●Kodi Berberine ndi chiyani?
Berberine ndi alkaloid wachilengedwe wotengedwa ku mizu, zimayambira ndi khungwa lazomera zosiyanasiyana, monga Coptis chinensis, Phellodendron amurense ndi Berberis vulgaris. Ndilo gawo lalikulu la Coptis chinensis la antibacterial effect.
Berberine ndi kristalo wachikasu wooneka ngati singano wokhala ndi kukoma kowawa. Chofunikira chachikulu mu Coptis chinensis ndi berberine hydrochloride. Ichi ndi isoquinoline alkaloid anagawira zosiyanasiyana zachilengedwe zitsamba. Imapezeka ku Coptis chinensis mu mawonekedwe a hydrochloride (berberine hydrochloride). Kafukufuku wapeza kuti mankhwalawa angagwiritsidwe ntchito pochiza zotupa, chiwindi, matenda a mtima, matenda oopsa, kutupa, matenda a bakiteriya ndi mavairasi, kutsegula m'mimba, matenda a Alzheimer ndi nyamakazi.
● Kodi Ubwino Wotani Paumoyo wa Berberine?
1.Antioxidant
M'mikhalidwe yabwinobwino, thupi la munthu limasunga bwino pakati pa ma antioxidants ndi ma prooxidants. Kupsinjika kwa okosijeni ndi njira yovulaza yomwe ingakhale mkhalapakati wofunikira pakuwonongeka kwa ma cell, potero kumayambitsa matenda osiyanasiyana monga matenda amtima, khansa, matenda amisempha ndi shuga. Kupanga mochulukira kwa mitundu ya okosijeni wa reactive (ROS), nthawi zambiri chifukwa chokondoweza kwambiri kwa NADPH ndi ma cytokines kapena kudzera mu unyolo wonyamula ma elekitironi wa mitochondrial ndi xanthine oxidase, kungayambitse kupsinjika kwa okosijeni. Mayesero asonyeza kuti berberine metabolites ndi berberine amasonyeza bwino kwambiri -OH ntchito yowonongeka, yomwe imakhala yofanana ndi antioxidant yamphamvu ya vitamini C. Ulamuliro wa berberine kwa makoswe a shuga ukhoza kuyang'anitsitsa kuwonjezeka kwa ntchito ya SOD (superoxide dismutase) ndi kuchepa kwa MDA (a) chizindikiro cha lipid peroxidation) milingo [1]. Zotsatira zina zikuwonetsa kuti ntchito yowononga ya berberine imagwirizana kwambiri ndi ferrous ion chelating ntchito, ndipo gulu la C-9 hydroxyl la berberine ndilofunika kwambiri.
2. Anti-chotupa
Pakhala pali malipoti ambiri okhudzana ndi zotsatira za anti-cancerberberine. Kafukufuku wosiyanasiyana m'zaka zaposachedwa wasonyeza kuti berberine ndi yofunika kwambiri pa chithandizo cha matenda aakulu a khansa monga khansa ya m'mawere, khansara ya endometrial, khansara ya khomo lachiberekero, khansa ya m'mawere, khansa ya m'mapapo, khansa ya colorectal, khansa ya impso, khansa ya chikhodzodzo, ndi khansa ya prostate. [2]. Berberine imatha kuletsa kuchuluka kwa maselo otupa polumikizana ndi zolinga ndi njira zosiyanasiyana. Ikhoza kusintha maonekedwe a oncogenes ndi majeremusi okhudzana ndi carcinogenesis kuti akwaniritse cholinga chowongolera ntchito ya ma enzymes okhudzana ndi kuletsa kufalikira.
3.Kutsitsa Lipids Zamagazi Ndi Kuteteza Matenda Amtima
Berberine amagwira ntchito yofunika kwambiri pochiza matenda amtima komanso amagwiritsidwa ntchito mosiyanasiyana. Berberine amakwaniritsa cholinga cha anti-arrhythmia mwa kuchepetsa kugunda kwa ventricular msanga komanso kulepheretsa kuchitika kwa ventricular tachycardia. Kachiwiri, dyslipidemia ndi chiopsezo chachikulu cha matenda a mtima, omwe amadziwika ndi kuchuluka kwa mafuta m'thupi, triglycerides, ndi otsika-density lipoprotein cholesterol (LDL), komanso kuchepa kwa high-density lipoprotein (HDL), ndi berberine akhoza kusunga kwambiri. kukhazikika kwa zizindikiro izi. Hyperlipidemia ya nthawi yayitali ndiyomwe imayambitsa mapangidwe a atherosclerotic plaque. Zimanenedwa kuti berberine imakhudza zolandilira za LDL mu hepatocytes kuti achepetse kuchuluka kwa cholesterol mu seramu yamunthu mu hepatocytes. Osati zokhazo,berberineali ndi zotsatira zabwino za inotropic ndipo amagwiritsidwa ntchito pochiza kulephera kwa mtima.
4.Imatsitsa shuga wamagazi ndikuwongolera Endocrine
Matenda a shuga mellitus (DM) ndi vuto la kagayidwe kachakudya lomwe limadziwika ndi kuchuluka kwa shuga m'magazi (hyperglycemia) komwe kumachitika chifukwa cha kulephera kwa ma cell a pancreatic B kupanga insulini yokwanira, kapena kutayika kwamphamvu kwa minofu yomwe imayang'aniridwa ndi insulin. Mphamvu ya hypoglycemic ya berberine idapezeka mwangozi m'zaka za m'ma 1980 pochiza odwala omwe ali ndi matenda otsegula m'mimba.
Kafukufuku wambiri wasonyeza zimenezoberberineamachepetsa shuga m'magazi kudzera m'njira izi:
● Imalepheretsa kutulutsa kwa glucose wa mitochondrial ndikuyambitsa glycolysis, kenako kumawonjezera kagayidwe ka shuga;
● Amachepetsa mlingo wa ATP mwa kulepheretsa ntchito ya mitochondrial m'chiwindi;
● Imalepheretsa ntchito ya DPP 4 (a ubiquitous serine protease), motero imadula ma peptide ena omwe amawonjezera kuchuluka kwa insulin pamaso pa hyperglycemia.
● Berberine imakhala ndi phindu pakusintha kukana insulini komanso kugwiritsa ntchito shuga m'maselo pochepetsa lipids (makamaka triglycerides) ndi kuchuluka kwa asidi wopanda mafuta m'madzi a m'magazi.
Chidule
Masiku ano,berberinezitha kupangidwa mongopeka ndikusinthidwa ndi njira zamakinala. Ili ndi zotsika mtengo komanso zamakono zamakono. Ndi chitukuko cha kafukufuku wamankhwala komanso kuzama kwa kafukufuku wamankhwala, berberine iwonetsadi mankhwala ambiri. Kumbali imodzi, berberine sanangopeza zotsatira zochititsa chidwi mu kafukufuku wakale wamankhwala mu antibacterial, antiviral, anti-inflammatory, anti-tumor, anti-diabetic, komanso chithandizo cha matenda amtima ndi cerebrovascular, komanso kapangidwe kake ka uinjiniya wa kristalo ndi kusanthula kwa morphological. alandira chisamaliro chachikulu. Chifukwa cha mphamvu zake zazikulu komanso kutsika kwapoizoni ndi zotsatira zake zoyipa, ili ndi kuthekera kwakukulu pakugwiritsa ntchito kwachipatala ndipo ili ndi chiyembekezo chachikulu. Ndi chitukuko cha cell biology, njira ya pharmacological ya berberine idzafotokozedwa bwino kuchokera pamlingo wa ma cell komanso ngakhale ma cell ndi chandamale, ndikupereka maziko ongoyerekeza pakugwiritsa ntchito kwake kuchipatala.
● Zatsopano ZatsopanoBerberine/Liposomal Berberine Powder/Capsules/Tablets
Nthawi yotumiza: Oct-28-2024
