiritsiridwa ntchito kwa Pranlukast kumayang'ana kwambiri pochiza matenda okhudzana ndi ziwengo, kuphatikiza izi:
1. Matupi awo sagwirizana rhinitis:Pranlukast amagwiritsidwa ntchito pochotsa zizindikiro za matupi awo sagwirizana rhinitis chifukwa cha mungu, nthata za fumbi, dander ya nyama, ndi zina zotere, monga kutsekeka kwa m'mphuno, mphuno, kuyetsemula ndi kuyabwa m'mphuno. Amachepetsa kuyankhidwa kotupa kwa mphuno mwa kutsutsa zotsatira za leukotrienes.
2. Chifuwa:Pranlukast imagwiritsidwa ntchito ngati chithandizo chothandizira matenda a mphumu kuti athandizire kuwongolera zizindikiro za mphumu ndikuchepetsa kuchuluka komanso kuopsa kwa mphumu. Itha kugwiritsidwa ntchito limodzi ndi mankhwala ena odana ndi mphumu (monga inhaled corticosteroids ndi bronchodilators) kuti apititse patsogolo chithandizo.
3. Bronchoconstriction Yochititsa Maseŵera olimbitsa thupi:Pranlukast ingagwiritsidwenso ntchito pazochitika zina kuti ateteze kulimbitsa thupi kwa bronchoconstriction, kuthandiza othamanga ndi anthu omwe ali okangalika kuwongolera mayankho awo apaulendo asanayambe kuchita masewera olimbitsa thupi.
4. Matenda Osakhalitsa:Pranlukast itha kuwonedwanso ngati gawo lamankhwala othandizira pakuwongolera matenda ena osakhalitsa.
Kugwiritsa ntchito
Pranlukast imapezeka ngati mapiritsi apakamwa, omwe odwala ayenera kumwa motsatira malangizo a dokotala, nthawi zambiri kamodzi patsiku.
Zolemba
Pogwiritsira ntchito Pranlukast, odwala ayenera kuuza dokotala ngati ali ndi matenda ena kapena akumwa mankhwala ena kuti apewe kuyanjana kwa mankhwala. Kuonjezera apo, pamene Pranlukast ingathandize kuthetsa zizindikiro za ziwengo ndi mphumu, sicholinga chochiza matenda a mphumu.
Pomaliza, Pranlukast ndi othandiza odana ndi matupi awo sagwirizana mankhwala, amagwiritsidwa ntchito pochiza matupi awo sagwirizana rhinitis ndi mphumu, kuthandiza odwala kusintha moyo wawo. Mukamagwiritsa ntchito, muyenera kutsatira malangizo a dokotala kuti muwonetsetse kuti ndinu otetezeka komanso ogwira mtima.
Phukusi & Kutumiza
