• Kodi N'chiyani?Tetrahydrocurcumin ?
Rhizoma Curcumae Longae ndi rhizoma youma ya Curcumae Longae L. Imagwiritsidwa ntchito kwambiri ngati chakudya chamtundu komanso fungo lonunkhira. Kapangidwe kake ka mankhwala kumaphatikizapo curcumin ndi mafuta osasinthika, kuphatikiza ma saccharides ndi sterols. Curcumin (CUR), monga polyphenol yachilengedwe mu chomera cha curcuma, yasonyezedwa kuti ili ndi zotsatira zosiyanasiyana za mankhwala, kuphatikizapo anti-inflammatory, antioxidant, oxygen free radical elimination, chitetezo cha chiwindi, anti-fibrosis, anti-tumor ntchito ndi kupewa. matenda a Alzheimer's (AD).
Curcumin imapangidwa mwachangu m'thupi kukhala glucuronic acid conjugates, sulfuric acid conjugates, dihydrocurcumin, tetrahydrocurcumin, ndi hexahydrocurcumin, zomwe zimasinthidwa kukhala tetrahydrocurcumin. Kafukufuku woyesera atsimikizira kuti curcumin ilibe kukhazikika kosakhazikika (onani chithunzithunzi), kusasungunuka kwamadzi komanso kuchepa kwa bioavailability. Chifukwa chake, gawo lake lalikulu la metabolic la tetrahydrocurcumin m'thupi lakhala malo opangira kafukufuku kunyumba ndi kunja m'zaka zaposachedwa.
Tetrahydrocurcumin(THC), monga metabolite yogwira kwambiri komanso yayikulu ya curcumin yomwe imapangidwa panthawi ya metabolism mu vivo, imatha kupatulidwa ndi cytoplasm ya m'matumbo ang'onoang'ono ndi chiwindi pambuyo pa kuwongolera kwa curcumin kwa munthu kapena mbewa. The molecular formula ndi C21H26O6, molekyulu yolemera ndi 372.2, kachulukidwe ndi 1.222, ndipo malo osungunuka ndi 95 ℃-97 ℃.
• Ubwino Wake Ndi Chiyani?TetrahydrocurcuminMukusamalira Khungu?
1. Zotsatira za kupanga melanin
Tetrahydrocurcumin imatha kuchepetsa melanin m'maselo a B16F10. Pamene lolingana ndende ya tetrahydrocurcumin (25, 50, 100, 200μmol/L) anapatsidwa, melanin okhutira utachepa kuchokera 100% kuti 74.34%, 80,14%, 34.37%, 21.40%, motero.
Tetrahydrocurcumin imatha kuletsa ntchito ya tyrosinase m'maselo a B16F10. Pamene lolingana ndende ya tetrahydrocurcumin (100 ndi 200μmol/L) anapatsidwa kwa maselo, okhudza maselo ambiri tyrosinase ntchito utachepa kwa 84,51% ndi 83.38%, motero.
2. Anti-photoaging
Chonde onani chithunzi cha mbewa pansipa: Ctrl (control), UV (UVA + UVB), THC (UVA + UVB + THC THC100 mg/kg, kusungunuka mu 0.5% sodium carboxymethyl cellulose). Zithunzi za khungu kumbuyo kwa mbewa za KM pa masabata a 10 mutatha kulandira chithandizo cha THC ndi kuwala kwa UVA. Magulu osiyanasiyana okhala ndi ma radiation ofanana a UVA flux to ukalamba wopepuka adawunikidwa ndi kuchuluka kwa Bissett. Miyezo yomwe yaperekedwa ndi njira yopatuka (N = 12/ gulu). *P<0.05,*P
Kuyambira maonekedwe, poyerekeza ndi yachibadwa kulamulira gulu, khungu la chitsanzo ulamuliro gulu anali akhakula, looneka erythema, zilonda, makwinya zakuya ndi unakhuthala limodzi ndi chikopa ngati kusintha, kusonyeza mmene photoaging chodabwitsa. Poyerekeza ndi gulu lowongolera lachitsanzo, kuchuluka kwa kuwonongeka kwatetrahydrocurcuminGulu la 100 mg / kg linali lotsika kwambiri kuposa la gulu lolamulira lachitsanzo, ndipo palibe nkhanambo ndi erythema zomwe zinapezeka pakhungu, kokha mtundu wochepa wa pigment ndi makwinya abwino anawoneka.
3. The antioxidant
Tetrahydrocurcumin ikhoza kuonjezera mlingo wa SOD, kuchepetsa mlingo wa LDH ndikuwonjezera mlingo wa GSH-PX m'maselo a HaCaT.
Kuchotsa ma radicals aulere a DPPH
Thetetrahydrocurcuminyankho anali kuchepetsedwa ndi 10, 50, 80, 100, 200, 400, 800, 1600 nthawi motsatizana, ndi njira chitsanzo anali bwinobwino wothira 0.1mmol/L DPPH njira pa chiŵerengero cha 1:5. Pambuyo pochita kutentha kwa firiji kwa 30min, kuchuluka kwa kuyamwa kunatsimikizika pa 517nm. Chotsatira chikuwonetsedwa pachithunzichi:
4. Pewani kutupa khungu
Kafukufuku woyeserera adawonetsa kuti machiritso a mbewa adawonedwa mosalekeza kwa masiku 14, pomwe gel osakaniza a THC-SLNS adagwiritsidwa ntchito motsatana, kuthamanga kwa machiritso ndi zotsatira za THC komanso kuwongolera bwino kunali kofulumira komanso kwabwinoko, kutsika kwake kunali gel osakaniza a THC-SLNS. >
THC > Kuwongolera kwabwino.
Pansipa pali zithunzi zoyimira zachitsanzo cha mbewa chodulidwa ndi kuwunika kwa histopathological, A1 ndi A6 zowonetsa khungu labwinobwino, A2 ndi A7 zowonetsa gel osakaniza THC SLN, A3 ndi A8 zowonetsa zowongolera zabwino, A4 ndi A9 zowonetsa gel osakaniza THC, ndi A5 ndi A10 zowonetsa zolimba zopanda kanthu. lipid nanoparticles (SLN), motero.
• Kugwiritsa NtchitoTetrahydrocurcuminMu Cosmetics
1.Zinthu zosamalira khungu:
Zoletsa Kukalamba:Amagwiritsidwa ntchito mu anti-aging creams ndi serums kuti athandize kuchepetsa makwinya ndi mizere yabwino ndikuwongolera khungu.
Whitening mankhwala:Zowonjezeredwa kuzinthu zoyera ndi zopakapaka kuti zithandizire kukonza khungu losagwirizana ndi mawanga.
2. Anti-inflammatory mankhwala:
Amagwiritsidwa ntchito pazinthu zosamalira khungu monga zotonthoza ndi kukonza zonona kuti muchepetse kufiira ndi kuyabwa.
3.Kuyeretsa Zogulitsa:
Onjezani zotsukira ndi zotulutsa kuti zithandizire kuyeretsa khungu komanso kupereka zopindulitsa za antibacterial kuti mupewe ziphuphu.
4.Zovala za Sunscreen:
Amagwira ntchito ngati antioxidant kuti apititse patsogolo mphamvu za sunscreen ndikuteteza khungu ku kuwala kwa UV.
5. Chigoba cha nkhope:
Amagwiritsidwa ntchito mu masks osiyanasiyana amaso kuti apereke chakudya chakuya ndi kukonza, kukonza khungu.
Tetrahydrocurcuminamagwiritsidwa ntchito kwambiri mu zodzoladzola, zophimba khungu, kuyeretsa, kuteteza dzuwa ndi zina. Amayamikiridwa chifukwa cha antioxidant, anti-inflammatory and whitening effect.
Nthawi yotumiza: Oct-10-2024
