Mzaka zaposachedwa,NMN, yomwe yadziwika padziko lonse lapansi, yasaka kwambiri. Kodi mumadziwa bwanji za NMN? Lero, tiyang'ana pa kuyambitsa NMN, yomwe imakondedwa ndi aliyense.
● KodiNMN?
NMN imatchedwa β-Nicotinamide Mononucleotide, kapena NMN mwachidule. NMN ili ndi ma diastereomer awiri: α ndi β. Kafukufuku wapeza kuti mtundu wa β-NMN wokha uli ndi zochitika zachilengedwe. Mwachilengedwe, molekyuyi imapangidwa ndi nicotinamide, ribose, ndi phosphate.
NMN ndi amodzi mwa otsogola a NAD +. Mwa kuyankhula kwina, zotsatira za NMN zimatheka kudzera mu kusinthidwa kukhala NAD+. Tikamakalamba, mulingo wa NAD + m'thupi la munthu umachepa pang'onopang'ono.
Mu 2018 Aging Biology Research Compilation, njira ziwiri zazikuluzikulu za ukalamba wa anthu zidafotokozedwa mwachidule:
1. Zowonongeka chifukwa cha kupsinjika kwa okosijeni (zizindikiro zimawonekera ngati matenda osiyanasiyana)
2. Kuchepa kwa NAD + m'maselo
Zambiri zomwe zapindula pamaphunziro a NAD + odana ndi kukalamba opangidwa ndi asayansi apamwamba padziko lonse lapansi zimathandizira mfundo yakuti kuwonjezeka kwa NAD + kumatha kupititsa patsogolo thanzi labwino pazinthu zambiri ndikuchedwetsa kukalamba.
● Kodi Ubwino Wathanzi Ndi ChiyaniNMN?
1.Onjezani zinthu za NAD+
NAD + ndi chinthu chofunikira kuti thupi lizigwira ntchito. Imakhala m'maselo onse ndipo imachita nawo masauzande a zochita za thupi m'thupi. Ma enzymes opitilira 500 m'thupi la munthu amafunikira NAD +.
Kuchokera pachithunzichi, titha kuwona kuti mapindu owonjezera NAD + ku ziwalo zosiyanasiyana akuphatikiza kuwongolera thanzi laubongo ndi dongosolo lamanjenje, chiwindi ndi impso, mitsempha yamagazi, mtima, mitsempha yamagazi, ziwalo zoberekera, kapamba, minofu ya adipose, ndi minofu.
Mu 2013, gulu lofufuza lotsogozedwa ndi Pulofesa David Sinclair wa Harvard Medical School adatsimikizira kudzera muzoyeserera kuti pambuyo poyang'anira pakamwa pa NMN kwa sabata imodzi, mulingo wa NAD + mu mbewa za miyezi 22 ukuwonjezeka, ndipo zizindikiro zazikulu za biochemical zokhudzana ndi mitochondrial homeostasis ndi ntchito ya minofu inabwezeretsedwa ku mkhalidwe wa mbewa zazing'ono zofanana ndi miyezi 6.
2. Yambitsani mapuloteni a SIR
Kafukufuku m'zaka zapitazi za 20 apeza kuti Sirtuins amagwira ntchito yaikulu yolamulira pafupifupi machitidwe onse a maselo, zomwe zimakhudza machitidwe a thupi monga kutupa, kukula kwa maselo, circadian rhythm, mphamvu ya metabolism, neuronal ntchito ndi kupsinjika maganizo.
Sirtuins nthawi zambiri amatchedwa banja la mapuloteni amoyo wautali, lomwe ndi banja la NAD + -dependent deacetylase proteins.
Mu 2019, Pulofesa Kane AE wa dipatimenti ya Genetics ku Harvard Medical School ndi ena adazindikira iziNMNndiye kalambulabwalo wofunikira pakuphatikizika kwa NAD + m'thupi. Pambuyo pa NMN kuonjezera mlingo wa NAD + m'maselo, zotsatira zake zambiri zopindulitsa (monga kupititsa patsogolo kagayidwe kachakudya, kuteteza dongosolo la mtima, etc.) zimapindula mwa kuyambitsa Sirtuins.
3. Konzani kuwonongeka kwa DNA
Kuphatikiza pa kukhudza zochita za Sirtuins, mulingo wa NAD + m'thupi ndi gawo lofunikira la DNA kukonza enzyme PARPs (poly ADP-ribose polymerase).
4. Limbikitsani kagayidwe
Metabolism ndi gulu lazinthu zomwe zimapangitsa kuti zamoyo zizikhala ndi moyo, zomwe zimawalola kuti akule ndi kuberekana, kusunga mawonekedwe awo, ndikuyankha chilengedwe. Metabolism ndi njira yomwe zamoyo zimasinthana mosalekeza zinthu ndi mphamvu. Ikangoyima, moyo wa chamoyo udzatha. Pulofesa Anthony wa ku yunivesite ya California ndi gulu lake adapeza kuti NAD+ metabolism yakhala chithandizo chothandizira kuwongolera matenda okhudzana ndi ukalamba komanso kukulitsa thanzi la anthu komanso moyo wautali.
5. Limbikitsani kusinthika kwa chotengera chamagazi ndikusunga zotumphukira zamagazi
Mitsempha yamagazi ndi minyewa yofunikira yonyamula mpweya ndi zakudya, kukonza mpweya wa carbon dioxide ndi metabolites, ndikuwongolera kutentha kwa thupi. Tikamakalamba, mitsempha yamagazi imasiya kusinthasintha pang'onopang'ono, imakhala yolimba, yakuda, komanso yopapatiza, zomwe zimayambitsa "arteriosclerosis."
Mu 2020, kafukufuku wa ophunzira ena a PhD ochokera ku Zhejiang University of Technology ku China, kuphatikiza Sh, adapeza kutiNMNkwa mbewa zopsinjika maganizo, zizindikiro za kuvutika maganizo zinachepetsedwa chifukwa cha kuchuluka kwa NAD+, kuyambitsa Sirtuin 3, ndi kukonza kagayidwe ka mphamvu ya mitochondrial mu hippocampus ndi maselo a chiwindi a ubongo wa mbewa.
6. Tetezani thanzi la mtima
Mtima ndi chiwalo chofunika kwambiri m’thupi la munthu ndipo n’chofunika kwambiri kuti mtima ugwire ntchito bwino. Kutsika kwa milingo ya NAD + kumakhudzana ndi matenda osiyanasiyana amtima. Maphunziro ambiri oyambira awonetsanso kuti kuwonjezera coenzyme I nditha kupindulitsa mitundu ya matenda amtima.
7. Sungani thanzi la ubongo
Kuwonongeka kwa mitsempha ya mitsempha kungayambitse kuwonongeka kwa chidziwitso choyambirira cha mitsempha ndi neurodegenerative. Kusunga magwiridwe antchito a neurovascular ndikofunikira popewa matenda a neurodegenerative.
Ziwopsezo monga matenda a shuga, kuthamanga kwa magazi kwapakati, kunenepa kwambiri kwapakati, kusachita masewera olimbitsa thupi komanso kusuta zonse zimayenderana ndi matenda a vascular dementia ndi Alzheimer's.
8. Kupititsa patsogolo chidwi cha insulin
Insulin sensitivity imatanthawuza kuchuluka kwa insulin kukana. Kutsika kwa chidwi cha insulin, kumachepetsa kuchepa kwa shuga.
Kukana kwa insulin kumatanthawuza kuchepa kwa kukhudzika kwa ziwalo zomwe zimayang'aniridwa ndi insulin kuti zigwire ntchito ya insulin, ndiye kuti, mkhalidwe womwe mulingo wabwinobwino wa insulin umatulutsa zocheperako kuposa momwe zimakhalira. Choyambitsa chachikulu cha matenda amtundu wa 2 ndi kuchepa kwa insulin komanso kutsika kwa insulin.
NMN, monga chowonjezera, chingathandize kuwongolera chidwi cha insulin mwa kukulitsa milingo ya NAD +, kuwongolera njira zama metabolic, ndikuwongolera magwiridwe antchito a mitochondrial.
9. Thandizo la kulemera kwa thupi
Kulemera sikumangokhudza ubwino wa moyo ndi thanzi, komanso kumakhala koyambitsa matenda ena aakulu. Kafukufuku wasonyeza kuti NAD precursor β-nicotinamide mononucleotide (NMN) ikhoza kusintha zina mwazoipa za zakudya zamafuta ambiri (HFD).
Mu 2017, Pulofesa David Sinclair wa ku Harvard Medical School ndi gulu lofufuza kuchokera ku Australian Medical School anayerekezera mbewa zazikazi zomwe zinkachita masewera olimbitsa thupi kwa masabata 9 kapena kubayidwa ndi NMN tsiku lililonse kwa masiku 18. Zotsatira zinawonetsa kuti NMN inkawoneka kuti ili ndi mphamvu yamphamvu pa metabolism yamafuta a chiwindi ndi kaphatikizidwe kuposa kuchita masewera olimbitsa thupi.
● Chitetezo chaNMN
NMN imatengedwa kuti ndi yotetezeka poyesera nyama, ndipo zotsatira zake ndi zolimbikitsa. Mayesero okwana 19 a zachipatala a anthu ayambika, omwe 2 adasindikiza zotsatira zoyesera.
Gulu lofufuza kuchokera ku Washington University School of Medicine ku St. Louis linasindikiza nkhani mu nyuzipepala yapamwamba ya sayansi "Sayansi", kuwulula zotsatira za mayesero oyambirira a anthu padziko lapansi, kutsimikizira ubwino wa metabolic wa NMN pa thupi la munthu.
●NEWGREEN Supply NMN Powder/Capsules/Liposomal NMN
Nthawi yotumiza: Oct-15-2024
