Kafukufuku akuwonetsa kuti pafupifupi akuluakulu 537 miliyoni padziko lonse lapansi ali ndi matenda a shuga a mtundu wachiwiri, ndipo chiwerengerochi chikukwera. Kuchuluka kwa shuga m'magazi chifukwa cha matenda a shuga kungayambitse mikhalidwe yowopsa, monga matenda amtima, kusawona bwino, kulephera kwa impso, ndi matenda ena akuluakulu. Zonsezi zimatha kufulumizitsa ukalamba kwambiri.
Tetrahydrocurcumin, yochokera ku muzu wa turmeric, yasonyezedwa mu maphunziro a zachipatala kuti athandize kuchepetsa zifukwa zambiri zowopsa za matenda a shuga a 2 komanso kuchepetsa shuga wa magazi mwa anthu omwe ali ndi matenda a shuga kapena prediabetes. Kuchiza matenda amtundu wa 2 kumatha kukhala kovuta kwa odwala komanso madokotala. Ngakhale kuti madokotala nthawi zambiri amalimbikitsa zakudya, masewera olimbitsa thupi, ndi mankhwala ochizira anthu omwe ali ndi matenda a shuga a mtundu wa 2, kafukufuku amasonyeza kutitetrahydrocurcuminakhoza kupereka chithandizo chowonjezera.
• Kukaniza kwa insulin ndi Matenda a Shuga
Tikamadya, shuga m’magazi amakwera. Izi zimathandizira kuti kapamba atulutse mahomoni otchedwa insulin, omwe amathandiza maselo kugwiritsa ntchito shuga kuti apange mphamvu. Zotsatira zake, shuga wamagazi amatsikanso. Matenda a shuga amtundu wa 2 amayamba chifukwa cha kukana kwa insulini chifukwa ma cell samayankha momwe timadzi ta timadzi tambiri tambiri. Mlingo wa shuga m'magazi umakhalabe wokwera, vuto lotchedwa hyperglycemia. Kuchuluka kwa shuga m'magazi kungayambitse zovuta zina, kuphatikizapo mtima, mitsempha ya magazi, impso, maso, ndi matenda a mitsempha, ndikuwonjezera chiopsezo cha khansa.
Kutupa kumatha kupangitsa kuti insulini isakane komanso kukulitsa hyperglycemia mwa anthu odwala matenda ashuga. [8,9] Kuchuluka kwa shuga m'magazi kumayambitsa kutupa kwambiri, komwe kumathandizira kukalamba ndikuwonjezera chiopsezo cha matenda aakulu, monga matenda a mtima ndi khansa. Glucose wochulukira amayambitsanso kupsinjika kwa okosijeni, komwe kumatha kuwononga kwambiri ma cell ndi minofu. Mwa mavuto ena, kupsinjika kwa okosijeni kungayambitse:kuchepa kwa kayendedwe ka shuga ndi insulin katulutsidwe, kuwonongeka kwa mapuloteni ndi DNA, komanso kuchuluka kwa mitsempha yamagazi.
• Ubwino Wake Ndi Chiyani?TetrahydrocurcuminMu Diabetes?
Monga chogwiritsidwa ntchito mu turmeric,TetrahydrocurcuminZingathandize kupewa kukula kwa matenda a shuga komanso kuwonongeka komwe kungayambitse m'njira zingapo, kuphatikiza:
1. Kutsegula kwa PPAR-γ, yomwe imayendetsa kagayidwe kachakudya kamene kamawonjezera chidwi cha insulini ndikuchepetsa kukana kwa insulini.
2. Zotsatira zotsutsa-kutupa, kuphatikizapo kulepheretsa zizindikiro za ma molekyulu zomwe zimawonjezera kutupa.
3. Kuchita bwino komanso thanzi la cell yotulutsa insulin.
4. Kuchepetsa mapangidwe a glycation end mankhwala ndikupewa kuwonongeka komwe kumayambitsa.
5. Antioxidant ntchito, yomwe imachepetsa kupsinjika kwa okosijeni.
6. Kupititsa patsogolo mbiri ya lipid ndikuchepetsa zizindikiro zina za kusokonezeka kwa kagayidwe kachakudya ndi matenda a mtima.
Mu zitsanzo za zinyama,tetrahydrocurcuminakuwonetsa kufunikira kothandizira kupewa kukula kwa matenda a shuga komanso kuchepetsa kukana kwa insulin.
• Ubwino Wake Ndi Chiyani?TetrahydrocurcuminMu mtima?
Kafukufuku wa 2012 wofalitsidwa mu International Journal of Pharmacology adawunikira zotsatira zatetrahydrocurcuminpa mbewa kung'ambika mphete kuona ngati pawiri anali cardioprotective katundu. Choyamba, ochita kafukufukuwo adatambasula mphete za aortic ndi carbachol, gulu lomwe limadziwika kuti limayambitsa vasodilation. Kenako, mbewazo zidabayidwa ndi homocysteine thiolactone (HTL) kuti aletse vasodilation. [16] Pomaliza, ofufuzawo adabaya mbewa ndi 10 μM kapena 30 μM ya.tetrahydrocurcuminndipo adapeza kuti adayambitsa vasodilation pamilingo yofanana ndi carbachol.
Malinga ndi kafukufukuyu, HTL imapanga vasoconstriction pochepetsa kuchuluka kwa nitric oxide m'mitsempha yamagazi ndikuwonjezera kupanga ma free radicals. Chifukwa chake,tetrahydrocurcuminziyenera kukhudza kupanga nitric oxide ndi/kapena free radicals kuti abwezeretse vasodilation. Kuyambiratetrahydrocurcuminali ndi mphamvu ya antioxidant, amatha kuwononga ma free radicals.
• Ubwino Wake Ndi Chiyani?TetrahydrocurcuminMu Hypertension?
Ngakhale kuti kuthamanga kwa magazi kungakhale ndi zifukwa zosiyanasiyana, nthawi zambiri kumakhala chifukwa cha kutsekeka kwambiri kwa mitsempha ya magazi, zomwe zimapangitsa kuti mitsempha ya magazi ikhale yochepa.
Mu kafukufuku wa 2011, ofufuza adaperekatetrahydrocurcuminkuti mbewa ziwone momwe zimakhudzira kuthamanga kwa magazi. Pofuna kuyambitsa kusokonezeka kwa mitsempha, ofufuzawo adagwiritsa ntchito L-arginine methyl ester (L-NAME). Mbewa zinagawidwa m’magulu atatu. Gulu loyamba linalandira L-NAME, gulu lachiwiri linalandira tetrahydrocurcumin (50mg/kg kulemera kwa thupi) ndi L-NAME, ndipo gulu lachitatu linalandira.tetrahydrocurcumin(100mg/kg kulemera kwa thupi) ndi L-NAME.
Pambuyo pa masabata atatu a tsiku ndi tsiku, mlingo umathatetrahydrocurcumingulu linasonyeza kuchepa kwakukulu kwa kuthamanga kwa magazi poyerekeza ndi gulu lomwe linangotenga L-NAME. Gulu lomwe linapatsidwa mlingo wapamwamba linali ndi zotsatira zabwino kuposa gulu lomwe linapatsidwa mlingo wochepa. Ochita kafukufukuwo ananena kuti zotsatira zake zabwino zachitika chifukwa cha zimenezitetrahydrocurcuminkuthekera koyambitsa vasodilation.
Nthawi yotumiza: Oct-10-2024
