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Mafotokozedwe Akatundu
Cyclosporin ndi immunosuppressant yomwe imagwiritsidwa ntchito makamaka kupewa kukanidwa kwa kuyika ziwalo ndikuchiza matenda ena a autoimmune. Imachotsedwa ku bowa m'nthaka ndipo imakhala ndi zotsatira zoletsa mwasankha T cell activation.
Main Mechanics
Imalepheretsa T cell kuyambitsa:
Cyclosporin imalepheretsa ntchito ya phosphatase yodalira calmodulin (calcineurin) pomanga mapuloteni omanga cyclophilin m'maselo, potero amalepheretsa kuyambitsa ndi kufalikira kwa ma T cell ndikuchepetsa kuyankha kwa chitetezo chamthupi.
Zizindikiro
Cyclosporin amagwiritsidwa ntchito makamaka pazifukwa izi:
Organ Transplant: Amagwiritsidwa ntchito poletsa kukanidwa kwa ziwalo monga impso, chiwindi, ndi mitima pambuyo pa kuikidwa, kawirikawiri kuphatikiza ndi ma immunosuppressants ena.
Matenda a Autoimmune: Atha kugwiritsidwa ntchito pochiza matenda a autoimmune monga nyamakazi ya nyamakazi, psoriasis, Sjögren's syndrome, ndi zina zambiri.
Zizindikiro zina: Nthawi zina, Cyclosporin imagwiritsidwanso ntchito pochiza matenda oopsa komanso zovuta zina zapakhungu.
COA
Zinthu | Zofotokozera | Zotsatira |
Maonekedwe | White ufa | Zimagwirizana |
Order | Khalidwe | Zimagwirizana |
Kuyesa | ≥99.0% | 99.8% |
Kulawa | Khalidwe | Zimagwirizana |
Kutaya pa Kuyanika | 4-7(%) | 4.12% |
Zonse Ash | 8% Max | 4.85% |
Chitsulo Cholemera | ≤10(ppm) | Zimagwirizana |
Arsenic (As) | 0.5ppm Max | Zimagwirizana |
Kutsogolera (Pb) | 1 ppm pa | Zimagwirizana |
Mercury (Hg) | 0.1ppm Max | Zimagwirizana |
Total Plate Count | 10000cfu/g Max. | 100cfu/g |
Yisiti & Mold | 100cfu/g Max. | >20cfu/g |
Salmonella | Zoipa | Zimagwirizana |
E.Coli. | Zoipa | Zimagwirizana |
Staphylococcus | Zoipa | Zimagwirizana |
Mapeto | Woyenerera | |
Kusungirako | Sungani pamalo otsekedwa bwino ndi kutentha pang'ono nthawi zonse komanso popanda kuwala kwa dzuwa. | |
Alumali moyo | 2 years atasungidwa bwino |
Ntchito
Mbali Zotsatira
Cyclosporin ingayambitse zotsatira zina, kuphatikizapo:
Nephrotoxicity:Zitha kuyambitsa kuwonongeka kwaimpso ndipo zimafunika kuwunika pafupipafupi ntchito yaimpso.
Kuthamanga kwa magazi:Kugwiritsa ntchito Cyclosporin kungayambitse kuthamanga kwa magazi.
Chiwopsezo cha matenda:Chifukwa cha immunosuppression, odwala amatha kutenga matenda.
Zotsatira zina:monga mutu, kupweteka kwa m'mimba, gingival hyperplasia, etc.
Zolemba
Kuyang'anira:Mukamagwiritsa ntchito Cyclosporin, ntchito yaimpso, kuthamanga kwa magazi ndi kuchuluka kwa mankhwala amagazi kuyenera kuyang'aniridwa pafupipafupi.
Kuyanjana ndi Mankhwala:Cyclosporin imatha kuyanjana ndi mankhwala ena. Muyenera kudziwitsa dokotala za mankhwala onse omwe mukumwa musanagwiritse ntchito.
Mimba ndi Kuyamwitsa:Cyclosporin ayenera kugwiritsidwa ntchito mosamala pa mimba ndi kuyamwitsa ndi kukaonana ndi dokotala chofunika.
Phukusi & Kutumiza
Ntchito
Ntchito ya Nerol
Nerol ndi mowa wachilengedwe wa monoterpene wokhala ndi chilinganizo chamankhwala C10H18O. Amapezeka makamaka m'mafuta ofunikira a zomera zosiyanasiyana, monga rose, lemongrass ndi timbewu tonunkhira. Nerol ali ndi ntchito zambiri ndi ntchito, makamaka kuphatikiza zotsatirazi:
1. Fungo ndi Fungo:Nerol ali ndi fungo labwino, lamaluwa ndipo nthawi zambiri amagwiritsidwa ntchito muzonunkhiritsa ndi zonunkhira ngati fungo lowonjezera kukopa kwa mankhwalawa. Ikhoza kuwonjezera zolemba zofewa zamaluwa ku zonunkhira.
2. Zodzoladzola: M'makampani opanga zodzoladzola, Nerol amagwiritsidwa ntchito ngati fungo lonunkhira ndipo nthawi zambiri amapezeka muzinthu monga zosamalira khungu, ma shampoos ndi ma gels osambira kuti apititse patsogolo luso la wogwiritsa ntchito.
3. Zakudya zowonjezera:Nerol ikhoza kugwiritsidwa ntchito ngati chokometsera chakudya ndikuwonjezeredwa ku zakumwa, maswiti ndi zakudya zina kuti apereke kununkhira kwamaluwa.
4. Zochita Zachilengedwe:Kafukufuku wasonyeza kuti Nerol akhoza kukhala ndi antibacterial, antioxidant ndi anti-inflammatory biological activities, zomwe zimapangitsa chidwi pa chitukuko cha mankhwala ndi zowonjezera thanzi.
5. Chothamangitsa tizilombo:Nerol yapezeka kuti ili ndi zotsatira zothamangitsa tizilombo ndipo imatha kugwiritsidwa ntchito ngati mankhwala achilengedwe othamangitsa tizilombo kuti tipewe kufalikira kwa tizilombo.
6. Aromatherapy:Mu aromatherapy, Nerol amagwiritsidwa ntchito popumula komanso kupsinjika maganizo chifukwa cha fungo lake lokhazika mtima pansi, kuthandiza kusintha malingaliro ndi malingaliro.
Pomaliza, Nerol amatenga gawo lofunikira m'magawo ambiri monga mafuta onunkhira, zodzoladzola, chakudya, kafukufuku wamankhwala ndi aromatherapy chifukwa cha fungo lake lapadera komanso zochitika zingapo zamoyo.